Ignite Creation Date:
2025-12-24 @ 11:24 PM
Ignite Modification Date:
2026-01-05 @ 12:13 AM
Study NCT ID:
NCT02615756
Status:
COMPLETED
Last Update Posted:
2021-03-09
First Post:
2014-09-10
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Molecular and Functional Neurobiology of Physical Exercise
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D015444', 'term': 'Exercise'}], 'ancestors': [{'id': 'D009043', 'term': 'Motor Activity'}, {'id': 'D009068', 'term': 'Movement'}, {'id': 'D009142', 'term': 'Musculoskeletal Physiological Phenomena'}, {'id': 'D055687', 'term': 'Musculoskeletal and Neural Physiological Phenomena'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 24}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2013-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2021-03', 'completionDateStruct': {'date': '2018-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2021-03-04', 'studyFirstSubmitDate': '2014-09-10', 'studyFirstSubmitQcDate': '2015-11-23', 'lastUpdatePostDateStruct': {'date': '2021-03-09', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2015-11-26', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2018-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Binding of [11C]carfentanil in brain confirmed by positron emission tomography', 'timeFrame': 'Baseline and 20 min after physical exercise completion', 'description': 'Change in binding of \\[11C\\]carfentanil in baseline and 20 min after physical exercise completion'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Physical Exercise Behavior (Liking/Aversion)']}, 'descriptionModule': {'briefSummary': 'In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Native Finnish speaker\n2. Age \\> 18 years\n3. Western Caucasian origin\n\nExclusion Criteria:\n\n1. Age \\< 18 or \\> 65\n2. History or current mental disorder\n3. BMI \\> 27 kg/m2\n4. Use of drugs that influence the central nervous system, including nicotine\n5. Poor compliance\n6. Any chronic medical defect or injury which hinder or interfere everyday life\n7. Eating disorder\n8. Current or past excessive use of alcohol or substance abuse\n9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv\n10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results\n11. Presence of any ferromagnetic objects that would make MR imaging contraindicated'}, 'identificationModule': {'nctId': 'NCT02615756', 'acronym': 'EXEBRAIN', 'briefTitle': 'Molecular and Functional Neurobiology of Physical Exercise', 'organization': {'class': 'OTHER_GOV', 'fullName': 'Turku University Hospital'}, 'officialTitle': 'Molecular and Functional Neurobiology of Physical Exercise', 'orgStudyIdInfo': {'id': '19/180/2013'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Physical exercise', 'interventionNames': ['Behavioral: Exercise']}], 'interventions': [{'name': 'Exercise', 'type': 'BEHAVIORAL', 'armGroupLabels': ['Physical exercise']}]}, 'contactsLocationsModule': {'locations': [{'zip': '20810', 'city': 'Turku', 'country': 'Finland', 'facility': 'Turku PET Centre', 'geoPoint': {'lat': 60.45148, 'lon': 22.26869}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Turku University Hospital', 'class': 'OTHER_GOV'}, 'collaborators': [{'name': 'Academy of Finland', 'class': 'OTHER'}, {'name': 'Novo Nordisk A/S', 'class': 'INDUSTRY'}, {'name': 'Juho Vainio Foundation', 'class': 'OTHER'}, {'name': 'University of Turku', 'class': 'OTHER'}], 'responsibleParty': {'type': 'SPONSOR'}}}}