Ignite Creation Date:
2025-12-24 @ 11:16 PM
Ignite Modification Date:
2025-12-25 @ 8:54 PM
Study NCT ID:
NCT04352556
Status:
UNKNOWN
Last Update Posted:
2022-09-23
First Post:
2020-04-09
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
COVID19-hematological Malignancies: the Italian Hematology Alliance
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000086382', 'term': 'COVID-19'}, {'id': 'D019337', 'term': 'Hematologic Neoplasms'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D009101', 'term': 'Multiple Myeloma'}], 'ancestors': [{'id': 'D011024', 'term': 'Pneumonia, Viral'}, {'id': 'D011014', 'term': 'Pneumonia'}, {'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D018352', 'term': 'Coronavirus Infections'}, {'id': 'D003333', 'term': 'Coronaviridae Infections'}, {'id': 'D030341', 'term': 'Nidovirales Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 250}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-04-07', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-09', 'completionDateStruct': {'date': '2022-10-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2022-09-22', 'studyFirstSubmitDate': '2020-04-09', 'studyFirstSubmitQcDate': '2020-04-16', 'lastUpdatePostDateStruct': {'date': '2022-09-23', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-04-20', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-10-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'To evaluate mortality.', 'timeFrame': 'At 2 months from study initiation', 'description': 'The percentage of HM patients with COVID-19 who died.'}, {'measure': 'To evaluate potential predictive biochemical parameters of mortality.', 'timeFrame': 'At 2 months from study initiation', 'description': 'We will assess the correlation between some biochemical parameters at diagnosis of COVID (i.e. hemoglobin, platelets, lymphocytes, clotting tests, CRP), each on the basis of its specific unit of measure, and mortality.'}, {'measure': 'To evaluate potential predictive HM-related parameters of mortality.', 'timeFrame': 'At 2 months from study initiation', 'description': 'We will assess the correlation between HM-related parameters at diagnosis of COVID \\[i.e. disease type (leukemia, lymphomas, myeloma), disease status (remission / stable / progression), therapy status (on / off therapy)\\] and mortality.'}, {'measure': 'To evaluate COVID severity as predictive parameter of mortality.', 'timeFrame': 'At 2 months from study initiation', 'description': 'We will assess the correlation between COVID severity \\[mild (non-pneumonia and mild pneumonia), severe (dyspnea, respiratory frequency ≥ 30/min, SpO2 ≤ 93%, PaO2/FiO2 \\< 300 and/or lung infiltrates \\> 50%) and critical (respiratory failure, septic shock, and/or multiple organ disfunction or failure)\\] and mortality'}], 'secondaryOutcomes': [{'measure': 'Epidemiology of patients with HM infected by SARS-CoV-2with any spectrum of illness severity', 'timeFrame': 'At 6 months from study initiation', 'description': 'Description of the different types of hematological malignancies (WHO criteria) in patients with SARS-CoV-2 infection. All aggregated data will be stratified on the basis of COVID severity: mild (non-pneumonia and mild pneumonia), severe (dyspnea, respiratory frequency ≥ 30/min, SpO2 ≤ 93%, PaO2/FiO2 \\< 300 and/or lung infiltrates \\> 50%) and critical disease (respiratory failure, septic shock, and/or multiple organ disfunction or failure)'}, {'measure': 'Definition of complete clinical picture of COVID-19 in HM', 'timeFrame': 'At 2 months from study initiation', 'description': 'Characterization of clinical and biochemical profile of patients with SARS-CoV-2 positivity.'}, {'measure': 'Evolution of HM', 'timeFrame': 'At 2 months from study initiation', 'description': 'Assessment of HM status post SARS-CoV-2 infection stratified as no implication, loss of response, progression of the hematological disease.'}, {'measure': 'To evaluate admission to ICU requiring mechanical ventilation or death per characteristics', 'timeFrame': 'At 2 months from study initiation', 'description': 'Percentage of HM patients being admitted to ICU requiring mechanical ventilation, or death stratified per disease type, status, per off-therapy/on-therapy, per type of therapy (chemo, immunotherapy, cell therapy, stem cell transplant).'}, {'measure': 'Viral dynamics in infected HM patients', 'timeFrame': 'At 12 months from study initiation'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Hematological Malignancies', 'Covid-19', 'SARS-CoV-2', 'Italian Hematology Alliance', 'Leukemia', 'Lymphoma', 'Multiple Myeloma'], 'conditions': ['SARS-CoV-2 Infection', 'Hematological Malignancies']}, 'referencesModule': {'references': [{'pmid': '32109013', 'type': 'BACKGROUND', 'citation': 'Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.'}, {'pmid': '32007145', 'type': 'BACKGROUND', 'citation': 'Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.'}, {'pmid': '32142622', 'type': 'BACKGROUND', 'citation': 'Xia Y, Jin R, Zhao J, Li W, Shen H. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020 Apr;21(4):e180. doi: 10.1016/S1470-2045(20)30150-9. Epub 2020 Mar 3. No abstract available.'}, {'pmid': '32142621', 'type': 'BACKGROUND', 'citation': 'Wang H, Zhang L. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020 Apr;21(4):e181. doi: 10.1016/S1470-2045(20)30149-2. Epub 2020 Mar 3. No abstract available.'}, {'pmid': '29282274', 'type': 'BACKGROUND', 'citation': 'Corrao G, Rea F, Di Martino M, De Palma R, Scondotto S, Fusco D, Lallo A, Belotti LMB, Ferrante M, Pollina Addario S, Merlino L, Mancia G, Carle F. Developing and validating a novel multisource comorbidity score from administrative data: a large population-based cohort study from Italy. BMJ Open. 2017 Dec 26;7(12):e019503. doi: 10.1136/bmjopen-2017-019503.'}, {'pmid': '34644385', 'type': 'DERIVED', 'citation': 'Visco C, Marcheselli L, Mina R, Sassone M, Guidetti A, Penna D, Cattaneo C, Bonuomo V, Busca A, Ferreri AJM, Bruna R, Petrucci L, Cairoli R, Salvini M, Bertu L, Ladetto M, Pilerci S, Pinto A, Ramadan S, Marchesi F, Cavo M, Arcaini L, Coviello E, Romano A, Musto P, Massaia M, Fracchiolla N, Marchetti M, Scattolin A, Tisi MC, Cuneo A, Della Porta M, Trentin L, Turrini M, Gherlinzoni F, Tafuri A, Galimberti S, Bocchia M, Cardinali V, Cilloni D, Corso A, Armiento D, Rigacci L, La Barbera EO, Gambacorti-Passerini C, Visani G, Vallisa D, Venditti A, Selleri C, Conconi A, Tosi P, Lanza F, Candoni A, Krampera M, Corradini P, Passamonti F, Merli F; ITA-HEMA-COV investigators. A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. Blood Adv. 2022 Jan 11;6(1):327-338. doi: 10.1182/bloodadvances.2021005691.'}, {'pmid': '32798473', 'type': 'DERIVED', 'citation': 'Passamonti F, Cattaneo C, Arcaini L, Bruna R, Cavo M, Merli F, Angelucci E, Krampera M, Cairoli R, Della Porta MG, Fracchiolla N, Ladetto M, Gambacorti Passerini C, Salvini M, Marchetti M, Lemoli R, Molteni A, Busca A, Cuneo A, Romano A, Giuliani N, Galimberti S, Corso A, Morotti A, Falini B, Billio A, Gherlinzoni F, Visani G, Tisi MC, Tafuri A, Tosi P, Lanza F, Massaia M, Turrini M, Ferrara F, Gurrieri C, Vallisa D, Martelli M, Derenzini E, Guarini A, Conconi A, Cuccaro A, Cudillo L, Russo D, Ciambelli F, Scattolin AM, Luppi M, Selleri C, Ortu La Barbera E, Ferrandina C, Di Renzo N, Olivieri A, Bocchia M, Gentile M, Marchesi F, Musto P, Federici AB, Candoni A, Venditti A, Fava C, Pinto A, Galieni P, Rigacci L, Armiento D, Pane F, Oberti M, Zappasodi P, Visco C, Franchi M, Grossi PA, Bertu L, Corrao G, Pagano L, Corradini P; ITA-HEMA-COV Investigators. Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study. Lancet Haematol. 2020 Oct;7(10):e737-e745. doi: 10.1016/S2352-3026(20)30251-9. Epub 2020 Aug 13.'}]}, 'descriptionModule': {'briefSummary': 'This is a retrospective/prospective, cohort, non-interventional observational study. This means that all patients with documented COVID and HM diagnosed between February 2020 and study initiation will compose the retrospective part, while those diagnosed after study approval will enter prospective part.\n\nThe total duration of the study will be 12 months.\n\nThe study population will must be older than 18 years of age with HM and SARS-CoV-2 infection. All patients with documented SARS-CoV-2 infection (COVID) and history or active hematological malignancies, who refer to any Hematological Unit will be included.', 'detailedDescription': 'This is a retrospective/prospective, cohort, non-interventional observational study. An informed consensus for the participation is available. In this section we provide informations on sample size and statistical analysis.\n\nIn Italy, the projected estimate of complete HM prevalence at Jan 1, 2020 has been established as 48,254 cases for Hodgkin lymphoma, 110.715 cases for non Hodgkin Lymphomas, 67,301 for leukemias, and 25,066 for multiple myeloma (Guzzinati et al, BMC Cancer 2018). The Italian Dipartimento della Protezione Civile website reported (March 23, 2020) that 63,927 cases are currently infected with SARS-CoV-2. No formal sample size calculation was made for this project but, on the basis of data available to date, considering the prevalence of hematological patients in Italy (0.4%) and assuming that these patients have the same risk of contracting COVID-19 as the general population, we supposed to enroll at least 250 patients (at March 24, 2020).\n\nStatistical analyses All data collected will be summarized using appropriate descriptive statistics: absolute and relative frequencies for discrete variables; mean, standard deviation, median and interquartile range for continuous ones. To identify factors significantly associated with composite endpoint, log-binomial regression will be used for modelling risk ratio together with 95% confidence interval estimated.\n\nThe least absolute shrinkage and selection operator (LASSO) method will be applied for selecting the factors able to independently predict primary end-point. LASSO selects variables correlates to the measured outcome by shrinking coefficients weights, down to zero for the ones not correlated to outcome. In addition, machine learning techniques will be used for validating results from LASSO. A weight will be assigned to each coefficient of the selected predictors and weights will be summed to produce a total aggregate score. Predictive performance will be assessed through discrimination and calibration. Discrimination indicates how well the model can distinguish individuals with the outcome from those without the outcome. Two, the net reclassification improvement (NRI) will be calculated for assessing the \'net\' number of individuals correctly reclassified using "the new model" over a comparator index \\[i.e., CCI (Charlson Comorbidity Score) or MCS (Multisource Comorbidity Score), or HM-disease specific\\]. Calibration ascertains the concordance between the model\'s predictions and observed outcomes, which we evaluated using a calibration plot. Cartographic and geostatistical methods will be used to exploring the spatial patterns of disease. An Exploratory Spatial Data Analysis (ESDA) and the Kriging method will be also applied to describe and model spatial (geographical) pattern.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The study population will must be older than 18 years of age with Hematological malignancies and SARS-CoV-2 infection.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age equal to or greater than 18 years of age.\n* History of hematological malignancies (acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, lymphomas, myeloma).\n* Active hematological malignancies (acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, lymphomas, myeloma) at any stage/status.\n* SARS-CoV-2 positive test (nasopharyngeal, BAL, fecal), documented by Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panels.\n\nExclusion Criteria:\n\n* Hematological diseases, other than hematological malignancies.\n* SARS-CoV-2 negative test.'}, 'identificationModule': {'nctId': 'NCT04352556', 'briefTitle': 'COVID19-hematological Malignancies: the Italian Hematology Alliance', 'organization': {'class': 'OTHER', 'fullName': 'Ospedale di Circolo - Fondazione Macchi'}, 'officialTitle': 'SARS-CoV-2 Infection in Patients With Hematological Malignancies: the Italian Hematology Alliance', 'orgStudyIdInfo': {'id': 'HM-COVID19-Italy'}}, 'contactsLocationsModule': {'locations': [{'city': 'Alessandria', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Marco Ladetto, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia Ospedale SS Antonio e Biagio e Cesare Arrigo', 'geoPoint': {'lat': 44.90924, 'lon': 8.61007}}, {'city': 'Ancona', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Attilio Olivieri, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, Ospedali Riuniti', 'geoPoint': {'lat': 43.60717, 'lon': 13.5103}}, {'city': 'Ascoli Piceno', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Piero Galieni, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia e Terapia Cellulare, Ospedale Mazzoni', 'geoPoint': {'lat': 42.85351, 'lon': 13.57395}}, {'city': 'Aviano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michele Spina, MD', 'role': 'CONTACT'}], 'facility': 'SC Oncologia Medica, CRO', 'geoPoint': {'lat': 46.07056, 'lon': 12.59472}}, {'city': 'Bari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Pellegrino Musto, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia, Policlinico Bari', 'geoPoint': {'lat': 41.12066, 'lon': 16.86982}}, {'city': 'Bari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Attilio Guarini, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, I.R.C.C.S Istituto Tumori Giovanni Paolo II', 'geoPoint': {'lat': 41.12066, 'lon': 16.86982}}, {'city': 'Biella', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Anna Conconi, MD', 'role': 'CONTACT'}], 'facility': 'SSD Ematologia, Ospedale degli Infermi', 'geoPoint': {'lat': 45.56304, 'lon': 8.05796}}, {'city': 'Bologna', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michele Cavo, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, Azienda Ospedaliero-Universitaria Policlinico S.Orsola-Malpighi,', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'city': 'Bolzano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Atto Billio, MD', 'role': 'CONTACT'}], 'facility': 'Ematologia e Centro Trapianto Midollo Osseo, Ospedale di Bolzano', 'geoPoint': {'lat': 46.49067, 'lon': 11.33982}}, {'city': 'Brescia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Domenico Russo, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia e CTMO, ASST Spedali Civili', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'city': 'Brescia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Chiara Cattaneo, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia e CTMO, ASST Spedali Civili', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'city': 'Busto Arsizio', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Fabrizio Ciambelli, MD', 'role': 'CONTACT'}], 'facility': 'UOC Onco-Ematologia ASST Valle Olona', 'geoPoint': {'lat': 45.61128, 'lon': 8.84914}}, {'city': 'Cagliari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giorgio La Nasa, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia e CTMO AZIENDA OSPEDALIERA "G. BROTZU" - OSPEDALE ONCOLOGICO BUSINCO', 'geoPoint': {'lat': 39.23054, 'lon': 9.11917}}, {'city': 'Catania', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Francesco Di Raimondo, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, AOU Policlinico Vittorio Emanuele', 'geoPoint': {'lat': 37.49223, 'lon': 15.07041}}, {'city': 'Como', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Mauro Turrini, MD', 'role': 'CONTACT'}], 'facility': 'Ematologia, Ospedale Valduce', 'geoPoint': {'lat': 45.80819, 'lon': 9.0832}}, {'city': 'Cosenza', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Massimo Gentile, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, Azienda Ospedaliera di Cosenza', 'geoPoint': {'lat': 39.2989, 'lon': 16.25307}}, {'city': 'Cremona', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alfredo Molteni, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia e CTMO, ASST Cremona', 'geoPoint': {'lat': 45.13325, 'lon': 10.02129}}, {'city': 'Cuneo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Massimo Massaia, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia Ospedale S. Croce', 'geoPoint': {'lat': 44.39071, 'lon': 7.54828}}, {'city': 'Ferrara', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonio Cuneo, MD', 'role': 'CONTACT'}], 'facility': 'UOC, Ematologia Azienda Ospedaliero Universitaria Arcispedale S. Anna', 'geoPoint': {'lat': 44.83804, 'lon': 11.62057}}, {'city': 'Florence', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alberto Bosi, MD', 'role': 'CONTACT'}], 'facility': 'S.O.D. Ematologia, Azienda Ospedaliero Universitaria Careggi', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'city': 'Foggia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Celestino Ferrandina, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, Policlinico Ospedali Riuniti', 'geoPoint': {'lat': 41.45845, 'lon': 15.55188}}, {'city': 'Forlì', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giovanni Martinelli, MD', 'role': 'CONTACT'}], 'facility': 'IRST-IRCC di Meldola', 'geoPoint': {'lat': 44.22177, 'lon': 12.04144}}, {'city': 'Genova', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Roberto Lemoli, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia, Ospedale Policlinico S.Martino IRCCS', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'city': 'Genova', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Emanuele Angelucci, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia, Ospedale Policlinico San Martino', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'city': 'Lecce', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nicola Di Renzo, MD', 'role': 'CONTACT'}], 'facility': 'UOC di Ematologia e Trapianto di Cellule Staminali, P.O. Vito Fazzi', 'geoPoint': {'lat': 40.35481, 'lon': 18.17244}}, {'city': 'Legnano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alessandro Corso, MD', 'role': 'CONTACT'}], 'facility': 'UOC di Ematologia, Ospedale di Legnano', 'geoPoint': {'lat': 45.59788, 'lon': 8.91506}}, {'city': 'Livorno', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Annarosa Cuccaro, MD', 'role': 'CONTACT'}], 'facility': 'UO Dipartimento di Ematologia, USL 6', 'geoPoint': {'lat': 43.54427, 'lon': 10.32615}}, {'city': 'Lodi', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alessandro Inzoli, MD', 'role': 'CONTACT'}], 'facility': 'UOC Oncologia ASST Lodi', 'geoPoint': {'lat': 45.30989, 'lon': 9.50085}}, {'city': 'Messina', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Caterina Musolino, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia Azienda Ospedaliera Universitaria "G.Martino"', 'geoPoint': {'lat': 38.19394, 'lon': 15.55256}}, {'city': 'Mestre', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Renato Bassan, MD', 'role': 'CONTACT'}], 'facility': "UO Ematologia, Ospedale dell'Angelo di Mestre", 'geoPoint': {'lat': 45.49167, 'lon': 12.24538}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Corrado Tarella, MD', 'role': 'CONTACT'}], 'facility': 'Ematologia, IEO', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Paolo Corradini, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia, Istituto Nazionale dei Tumori', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Roberto Cairoli, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia, Ospedale Niguarda', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Fabio Ciceri, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia, IRCCS Ospedale San Raffaele', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Augusto Federici, MD', 'role': 'CONTACT'}], 'facility': 'UO Servizio di Ematologia e Medicina Trasfusionale, Ospedale Luigi Sacco', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nicola Fracchiolla, MD', 'role': 'CONTACT'}], 'facility': "UOC Ematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico", 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Modena', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Mario Luppi, MD', 'role': 'CONTACT'}], 'facility': 'UO Ematologia Policlinico di Modena', 'geoPoint': {'lat': 44.64783, 'lon': 10.92539}}, {'city': 'Monza', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Carlo Gambacorti Passerini, MD', 'role': 'CONTACT'}], 'facility': 'UOC Ematologia, Ospedale S. Gerardo', 'geoPoint': {'lat': 45.58005, 'lon': 9.27246}}, {'city': 'Napoli', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonio Pinto, MD', 'role': 'CONTACT'}], 'facility': 'SC Ematologia Istituto Nazionale Tumori - IRCCS "Fondazione G. 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