Viewing Study NCT06221969


Ignite Creation Date: 2025-12-24 @ 10:58 PM
Ignite Modification Date: 2025-12-25 @ 8:27 PM
Study NCT ID: NCT06221969
Status: ACTIVE_NOT_RECRUITING
Last Update Posted: 2025-12-17
First Post: 2024-01-15
Is NOT Gene Therapy: False
Has Adverse Events: False

Brief Title: A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
Sponsor:
Organization:

Raw JSON

{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Czechia', 'France', 'Germany', 'Greece', 'Hungary', 'Poland', 'Romania', 'Spain']}, 'conditionBrowseModule': {'meshes': [{'id': 'D003924', 'term': 'Diabetes Mellitus, Type 2'}], 'ancestors': [{'id': 'D003920', 'term': 'Diabetes Mellitus'}, {'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000717792', 'term': 'cagrilintide'}, {'id': 'C000591245', 'term': 'semaglutide'}, {'id': 'D000098860', 'term': 'Tirzepatide'}], 'ancestors': [{'id': 'D000067757', 'term': 'Glucagon-Like Peptide-1 Receptor'}, {'id': 'D000067756', 'term': 'Glucagon-Like Peptide Receptors'}, {'id': 'D043562', 'term': 'Receptors, G-Protein-Coupled'}, {'id': 'D011956', 'term': 'Receptors, Cell Surface'}, {'id': 'D008565', 'term': 'Membrane Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D011964', 'term': 'Receptors, Gastrointestinal Hormone'}, {'id': 'D018000', 'term': 'Receptors, Peptide'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 1000}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-01-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2026-04-03', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-15', 'studyFirstSubmitDate': '2024-01-15', 'studyFirstSubmitQcDate': '2024-01-15', 'lastUpdatePostDateStruct': {'date': '2025-12-17', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-01-24', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-02-20', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in glycated haemoglobin (HbA1c)', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in percentage (%)-points.'}, {'measure': 'Relative change in body weight', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in percentage (%).'}], 'secondaryOutcomes': [{'measure': 'Change in HbA1c', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in %-points.'}, {'measure': 'Change in fasting plasma glucose (FPG)', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in millimoles per liter (mmol/L).'}, {'measure': 'Achievement of HbA1c target values of less than (<) 7.0% (<53 millimole per mole [mmol/mol])', 'timeFrame': 'At end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Achievement of HbA1c target values of less than or equal to (≤) 6.5% (≤ 48 mmol/mol)', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Achievement of greater than or equal to (≥) 5% weight reduction', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Achievement of ≥ 10% weight reduction', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Achievement of ≥ 15 % weight reduction', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Achievement of ≥ 20 % weight reduction', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Count of participant'}, {'measure': 'Change in systolic blood pressure', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in millimeters of mercury(mmHg).'}, {'measure': 'Change in diastolic blood pressure', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in mmHg.'}, {'measure': 'Change in waist circumference', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in centimeter (cm).'}, {'measure': 'Ratio to baseline in lipids: Total cholesterol', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Ratio to baseline in lipids: High-density lipoprotein (HDL) cholesterol', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Ratio to baseline in lipids: Low-density lipoprotein (LDL) cholesterol', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Ratio to baseline in lipids: Very low-density lipoprotein (VLDL) cholesterol', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Ratio to baseline in lipids: Triglycerides', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Ratio to baseline in lipids: non-HDL cholesterol', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'Measured in ratio.'}, {'measure': 'Change From Baseline in Short Form-36 Version 2 (SF-36v2) (Acute Version) Health Survey', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'The SF-36 v2 will be used to measure differences in quality of life and mental wellbeing. The scores 0-100 (where higher scores indicated a better quality of life and mental wellbeing) from the SF-36 will be converted to a norm-based score using a T-score transformation in order to obtain a direct interpretation in relation to the distribution of the scores in the 1998 United States general population. Measured as score on a scale.'}, {'measure': 'Change in Impact of Weight on Quality of Life-Lite Clinical Trials (IWQOL-Lite-CT) version 3', 'timeFrame': 'From baseline (week 0) to end of treatment (week 68)', 'description': 'IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Higher scores indicate better levels of functioning. Composite scores (score range): Physical composite (0-100), Psychosocial composite (0-100), Physical Function composite (0-100). Total score (0-100). Higher scores indicate better level of functioning.'}, {'measure': 'Number of Treatment-emergent Adverse Events (TEAEs)', 'timeFrame': 'From baseline (week 0) to end of study (week 74)', 'description': 'Count of events'}, {'measure': 'Number of clinically significant hypoglycaemic episodes (level 2) (<3.0 mmol/L (<54 milligram per deciliter [mg/dL]), confirmed by blood glucose meter)', 'timeFrame': 'From baseline (week 0) to end of study (week 74)', 'description': 'Count of episodes'}, {'measure': 'Number of severe hypoglycaemic episodes (level 3): hypoglycaemia associated with severe cognitive impairment requiring external assistance for recovery, with no specific glucose threshold', 'timeFrame': 'From baseline (week 0) to end of study (week 74)', 'description': 'Count of episodes'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Type 2 Diabetes']}, 'descriptionModule': {'briefSummary': 'This study will look at how well CagriSema helps people with type 2 diabetes lower their blood sugar and body weight. CagriSema is a new investigational medicine. Doctors may not yet prescribe CagriSema. CagriSema will be compared to a medicine called tirzepatide that doctors may prescribe in some countries. Participants will get either CagriSema or tirzepatide. Which treatment participant get is decided by chance like flipping a coin. Participant will have an equal chance of receiving either drug. For each participant, the study will last for up to one and a half years.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Male or female (sex at birth).\n* Age 18 years or above at the time of signing the informed consent.\n* Diagnosed with type 2 diabetes ≥ 180 days before screening.\n* Stable daily dose(s) ≥ 90 days before screening of any of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator: metformin with or without an sodium-glucose co-transporter-2 (SGLT2) inhibitor.\n* HbA1c 7.0-10.5% (53-91 mmol/mol) (both inclusive) as determined by central laboratory at screening.\n* Body mass index (BMI) of ≥ 30.0 kilogram per square meter (kg/m\\^2) at screening. BMI will be calculated in the electronic case report form (eCRF) based on height and body weight at screening.\n\nExclusion Criteria:\n\n* Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using a highly effective contraceptive method.\n* Renal impairment with estimated Glomerular Filtration Rate \\< 30 milliliter per minute per 1.73 square meter (mL/min/1.73 m\\^2) as determined by central laboratory at screening.\n* Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed.\n* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.'}, 'identificationModule': {'nctId': 'NCT06221969', 'briefTitle': 'A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor', 'organization': {'class': 'INDUSTRY', 'fullName': 'Novo Nordisk A/S'}, 'officialTitle': 'Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) 2.4 mg/2.4 mg s.c. Once Weekly Versus Tirzepatide 15 mg s.c. Once Weekly in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor', 'orgStudyIdInfo': {'id': 'NN9388-4894'}, 'secondaryIdInfos': [{'id': 'U1111-1282-5561', 'type': 'OTHER', 'domain': 'World Health Organization (WHO)'}, {'id': '2023-503789-21-00', 'type': 'OTHER', 'domain': 'European Medical Agency (EMA)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CagriSema', 'description': 'Participants will receive cagrilintide dose 1 and semaglutide dose 2 subcutaneously once-weekly (dose escalation period of 16 weeks) for up to 68 weeks.', 'interventionNames': ['Drug: Cagrilintide', 'Drug: Semaglutide']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Tirzepatide', 'description': 'Participants will receive tirzepatide dose 1 subcutaneously once-weekly (dose escalation period of 20 weeks) for up to 68 weeks.', 'interventionNames': ['Drug: Tirzepatide']}], 'interventions': [{'name': 'Cagrilintide', 'type': 'DRUG', 'description': 'Cagrilintide will be administered subcutaneously.', 'armGroupLabels': ['CagriSema']}, {'name': 'Semaglutide', 'type': 'DRUG', 'description': 'Semaglutide will be administered subcutaneously.', 'armGroupLabels': ['CagriSema']}, {'name': 'Tirzepatide', 'type': 'DRUG', 'description': 'Tirzepatide will be administered subcutaneously.', 'armGroupLabels': ['Tirzepatide']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35211', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Synexus Clin Res-Birmingham', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Univ of Alabama_Birmingham', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85296', 'city': 'Gilbert', 'state': 'Arizona', 'country': 'United States', 'facility': 'Prime Medical Group, LLC', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '85006', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Velocity Clinical Research-Phoenix', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85020', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Synexus Rsch /Cnt Phnx Med C', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Arkansas Clinical Research', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '72143', 'city': 'Searcy', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Unity Health-Searcy Medical Center', 'geoPoint': {'lat': 35.25064, 'lon': -91.73625}}, {'zip': '91911', 'city': 'Chula Vista', 'state': 'California', 'country': 'United States', 'facility': 'Velocity Clin Res-Chula Vista', 'geoPoint': {'lat': 32.64005, 'lon': -117.0842}}, {'zip': '92025', 'city': 'Escondido', 'state': 'California', 'country': 'United States', 'facility': 'Headlands Research California, LLC', 'geoPoint': {'lat': 33.11921, 'lon': -117.08642}}, {'zip': '92025', 'city': 'Escondido', 'state': 'California', 'country': 'United States', 'facility': 'Neighborhood Healthcare', 'geoPoint': {'lat': 33.11921, 'lon': -117.08642}}, {'zip': '92835', 'city': 'Fullerton', 'state': 'California', 'country': 'United States', 'facility': 'St. Jude Heritage Yorba Linda - Pediatric Ste D', 'geoPoint': {'lat': 33.87029, 'lon': -117.92534}}, {'zip': '91942', 'city': 'La Mesa', 'state': 'California', 'country': 'United States', 'facility': 'Diabetes & Endocrine Specialists - La Mesa', 'geoPoint': {'lat': 32.76783, 'lon': -117.02308}}, {'zip': '91942', 'city': 'La Mesa', 'state': 'California', 'country': 'United States', 'facility': 'Diabetes and Endocrine Specialists - La Mesa', 'geoPoint': {'lat': 32.76783, 'lon': -117.02308}}, {'zip': '91942', 'city': 'La Mesa', 'state': 'California', 'country': 'United States', 'facility': 'Velocity Clin Res San Diego', 'geoPoint': {'lat': 32.76783, 'lon': -117.02308}}, {'zip': '95648', 'city': 'Lincoln', 'state': 'California', 'country': 'United States', 'facility': 'Clinical Trials Research', 'geoPoint': {'lat': 38.89156, 'lon': -121.29301}}, {'zip': '92354', 'city': 'Loma Linda', 'state': 'California', 'country': 'United States', 'facility': 'Loma Linda Univ Hlth Cr Endo', 'geoPoint': {'lat': 34.04835, 'lon': -117.26115}}, {'zip': '91325', 'city': 'Northridge', 'state': 'California', 'country': 'United States', 'facility': 'Valley Clinical Trials, Inc.', 'geoPoint': {'lat': 34.22834, 'lon': -118.53675}}, {'zip': '92262', 'city': 'Palm Springs', 'state': 'California', 'country': 'United States', 'facility': 'Desert Oasis Healthcare', 'geoPoint': {'lat': 33.8303, 'lon': -116.54529}}, {'zip': '91402', 'city': 'Panorama City', 'state': 'California', 'country': 'United States', 'facility': 'Velocity Clin Res - Panorama', 'geoPoint': {'lat': 34.22473, 'lon': -118.44981}}, {'zip': '91766', 'city': 'Pomona', 'state': 'California', 'country': 'United States', 'facility': 'Western University of Health Sciences', 'geoPoint': {'lat': 34.05529, 'lon': -117.75228}}, {'zip': '95148', 'city': 'San Jose', 'state': 'California', 'country': 'United States', 'facility': 'Endocrinology Josel Cabaccan', 'geoPoint': {'lat': 37.33939, 'lon': -121.89496}}, {'zip': '94401', 'city': 'San Mateo', 'state': 'California', 'country': 'United States', 'facility': 'Mills-Peninsula Medical Center', 'geoPoint': {'lat': 37.56299, 'lon': -122.32553}}, {'zip': '94583', 'city': 'San Ramon', 'state': 'California', 'country': 'United States', 'facility': 'NorCal Endocrinology and Internal Medicine', 'geoPoint': {'lat': 37.77993, 'lon': -121.97802}}, {'zip': '91602', 'city': 'Toluca Lake', 'state': 'California', 'country': 'United States', 'facility': 'Premier Medical Center, Inc.', 'geoPoint': {'lat': 34.15206, 'lon': -118.35719}}, {'zip': '91405', 'city': 'Van Nuys', 'state': 'California', 'country': 'United States', 'facility': 'Velocity Clin Res - Panorama', 'geoPoint': {'lat': 34.18667, 'lon': -118.44897}}, {'zip': '94598', 'city': 'Walnut Creek', 'state': 'California', 'country': 'United States', 'facility': 'Diablo Clinical Research, Inc.', 'geoPoint': {'lat': 37.90631, 'lon': -122.06496}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'country': 'United States', 'facility': 'University of Colorado Hospital', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80906', 'city': 'Colorado Springs', 'state': 'Colorado', 'country': 'United States', 'facility': 'Optumcare Clinical Trials,LLC-Golden', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Northeast Res Inst. Inc.', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33144', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Clinical Trial Services Corp', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33155', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Bioclinical Research Alliance', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33165', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'New Horizon Research Center', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33027', 'city': 'Miramar', 'state': 'Florida', 'country': 'United States', 'facility': 'South Broward Research LLC', 'geoPoint': {'lat': 25.98731, 'lon': -80.23227}}, {'zip': '34761', 'city': 'Ocoee', 'state': 'Florida', 'country': 'United States', 'facility': 'West Orange Endocrinology', 'geoPoint': {'lat': 28.56917, 'lon': -81.54396}}, {'zip': '32763', 'city': 'Orange City', 'state': 'Florida', 'country': 'United States', 'facility': 'Optimal Research Sites', 'geoPoint': {'lat': 28.94888, 'lon': -81.29867}}, {'zip': '32804', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Trans Res Inst for Met & Diab', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32765', 'city': 'Oviedo', 'state': 'Florida', 'country': 'United States', 'facility': 'Oviedo Medical Research, LLC', 'geoPoint': {'lat': 28.67, 'lon': -81.20812}}, {'zip': '30094', 'city': 'Conyers', 'state': 'Georgia', 'country': 'United States', 'facility': 'Hope Clin Res & Wellness', 'geoPoint': {'lat': 33.66761, 'lon': -84.01769}}, {'zip': '30501', 'city': 'Gainesville', 'state': 'Georgia', 'country': 'United States', 'facility': 'Center for Adv Res & Education', 'geoPoint': {'lat': 34.29788, 'lon': -83.82407}}, {'zip': '30067', 'city': 'Marietta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Urban Family Practice Assoc', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '30076', 'city': 'Roswell', 'state': 'Georgia', 'country': 'United States', 'facility': 'Endocrine Research Solutions', 'geoPoint': {'lat': 34.02316, 'lon': -84.36159}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Pacific Diabetes & Endo Ctr', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '83702', 'city': 'Boise', 'state': 'Idaho', 'country': 'United States', 'facility': "St. Luke's Health System", 'geoPoint': {'lat': 43.6135, 'lon': -116.20345}}, {'zip': '83646', 'city': 'Meridian', 'state': 'Idaho', 'country': 'United States', 'facility': 'Solaris Clinical Research', 'geoPoint': {'lat': 43.61211, 'lon': -116.39151}}, {'zip': '60607', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Cedar-Crosse Research Center', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60031', 'city': 'Gurnee', 'state': 'Illinois', 'country': 'United States', 'facility': 'Clinical Invest Special_Gurnee', 'geoPoint': {'lat': 42.3703, 'lon': -87.90202}}, {'zip': '60077', 'city': 'Skokie', 'state': 'Illinois', 'country': 'United States', 'facility': 'Endeavor Health', 'geoPoint': {'lat': 42.03336, 'lon': -87.73339}}, {'zip': '60077', 'city': 'Skokie', 'state': 'Illinois', 'country': 'United States', 'facility': 'Evanston Premier Hlthcr Res', 'geoPoint': {'lat': 42.03336, 'lon': -87.73339}}, {'zip': '46140', 'city': 'Greenfield', 'state': 'Indiana', 'country': 'United States', 'facility': 'American Health Network of Indiana, LLC_Greenfield', 'geoPoint': {'lat': 39.78504, 'lon': -85.76942}}, {'zip': '50266', 'city': 'West Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Iowa Diabetes & Endo Res Ctr', 'geoPoint': {'lat': 41.57721, 'lon': -93.71133}}, {'zip': '66606', 'city': 'Topeka', 'state': 'Kansas', 'country': 'United States', 'facility': "Cotton-O'Neil Diab & Endo Ctr", 'geoPoint': {'lat': 39.04833, 'lon': -95.67804}}, {'zip': '70508', 'city': 'Lafayette', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Velocity Clin Res Lafayette', 'geoPoint': {'lat': 30.22409, 'lon': -92.01984}}, {'zip': '20782', 'city': 'Hyattsville', 'state': 'Maryland', 'country': 'United States', 'facility': 'MedStar Hlth Res Institute', 'geoPoint': {'lat': 38.95594, 'lon': -76.94553}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Joslin Diabetes Center', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '55416', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'International Diabetes Center', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '39038', 'city': 'Belzoni', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Belzoni Clinical Research', 'geoPoint': {'lat': 33.18429, 'lon': -90.48926}}, {'zip': '39503', 'city': 'Gulfport', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Velocity Clin Res Gulfport', 'geoPoint': {'lat': 30.36742, 'lon': -89.09282}}, {'zip': '63017', 'city': 'Chesterfield', 'state': 'Missouri', 'country': 'United States', 'facility': 'Diabetes & Endo Specialists Inc', 'geoPoint': {'lat': 38.66311, 'lon': -90.57707}}, {'zip': '63303', 'city': 'City of Saint Peters', 'state': 'Missouri', 'country': 'United States', 'facility': 'StudyMetrix Research LLC', 'geoPoint': {'lat': 38.80033, 'lon': -90.62651}}, {'zip': '63128', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': 'Amicis Centers of Clinical Research', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '87107', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'Velocity Clin Res Albuquerque', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '12203', 'city': 'Albany', 'state': 'New York', 'country': 'United States', 'facility': 'AMC Community Endocrinology', 'geoPoint': {'lat': 42.65258, 'lon': -73.75623}}, 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