Ignite Creation Date:
2025-12-24 @ 10:55 PM
Ignite Modification Date:
2026-02-23 @ 4:30 AM
Study NCT ID:
NCT02566369
Status:
COMPLETED
Last Update Posted:
2019-11-12
First Post:
2015-10-01
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Efficacy and Safety of CD5789 (Trifarotene) 50μg/g Cream Versus Vehicle Cream in Acne Vulgaris
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000152', 'term': 'Acne Vulgaris'}], 'ancestors': [{'id': 'D017486', 'term': 'Acneiform Eruptions'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D012625', 'term': 'Sebaceous Gland Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000629420', 'term': 'trifarotene'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'anne.fulton@galderma.com', 'phone': '+1 817-961-5203', 'title': 'Anne Fulton', 'organization': 'Galderma S.A.'}, 'certainAgreement': {'restrictionType': 'LTE60', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': "Each participant's adverse events were collected starting at the first visit (screening) until the last visit (Week 12).", 'eventGroups': [{'id': 'EG000', 'title': 'CD5789 (Trifarotene) 50μg/g Cream', 'description': 'CD5789 (trifarotene) 50µg/g cream applied once daily for 12 weeks.', 'otherNumAtRisk': 612, 'deathsNumAtRisk': 612, 'otherNumAffected': 177, 'seriousNumAtRisk': 612, 'deathsNumAffected': 0, 'seriousNumAffected': 4}, {'id': 'EG001', 'title': 'Placebo Cream', 'description': 'Placebo cream applied once daily for 12 weeks', 'otherNumAtRisk': 596, 'deathsNumAtRisk': 596, 'otherNumAffected': 74, 'seriousNumAtRisk': 596, 'deathsNumAffected': 0, 'seriousNumAffected': 2}], 'otherEvents': [{'term': 'Sunburn', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 27}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 5}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 12}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Application Site Irritation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 66}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 4}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Application Site Pruritis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 24}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 8}], 'organSystem': 'General disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Skin Irritation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 8}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 0}], 'organSystem': 'Skin and subcutaneous tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Nasopharyngitis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 24}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 27}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Upper Respiratory Tract Infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 10}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 8}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Influenza', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 9}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Sinusitis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 1}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'seriousEvents': [{'term': 'Facial Bones Fracture', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Hereditary angioedema', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 1}], 'organSystem': 'Congenital, familial and genetic disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Procedural dizziness', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Urinary Tract Infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 1}], 'organSystem': 'Renal and urinary disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Infectious Mononucleosis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Cellulitis', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Atypical Pneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 612, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 596, 'numAffected': 1}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Investigator Global Assessment (IGA) Success Rate at Week 12', 'denoms': [{'units': 'Participants', 'counts': [{'value': '612', 'groupId': 'OG000'}, {'value': '596', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'CD5789 (Trifarotene) 50μg/g Cream', 'description': 'CD5789 (trifarotene) 50µg/g cream applied once daily for 12 weeks.'}, {'id': 'OG001', 'title': 'Placebo Cream', 'description': 'Placebo cream applied once daily for 12 weeks'}], 'classes': [{'categories': [{'measurements': [{'value': '180', 'groupId': 'OG000'}, {'value': '116', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'From Baseline to Week 12', 'description': 'Number of subjects who achieved an Investigator Global Assessment (IGA) score of 1 (almost clear) or 0 (Clear) and at least a 2-grade improvement from Baseline to Week 12.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'CD5789 (Trifarotene) 50μg/g Cream', 'description': 'CD5789 (trifarotene) 50µg/g cream applied once daily for 12 weeks.'}, {'id': 'FG001', 'title': 'Placebo Cream', 'description': 'Placebo cream applied once daily for 12 weeks'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '612'}, {'groupId': 'FG001', 'numSubjects': '596'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '540'}, {'groupId': 'FG001', 'numSubjects': '535'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '72'}, {'groupId': 'FG001', 'numSubjects': '61'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '612', 'groupId': 'BG000'}, {'value': '596', 'groupId': 'BG001'}, {'value': '1208', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'CD5789 (Trifarotene) 50μg/g Cream', 'description': 'CD5789 (trifarotene) 50µg/g cream applied once daily for 12 weeks.'}, {'id': 'BG001', 'title': 'Placebo Cream', 'description': 'Placebo cream applied once daily for 12 weeks'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '314', 'groupId': 'BG000'}, {'value': '278', 'groupId': 'BG001'}, {'value': '592', 'groupId': 'BG002'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '298', 'groupId': 'BG000'}, {'value': '318', 'groupId': 'BG001'}, {'value': '616', 'groupId': 'BG002'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '305', 'groupId': 'BG000'}, {'value': '324', 'groupId': 'BG001'}, {'value': '629', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '307', 'groupId': 'BG000'}, {'value': '272', 'groupId': 'BG001'}, {'value': '579', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '135', 'groupId': 'BG000'}, {'value': '148', 'groupId': 'BG001'}, {'value': '283', 'groupId': 'BG002'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '477', 'groupId': 'BG000'}, {'value': '448', 'groupId': 'BG001'}, {'value': '925', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '16', 'groupId': 'BG002'}]}, {'title': 'Asian', 'measurements': [{'value': '23', 'groupId': 'BG000'}, {'value': '32', 'groupId': 'BG001'}, {'value': '55', 'groupId': 'BG002'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}, {'title': 'Black or African American', 'measurements': [{'value': '47', 'groupId': 'BG000'}, {'value': '49', 'groupId': 'BG001'}, {'value': '96', 'groupId': 'BG002'}]}, {'title': 'White', 'measurements': [{'value': '508', 'groupId': 'BG000'}, {'value': '484', 'groupId': 'BG001'}, {'value': '992', 'groupId': 'BG002'}]}, {'title': 'More than one race', 'measurements': [{'value': '8', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '18', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '14', 'groupId': 'BG000'}, {'value': '15', 'groupId': 'BG001'}, {'value': '29', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Canada', 'categories': [{'measurements': [{'value': '70', 'groupId': 'BG000'}, {'value': '69', 'groupId': 'BG001'}, {'value': '139', 'groupId': 'BG002'}]}]}, {'title': 'Puerto Rico', 'categories': [{'measurements': [{'value': '27', 'groupId': 'BG000'}, {'value': '28', 'groupId': 'BG001'}, {'value': '55', 'groupId': 'BG002'}]}]}, {'title': 'Hungary', 'categories': [{'measurements': [{'value': '44', 'groupId': 'BG000'}, {'value': '44', 'groupId': 'BG001'}, {'value': '88', 'groupId': 'BG002'}]}]}, {'title': 'United States', 'categories': [{'measurements': [{'value': '407', 'groupId': 'BG000'}, {'value': '395', 'groupId': 'BG001'}, {'value': '802', 'groupId': 'BG002'}]}]}, {'title': 'Germany', 'categories': [{'measurements': [{'value': '64', 'groupId': 'BG000'}, {'value': '60', 'groupId': 'BG001'}, {'value': '124', 'groupId': 'BG002'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'Physician Global Assessment Scale Face', 'classes': [{'categories': [{'title': 'Clear', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Almost Clear', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Mild', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Moderate', 'measurements': [{'value': '612', 'groupId': 'BG000'}, {'value': '596', 'groupId': 'BG001'}, {'value': '1208', 'groupId': 'BG002'}]}, {'title': 'Severe', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'description': '0 - Clear (Clear skin with no inflammatory or non-inflammatory lesions.)\n\n1. \\- Almost Clear (A few scattered comedones and a few small papules.)\n2. \\- Mild (Easily recognizable; less than half the surface is involved. Some comedones and some papules and pustules.)\n3. \\- Moderate (More than half of the surface is involved. Many comedones, papules and pustules. One nodule may be present.)\n4. \\- Severe (Entire surface is involved. Covered with comedones, numerous papules and pustules. Few nodules may be present.)', 'unitOfMeasure': 'Participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2017-03-10', 'size': 346971, 'label': 'Study Protocol', 'hasIcf': False, 'hasSap': False, 'filename': 'Prot_000.pdf', 'typeAbbrev': 'Prot', 'uploadDate': '2019-04-17T12:16', 'hasProtocol': True}, {'date': '2015-10-05', 'size': 5606170, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_002.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2019-10-28T10:50', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1208}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2015-11-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-07', 'dispFirstSubmitDate': '2018-05-15', 'completionDateStruct': {'date': '2017-11-14', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-10-28', 'studyFirstSubmitDate': '2015-10-01', 'dispFirstSubmitQcDate': '2018-05-17', 'resultsFirstSubmitDate': '2019-04-18', 'studyFirstSubmitQcDate': '2015-10-01', 'dispFirstPostDateStruct': {'date': '2018-05-18', 'type': 'ACTUAL'}, 'lastUpdatePostDateStruct': {'date': '2019-11-12', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2019-08-05', 'studyFirstPostDateStruct': {'date': '2015-10-02', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2019-08-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2017-11-14', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Investigator Global Assessment (IGA) Success Rate at Week 12', 'timeFrame': 'From Baseline to Week 12', 'description': 'Number of subjects who achieved an Investigator Global Assessment (IGA) score of 1 (almost clear) or 0 (Clear) and at least a 2-grade improvement from Baseline to Week 12.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Efficacy', 'Safety', 'Acne vulgaris'], 'conditions': ['Acne Vulgaris']}, 'descriptionModule': {'briefSummary': 'Assessment of the efficacy and safety of CD5789 (trifarotene) 50μg/g cream applied once daily for 12 weeks in subjects with acne vulgaris.', 'detailedDescription': 'Clinical Trial for each subject is approximately 14 weeks and are randomized to one of the two treatments for 12 weeks. Subjects must be 9 years of age and older with acne vulgaris.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '9 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* The subject is a male or female, 9 years of age or older, at Screening visit.\n* The Subject has moderate acne at Screening and Baseline.\n* The subject is a female of non childbearing potential\n* The subject is a female of childbearing potential with a negative pregnancy test and who is strictly abstinent or who agrees to use an effective and approved contraceptive method for the duration of the study and at least 1 month after the last study drug application.\n\nExclusion Criteria:\n\n* The subject has severe forms of acne (e.g., acne conglobate, acne fulminant) or secondary acne form (e.g.,chloracne, drug-induced acne, etc.).\n* The subject has any uncontrolled or serious disease or any medical or surgical condition that may either interfere with the interpretation of the trial results and/or put the subject at significant risk (according to the Investigator's judgment) if the subject takes part to the trial.\n* The subject has been exposed to excessive ultraviolet (UV) radiation within one month prior to the Baseline visit or the subject is planning intense UV exposure during the study (i.e., occupational exposure to the sun, sunbathing, tanning salon use, phototherapy, etc.)\n* The subject is unwilling to refrain from use of prohibited medication during the clinical trial"}, 'identificationModule': {'nctId': 'NCT02566369', 'briefTitle': 'Efficacy and Safety of CD5789 (Trifarotene) 50μg/g Cream Versus Vehicle Cream in Acne Vulgaris', 'organization': {'class': 'INDUSTRY', 'fullName': 'Galderma R&D'}, 'officialTitle': 'A Multi-Center, Randomized, Double-Blind, Parallel-Group Vehicle Controlled Study To Compare The Efficacy And Safety Of CD5789 (Trifarotene) 50μg/g Cream Versus Vehicle Cream In Subjects With Acne Vulgaris', 'orgStudyIdInfo': {'id': 'RD.06.SPR.18251'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CD5789 (trifarotene) 50μg/g Cream', 'description': 'CD5789 (trifarotene) 50μg/g Cream', 'interventionNames': ['Drug: CD5789 (trifarotene) 50μg/g cream']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Cream', 'description': 'Placebo cream', 'interventionNames': ['Drug: Placebo cream']}], 'interventions': [{'name': 'CD5789 (trifarotene) 50μg/g cream', 'type': 'DRUG', 'description': 'CD5789 (trifarotene) 50µg/g cream applied once daily for 12 weeks.', 'armGroupLabels': ['CD5789 (trifarotene) 50μg/g Cream']}, {'name': 'Placebo cream', 'type': 'DRUG', 'description': 'Placebo cream applied once daily for 12 weeks', 'armGroupLabels': ['Placebo Cream']}]}, 'contactsLocationsModule': {'locations': [{'zip': '36608', 'city': 'Mobile', 'state': 'Alabama', 'country': 'United States', 'facility': 'Galderma Investigational Site (8258)', 'geoPoint': {'lat': 30.69436, 'lon': -88.04305}}, {'zip': '85308', 'city': 'Glendale', 'state': 'Arizona', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8530)', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '85018', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8511)', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '71913', 'city': 'Hot Springs', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8009)', 'geoPoint': {'lat': 34.5037, 'lon': -93.05518}}, {'zip': '72758', 'city': 'Rogers', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8355)', 'geoPoint': {'lat': 36.33202, 'lon': -94.11854}}, {'zip': '90212', 'city': 'Beverly Hills', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8456)', 'geoPoint': {'lat': 34.07362, 'lon': -118.40036}}, {'zip': '90703', 'city': 'Cerritos', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational site (8578)', 'geoPoint': {'lat': 33.85835, 'lon': -118.06479}}, {'zip': '93612', 'city': 'Clovis', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8526)', 'geoPoint': {'lat': 36.82523, 'lon': -119.70292}}, {'zip': '92024', 'city': 'Encinitas', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (8577)', 'geoPoint': {'lat': 33.03699, 'lon': -117.29198}}, {'zip': '94538', 'city': 'Fremont', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8224)', 'geoPoint': {'lat': 37.54827, 'lon': -121.98857}}, {'zip': '92835', 'city': 'Fullerton', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8509)', 'geoPoint': {'lat': 33.87029, 'lon': -117.92534}}, {'zip': '92647', 'city': 'Huntington Beach', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8507)', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '92663', 'city': 'Newport Beach', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8425)', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '92056', 'city': 'Oceanside', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8052)', 'geoPoint': {'lat': 33.19587, 'lon': -117.37948}}, {'zip': '92701', 'city': 'Santa Ana', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8528)', 'geoPoint': {'lat': 33.74557, 'lon': -117.86783}}, {'zip': '91301', 'city': 'Santa Monica', 'state': 'California', 'country': 'United States', 'facility': 'Galderma Investigational Site (# 8160)', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '92592', 'city': 'Temecula', 'state': 'California', 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