Ignite Creation Date:
2025-12-24 @ 10:51 PM
Ignite Modification Date:
2025-12-25 @ 8:20 PM
Study NCT ID:
NCT05568069
Status:
RECRUITING
Last Update Posted:
2025-01-28
First Post:
2022-09-27
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006333', 'term': 'Heart Failure'}], 'ancestors': [{'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D017147', 'term': 'Defibrillators, Implantable'}], 'ancestors': [{'id': 'D047548', 'term': 'Defibrillators'}, {'id': 'D004566', 'term': 'Electrodes'}, {'id': 'D055615', 'term': 'Electrical Equipment and Supplies'}, {'id': 'D004864', 'term': 'Equipment and Supplies'}, {'id': 'D004567', 'term': 'Electrodes, Implanted'}, {'id': 'D019736', 'term': 'Prostheses and Implants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Eligible patients will be randomised in a controlled fashion into two arms (n=1252):\n\nArm A: ICD implantation Arm B: No ICD implantation Patients with no scar on CMR will be followed up in a registry (n=1252)'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2504}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-04-12', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-01', 'completionDateStruct': {'date': '2036-04-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-23', 'studyFirstSubmitDate': '2022-09-27', 'studyFirstSubmitQcDate': '2022-09-30', 'lastUpdatePostDateStruct': {'date': '2025-01-28', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-10-05', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-04-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Percentage of patients alive', 'timeFrame': '3 years', 'description': 'All-cause mortality'}], 'secondaryOutcomes': [{'measure': 'Change in health-related quality of life measured using KCCQ-12', 'timeFrame': '3 years', 'description': 'Short questionnaire including questions related to heart failure symptoms and how they affect daily activities'}, {'measure': 'Change in health-related quality of life measured using EQ-5D-5L', 'timeFrame': '3 years', 'description': 'Questionnaire consisting of 5 questions to evaluate a patients quality of life'}, {'measure': 'Cardiovascular Death', 'timeFrame': '3 years', 'description': 'Percentage of patients that have cardiovascular death'}, {'measure': 'Sudden cardiac death', 'timeFrame': '3 years', 'description': 'Percentage of patients that have sudden cardiac death'}, {'measure': 'Aborted sudden cardiac death', 'timeFrame': '3 years', 'description': 'Percentage of patients that have aborted sudden cardiac death'}, {'measure': 'Appropriate ICD Therapy', 'timeFrame': '3 years', 'description': 'Percentage of patients that have appropriate ICD therapy'}, {'measure': 'Inappropriate ICD Therapy', 'timeFrame': '3 years', 'description': 'Percentage of patients that have inappropriate ICD therapy'}, {'measure': 'Significant ventricular arrhythmias', 'timeFrame': '3 years', 'description': 'Percentage of patients that have significant ventricular arrhythmias'}, {'measure': 'NYHA Status', 'timeFrame': '3 years', 'description': 'Percentage of patients in each category'}, {'measure': 'Heart failure hospitalisations', 'timeFrame': '3 years', 'description': 'Number of events'}, {'measure': 'Cardiac hospitalisations', 'timeFrame': '3 years', 'description': 'Number of events'}, {'measure': 'Procedures related to implanted device', 'timeFrame': '3 years', 'description': 'Number of events'}, {'measure': 'Percentage of patients alive', 'timeFrame': 'At 5 and 10 years', 'description': 'Mortality'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Cardiac Magnetic Resonance Imaging (CMR)', 'Implantable Cardioverter Device', 'Implantable Loop Recorder', 'Left ventricular ejection fraction (LVEF)', 'Myocardial scar'], 'conditions': ['Heart Failure']}, 'descriptionModule': {'briefSummary': 'BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries. Participants will be randomised into two groups. Half the participants will receive an Implantable Cardioverter-Defibrillator (ICD) and the other half will not. The aim of the study will be to compare all-cause mortality (death from any cause) between these two groups at 36 months, and longer-term to 10 years. The study has the potential to change international heart failure treatment guidelines and to improve how patients with this condition are managed.', 'detailedDescription': "Patients with Non-Ischemic Cardiomyopathy (NICM) have a higher risk of experiencing serious abnormal heart rhythms that might be life-threatening. Current guidelines recommend fitting a device that can correct these serious heart rhythms (Implantable Cardioverter-Defibrillator (ICD)). However, research studies have shown that 90% of patients who have an ICD will never use it because they won't experience any serious heart rhythms. A recent large trial (DANISH) of over one thousand patients with severe Non-Ischemic Cardiomyopathy has called the current guidelines into question. The trial concluded that for patients who received an ICD, there was no difference in the likelihood of dying when compared to patients that didn't have an ICD fitted. As a result, many doctors are choosing not to implant an ICD in patients with this type of heart failure, as they believe there is no overall survival benefit. However, there are clues that some patients with NICM may still benefit from an ICD, even though the headline results suggest they are not necessary. It's likely that it's the patients who are at increased risk of having a serious abnormal heart rhythm that stand to benefit from ICDs. But having an ICD fitted carries with it a significant risk of problems developing e.g. bleeding, infection, lead problems, and inappropriate shocks. These risks may not outweigh the benefits and it is this question which BRITISH will address. The study will randomly assign (like the toss of a coin), half the study participants to receive an ICD and the other half to no ICD.\n\nBoth groups will be followed up to decide whether having an ICD fitted reduces the chances of dying."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. A diagnosis of NICM on contrast-enhanced cardiovascular magnetic resonance imaging\n2. LV scar on routine CMR (patient without scar can enter the registry)\n3. New York Heart Association (NYHA) Heart Failure (HF) functional class I-III and severely impaired left ventricular function (LVEF ≤ 35% on any imaging modality) after a minimum of 3 months of treatment with optimal medical therapy (OMT) as recommended by National Institute for Health and Care Excellence (NICE)\n4. Able and willing to provide informed consent\n\nExclusion Criteria:\n\n1. New York Heart Association (NYHA) HF functional class IV after 3 months of optimal medical therapy (OMT)\n2. Acute decompensated heart failure\n3. Previous implantable device in situ (PPM, Cardiac Resynchronisation Therapy (CRT) or ICD)\n4. Ischemic cardiomyopathy (ICM) is defined as segmental wall motion abnormalities or wall thinning in a particular coronary territory with subendocardial or transmural late gadolinium enhancement (LGE). Patients with an LVEF ≤35% and a small amount of ischemic LGE (i.e. an infarct out of keeping with the amount of LV dysfunction) will not be excluded (so-called dual pathology patients)\n5. Known diagnosis of amyloidosis, sarcoidosis, arrhythmogenic right ventricular cardiomyopathy, or hypertrophic cardiomyopathy (diseases in which there are specific guidelines regarding defibrillator therapy)\n6. Known Lamin gene mutation or a positive family history of a Lamin gene mutation\n7. Valve disease is considered likely to require surgery during the 3 years follow-up period\n8. Complex congenital heart disease\n9. Any secondary prevention ICD indication\n10. Heart transplant recipient or admitted for cardiac transplantation/ left ventricular assist device\n11. Clinically apparent myocardial ischemia which requires revascularization\n12. Intracardiac mass which requires surgery\n13. Active endocarditis\n14. Active Septicaemia\n15. Pregnancy\n16. Life expectancy \\<2 years secondary to any other cause (i.e. malignancy)\n17. Active treatment with chemotherapy\n18. Severe renal failure (GFR \\<30)\n19. Actively participating in another study without prior agreement between both Chief Investigators'}, 'identificationModule': {'nctId': 'NCT05568069', 'acronym': 'BRITISH', 'briefTitle': 'RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital Southampton NHS Foundation Trust'}, 'officialTitle': 'Using Cardiovascular Magnetic Resonance Identified Scar as the Benchmark Risk Indication Tool for Implantable Cardioverter Defibrillators in Patients With Non-Ischemic Cardiomyopathy and Severe Systolic Heart Failure', 'orgStudyIdInfo': {'id': 'RHMCAR0581'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Intervention', 'description': 'ICD or CRTD fitted', 'interventionNames': ['Device: Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD)']}, {'type': 'NO_INTERVENTION', 'label': 'Control', 'description': 'No ICD fitted (with Implantable Loop Recorder) or Cardiac Resynchronisation Therapy Pacemaker (CRTP)'}, {'type': 'NO_INTERVENTION', 'label': 'Registry', 'description': 'Usual medical care'}], 'interventions': [{'name': 'Implantable Cardioverter-Defibrillator (ICD) or Cardiac Resynchronisation Therapy Defibrillator (CRTD)', 'type': 'DEVICE', 'description': 'An ICD is a device that is implanted under the skin under a local anesthetic. It has a battery/generator component and leads which are fixed into the heart chambers. It has the ability to detect dangerous heart rhythms if they occur, and deliver a shock to treat this to help prevent sudden cardiac death. A CRTD is a pacemaker with a defibrillator function.', 'armGroupLabels': ['Intervention']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'HP11 2TT', 'city': 'High Wycombe', 'state': 'Buckinghamshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Nadine Ali, Dr', 'role': 'CONTACT', 'phone': '01494 425958'}], 'facility': 'Wycombe Hospital', 'geoPoint': {'lat': 51.62907, 'lon': -0.74934}}, {'zip': 'PL6 8DH', 'city': 'Plymouth', 'state': 'Devon', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Ben Sieniewicz, Dr', 'role': 'CONTACT', 'phone': '01752 202082'}], 'facility': 'Derriford Hospital', 'geoPoint': {'lat': 50.37153, 'lon': -4.14305}}, {'zip': 'BH7 7DW', 'city': 'Bournemouth', 'state': 'Dorset', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Chris Critoph', 'role': 'CONTACT', 'phone': '01202 303626'}], 'facility': 'Royal Bournemouth Hospital', 'geoPoint': {'lat': 50.72048, 'lon': -1.8795}}, {'zip': 'DL3 6HX', 'city': 'Darlington', 'state': 'Durham', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Darragh Twomey, MD', 'role': 'CONTACT', 'phone': '01325380100'}], 'facility': 'Durham & Darlington NHS Foundation Trust', 'geoPoint': {'lat': 54.52429, 'lon': -1.55039}}, {'zip': 'BN2 5BE', 'city': 'Brighton', 'state': 'East Sussex', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Steve Coombs', 'role': 'CONTACT', 'phone': '01273 696955'}], 'facility': 'Royal Sussex County Hospital', 'geoPoint': {'lat': 50.82838, 'lon': -0.13947}}, {'zip': 'SS16 5NL', 'city': 'Basildon', 'state': 'Essex', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Jason Dungu', 'role': 'CONTACT', 'phone': '01268 524900'}], 'facility': 'Essex Cardiothoracic Centre', 'geoPoint': {'lat': 51.56844, 'lon': 0.45782}}, {'zip': 'NR31 6LA', 'city': 'Gorleston-on-Sea', 'state': 'Great Yarmouth', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Sunil Nair, Dr', 'role': 'CONTACT', 'phone': '01493 452452'}], 'facility': 'James Paget University Hospitals NHS FT', 'geoPoint': {'lat': 52.57301, 'lon': 1.73069}}, {'zip': 'PO6 3LY', 'city': 'Portsmouth', 'state': 'Hampshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Geraint Morton', 'role': 'CONTACT', 'phone': '02392286000'}], 'facility': 'Portsmouth Hospitals University NHS Trust', 'geoPoint': {'lat': 50.79899, 'lon': -1.09125}}, {'zip': 'SO16 6YD', 'city': 'Southampton', 'state': 'Hampshire', 'status': 'NOT_YET_RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Jacqui Nuttall', 'role': 'CONTACT', 'email': 'J.Nuttall@soton.ac.uk', 'phone': '023 8120 3866'}, {'name': 'Zina Eminton', 'role': 'CONTACT', 'email': 'Z.B.Eminton@soton.ac.uk', 'phone': '023 8026 8125'}, {'name': 'Andrew Flett, BSc, MBBS, FRCP, MD(Res)', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Nick Curzen, BM(Hons) PhD FRCP', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Southampton Clinical Trials Unit', 'geoPoint': {'lat': 50.90395, 'lon': -1.40428}}, {'zip': 'SO16 6YD', 'city': 'Southampton', 'state': 'Hampshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Andrew Flett', 'role': 'CONTACT', 'email': 'andrew.flett@uhs.nhs.uk', 'phone': '+44 (0)23 8120 8538'}, {'name': 'Zoe Nicholas', 'role': 'CONTACT', 'email': 'zoe.nicholas@uhs.nhs.uk', 'phone': '+44 (0)23 8120 8538'}], 'facility': 'University Hospital Southampton NHS Foundation Trust', 'geoPoint': {'lat': 50.90395, 'lon': -1.40428}}, {'zip': 'CT1 3NG', 'city': 'Canterbury', 'state': 'Kent', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Steven White', 'role': 'CONTACT', 'phone': '01227 766877'}], 'facility': 'Kent & Canterbury Hospital', 'geoPoint': {'lat': 51.27904, 'lon': 1.07992}}, {'zip': 'ME16 9QQ', 'city': 'Maidstone', 'state': 'Kent', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Laurence Nunn', 'role': 'CONTACT', 'phone': '01622 729000'}], 'facility': 'Maidstone Hospital, Maidstone & Tunbridge Wells NHS Trust', 'geoPoint': {'lat': 51.26667, 'lon': 0.51667}}, {'zip': 'FY3 8NR', 'city': 'Blackpool', 'state': 'Lancashire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Alison Seed, Dr', 'role': 'CONTACT', 'phone': '01253 300000'}], 'facility': 'Blackpool Victoria Hospiatal', 'geoPoint': {'lat': 53.81667, 'lon': -3.05}}, {'zip': 'L14 3PE', 'city': 'Liverpool', 'state': 'Lancashire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Archie Rao', 'role': 'CONTACT', 'phone': '0151 600 1616'}], 'facility': 'Liverpool Heart & Chest', 'geoPoint': {'lat': 53.41058, 'lon': -2.97794}}, {'zip': 'LE3 9QP', 'city': 'Leicester', 'state': 'Leicestershire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Ian Loke', 'role': 'CONTACT', 'phone': '01268 524900'}], 'facility': 'Glenfield Hospital', 'geoPoint': {'lat': 52.6386, 'lon': -1.13169}}, {'zip': 'EC1A 7BE', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Kostas Savvatis', 'role': 'CONTACT', 'phone': '0207 3777 000'}], 'facility': "St Bartholomew's Hospital", 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'NW3 2QG', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Gabriella Captur', 'role': 'CONTACT', 'phone': '020 7794 0500'}], 'facility': 'Royal Free Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'SE1 9RT', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Anoop Shetty', 'role': 'CONTACT', 'phone': '020 7188 7188'}], 'facility': "Guy's Hospital", 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'SE5 9RS', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Daniel Sado, Dr', 'role': 'CONTACT', 'phone': '020 3299 9000'}], 'facility': "King's College Hospital", 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'SW3 6NP', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Sanjay Prasad, MD', 'role': 'CONTACT', 'phone': '02073528121'}], 'facility': 'Royal Brompton Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'Wq12 0HS', 'city': 'London', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Graham Cole', 'role': 'CONTACT', 'phone': '020 3313 1000'}], 'facility': 'Hammersmith Hospital, Imperial College Healthcare NHS Trust', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'SW17 0QT', 'city': 'Tooting', 'state': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Fadi Jouhra, Dr', 'role': 'CONTACT', 'phone': '02086721255'}], 'facility': "St George's Hospital", 'geoPoint': {'lat': 51.42524, 'lon': -0.16394}}, {'zip': 'BL9 7TD', 'city': 'Manchester', 'state': 'Manchester', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Yuran Zheng', 'role': 'CONTACT', 'phone': '0161 624 0420'}], 'facility': 'Fairfield General Hospital, Northern Care Alliance NHS FT', 'geoPoint': {'lat': 53.48095, 'lon': -2.23743}}, {'zip': 'NE7 7DN', 'city': 'Newcastle', 'state': 'Newcastle upon Tyne', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Hanney Gonna, MD', 'role': 'CONTACT', 'phone': '01912336161'}], 'facility': 'Newcastle Freeman Hospital', 'geoPoint': {'lat': 54.21804, 'lon': -5.88979}}, {'zip': 'TS4 3BW', 'city': 'Middlesbrough', 'state': 'North Yorkshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Michael Chapman, Dr', 'role': 'CONTACT', 'phone': '01642 850850'}], 'facility': 'The James Cook University Hospital', 'geoPoint': {'lat': 54.57623, 'lon': -1.23483}}, {'zip': 'NE63 9JJ', 'city': 'Ashington', 'state': 'Northumbria', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United Kingdom', 'facility': 'Wansbeck General Hospital', 'geoPoint': {'lat': 55.17719, 'lon': -1.56412}}, {'zip': 'YO12 6QL', 'city': 'Scarborough', 'state': 'Nortrh Yorkshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Daniel Swarbrick, Dr', 'role': 'CONTACT', 'phone': '01723 368111'}], 'facility': 'Scarborough Hospital', 'geoPoint': {'lat': 54.27966, 'lon': -0.40443}}, {'zip': 'NG5 1PB', 'city': 'Nottingham', 'state': 'Nottinghamshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Jenny Chuen, Dr', 'role': 'CONTACT', 'phone': '0115 969 1169'}], 'facility': 'Nottingham City Hospital', 'geoPoint': {'lat': 52.9536, 'lon': -1.15047}}, {'zip': 'OX3 9DU', 'city': 'Oxford', 'state': 'Oxfordshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Julian Ormerod, Dr', 'role': 'CONTACT', 'phone': '0300 304 7777'}], 'facility': 'The John Radcliffe Hospital', 'geoPoint': {'lat': 51.75222, 'lon': -1.25596}}, {'zip': 'AB25 2ZN', 'city': 'Aberdeen', 'state': 'Scotland', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Dana Dawson', 'role': 'CONTACT', 'phone': '03454566000'}], 'facility': 'Aberdeen Royal Infirmary', 'geoPoint': {'lat': 57.14369, 'lon': -2.09814}}, {'zip': 'EH16 4SA', 'city': 'Edinburgh', 'state': 'Scotland', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Marc Dweck', 'role': 'CONTACT', 'phone': '0131 536 1000'}], 'facility': 'Royal Infirmary of Edinburgh', 'geoPoint': {'lat': 55.95206, 'lon': -3.19648}}, {'zip': 'TA1 5DA', 'city': 'Taunton', 'state': 'Somerset', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United Kingdom', 'facility': 'Musgrove Park Hospital', 'geoPoint': {'lat': 51.01494, 'lon': -3.10293}}, {'zip': 'S5 7AU', 'city': 'Sheffield', 'state': 'South Yorkshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Dominic Rogers, Dr', 'role': 'CONTACT', 'phone': '0114 243 4343'}], 'facility': 'Northern General Hospital', 'geoPoint': {'lat': 53.38297, 'lon': -1.4659}}, {'zip': 'TS19 8PE', 'city': 'Hardwick', 'state': 'Stockton-on-Tees', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Matthew Dewhurst, Dr', 'role': 'CONTACT', 'phone': '01642 617617'}], 'facility': 'University Hospital of North Tees', 'geoPoint': {'lat': 52.46032, 'lon': 1.26746}}, {'zip': 'GU16 7UJ', 'city': 'Camberley', 'state': 'Surrey', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Lydia Sturridge, Dr', 'role': 'CONTACT', 'phone': '0300 614 5000'}], 'facility': 'Frimley Park Hospital', 'geoPoint': {'lat': 51.33705, 'lon': -0.74261}}, {'zip': 'RH1 5RH', 'city': 'Redhill', 'state': 'Surrey', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Cheuk Chan, Dr', 'role': 'CONTACT', 'phone': '01737 768511'}], 'facility': 'Surrey & Sussex Healthcare NHS Trust', 'geoPoint': {'lat': 51.24048, 'lon': -0.17044}}, {'zip': 'CF14 4XW', 'city': 'Cardiff', 'state': 'Wales', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Abbas Zaidi', 'role': 'CONTACT', 'phone': '029 2074 7747'}], 'facility': 'University Hospital of Wales', 'geoPoint': {'lat': 51.48, 'lon': -3.18}}, {'zip': 'CV2 2DX', 'city': 'Coventry', 'state': 'Warwickshire', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Michael Kuehl', 'role': 'CONTACT', 'phone': '024 7696 4000'}], 'facility': 'University Hospital Coventry', 'geoPoint': {'lat': 52.40656, 'lon': -1.51217}}, {'zip': 'WV10 0QP', 'city': 'Wolverhampton', 'state': 'West Midlands', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Anita Arya', 'role': 'CONTACT', 'phone': '01902 307999'}], 'facility': 'New Cross Hospital', 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