Ignite Creation Date:
2025-12-24 @ 10:49 PM
Ignite Modification Date:
2026-01-02 @ 5:09 AM
Study NCT ID:
NCT00043069
Status:
COMPLETED
Last Update Posted:
2016-12-07
First Post:
2002-08-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010024', 'term': 'Osteoporosis'}, {'id': 'D011471', 'term': 'Prostatic Neoplasms'}], 'ancestors': [{'id': 'D001851', 'term': 'Bone Diseases, Metabolic'}, {'id': 'D001847', 'term': 'Bone Diseases'}, {'id': 'D009140', 'term': 'Musculoskeletal Diseases'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D005834', 'term': 'Genital Neoplasms, Male'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D005832', 'term': 'Genital Diseases, Male'}, {'id': 'D000091662', 'term': 'Genital Diseases'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D011469', 'term': 'Prostatic Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D002119', 'term': 'Calcium Carbonate'}, {'id': 'D002762', 'term': 'Cholecalciferol'}, {'id': 'D004965', 'term': 'Estrogen Antagonists'}, {'id': 'D000068296', 'term': 'Risedronic Acid'}], 'ancestors': [{'id': 'D017610', 'term': 'Calcium Compounds'}, {'id': 'D007287', 'term': 'Inorganic Chemicals'}, {'id': 'D002254', 'term': 'Carbonates'}, {'id': 'D002255', 'term': 'Carbonic Acid'}, {'id': 'D017554', 'term': 'Carbon Compounds, Inorganic'}, {'id': 'D008903', 'term': 'Minerals'}, {'id': 'D002782', 'term': 'Cholestenes'}, {'id': 'D002776', 'term': 'Cholestanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D013261', 'term': 'Sterols'}, {'id': 'D014807', 'term': 'Vitamin D'}, {'id': 'D012632', 'term': 'Secosteroids'}, {'id': 'D008563', 'term': 'Membrane Lipids'}, {'id': 'D008055', 'term': 'Lipids'}, {'id': 'D006727', 'term': 'Hormone Antagonists'}, {'id': 'D006730', 'term': 'Hormones, Hormone Substitutes, and Hormone Antagonists'}, {'id': 'D045505', 'term': 'Physiological Effects of Drugs'}, {'id': 'D020228', 'term': 'Pharmacologic Actions'}, {'id': 'D020164', 'term': 'Chemical Actions and Uses'}, {'id': 'D004164', 'term': 'Diphosphonates'}, {'id': 'D063065', 'term': 'Organophosphonates'}, {'id': 'D009943', 'term': 'Organophosphorus Compounds'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D011725', 'term': 'Pyridines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'SUPPORTIVE_CARE', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 71}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2002-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2016-12', 'completionDateStruct': {'date': '2010-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2016-12-05', 'studyFirstSubmitDate': '2002-08-05', 'studyFirstSubmitQcDate': '2003-01-26', 'lastUpdatePostDateStruct': {'date': '2016-12-07', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2003-01-27', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2006-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Bone mineral density by test at 1 and 2 years', 'timeFrame': 'Up to 2 years'}], 'secondaryOutcomes': [{'measure': 'Toxicity questionnaires every 6 months', 'timeFrame': '6 months'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['osteoporosis', 'stage I prostate cancer', 'stage IIB prostate cancer', 'stage IIA prostate cancer', 'stage III prostate cancer'], 'conditions': ['Osteoporosis', 'Prostate Cancer']}, 'referencesModule': {'references': [{'pmid': '19468757', 'type': 'RESULT', 'citation': 'Kearns AE, Northfelt DW, Dueck AC, Atherton PJ, Dakhil SR, Rowland KM Jr, Fuloria J, Flynn PJ, Dentchev T, Loprinzi CL. Osteoporosis prevention in prostate cancer patients receiving androgen ablation therapy: placebo-controlled double-blind study of estradiol and risedronate: N01C8. Support Care Cancer. 2010 Mar;18(3):321-8. doi: 10.1007/s00520-009-0655-x. Epub 2009 May 27.'}]}, 'descriptionModule': {'briefSummary': 'RATIONALE: Preventing bone loss in patients who are undergoing androgen ablation for prostate cancer may decrease the risk of fractures and may help patients live more comfortably. It is not yet known whether calcium is more effective with or without estrogen and/or risedronate in preventing osteoporosis.\n\nPURPOSE: Randomized phase III trial to compare the effectiveness of two forms of calcium with or without estrogen and/or risedronate in preventing osteoporosis in patients with prostate cancer who are receiving androgen ablation therapy.', 'detailedDescription': 'OBJECTIVES:\n\n* Compare the change in bone mineral density in patients with prostate cancer who are receiving androgen-ablation therapy treated with calcium and cholecalciferol with or without conjugated estrogens and with or without risedronate.\n* Compare the toxicity of these regimens in these patients.\n* Compare the changes in bone markers in patients treated with these regimens.\n* Compare the quality of life of patients treated with these regimens.\n* Compare hot flashes in patients treated with these regimens.\n\nOUTLINE: This is a randomized, double-blind, placebo-controlled, multicenter study. Patients are stratified according to duration of therapy with luteinizing hormone-releasing hormone agonists (no more than 30 days vs 31 to 150 days vs 151 to 365 days vs more than 365 days). Patients are randomized to 1 of 4 treatment arms.\n\n* Arm I: Patients receive oral calcium, oral cholecalciferol, oral risedronate placebo, and oral estrogen placebo daily.\n* Arm II: Patients receive oral calcium, oral cholecalciferol, oral risedronate, and oral estrogen placebo daily.\n* Arm III: Patients receive oral calcium, oral cholecalciferol, low-dose oral conjugated estrogens, and oral risedronate placebo daily.\n* Arm IV: Patients receive oral calcium, oral cholecalciferol, low-dose oral conjugated estrogens, and oral risedronate daily.\n\nTreatment in all arms continues for 2 years.\n\nQuality of life is assessed at baseline, monthly for 6 months, and then at 1 and 2 years.\n\nBone mineral density is assessed at baseline, 6 months, and 1 and 2 years.\n\nPROJECTED ACCRUAL: A total of 282 patients (70 per treatment arm) will be accrued for this study within 14 months.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'DISEASE CHARACTERISTICS:\n\n* History of prostate cancer\n\n * No evidence of metastatic bony disease\\* NOTE: \\*Elevated prostate-specific antigen (PSA) allowed\n* Meets one of the following criteria:\n\n * Currently on treatment with androgen-ablation therapy in the adjuvant setting\n * Rising PSA without other evidence of recurrent disease with planned treatment for at least 6 months\n* No known osteoporosis or prior osteoporotic fracture\n\n * Osteoporosis defined as bone density at the hip or spine of more than 2.5 standard deviations below the mean for young men\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* 18 and over\n\nPerformance status\n\n* Not specified\n\nLife expectancy\n\n* Not specified\n\nHematopoietic\n\n* Not specified\n\nHepatic\n\n* SGOT or SGPT no greater than 1.5 times upper limit of normal (ULN)\n* Alkaline phosphatase normal OR no greater than 1.5 times ULN with a normal bone scan\n\nRenal\n\n* Creatinine no greater than 1.5 times ULN\n* No prior symptomatic hypercalcemia or hypocalcemia\n\nCardiovascular\n\n* No active heart disease\n* No congestive heart failure under active treatment\n* No myocardial infarction within the past 5 years\n* No coronary artery disease (CAD) with recent myocardial infarction\n\n * Patients with a remote history of CAD who are only on medical treatment (e.g., antilipid agents) are allowed\n* No prior thrombosis (deep vein thrombosis, stroke, or pulmonary embolism) or other known hypercoagulable state other than cancer\n\nOther\n\n* Fertile patients must use effective contraception\n* Triglycerides no greater than 250 mg/dL (treatment allowed)\n* Able to complete questionnaire(s) by self or with assistance\n* Able to swallow pills\n* No prior hyperlipidemia (e.g., prior familial hyperlipidemia or fasting triglyceride greater than 250 mg/dL within the past 6 months)\n* No sarcoidosis\n* No parathyroid dysfunction\n* No intolerance to bisphosphonates\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* Not specified\n\nChemotherapy\n\n* No concurrent chemotherapy\n\nEndocrine therapy\n\n* See Disease Characteristics\n* No concurrent systemic steroids\n\nRadiotherapy\n\n* No concurrent radiotherapy\n\nSurgery\n\n* More than 3 months since prior and no concurrent dental extraction, root canal, or dental implantation\n\nOther\n\n* No prior bisphosphonates\n* More than 5 years since prior percutaneous transluminal coronary angioplasty'}, 'identificationModule': {'nctId': 'NCT00043069', 'briefTitle': 'Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Alliance for Clinical Trials in Oncology'}, 'officialTitle': 'Osteoporosis Prevention in Prostate Cancer Patients Receiving Androgen Ablation Therapy: A Phase III Randomized, Placebo-Controlled, Double-Blind Study', 'orgStudyIdInfo': {'id': 'NCCTG-N01C8'}, 'secondaryIdInfos': [{'id': 'NCI-2012-02482', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trials Reporting System)'}, {'id': 'NCI-P02-0229'}, {'id': 'CDR0000069502', 'type': 'REGISTRY', 'domain': 'PDQ (Physician Data Query)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Arm I: calcium + cholecalciferol + placebo + estrogen', 'description': 'Patients receive oral calcium, oral cholecalciferol, oral risedronate placebo, and oral estrogen placebo daily.\n\nTreatment in all arms continues for 2 years.\n\nQuality of life is assessed at baseline, monthly for 6 months, and then at 1 and 2 years.\n\nBone mineral density is assessed at baseline, 6 months, and 1 and 2 years.', 'interventionNames': ['Dietary Supplement: calcium carbonate', 'Dietary Supplement: cholecalciferol', 'Drug: Estrogen Antagonists', 'Other: placebo']}, {'type': 'EXPERIMENTAL', 'label': 'Arm II: calcium + cholecalciferol + risedronate + estrogen', 'description': 'Patients receive oral calcium, oral cholecalciferol, oral risedronate, and oral estrogen placebo daily.\n\nTreatment in all arms continues for 2 years.\n\nQuality of life is assessed at baseline, monthly for 6 months, and then at 1 and 2 years.\n\nBone mineral density is assessed at baseline, 6 months, and 1 and 2 years.', 'interventionNames': ['Dietary Supplement: calcium carbonate', 'Dietary Supplement: cholecalciferol', 'Drug: Estrogen Antagonists', 'Drug: risedronate sodium']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Arm III: calcium + cholecalciferol + placebo + estrogen', 'description': 'Patients receive oral calcium, oral cholecalciferol, low-dose oral conjugated estrogens, and oral risedronate placebo daily.\n\nTreatment in all arms continues for 2 years.\n\nQuality of life is assessed at baseline, monthly for 6 months, and then at 1 and 2 years.\n\nBone mineral density is assessed at baseline, 6 months, and 1 and 2 years.', 'interventionNames': ['Dietary Supplement: calcium carbonate', 'Dietary Supplement: cholecalciferol', 'Drug: Estrogen Antagonists', 'Other: placebo']}, {'type': 'EXPERIMENTAL', 'label': 'Arm IV: calcium + cholecalciferol + risedronate + estrogen', 'description': 'Patients receive oral calcium, oral cholecalciferol, low-dose oral conjugated estrogens, and oral risedronate daily.\n\nTreatment in all arms continues for 2 years.\n\nQuality of life is assessed at baseline, monthly for 6 months, and then at 1 and 2 years.\n\nBone mineral density is assessed at baseline, 6 months, and 1 and 2 years.', 'interventionNames': ['Dietary Supplement: calcium carbonate', 'Dietary Supplement: cholecalciferol', 'Drug: Estrogen Antagonists', 'Drug: risedronate sodium']}], 'interventions': [{'name': 'calcium carbonate', 'type': 'DIETARY_SUPPLEMENT', 'armGroupLabels': ['Arm I: calcium + cholecalciferol + placebo + estrogen', 'Arm II: calcium + cholecalciferol + risedronate + estrogen', 'Arm III: calcium + cholecalciferol + placebo + estrogen', 'Arm IV: calcium + cholecalciferol + risedronate + estrogen']}, {'name': 'cholecalciferol', 'type': 'DIETARY_SUPPLEMENT', 'armGroupLabels': ['Arm I: calcium + cholecalciferol + placebo + estrogen', 'Arm II: calcium + cholecalciferol + risedronate + estrogen', 'Arm III: calcium + cholecalciferol + placebo + estrogen', 'Arm IV: calcium + cholecalciferol + risedronate + estrogen']}, {'name': 'Estrogen Antagonists', 'type': 'DRUG', 'armGroupLabels': ['Arm I: calcium + cholecalciferol + placebo + estrogen', 'Arm II: calcium + cholecalciferol + risedronate + estrogen', 'Arm III: calcium + cholecalciferol + placebo + estrogen', 'Arm IV: calcium + cholecalciferol + risedronate + estrogen']}, {'name': 'risedronate sodium', 'type': 'DRUG', 'armGroupLabels': ['Arm II: calcium + cholecalciferol + risedronate + estrogen', 'Arm IV: calcium + cholecalciferol + risedronate + estrogen']}, {'name': 'placebo', 'type': 'OTHER', 'armGroupLabels': ['Arm I: calcium + cholecalciferol + placebo + estrogen', 'Arm III: calcium + cholecalciferol + placebo + estrogen']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85259', 'city': 'Scottsdale', 'state': 'Arizona', 'country': 'United States', 'facility': 'CCOP - Mayo Clinic Scottsdale Oncology Program', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '32224-9980', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Mayo Clinic - Jacksonville', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '60507', 'city': 'Aurora', 'state': 'Illinois', 'country': 'United States', 'facility': 'Rush-Copley Cancer Care Center', 'geoPoint': {'lat': 41.76058, 'lon': -88.32007}}, {'zip': '61701', 'city': 'Bloomington', 'state': 'Illinois', 'country': 'United States', 'facility': 'St. Joseph Medical Center', 'geoPoint': {'lat': 40.4842, 'lon': -88.99369}}, {'zip': '61520', 'city': 'Canton', 'state': 'Illinois', 'country': 'United States', 'facility': 'Graham Hospital', 'geoPoint': {'lat': 40.55809, 'lon': -90.03512}}, {'zip': '62321', 'city': 'Carthage', 'state': 'Illinois', 'country': 'United States', 'facility': 'Memorial Hospital', 'geoPoint': {'lat': 40.41643, 'lon': -91.13625}}, {'zip': '61530', 'city': 'Eureka', 'state': 'Illinois', 'country': 'United States', 'facility': 'Eureka Hospital', 'geoPoint': {'lat': 40.72143, 'lon': -89.27286}}, {'zip': '61401', 'city': 'Galesburg', 'state': 'Illinois', 'country': 'United States', 'facility': 'Galesburg Clinic', 'geoPoint': {'lat': 40.94782, 'lon': -90.37124}}, {'zip': '61401', 'city': 'Galesburg', 'state': 'Illinois', 'country': 'United States', 'facility': 'Galesburg Cottage Hospital', 'geoPoint': {'lat': 40.94782, 'lon': -90.37124}}, {'zip': '61401', 'city': 'Galesburg', 'state': 'Illinois', 'country': 'United States', 'facility': 'InterCommunity Cancer Center of Western Illinois', 'geoPoint': {'lat': 40.94782, 'lon': -90.37124}}, {'zip': '62644', 'city': 'Havana', 'state': 'Illinois', 'country': 'United States', 'facility': 'Mason District Hospital', 'geoPoint': {'lat': 40.30004, 'lon': -90.06095}}, {'zip': '61747', 'city': 'Hopedale', 'state': 'Illinois', 'country': 'United States', 'facility': 'Hopedale Medical Complex', 'geoPoint': {'lat': 40.42087, 'lon': -89.41454}}, {'zip': '60435', 'city': 'Joliet', 'state': 'Illinois', 'country': 'United States', 'facility': 'Joliet Oncology Hematology Associates, Limited - West', 'geoPoint': {'lat': 41.52519, 'lon': -88.0834}}, {'zip': '61443', 'city': 'Kewanee', 'state': 'Illinois', 'country': 'United States', 'facility': 'Kewanee Hospital', 'geoPoint': {'lat': 41.24559, 'lon': -89.92483}}, {'zip': '61455', 'city': 'Macomb', 'state': 'Illinois', 'country': 'United States', 'facility': 'McDonough District Hospital', 'geoPoint': {'lat': 40.45921, 'lon': -90.6718}}, {'zip': '61761', 'city': 'Normal', 'state': 'Illinois', 'country': 'United States', 'facility': 'BroMenn Regional Medical Center', 'geoPoint': {'lat': 40.5142, 'lon': -88.99063}}, {'zip': '61761', 'city': 'Normal', 'state': 'Illinois', 'country': 'United States', 'facility': 'Community Cancer Center', 'geoPoint': {'lat': 40.5142, 'lon': -88.99063}}, {'zip': '61350', 'city': 'Ottawa', 'state': 'Illinois', 'country': 'United States', 'facility': 'Community Hospital of Ottawa', 'geoPoint': {'lat': 41.34559, 'lon': -88.84258}}, {'zip': '61350', 'city': 'Ottawa', 'state': 'Illinois', 'country': 'United States', 'facility': 'Oncology Hematology Associates of Central Illinois - Ottawa', 'geoPoint': {'lat': 41.34559, 'lon': -88.84258}}, {'zip': '61554', 'city': 'Pekin', 'state': 'Illinois', 'country': 'United States', 'facility': 'Cancer Treatment Center at Pekin Hospital', 'geoPoint': {'lat': 40.56754, 'lon': -89.64066}}, {'zip': '61603', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'Methodist Medical Center of Illinois', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '61614', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'Proctor Hospital', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '61615', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'CCOP - Illinois Oncology Research Association', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '61615', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'Oncology/Hematology Associates of Central Illinois, P.C.', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '61637', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'OSF St. Francis Medical Center', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '61354', 'city': 'Peru', 'state': 'Illinois', 'country': 'United States', 'facility': 'Illinois Valley Community Hospital', 'geoPoint': {'lat': 41.32753, 'lon': -89.12897}}, {'zip': '61356', 'city': 'Princeton', 'state': 'Illinois', 'country': 'United States', 'facility': 'Perry Memorial Hospital', 'geoPoint': {'lat': 41.36809, 'lon': -89.46481}}, {'zip': '61362', 'city': 'Spring Valley', 'state': 'Illinois', 'country': 'United States', 'facility': "St. Margaret's Hospital", 'geoPoint': {'lat': 41.32754, 'lon': -89.19981}}, {'zip': '61362', 'city': 'Spring Valley', 'state': 'Illinois', 'country': 'United States', 'facility': 'Valley Cancer Center', 'geoPoint': {'lat': 41.32754, 'lon': -89.19981}}, {'zip': '61801', 'city': 'Urbana', 'state': 'Illinois', 'country': 'United States', 'facility': 'Carle Cancer Center at Carle Foundation Hospital', 'geoPoint': {'lat': 40.11059, 'lon': -88.20727}}, {'zip': '61801', 'city': 'Urbana', 'state': 'Illinois', 'country': 'United States', 'facility': 'CCOP - Carle Cancer Center', 'geoPoint': {'lat': 40.11059, 'lon': -88.20727}}, {'zip': '46360', 'city': 'Michigan City', 'state': 'Indiana', 'country': 'United States', 'facility': 'Saint Anthony Memorial Health Centers', 'geoPoint': {'lat': 41.70754, 'lon': -86.89503}}, {'zip': '50010', 'city': 'Ames', 'state': 'Iowa', 'country': 'United States', 'facility': 'McFarland Clinic, P.C.', 'geoPoint': {'lat': 42.03471, 'lon': -93.61994}}, {'zip': '51401', 'city': 'Carroll', 'state': 'Iowa', 'country': 'United States', 'facility': 'Saint Anthony Regional Hospital', 'geoPoint': {'lat': 42.06582, 'lon': -94.86693}}, {'zip': '51503', 'city': 'Council Bluffs', 'state': 'Iowa', 'country': 'United States', 'facility': 'Alegent Health Mercy Hospital', 'geoPoint': {'lat': 41.26194, 'lon': -95.86083}}, {'zip': '50307', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Mercy Capitol Hospital', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50309', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'CCOP - Iowa Oncology Research Association', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50309', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'John Stoddard Cancer Center at Iowa Methodist Medical Center', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50309', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Medical Oncology and Hematology Associates at John Stoddard Cancer Center', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50314', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Medical Oncology and Hematology Associates at Mercy Cancer Center', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50314', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'Mercy Cancer Center at Mercy Medical Center - Des Moines', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50316', 'city': 'Des Moines', 'state': 'Iowa', 'country': 'United States', 'facility': 'John Stoddard Cancer Center at Iowa Lutheran Hospital', 'geoPoint': {'lat': 41.60054, 'lon': -93.60911}}, {'zip': '50401', 'city': 'Mason City', 'state': 'Iowa', 'country': 'United States', 'facility': 'Mercy Cancer Center at Mercy Medical Center - North Iowa', 'geoPoint': {'lat': 43.15357, 'lon': -93.20104}}, {'zip': '51555', 'city': 'Missouri Valley', 'state': 'Iowa', 'country': 'United States', 'facility': 'Alegent Health Community Memorial Hospital', 'geoPoint': {'lat': 41.55638, 'lon': -95.88779}}, {'zip': '51040', 'city': 'Onawa', 'state': 'Iowa', 'country': 'United States', 'facility': 'Burgess Health Center', 'geoPoint': {'lat': 42.02665, 'lon': -96.09724}}, {'zip': '52501', 'city': 'Ottumwa', 'state': 'Iowa', 'country': 'United States', 'facility': 'Cancer Center at Ottumwa Regional Health Center', 'geoPoint': {'lat': 41.02001, 'lon': -92.4113}}, {'zip': '51101-1733', 'city': 'Sioux City', 'state': 'Iowa', 'country': 'United States', 'facility': 'Siouxland Regional Cancer Center', 'geoPoint': {'lat': 42.49999, 'lon': -96.40031}}, {'zip': '51101', 'city': 'Sioux City', 'state': 'Iowa', 'country': 'United States', 'facility': 'Siouxland Hematology-Oncology Associates', 'geoPoint': {'lat': 42.49999, 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