Ignite Creation Date:
2025-12-24 @ 10:47 PM
Ignite Modification Date:
2025-12-25 @ 8:17 PM
Study NCT ID:
NCT05638269
Status:
RECRUITING
Last Update Posted:
2024-07-29
First Post:
2022-09-26
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000075222', 'term': 'Essential Hypertension'}, {'id': 'D008113', 'term': 'Liver Neoplasms'}, {'id': 'D009303', 'term': 'Nasopharyngeal Neoplasms'}, {'id': 'D010190', 'term': 'Pancreatic Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D051436', 'term': 'Renal Insufficiency, Chronic'}, {'id': 'D054058', 'term': 'Acute Coronary Syndrome'}, {'id': 'D004827', 'term': 'Epilepsy'}, {'id': 'D013274', 'term': 'Stomach Neoplasms'}, {'id': 'D006929', 'term': 'Hyperaldosteronism'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}], 'ancestors': [{'id': 'D006973', 'term': 'Hypertension'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D008107', 'term': 'Liver Diseases'}, {'id': 'D010610', 'term': 'Pharyngeal Neoplasms'}, {'id': 'D010039', 'term': 'Otorhinolaryngologic Neoplasms'}, {'id': 'D006258', 'term': 'Head and Neck Neoplasms'}, {'id': 'D009302', 'term': 'Nasopharyngeal Diseases'}, {'id': 'D010608', 'term': 'Pharyngeal Diseases'}, {'id': 'D009057', 'term': 'Stomatognathic Diseases'}, {'id': 'D010038', 'term': 'Otorhinolaryngologic Diseases'}, {'id': 'D004701', 'term': 'Endocrine Gland Neoplasms'}, {'id': 'D010182', 'term': 'Pancreatic Diseases'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D051437', 'term': 'Renal Insufficiency'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D017202', 'term': 'Myocardial Ischemia'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D013272', 'term': 'Stomach Diseases'}, {'id': 'D000308', 'term': 'Adrenocortical Hyperfunction'}, {'id': 'D000307', 'term': 'Adrenal Gland Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Feces, saliva, urine, serum, plasma and buffy coat'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 12000}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-03-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-07', 'completionDateStruct': {'date': '2025-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-07-26', 'studyFirstSubmitDate': '2022-09-26', 'studyFirstSubmitQcDate': '2022-11-25', 'lastUpdatePostDateStruct': {'date': '2024-07-29', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-12-06', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'microbiome', 'timeFrame': 'baseline', 'description': 'The microbial composition of the stool and saliva samples was determined by 16S rRNA (ribosomal ribonucleic acid) gene sequencing analysis and metagenomics. Comparison of microbial abundance and diversity of healthy volunteers and patients with various diseases.'}], 'secondaryOutcomes': [{'measure': 'biochemistry', 'timeFrame': 'baseline', 'description': 'Comparison of serum markers of healthy volunteers and patients with various diseases.'}, {'measure': 'metabonomics', 'timeFrame': 'baseline', 'description': 'Comparison of metabolites of healthy volunteers and patients with various diseases.'}, {'measure': 'proteomics', 'timeFrame': 'baseline', 'description': 'Comparison of peptides of healthy volunteers and patients with various diseases using mass spectrometry.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['cardiovascular disease', 'exctracoonic cancer', 'nervous system diseases', 'endocrine diseases', 'urological diseases', 'microbial dysbiosis'], 'conditions': ['Essential Hypertension', 'Liver Cancer', 'Nasopharyngeal Cancer', 'Pancreatic Cancer', 'Lung Cancer', 'Chronic Kidney Diseases', 'Acute Coronary Syndrome', 'Epilepsy', 'Gastric Cancer', 'Primary Aldosteronism', 'Subclinical hypothyroïdism']}, 'referencesModule': {'references': [{'pmid': '30150716', 'type': 'BACKGROUND', 'citation': 'He Y, Wu W, Zheng HM, Li P, McDonald D, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZD, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Knight R, Ma WJ, Zhou HW. Regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nat Med. 2018 Oct;24(10):1532-1535. doi: 10.1038/s41591-018-0164-x. Epub 2018 Aug 27.'}]}, 'descriptionModule': {'briefSummary': 'The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them. This study aims to systematically characterize the gut microbiota of various critical chronic diseases, compare the similarities and differences of the microbiome signatures linked to different regions and diseases, and further investigate their impacts on microbiota-based diagnostic models.', 'detailedDescription': 'Many studies demonstrate that microbial dysbiosis has been linked to many human pathologies. However, the current understanding of the identification of the disease-associated microbiome signatures remains limited, largely owing to the heterogeneity of microbial community structures which are shaped by the host. Undoubtedly, profiles of microbial biomarkers require validation in large, independent, population-based cohorts from different districts. Based on these, the investigator plan to organize a multicentric cross-sectional cohort, not only to systematically characterize the gut microbiota of various critical chronic diseases, such as liver cancer, gastric cancer, pancreatic cancer, lung cancer, nasopharyngeal cancer, hypertension, acute coronary syndrome, primary aldosteronism, epilepsy, chronic kidney disease, and subclinical hypothyroidism but also to compare the similarities and differences of the microbiome signatures linked to different regions and different diseases and to further investigate their impacts on microbiota-based diagnostic models. In this study, for each kind of disease, the investigators expect to recruit 500 patients with a confirmed diagnosis and 500 sex- and age-matched controls, to record their information related to demography, body measurement, lifestyle, diet, medication, diseases, and biochemistry, and to collect their feces, saliva, urine and blood samples.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'All the patients with essential Hypertension, liver cancer, nasopharyngeal cancer, pancreatic cancer, lung cancer, chronic kidney disease, acute coronary syndrome, epilepsy, gastric cancer, primary aldosteronism or subclinical hypothyroidism hospitalized in our participant hospitals will be eligible to be enrolled. Also, their age- and sex-matched controls making a physical examination in the same hospital will be eligible to be enrolled.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. aged 18-75 years;\n2. living in the province where the hospital is located in the last three years;\n3. with a medical diagnosis of one of the target diseases;\n4. willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. female in pregnancy or lactation(unless the subject is pregnant women);\n2. with medical diagnoses of other serious illnesses;\n3. with a history of bariatric surgery or intestinal resection, except for appendectomy；\n4. individual who was treated with drugs in the preceding 1 month, including antibiotics, metformin, statins, acid inhibitor, probiotics, and probiotics; individuals having consumed yogurt more than 3 times in the preceding 1 month; heavy drinkers who have consumed more than 4 taels of liquor or 1000ml of beer; frequent alcohol consumers who have drunk per week in the last month.'}, 'identificationModule': {'nctId': 'NCT05638269', 'briefTitle': 'A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China', 'organization': {'class': 'OTHER', 'fullName': 'Zhujiang Hospital'}, 'officialTitle': 'A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China', 'orgStudyIdInfo': {'id': 'CALM2101'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'disease group', 'description': 'no intervention', 'interventionNames': ['Other: no intervention']}, {'label': 'control group', 'description': 'no intervention', 'interventionNames': ['Other: no intervention']}], 'interventions': [{'name': 'no intervention', 'type': 'OTHER', 'description': 'Observational studies, no intervention', 'armGroupLabels': ['control group', 'disease group']}]}, 'contactsLocationsModule': {'locations': [{'zip': '100028', 'city': 'Chaoyang', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hui Xu', 'role': 'CONTACT', 'phone': '13693568626'}], 'facility': 'Emergency General Hospital'}, {'zip': '408400', 'city': 'Nanchuan', 'state': 'Chongqing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenming Wang', 'role': 'CONTACT', 'phone': '13996856392'}], 'facility': "The People's Hospital Of Nanchuan Chongqing", 'geoPoint': {'lat': 29.15201, 'lon': 107.10335}}, {'zip': '402177', 'city': 'Yongchuan', 'state': 'Chongqing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoli Zhang', 'role': 'CONTACT', 'phone': '13504549189'}], 'facility': 'YongChuan hospital of Chongqing Medical Univeristy', 'geoPoint': {'lat': 29.35376, 'lon': 105.89392}}, {'zip': '350001', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yingping Cao', 'role': 'CONTACT', 'phone': '13365910806'}], 'facility': 'Fujian Medical University Union Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '350001', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Falin Chen', 'role': 'CONTACT', 'phone': '13600807079'}], 'facility': 'Fujian Provincial Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '350014', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yan Chen', 'role': 'CONTACT', 'phone': '13905010494'}], 'facility': 'Fujian Cancer Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '730000', 'city': 'Lanzhou', 'state': 'Gansu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Liqiong Yao', 'role': 'CONTACT', 'phone': '13919300448'}], 'facility': 'The First Hospital of Lanzhou University', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '730030', 'city': 'Lanzhou', 'state': 'Gansu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Gechong Yong', 'role': 'CONTACT', 'phone': '13919309189'}], 'facility': 'Lanzhou University Second Hospital', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '528200', 'city': 'Foshan', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tian Cai', 'role': 'CONTACT', 'phone': '13106598603'}], 'facility': "The Sixth Affiliated Hospital of South China University of Technology (Foshan Nanhai District People's Hospital )", 'geoPoint': {'lat': 23.02677, 'lon': 113.13148}}, {'zip': '510600', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Minmin Li', 'role': 'CONTACT', 'phone': '18903078510'}], 'facility': 'The First Affiliated Hospital of Jinan University（Guangzhou Overseas Chinese Hospital ）', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '518107', 'city': 'Shenzhen', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhaofan Luo', 'role': 'CONTACT', 'phone': '18002295130'}], 'facility': 'The seventh Affiliated Hospital, Sun Yat-sen University', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '564000', 'city': 'Zhongshan', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Kang Chen', 'role': 'CONTACT', 'phone': '18898389835'}], 'facility': "Zhongshan City People's Hospital", 'geoPoint': {'lat': 22.52306, 'lon': 113.37912}}, {'zip': '530007', 'city': 'Nanning', 'state': 'Guangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Li Xie', 'role': 'CONTACT', 'phone': '13737089977'}], 'facility': 'The Second Affiliated Hospital of Guangxi Medical University', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '530021', 'city': 'Nanning', 'state': 'Guangxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yulin Yuan', 'role': 'CONTACT', 'phone': '13878813926'}], 'facility': "People's Hospital of Guangxi Zhuang Autonomous Region", 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '543002', 'city': 'Tongliao', 'state': 'Guangxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Minzhong Tang', 'role': 'CONTACT', 'phone': '13481411516'}], 'facility': 'Wuzhou Red Cross Hospital'}, {'zip': '550001', 'city': 'Guiyang', 'state': 'Guizhou', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wei Wang', 'role': 'CONTACT', 'phone': '18786126238'}], 'facility': 'The Affiliated Cancer Hospital of Guizhou Medical University', 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'zip': '550004', 'city': 'Guiyang', 'state': 'Guizhou', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hai Huang', 'role': 'CONTACT', 'phone': '18985111828'}], 'facility': 'The Affiliated Hospital of Guizhou Medical University', 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'zip': '570100', 'city': 'Haikou', 'state': 'Hainan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiang Wu', 'role': 'CONTACT', 'phone': '13337600255'}], 'facility': 'Hainan Traditional Chinese Medicine Hospital', 'geoPoint': {'lat': 20.03421, 'lon': 110.34651}}, {'zip': '163316', 'city': 'Daqing', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dejun Yun', 'role': 'CONTACT', 'phone': '13304690977'}], 'facility': "Daqing People's Hospital（The Fifth Affiliated Hospital of Harbin Medical University）", 'geoPoint': {'lat': 46.58333, 'lon': 125.0}}, {'zip': '150007', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yingyu Jin', 'role': 'CONTACT', 'phone': '13796029276'}], 'facility': 'The First Affiliated Hospital of Harbin Medical University', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '150088', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Haiyan Gao', 'role': 'CONTACT', 'phone': '15545545606'}], 'facility': 'The Sixth Affiliated Hospital of Harbin Medical University', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'city': 'Jixi', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jinyu Yang', 'role': 'CONTACT', 'phone': '13763665650'}], 'facility': 'Jixi Ji Mine Hospital', 'geoPoint': {'lat': 45.29322, 'lon': 130.96217}}, {'zip': '161005', 'city': 'Qiqihar', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenxiu Liu', 'role': 'CONTACT', 'phone': '15904526839'}], 'facility': 'Qiqihar Hospital of Traditional Chinese Medicine', 'geoPoint': {'lat': 47.33922, 'lon': 123.96154}}, {'zip': '471000', 'city': 'Luoyang', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhanjun Zhang', 'role': 'CONTACT', 'phone': '13939926329'}], 'facility': 'Luoyang Maternal and Child Health Hospital', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '471003', 'city': 'Luoyang', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tao Jiang', 'role': 'CONTACT', 'phone': '13837988831'}], 'facility': 'Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine,Medical College of Henan University of Science and Technology', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '476100', 'city': 'Shangqiu', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weibing Yin', 'role': 'CONTACT', 'phone': '13937057566'}], 'facility': "Shangqiu First People's Hospital", 'geoPoint': {'lat': 34.45, 'lon': 115.65}}, {'zip': '430012', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoliang Zhou', 'role': 'CONTACT', 'phone': '18108650781'}], 'facility': 'Wuhan Mental Health Center', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '441021', 'city': 'Xiangyang', 'state': 'Hubei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhengjiang Cheng', 'role': 'CONTACT', 'phone': '15207275328'}], 'facility': 'Xiangyang Central Hospital', 'geoPoint': {'lat': 32.0422, 'lon': 112.14479}}, {'zip': '441599', 'city': 'Xianyang', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xuesheng Li', 'role': 'CONTACT', 'phone': '15871057798'}], 'facility': "Nanzhang People's Hospital"}, {'zip': '412007', 'city': 'Zhuzhou', 'state': 'Hunan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zuiming Jiang', 'role': 'CONTACT', 'phone': '13873381276'}], 'facility': 'Zhuzhou Central Hospital', 'geoPoint': {'lat': 27.83333, 'lon': 113.15}}, {'zip': '028000', 'city': 'Wuzhou', 'state': 'Inner Mongolia', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guoli Liu', 'role': 'CONTACT', 'phone': '15247519335'}], 'facility': 'Affiliated Hospital of Inner Mongolia Minzu University'}, {'zip': '214002', 'city': 'Wuxi', 'state': 'Jiangsu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongyu Huang', 'role': 'CONTACT', 'phone': '13861740103'}], 'facility': "Wuxi No.2 People's Hospital", 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '343000', 'city': 'Ji’an', 'state': 'Jiangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Honghou Dai', 'role': 'CONTACT', 'phone': '13807968267'}], 'facility': 'Affiliated Hospital of Jinggangshan University', 'geoPoint': {'lat': 27.11716, 'lon': 114.97927}}, {'zip': '341000', 'city': 'Ganzhou', 'state': 'Jiangx', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tianyu Zhong', 'role': 'CONTACT', 'phone': '15279799667'}], 'facility': 'First Affiliated Hospital of Gannan Medical University', 'geoPoint': {'lat': 25.84664, 'lon': 114.9326}}, {'zip': '330000', 'city': 'Nanchang', 'state': 'Jiangx', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaozhong Wang', 'role': 'CONTACT', 'phone': '13576041466'}], 'facility': 'The Second Affiliated Hospital of Nanchang University', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '046011', 'city': 'Changzhi', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jufen Ma', 'role': 'CONTACT', 'phone': '15935530258'}], 'facility': 'Chang Zhi Yi Xue Yuan Fu Shu He Ji Yi Yuan', 'geoPoint': {'lat': 36.18389, 'lon': 113.10528}}, {'zip': '030001', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Kunping Guan', 'role': 'CONTACT', 'phone': '13700514558'}], 'facility': 'The Second Hospital of Shanxi Medical University', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '030024', 'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yuanyuan Pan', 'role': 'CONTACT', 'phone': '13934151016'}], 'facility': 'The Hospital of Shanxi University of Chinese Medicine', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '710004', 'city': 'Xi’an', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongli Liu', 'role': 'CONTACT'}], 'facility': "Xi'an People's Hospital (Xi'an Fourth Hospital)", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '710077', 'city': 'Xi’an', 'state': 'Shanxi', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhuo Li', 'role': 'CONTACT', 'phone': '13363963035'}], 'facility': "The First Affiliated Hospital of Xi'an Medical University", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '610083', 'city': 'Chengdu', 'state': 'Sichuan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yuan Liu', 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'city': 'Dayingmen', 'state': 'Tianjin Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Li Ren', 'role': 'CONTACT', 'phone': '18622221306'}], 'facility': 'Tianjing Medical University Cancer Institute & Hospital', 'geoPoint': {'lat': 39.10734, 'lon': 117.20958}}, {'zip': '300400', 'city': 'Guoyuan Xincun', 'state': 'Tianjin Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Kai Chen', 'role': 'CONTACT', 'phone': '18630922553'}], 'facility': 'Tianjin Beichen Hospital', 'geoPoint': {'lat': 39.22187, 'lon': 117.13018}}, {'zip': '844000', 'city': 'Kashgar', 'state': 'Xinjiang Uygur Autonomous Region', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Aimin Xu', 'role': 'CONTACT', 'phone': '18909981658'}], 'facility': "The First People's Hospital of Kashgar Prefecture", 'geoPoint': {'lat': 39.46718, 'lon': 75.98675}}, {'zip': '650032', 'city': 'Kunming', 'state': 'Yunnan', 'status': 'RECRUITING', 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