Ignite Creation Date:
2025-12-24 @ 10:47 PM
Ignite Modification Date:
2026-02-22 @ 5:09 PM
Study NCT ID:
NCT03012269
Status:
UNKNOWN
Last Update Posted:
2017-01-06
First Post:
2016-12-31
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Neural Substrates for Working Memory Training
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 40}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2012-10'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-01', 'lastUpdateSubmitDate': '2017-01-04', 'studyFirstSubmitDate': '2016-12-31', 'studyFirstSubmitQcDate': '2017-01-04', 'lastUpdatePostDateStruct': {'date': '2017-01-06', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2017-01-06', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2018-10', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Training-induced brain activations during working memory tasks in fMRI', 'timeFrame': 'six weeks', 'description': 'Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline'}], 'secondaryOutcomes': [{'measure': "The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test", 'timeFrame': 'six weeks'}, {'measure': 'Attention ability assessed by Stroop color-word test', 'timeFrame': 'six weeks'}]}, 'conditionsModule': {'conditions': ['Rehabilitation', 'Working Memory']}, 'descriptionModule': {'briefSummary': 'This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '55 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Right handedness\n* Diagnosis of traumatic brain injury or stroke\n* Course of disease within one year\n* The score of MoCA test \\> 24\n* Able to understand instructions\n\nExclusion Criteria:\n\n* Aphasia, unilateral spatial neglect, agnosia, apraxia\n* Hearing impairment or visual impairment\n* History of taking psychiatric drugs'}, 'identificationModule': {'nctId': 'NCT03012269', 'acronym': 'WMT', 'briefTitle': 'The Neural Substrates for Working Memory Training', 'organization': {'class': 'OTHER_GOV', 'fullName': 'China Rehabilitation Research Center'}, 'officialTitle': 'The Study on the Brain Mechanisms for the Rehabilitation of Working Memory Deficits in Patients With Acquired Brain Injury Using Multimodal Magnetic Resonance Imaging', 'orgStudyIdInfo': {'id': 'NSFC-81272165'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Working Memory Training', 'description': 'The subjects of experimental group received a series of working memory training, 30 min for 5 days per week during 6 weeks.', 'interventionNames': ['Behavioral: Working memory training']}, {'type': 'NO_INTERVENTION', 'label': 'Non-Working Memory Training', 'description': 'The subjects of control group performed traditional cognitive rehabilitation without working memory training, 30 min for 5 days per week during 6 weeks.'}], 'interventions': [{'name': 'Working memory training', 'type': 'BEHAVIORAL', 'armGroupLabels': ['Working Memory Training']}]}, 'contactsLocationsModule': {'locations': [{'zip': '100068', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoping Yun, MD', 'role': 'CONTACT', 'email': 'xiaoping_yun@163.com', 'phone': '8601067574465'}], 'facility': 'Department of Rehabilitation Evaluation, China Rehabilitation Research Center', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}], 'centralContacts': [{'name': 'Xiaoping Yun, MD', 'role': 'CONTACT', 'email': 'xiaoping_yun@163.com', 'phone': '86-01067574465'}], 'overallOfficials': [{'name': 'Xiaoping Yun, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Department of Rehabilitation Evaluation, China Rehabilitation Research Center'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'China Rehabilitation Research Center', 'class': 'OTHER_GOV'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Director of Department of Rehabilitation Evaluation', 'investigatorFullName': 'Yun XiaoPing', 'investigatorAffiliation': 'China Rehabilitation Research Center'}}}}