Ignite Creation Date:
2025-12-24 @ 10:47 PM
Ignite Modification Date:
2026-01-01 @ 4:18 AM
Study NCT ID:
NCT06374069
Status:
RECRUITING
Last Update Posted:
2024-04-18
First Post:
2024-03-20
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Longevity Families of the Netherlands
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'FAMILY_BASED'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 600}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-09-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-04', 'completionDateStruct': {'date': '2026-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-04-15', 'studyFirstSubmitDate': '2024-03-20', 'studyFirstSubmitQcDate': '2024-04-15', 'lastUpdatePostDateStruct': {'date': '2024-04-18', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-04-18', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Identifying the genetic variants of Familial Longevity', 'timeFrame': 'through study completion, an average of 2 years', 'description': 'To identify gene variants associated with healthy aging and protection from (multi)morbidity'}], 'secondaryOutcomes': [{'measure': 'Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component', 'timeFrame': 'through study completion, an average of 2 years', 'description': 'To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Longevity', 'Familial Longevity', 'Extreme Longevity', 'Aging']}, 'descriptionModule': {'briefSummary': 'The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.\n\nThe purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['OLDER_ADULT'], 'minimumAge': '75 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Dutch Caucasian descent:\n\nAges 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity\n* Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity\n\nExclusion Criteria:\n\n\\-'}, 'identificationModule': {'nctId': 'NCT06374069', 'acronym': 'LOF-NL', 'briefTitle': 'Longevity Families of the Netherlands', 'organization': {'class': 'OTHER', 'fullName': 'Leiden University Medical Center'}, 'officialTitle': 'Longevity Families of the Netherlands', 'orgStudyIdInfo': {'id': 'NL81887.058.23'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Cases - Enriched for familial longevity', 'description': 'Siblings of dutch Caucasian descent ages 75 and older'}, {'label': 'Controls - Non-enriched for familial longevity', 'description': 'Individuals of dutch Caucasian descent ages 75 and older solely in their family.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '2333ZA', 'city': 'Leiden', 'state': 'South Holland', 'status': 'RECRUITING', 'country': 'Netherlands', 'facility': 'Leiden University Medical Center', 'geoPoint': {'lat': 52.15833, 'lon': 4.49306}}], 'centralContacts': [{'name': '(Eline) P. Slagboom, Prof. dr.', 'role': 'CONTACT', 'email': 'p.slagboom@lumc.nl', 'phone': '+31(0)71 5269 730'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Leiden University Medical Center', 'class': 'OTHER'}, 'collaborators': [{'name': 'Jacobijn Gussekloo, Prof. dr.', 'class': 'UNKNOWN'}, {'name': 'Simon P. Mooijaart, Prof. dr.', 'class': 'UNKNOWN'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Eline Slagboom, Prof. dr.', 'investigatorFullName': 'Eline Slagboom', 'investigatorAffiliation': 'Leiden University Medical Center'}}}}