Ignite Creation Date:
2025-12-24 @ 10:46 PM
Ignite Modification Date:
2025-12-25 @ 8:16 PM
Study NCT ID:
NCT04637269
Status:
UNKNOWN
Last Update Posted:
2020-11-19
First Post:
2020-11-12
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Anti-BCMA CAR-T Cell Therapy for the R/R Multiple Myeloma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D009101', 'term': 'Multiple Myeloma'}], 'ancestors': [{'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['EARLY_PHASE1'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 16}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-11-17', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-11', 'completionDateStruct': {'date': '2023-11-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2020-11-14', 'studyFirstSubmitDate': '2020-11-12', 'studyFirstSubmitQcDate': '2020-11-14', 'lastUpdatePostDateStruct': {'date': '2020-11-19', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-11-19', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2021-11-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Incidence of dose limiting toxicity (DLTs)', 'timeFrame': 'within 4 weeks after infusion', 'description': 'To characterize the safety, tolerability, and determine the recommended dosage of Anti-BCMA CAR-T Cells for the R/R Multiple Myeloma'}, {'measure': 'Incidence and severity of AEs and SAEs', 'timeFrame': 'Up to 24 months', 'description': 'To characterize the safety, tolerability, and determine the recommended dosage of Anti-BCMA CAR-T Cells for the R/R Multiple Myeloma'}], 'secondaryOutcomes': [{'measure': 'Best Overall Response', 'timeFrame': 'up to 24 months after infusion', 'description': 'Response assessed by International Myeloma Working Group (IMWG) criteria'}, {'measure': 'Duration of Response', 'timeFrame': 'up to 24 months after infusion', 'description': 'Response assessed by International Myeloma Working Group (IMWG) criteria'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Multiple Myeloma']}, 'descriptionModule': {'briefSummary': 'Although the anti-CD19 CAR-T cell therapies have gained significant results in patients with relapsed and refractory B-cell hematologic malignancies. There are few effective treatments for MM(multiple myeloma). BCMA (B cell maturation antigen) is a promising target for malignant plasma cells. Therefore, we designed a clinical trial using anti-BCMA CAR-T cell therapy for patients with relapsed and refractory multiple myeloma.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\nSubjects must meet the following criteria for inclusion in the study： 1) Male or female subjects between the ages of 18 and 75（including critical values）； 2) Subjects histologically confirmed as relapsed and refractory multiple myeloma.\n\nPositive expression of BCMA(\\>50%) in malignant plasma cells； Approved anti-tumor therapies, such as systemic chemotherapy, systemic radiotherapy, and immunotherapy, have been completed for at least 2 weeks before the precondition.\n\nECOG≤1； Life expectancy ≥ 3 months； Neutrophil absolute count ≥ 1×10\\^9/L； platelet count ≥ 50×10\\^9/L； Absolute lymphocyte count ≥ 1×10\\^8/L ；\n\nAdequate organ function reserve :\n\nGPT, GST ≤ 2.5× UNL（upper normal limit）； Creatinine clearance (Cockcroft Gault method）≥60mL/min； Serum total bilirubin ≤1.5× UNL； The left ventricular ejection fraction (LVEF) ≥ 50% was diagnosed by echocardiography, and there was no clinically significant pericardial effusion and ECG abnormality； Basic oxygen saturation in indoor natural air environment \\> 92%； It can establish the venous access needed for collection without the contraindications of leukocyte collection； For female subjects of childbearing age, results are negative in urine pregnancy test before screening and administration, and subjects agree to take effective contraceptive measures at least one year after infusion; Male subjects with partners' fertility must agree to use effective barrier contraceptive methods at least one year after infusion, and avoid sperm donation； Voluntary signing of informed consent;\n\nExclusion Criteria:\n\nAny of the following points shall be deemed as no entry into this study：\n\nOther tumors except cured non-melanoma skin cancer, cervical cancer in situ, superficial bladder cancer, breast duct cancer in situ, or other malignant tumors with complete remission of more than 5 years)； Severe mental disorders； A history of genetic diseases such as Fanconi anemia, Shudder-Dale syndrome, Costman syndrome, or any other known bone marrow failure syndrome； Heart disease with grade III-IV heart failure \\[NYHA classification\\], myocardial infarction, angioplasty or stenting, unstable angina or other heart diseases with prominent clinical symptoms within one year before admission； Subjects with any indwelling catheter or drainage tube (such as percutaneous nephrostomy tube, bile drainage tube or pleura/peritoneum/pericardium catheter), should be excluded. (Special central venous catheter is allowed)； Subjects with a history of CNS lymphoma, CSF malignant cells, or brain metastasis； Subjects with a history of CNS disease,such as epilepsy, cerebral ischemia/hemorrhage, dementia, cerebellar disease, or any autoimmune disease involving CNS； Any of the following virological ELISA results are positive: HIV antibody, HCV antibody, TPPA, HBsAg； Active infection requiring systematic treatment within 2 weeks before single collection； Subjects with known severe allergic reactions to cyclophosphamide or fludarabine, or diagnosed as the allergy； History of autoimmune diseases (e.g. Crohn disease, rheumatoid arthritis, systemic lupus erythematosus) that cause end-organ damage or require systemic immunosuppressive medications or systemic disease modifying drugs in the past 2 years； Presence of pulmonary fibrosis； Subjects who have received other clinical trial treatment within 4 weeks before participating in this trial should be excluded. Or the signing date of informed consent is within 5 half-lives of the last application of another clinical trial (whichever is longer)； Subjects with poor compliance due to physiological, family, social, geographical and other factors, or those unable to cooperate with the study plan or follow-up； At the discretion of the investigator, there are complications requiring systemic corticosteroid therapy (≥ 5mg / day of prednisone or equivalent dose of other corticosteroids) or other immunosuppressive drugs within 6 months after this clinical research treatment； The lactating woman who is reluctant to stop breastfeeding； Any other condition considered unsuitable by the investigator."}, 'identificationModule': {'nctId': 'NCT04637269', 'briefTitle': 'Anti-BCMA CAR-T Cell Therapy for the R/R Multiple Myeloma', 'organization': {'class': 'OTHER', 'fullName': 'Xinqiao Hospital of Chongqing'}, 'officialTitle': 'Anti-BCMA CAR-T Cell Therapy for the Relapsed or Refractory Multiple Myeloma: a Multi-center, Uncontrolled Trial.', 'orgStudyIdInfo': {'id': 'BCMA CAR-T cell'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'BCMA CAR-T', 'description': 'The study will employ dose level cohorts of three patients that will be treated at each level described below, based on the number of T cells to be infused using the "3 + 3" dose-escalation strategy to find MTD followed by a dose-expansion phase at determined optimal dosage.', 'interventionNames': ['Biological: anti-BCMA CAR-T']}], 'interventions': [{'name': 'anti-BCMA CAR-T', 'type': 'BIOLOGICAL', 'description': '5×10\\^7 /KG 15×10\\^7 /KG 45×10\\^7/KG Treatment follows a lymphodepletion, chemotherapy regimen that consists of Fludarabine (30 mg/m2 per day) and Cyclophosphamide (300mg/m2 per day) for 3 days prior to cell infusion.', 'armGroupLabels': ['BCMA CAR-T']}]}, 'contactsLocationsModule': {'locations': [{'zip': '400037', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xi Zhang, MD', 'role': 'CONTACT', 'email': 'zhangxxi@sina.com', 'phone': '+8613808310064', 'phoneExt': '+8613808310064'}, {'name': 'Ruihao Huang', 'role': 'CONTACT', 'email': '1169731117@qq.com', 'phone': '+8618984398751', 'phoneExt': '+8618984398751'}], 'facility': 'Department of Hematology, Xinqiao Hospital', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}], 'centralContacts': [{'name': 'Xi Zhang, MD phD', 'role': 'CONTACT', 'email': 'zhangxxi@sina.com', 'phone': '13808310064', 'phoneExt': '+86'}, {'name': 'Ruihao Huang', 'role': 'CONTACT', 'email': '1169731117@qq.com', 'phone': '18984398751', 'phoneExt': '+86'}], 'overallOfficials': [{'name': 'Xi Zhang', 'role': 'STUDY_CHAIR', 'affiliation': 'Xinqiao Hospital of Chongqing'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Xinqiao Hospital of Chongqing', 'class': 'OTHER'}, 'collaborators': [{'name': 'Carbiogene Therapeutics Co. Ltd.', 'class': 'INDUSTRY'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Chef of Hematology Department', 'investigatorFullName': 'Xi Zhang, MD', 'investigatorAffiliation': 'Xinqiao Hospital of Chongqing'}}}}