Ignite Creation Date:
2025-12-24 @ 10:34 PM
Ignite Modification Date:
2026-02-20 @ 6:04 PM
Study NCT ID:
NCT02693535
Status:
RECRUITING
Last Update Posted:
2025-08-26
First Post:
2016-02-11
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}, {'id': 'D009101', 'term': 'Multiple Myeloma'}, {'id': 'D009369', 'term': 'Neoplasms'}], 'ancestors': [{'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C500026', 'term': 'palbociclib'}, {'id': 'D000077210', 'term': 'Sunitinib'}, {'id': 'C401859', 'term': 'temsirolimus'}, {'id': 'D000068878', 'term': 'Trastuzumab'}, {'id': 'C485206', 'term': 'pertuzumab'}, {'id': 'D000077484', 'term': 'Vemurafenib'}, {'id': 'C574276', 'term': 'cobimetinib'}, {'id': 'C559147', 'term': 'regorafenib'}, {'id': 'C531550', 'term': 'olaparib'}, {'id': 'C582435', 'term': 'pembrolizumab'}, {'id': 'D000077594', 'term': 'Nivolumab'}, {'id': 'D000074324', 'term': 'Ipilimumab'}, {'id': 'C000590451', 'term': 'abemaciclib'}, {'id': 'C586365', 'term': 'talazoparib'}, {'id': 'C000594389', 'term': 'atezolizumab'}, {'id': 'C000607349', 'term': 'entrectinib'}, {'id': 'C000609083', 'term': 'larotrectinib'}, {'id': 'C000705452', 'term': 'tucatinib'}, {'id': 'C000713257', 'term': 'futibatinib'}], 'ancestors': [{'id': 'D011758', 'term': 'Pyrroles'}, {'id': 'D001393', 'term': 'Azoles'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D007211', 'term': 'Indoles'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D061067', 'term': 'Antibodies, Monoclonal, Humanized'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D013449', 'term': 'Sulfonamides'}, {'id': 'D000577', 'term': 'Amides'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D013450', 'term': 'Sulfones'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 4200}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2016-03-14', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2028-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-08-25', 'studyFirstSubmitDate': '2016-02-11', 'studyFirstSubmitQcDate': '2016-02-23', 'lastUpdatePostDateStruct': {'date': '2025-08-26', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2016-02-26', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2027-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Objective Response Rate defined as % of participants in a cohort with complete or partial response or with stable disease according to standard response criteria', 'timeFrame': 'Assessed at 16 weeks of treatment', 'description': 'Each cohort includes participants with the same tumor type, genomic variant and study drug. For solid tumors, the Response Evaluation Criteria for Solid Tumors (RECIST) criteria will be used, for non-Hodgkin Lymphoma, the Lugano Criteria will be used, and for multiple myeloma, the International Uniform Response Criteria for Multiple Myeloma will be used.'}], 'secondaryOutcomes': [{'measure': 'Overall survival (OS)', 'timeFrame': 'Duration of survival from registration on study until death from any cause, assessed throughout end of study, up to 3 years', 'description': 'OS will be estimated using the Kaplan-Meier method'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['cancer', 'off-label', 'precision medicine', 'targeted therapy'], 'conditions': ['Lymphoma, Non-Hodgkin', 'Multiple Myeloma', 'Advanced Solid Tumors']}, 'referencesModule': {'references': [{'pmid': '41100773', 'type': 'DERIVED', 'citation': 'Al Baghdadi T, Rothe M, Mangat PK, Garrett-Mayer E, Crysler OV, Mileham KF, Farrington LC, Adesunloye B, Dublis SA, Astsaturov I, Calfa CJ, Bleeker J, Khalil M, Thota R, Cannon TL, Alese OB, Gold PJ, Hafez N, Baron AD, Meric-Bernstam F, Hobbs E, Marr AS, Rueter J, Tawfik B, Hinshaw DC, Gregory A, Grantham GN, Halabi S, Schilsky RL. Olaparib in Patients With Solid Tumors With BRCA1/2 Alterations: Results From The Targeted Agent and Profiling Utilization Registry (TAPUR) Study. JCO Precis Oncol. 2025 Oct;9:e2500649. doi: 10.1200/PO-25-00649. Epub 2025 Oct 16.'}, {'pmid': '40610648', 'type': 'DERIVED', 'citation': 'Mangat PK, Kirkwood MK, Hinshaw DC, Garrett-Mayer E, Schilsky RL. Prevalence of targetable genomic alterations among a diverse population participating in the ASCO TAPUR Study. NPJ Precis Oncol. 2025 Jul 3;9(1):222. doi: 10.1038/s41698-025-00962-1.'}, {'pmid': '39413339', 'type': 'DERIVED', 'citation': 'Worden FP, Pisick E, Rothe M, Mangat PK, Garrett-Mayer E, Khalil MF, Carrizosa DR, Bauman JR, Leidner RS, Duvivier HL, Fu S, Park MS, Yost KJ, Calfa CJ, Marr AS, Balmanoukian AS, Behl D, Cannon TL, Nabell L, Powell SF, Thota R, Hinshaw DC, Gregory A, Grantham GN, Halabi S, Schilsky RL. Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2024 Oct;8:e2400477. doi: 10.1200/PO-24-00477. Epub 2024 Oct 16.'}, {'pmid': '39013131', 'type': 'DERIVED', 'citation': 'Schuetze S, Rothe M, Mangat PK, Garrett-Mayer E, Meric-Bernstam F, Calfa CJ, Farrington LC, Livingston MB, Wentzel K, Behl D, Kier Y, Marr AS, von Mehren M, Press JZ, Thota R, Grantham GN, Gregory A, Hinshaw DC, Halabi S, Schilsky RL. Palbociclib in Patients With Soft Tissue Sarcoma With CDK4 Amplifications: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2024 Jul;8:e2400219. doi: 10.1200/PO.24.00219.'}, {'pmid': '38865672', 'type': 'DERIVED', 'citation': 'Srkalovic G, Rothe M, Mangat PK, Garrett-Mayer E, Ahn ER, Brouse G, Chan J, Mehmi I, Khalil M, Duvivier HL, Gaba A, Leuva H, Thota R, Yost KJ, Grantham GN, Gregory A, Hinshaw DC, Halabi S, Schilsky RL. Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2024 Jun;8:e2400026. doi: 10.1200/PO.24.00026.'}, {'pmid': '38748939', 'type': 'DERIVED', 'citation': 'Cannon TL, Rothe M, Mangat PK, Garrett-Mayer E, Chiu VK, Hwang J, Vijayvergia N, Alese OB, Dib EG, Duvivier HL, Klute KA, Sahai V, Ahn ER, Bedano P, Behl D, Sinclair S, Thota R, Urba WJ, Yang ES, Grantham GN, Hinshaw DC, Gregory A, Halabi S, Schilsky RL. Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study. J Clin Oncol. 2024 Sep 20;42(27):3228-3237. doi: 10.1200/JCO.23.02078. Epub 2024 May 15.'}, {'pmid': '38564684', 'type': 'DERIVED', 'citation': 'Perez JK, Kleber J, Rothe M, Mangat P, Garrett-Mayer E, Schilsky RL. Concordance in Molecular Tumor Board Case Reviews in the ASCO TAPUR Study. JCO Precis Oncol. 2024 Mar;8:e2300615. doi: 10.1200/PO.23.00615.'}, {'pmid': '38354330', 'type': 'DERIVED', 'citation': 'Calfa CJ, Rothe M, Mangat PK, Garrett-Mayer E, Ahn ER, Burness ML, Gogineni K, Rohatgi N, Al Baghdadi T, Conlin A, Gaba A, Hamid O, Krishnamurthy J, Gavini NJ, Gold PJ, Rodon J, Rueter J, Thota R, Grantham GN, Hinshaw DC, Gregory A, Halabi S, Schilsky RL. Sunitinib in Patients With Breast Cancer With FGFR1 or FGFR2 Amplifications or Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2024 Feb;8:e2300513. doi: 10.1200/PO.23.00513.'}, {'pmid': '38096472', 'type': 'DERIVED', 'citation': 'Meric-Bernstam F, Rothe M, Mangat PK, Garrett-Mayer E, Gutierrez R, Ahn ER, Cannon TL, Powell S, Krauss JC, Reynolds CM, von Mehren M, Behl D, Calfa CJ, Duvivier HL, Kaplan HG, Livingston MB, Sharma MR, Urba WJ, Grantham GN, Hinshaw DC, Gregory A, Halabi S, Schilsky RL. Cobimetinib Plus Vemurafenib in Patients With Solid Tumors With BRAF Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2023 Sep;7:e2300385. doi: 10.1200/PO.23.00385.'}, {'pmid': '38039429', 'type': 'DERIVED', 'citation': 'Rohatgi N, Rothe M, Mangat PK, Garrett-Mayer E, Meric-Bernstam F, Pisick E, Alese OB, Reynolds CM, Thota R, Vaccaro GM, von Mehren M, Arend RC, Chiu VK, Duvivier HL, Gold PJ, Hack K, Marr AS, Winer A, Grantham GN, Hinshaw DC, Gregory A, Halabi S, Schilsky RL. Nivolumab Plus Ipilimumab in Patients With Solid Tumors With ATM Mutations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. JCO Precis Oncol. 2023 Sep;7:e2300279. doi: 10.1200/PO.23.00279.'}, {'pmid': '37561967', 'type': 'DERIVED', 'citation': 'Duvivier HL, Rothe M, Mangat PK, Garrett-Mayer E, Ahn ER, Al Baghdadi T, Alva AS, Dublis SA, Cannon TL, Calfa CJ, Li R, Behl D, Chiu VK, Gold PJ, Marr AS, Mileham KF, Powell SF, Rodon J, Thota R, Grantham GN, Gregory A, Hinshaw DC, Halabi S, Schilsky RL. Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study. J Clin Oncol. 2023 Nov 20;41(33):5140-5150. doi: 10.1200/JCO.23.00702. Epub 2023 Aug 10.'}, {'pmid': '37489819', 'type': 'DERIVED', 'citation': 'Mangat PK, Garrett-Mayer E, Perez JK, Schilsky RL. The Targeted Agent and Profiling Utilization Registry Study: A pragmatic clinical trial. Clin Trials. 2023 Dec;20(6):699-707. doi: 10.1177/17407745231182013. Epub 2023 Jul 25.'}, {'pmid': '37315265', 'type': 'DERIVED', 'citation': 'Ganti AK, Rothe M, Mangat PK, Garrett-Mayer E, Dib EG, Duvivier HL, Ahn ER, Behl D, Borghaei H, Balmanoukian AS, Gaba A, Li R, Osei-Boateng K, Thota R, Grantham GN, Gregory A, Halabi S, Schilsky RL. Pertuzumab Plus Trastuzumab in Patients With Lung Cancer With ERBB2 Mutation or Amplification: Results From the Targeted Agent and Profiling Utilization Registry Study. JCO Precis Oncol. 2023 Jun;7:e2300041. doi: 10.1200/PO.23.00041.'}, {'pmid': '37027810', 'type': 'DERIVED', 'citation': "Ahn ER, Rothe M, Mangat PK, Garrett-Mayer E, Ali-Ahmad HM, Chan J, Maitland ML, Patel SR, Reese Z, Balmanoukian AS, Drescher CW, Li R, Tsimberidou AM, Leath CA 3rd, O'Lone R, Grantham GN, Halabi S, Schilsky RL. Pertuzumab Plus Trastuzumab in Patients With Endometrial Cancer With ERBB2/3 Amplification, Overexpression, or Mutation: Results From the TAPUR Study. JCO Precis Oncol. 2023 Apr;7:e2200609. doi: 10.1200/PO.22.00609."}, {'pmid': '36753688', 'type': 'DERIVED', 'citation': "Yang ES, Halabi S, Rothe M, Garrett-Mayer E, Mangat PK, Pisick E, Dib E, Burgess EF, Zakem M, Rohatgi N, Bilen MA, O'Lone R, Grantham GN, Schilsky RL. Olaparib in Patients With Metastatic Prostate Cancer With BRCA1/2 Mutation: Results From the TAPUR Study. JCO Precis Oncol. 2023 Feb;7:e2200505. doi: 10.1200/PO.22.00505."}, {'pmid': '36315917', 'type': 'DERIVED', 'citation': "Gupta R, Meric-Bernstam F, Rothe M, Garrett-Mayer E, Mangat PK, D'Andre S, Ahn ER, O'Lone R, Halabi S, Grantham GN, Schilsky RL. Pertuzumab Plus Trastuzumab in Patients With Colorectal Cancer With ERBB2 Amplification or ERBB2/3 Mutations: Results From the TAPUR Study. JCO Precis Oncol. 2022 Oct;6:e2200306. doi: 10.1200/PO.22.00306."}, {'pmid': '33844595', 'type': 'DERIVED', 'citation': 'Alva AS, Mangat PK, Garrett-Mayer E, Halabi S, Hansra D, Calfa CJ, Khalil MF, Ahn ER, Cannon TL, Crilley P, Fisher JG, Haslem DS, Shrestha S, Antonelli KR, Butler NL, Warren SL, Rygiel AL, Ranasinghe S, Bruinooge SS, Schilsky RL. Pembrolizumab in Patients With Metastatic Breast Cancer With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. J Clin Oncol. 2021 Aug 1;39(22):2443-2451. doi: 10.1200/JCO.20.02923. Epub 2021 Apr 12.'}, {'pmid': '33090333', 'type': 'DERIVED', 'citation': 'Fisher JG, Tait D, Garrett-Mayer E, Halabi S, Mangat PK, Schink JC, Alvarez RH, Veljovich D, Cannon TL, Crilley PA, Pollock T, Calfa CJ, Al Baghdadi T, Thota R, Fleming N, Cotta JA, Rygiel AL, Warren SL, Schilsky RL. Cetuximab in Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Ovarian Cancer Without KRAS, NRAS, or BRAF Mutations: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. Target Oncol. 2020 Dec;15(6):733-741. doi: 10.1007/s11523-020-00753-7.'}, {'pmid': '33068284', 'type': 'DERIVED', 'citation': 'Al Baghdadi T, Garrett-Mayer E, Halabi S, Mangat PK, Rich P, Ahn ER, Chai S, Rygiel AL, Osayameh O, Antonelli KR, Islam S, Bruinooge SS, Schilsky RL. Sunitinib in Patients with Metastatic Colorectal Cancer (mCRC) with FLT-3 Amplification: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study. Target Oncol. 2020 Dec;15(6):743-750. doi: 10.1007/s11523-020-00752-8.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug.\n\nNOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers).\n\n\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\n\nResults in publication or poster presentation format are posted as they become available for individual cohorts at www.tapur.org/news. The results may be accessed at any time. All results will be made available on clinicaltrials.gov at the end of the study. Indexing of available results on PubMed is in progress.\n\n\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*\\*', 'detailedDescription': 'The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a non-randomized clinical trial that aims to describe the safety and efficacy of commercially available, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic variant. TAPUR will study Food and Drug Administration (FDA)-approved targeted therapies that are contributed by collaborating pharmaceutical companies, catalogue the choice of molecular profiling test by clinical oncologists and develop hypotheses for additional clinical trials.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '12 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* 12 years of age or older (\\*Restrictions apply. Not all therapies are available for patients \\<18)\n* Histologically-proven locally advanced or metastatic solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma who is no longer benefiting from standard anti-cancer treatment or for whom, in the opinion of the treating physician, no such treatment is available or indicated\n* Performance status 0-2 (Per Eastern Cooperative Oncology Group (ECOG) criteria)\n* Patients must have acceptable organ function as defined below. However, as noted above, drug-specific inclusion/exclusion criteria specified in the protocol appendix for each agent will take precedence for this and all inclusion criteria:\n\n 1. Absolute neutrophil count ≥ 1.5 x 106/µl\n 2. Hemoglobin \\> 9.0 g/dl\n 3. Platelets \\> 75,000/µl\n 4. Total bilirubin \\< 2.0 mg/ dl, except in patients with Gilbert\'s Syndrome\n 5. Aspartate aminotransferase (AST) serum glutamic-oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT) serum glutamic-pyruvic transaminase (SGPT) \\< 2.5 x institutional upper limit of normal (ULN) (or \\< 5 x ULN in patients with known hepatic metastases)\n 6. Serum creatinine ≤ 1.5 × ULN or calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2\n* Patients must have disease that can be objectively measured by physical or radiographic exam (per RECIST v1.1 for solid tumor, Lugano criteria for non-Hodgkin lymphoma or International Myeloma Working Group criteria for multiple myeloma), defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm with conventional techniques or as ≥10 mm with spiral CT scan, MRI, or a subcutaneous or superficial lesion that can be measured with calipers by clinical exam. For lymph nodes, the short axis must be ≥15 mm. Patient\'s whose disease cannot be objectively measured by physical or radiographic examination (e.g., elevated serum tumor marker only, bone-only disease without an identifiable soft tissue component, or patients with only assessable non-measurable disease) are NOT eligible.\n* Results must be available from a genomic test or immunohistochemistry (IHC) test for protein expression performed in a Clinical Laboratory Improvement Amendments (CLIA)-certified and College of American Pathologists (CAP)-accredited or New York State accredited (for labs offering services to residents of NY) laboratory. Labs that have registered the test with the NIH Genetic Testing Registry or that provide a report that has been designated as optimized for TAPUR participation are preferred, but not required. The genomic or IHC test used to qualify a patient for participation in TAPUR may have been performed on any specimen of the patient\'s tumor obtained at any point during the patient\'s care at the discretion of the patient\'s treating physician. Genomic assays performed on cell-free DNA in plasma ("liquid biopsies") will also be acceptable if the genomic analysis is performed in a laboratory that meets the criteria described above.\n* Ability to understand and the willingness to sign a written informed consent/assent document.\n* Have a tumor genomic profile for which single agent treatment with one of the FDA approved targeted anti-cancer drugs included in this study has potential clinical benefit based on the criteria described in protocol.\n* For orally administered drugs, the patient must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.\n* Because of the risks of drug treatment to the developing fetus, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation, and for four months following completion of study therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study or if she is the partner of a male participant in this study and becomes pregnant while he is participating in this study, she should inform her or her partner\'s treating physician immediately as well as her obstetrician. Female study patients who become pregnant must immediately discontinue treatment with any study therapy. Male patients should avoid impregnating a female partner. Male study patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and for a specified amount of time the last dose of study drug, or completely abstain from sexual intercourse.\n\nNote: TAPUR does not explicitly exclude any type of solid tumor, but the patient must have measurable and evaluable disease per RECIST v1.1.\n\nExclusion Criteria:\n\n* Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible\n* Patients with primary brain tumors or leptomeningeal metastases are excluded.\n* Patients with previously treated brain metastases are eligible, provided that the patient has not experienced a seizure or had a clinically significant change in neurological status within the 3 months prior to registration. All patients with previously treated brain metastases must be clinically stable for at least 1 month after completion of treatment and off steroid treatment for one month prior to study enrollment.\n* Patients with known progressive brain metastases are eligible but additional eligibility criteria apply.\n\nNote: there are additional exclusion criteria that may apply'}, 'identificationModule': {'nctId': 'NCT02693535', 'acronym': 'TAPUR', 'briefTitle': 'TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer', 'organization': {'class': 'OTHER', 'fullName': 'American Society of Clinical Oncology'}, 'officialTitle': 'Targeted Agent and Profiling Utilization Registry (TAPUR) Study', 'orgStudyIdInfo': {'id': 'Pro00014171'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'OTHER', 'label': 'Group 4 (CDKN2A, CDK4, CDK6)', 'description': 'Participants receive palbociclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation', 'interventionNames': ['Drug: Palbociclib']}, {'type': 'OTHER', 'label': 'Group 5 (CSF1R,PDGFR,VEGFR)', 'description': 'Participants receive sunitinib - dosage, frequency and duration per label; acceptable genomic matches include CSF1R, PDGFR, VEGFR1/2/3, KIT, FLT-3, RET, FGFR1/2/3, VHL amplifications or mutations', 'interventionNames': ['Drug: Sunitinib']}, {'type': 'OTHER', 'label': 'Group 6 (mTOR, TSC)', 'description': 'Participants receive temsirolimus - dosage, frequency and duration per label; acceptable genomic matches include mTOR, TSC1/2, AKT1 mutations', 'interventionNames': ['Drug: Temsirolimus']}, {'type': 'OTHER', 'label': 'Group 8 (ERBB2)', 'description': 'Participants receive trastuzumab and pertuzumab - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations', 'interventionNames': ['Drug: Trastuzumab and Pertuzumab']}, {'type': 'OTHER', 'label': 'Group 9 (BRAF V600E/D/K/R)', 'description': 'Participants receive vemurafenib and cobimetinib - dosage, frequency and duration per label; acceptable genomic matches include BRAF V600E/D/K/R mutations', 'interventionNames': ['Drug: Vemurafenib and Cobimetinib']}, {'type': 'OTHER', 'label': 'Group 13 (RET,VEGFR1/2/3,KIT,PDGFRβ,RAF-1,BRAF)', 'description': 'Participants receive regorafenib - dosage, frequency and duration per label; acceptable genomic matches include RET, VEGFR1/2/3, KIT, PDGFRβ, RAF-1, BRAF mutations or amplifications', 'interventionNames': ['Drug: Regorafenib']}, {'type': 'OTHER', 'label': 'Group 14 (BRCA1/2; ATM)', 'description': 'Participants receive olaparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 inactivating mutations; ATM mutations or deletions', 'interventionNames': ['Drug: Olaparib']}, {'type': 'OTHER', 'label': 'Group 15 (POLE, POLD1)', 'description': 'Participants receive pembrolizumab - dosage, frequency and duration per label; acceptable genomic matches include specific POLE and POLD1 mutations', 'interventionNames': ['Drug: Pembrolizumab']}, {'type': 'OTHER', 'label': 'Group 16 (MSI-H, high mutational load and others)', 'description': 'Participants receive nivolumab and ipilimumab - dosage, frequency and duration per label; acceptable genomic matches include MSI high status, high tumor mutational burden, MLH1, MSH2/6, PMS2, EPCAM mutations, specific POLE or POLD1 mutations, BRCA1/2, ATM, MSH3, PMS1, MLH3, EXO1, RFC1/2/3/4/5, PCNA, RPA1/2/3/4, and SSBP1 loss of function mutations', 'interventionNames': ['Drug: Nivolumab and Ipilimumab']}, {'type': 'OTHER', 'label': 'Group 17 (CDKN2A, CDK4, CDK6)', 'description': 'Participants receive abemaciclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation', 'interventionNames': ['Drug: Abemaciclib']}, {'type': 'OTHER', 'label': 'Group 19 (BRCA1/2, PALB2)', 'description': 'Participants receive talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 and PALB2 mutations', 'interventionNames': ['Drug: Talazoparib']}, {'type': 'OTHER', 'label': 'Group 20 (ERBB2)', 'description': 'Participants receive atezolizumab plus PHESGO - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression', 'interventionNames': ['Drug: Atezolizumab and PHESGO']}, {'type': 'OTHER', 'label': 'Group 21 (BRCA1/2, PALB2, ATM, and others)', 'description': 'Participants receive atezolizumab plus talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic mutations in BRCA1/2, PALB2, ATM, ATR, CHEK2, FANCA, RAD51C, NBN, MLH1, MRE11A, CDK12; positive genomic instability score reported on the Myriad MyChoice CDx test; or Genomic Loss of Heterozygosity (LOH) Score above threshold as reported on a FoundationOne CDx test or another qualifying test for TAPUR with MTB approval', 'interventionNames': ['Drug: Atezolizumab and Talazoparib']}, {'type': 'OTHER', 'label': 'Group 22 (ROS1 fusion)', 'description': 'Participants receive entrectinib - dosage, frequency and duration per label; acceptable genomic matches include any ROS1 fusion', 'interventionNames': ['Drug: Entrectinib']}, {'type': 'OTHER', 'label': 'Group 23 (NTRK amplification)', 'description': 'Participants receive larotrectinib - dosage, frequency and duration per label; acceptable genomic matches include NTRK1/2/3 amplification', 'interventionNames': ['Drug: Larotrectinib']}, {'type': 'OTHER', 'label': 'Group 24 (ERBB2)', 'description': 'Participants receive tucatinib plus trastuzumab SC - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations', 'interventionNames': ['Drug: Tucatinib plus Trastuzumab Subcutaneous (SC)']}, {'type': 'OTHER', 'label': 'Group 25', 'description': 'Participants receive futibatinib- dosage, frequency and duration per label; acceptable genomic matches include FGFR 1,2,3,4 fusion (or other rearrangement) or mutation', 'interventionNames': ['Drug: Futibatinib']}], 'interventions': [{'name': 'Palbociclib', 'type': 'DRUG', 'otherNames': ['Ibrance'], 'description': 'drug', 'armGroupLabels': ['Group 4 (CDKN2A, CDK4, CDK6)']}, {'name': 'Sunitinib', 'type': 'DRUG', 'otherNames': ['Sutent'], 'description': 'drug', 'armGroupLabels': ['Group 5 (CSF1R,PDGFR,VEGFR)']}, {'name': 'Temsirolimus', 'type': 'DRUG', 'otherNames': ['Torisel'], 'description': 'drug', 'armGroupLabels': ['Group 6 (mTOR, TSC)']}, {'name': 'Trastuzumab and Pertuzumab', 'type': 'DRUG', 'otherNames': ['Herceptin and Perjeta'], 'description': 'drug', 'armGroupLabels': ['Group 8 (ERBB2)']}, {'name': 'Vemurafenib and Cobimetinib', 'type': 'DRUG', 'otherNames': ['Zelboraf and Cotellic'], 'description': 'drug', 'armGroupLabels': ['Group 9 (BRAF V600E/D/K/R)']}, {'name': 'Regorafenib', 'type': 'DRUG', 'otherNames': ['Stivarga'], 'description': 'drug', 'armGroupLabels': ['Group 13 (RET,VEGFR1/2/3,KIT,PDGFRβ,RAF-1,BRAF)']}, {'name': 'Olaparib', 'type': 'DRUG', 'otherNames': ['Lynparza'], 'description': 'drug', 'armGroupLabels': ['Group 14 (BRCA1/2; ATM)']}, {'name': 'Pembrolizumab', 'type': 'DRUG', 'otherNames': ['Keytruda'], 'description': 'drug', 'armGroupLabels': ['Group 15 (POLE, POLD1)']}, {'name': 'Nivolumab and Ipilimumab', 'type': 'DRUG', 'otherNames': ['Opdivo and Yervoy'], 'description': 'drug', 'armGroupLabels': ['Group 16 (MSI-H, high mutational load and others)']}, {'name': 'Abemaciclib', 'type': 'DRUG', 'otherNames': ['Verzenio'], 'description': 'drug', 'armGroupLabels': ['Group 17 (CDKN2A, CDK4, CDK6)']}, {'name': 'Talazoparib', 'type': 'DRUG', 'otherNames': ['Talzenna'], 'description': 'drug', 'armGroupLabels': ['Group 19 (BRCA1/2, PALB2)']}, {'name': 'Atezolizumab and PHESGO', 'type': 'DRUG', 'otherNames': ['Tecentriq and PHESGO'], 'description': 'drug', 'armGroupLabels': ['Group 20 (ERBB2)']}, {'name': 'Atezolizumab and Talazoparib', 'type': 'DRUG', 'otherNames': ['Tecentriq and Talzenna'], 'description': 'drug', 'armGroupLabels': ['Group 21 (BRCA1/2, PALB2, ATM, and others)']}, {'name': 'Entrectinib', 'type': 'DRUG', 'otherNames': ['Rozlytrek'], 'description': 'drug', 'armGroupLabels': ['Group 22 (ROS1 fusion)']}, {'name': 'Larotrectinib', 'type': 'DRUG', 'otherNames': ['Vitrakvi'], 'description': 'drug', 'armGroupLabels': ['Group 23 (NTRK amplification)']}, {'name': 'Tucatinib plus Trastuzumab Subcutaneous (SC)', 'type': 'DRUG', 'otherNames': ['Tukysa and Herceptin Hylecta'], 'description': 'drug', 'armGroupLabels': ['Group 24 (ERBB2)']}, {'name': 'Futibatinib', 'type': 'DRUG', 'otherNames': ['Lytgobi'], 'description': 'drug', 'armGroupLabels': ['Group 25']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35294', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kun Yuan', 'role': 'CONTACT', 'email': 'kunyuan@uabmc.edu', 'phone': '205-644-2584'}, {'name': 'Mehmet Akce, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Alabama at Birmingham Comprehensive Cancer Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85338', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Russell Fernandez', 'role': 'CONTACT', 'email': 'rfernandez@coh.org', 'phone': '623-207-3126'}, {'name': 'Sagun Shrestha, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cancer Treatment Centers of America-Phoenix', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '95602', 'city': 'Auburn', 'state': 'California', 'status': 'RECRUITING', 'country': 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South / Sarah Cannon Research Institute', 'geoPoint': {'lat': 26.56285, 'lon': -81.94953}}, {'zip': '33761', 'city': 'Clearwater', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Florida Cancer Specialists North / Sarah Cannon Research Institute', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33308', 'city': 'Fort Lauderdale', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'MCRCwebsitecontactform@trinity-health.org', 'phone': '734-712-3671'}, {'name': 'Zdenka Segota, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Holy Cross Hospital', 'geoPoint': {'lat': 26.12231, 'lon': -80.14338}}, {'zip': '33901', 'city': 'Fort Myers', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Florida Cancer Specialists South / Sarah Cannon Research Institute', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '33905', 'city': 'Fort Myers', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Florida Cancer Specialists South / Sarah Cannon Research Institute', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '33908', 'city': 'Fort Myers', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Florida Cancer Specialists South / Sarah Cannon Research Institute', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32605', 'city': 'Gainesville', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Florida Cancer Specialists North / Sarah Cannon Research Institute', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Matthew Crunden', 'role': 'CONTACT', 'email': 'Crunden@ufl.edu', 'phone': '352-265-5329'}, {'name': 'Thomas George, 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