Ignite Creation Date:
2025-12-24 @ 10:33 PM
Ignite Modification Date:
2025-12-30 @ 7:49 AM
Study NCT ID:
NCT05196035
Status:
RECRUITING
Last Update Posted:
2025-09-17
First Post:
2022-01-07
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['China']}, 'conditionBrowseModule': {'meshes': [{'id': 'D051436', 'term': 'Renal Insufficiency, Chronic'}, {'id': 'D011507', 'term': 'Proteinuria'}], 'ancestors': [{'id': 'D051437', 'term': 'Renal Insufficiency'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D014555', 'term': 'Urination Disorders'}, {'id': 'D020924', 'term': 'Urological Manifestations'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C576501', 'term': 'finerenone'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 219}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-03-28', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-09', 'completionDateStruct': {'date': '2027-08-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-09-15', 'studyFirstSubmitDate': '2022-01-07', 'studyFirstSubmitQcDate': '2022-01-07', 'lastUpdatePostDateStruct': {'date': '2025-09-17', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2022-01-19', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-07-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Urinary protein-to-creatinine ratio (UPCR) reduction of at least 30% from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7', 'description': 'Proportion of participants at day 180±7 with a \\>=30% reduction in UPCR compared to baseline.'}], 'secondaryOutcomes': [{'measure': 'Number participants with treatment emergent adverse events (TEAEs）', 'timeFrame': 'From the start of study intervention to last study intervention + 3 days (up to 190 days)', 'description': 'Below sub-categories will be considered:\n\n1. Serious Treatment Emergent Adverse Events (TEAEs)\n2. TEAEs and serious TEAEs leading to discontinuation of treatment\n3. Study drug related TEAEs and serious TEAEs\n4. TEAEs categorized by severity (mild, moderate, severe)\n5. TEAEs by maximum intensity\n6. Number of participants hospitalized with hyperkalemia,\n7. Number of participants discontinuing due to hyperkalemia,\n8. Number of participants with hospitalization for worsening of renal function\n9. Number of participants discontinuing due to worsening of renal function'}, {'measure': 'Change in serum potassium levels from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7'}, {'measure': 'Change in serum creatinine from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7'}, {'measure': 'Change in eGFR from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7', 'description': 'Estimated glomerular filtration rate (eGFR)'}, {'measure': 'Change in systolic blood pressure from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7'}, {'measure': 'Mean reduction from baseline to day 180±7 in UPCR', 'timeFrame': 'From baseline to day 180±7', 'description': 'Percent change from baseline to day 180±7 in UPCR will be calculated.'}, {'measure': 'Change in UACR from baseline to day 180±7', 'timeFrame': 'From baseline to day 180±7', 'description': 'Urinary albumin-to-creatinine ratio (UACR)'}, {'measure': 'Pharmacokinetics (PK) finerenone Cmax, md', 'timeFrame': 'Pre-dose, post-dose (1.5-5 hours after intake of intervention), up to day 180±7', 'description': 'Maximum observed finerenone concentration in plasma after multiple doses.'}, {'measure': 'Pharmacokinetics (PK) finerenone AUCτ,md', 'timeFrame': 'Pre-dose, post-dose (1.5-5 hours after intake of intervention), up to day 180±7', 'description': 'Area under the curve for finerenone concentration in plasma after multiple doses.'}, {'measure': 'Taste and texture questionnaire of the pediatric formulation', 'timeFrame': 'On day 30±3 and day 180±7'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Chronic Kidney Disease', 'Proteinuria']}, 'referencesModule': {'references': [{'pmid': '38509517', 'type': 'DERIVED', 'citation': 'Schaefer F, Montini G, Kang HG, Walle JV, Zaritsky J, Schreuder MF, Litwin M, Scalise A, Scott H, Potts J, Iveli P, Breitenstein S, Warady BA. Investigating the use of finerenone in children with chronic kidney disease and proteinuria: design of the FIONA and open-label extension studies. Trials. 2024 Mar 21;25(1):203. doi: 10.1186/s13063-024-08021-z.'}], 'seeAlsoLinks': [{'url': 'https://clinicaltrials.bayer.com/', 'label': 'Click here to find information for studies related to Bayer products. To find this study enter the ClinicalTrials.gov identifier (NCT) number or Bayer Study Identifier (ID) in the search field.'}]}, 'descriptionModule': {'briefSummary': 'Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine.\n\nThe kidneys filter waste and fluid from the blood to form urine. In children with CKD, the kidney´s filters do not work as well as they should. This can lead to accumulation of waste and fluid in the body and proteinuria. CKD can lead to other medical problems, such as high blood pressure, also known as hypertension. Vice versa, hypertension and proteinuria can also contribute to worsening of CKD. Therefore, the treatment of CKD aims to control blood pressure and proteinuria. There are treatments available for doctors to prescribe to children with CKD and hypertension and/or proteinuria. These include "angiotensin-converting enzyme inhibitors" (ACEI) and "angiotensin receptor blockers" (ARB). Both ACEI and ARB can improve kidney function by helping the renin-angiotensin-aldosterone system (RAAS) to work normally. The RAAS is a system that works with the kidneys to control blood pressure and the balance of fluid and electrolytes in the blood. In people with CKD, the RAAS is often too active, which can stop the kidneys from working properly and cause hypertension and proteinuria. However, ACEI or ARB treatment alone does not work for all patients with CKD as they only target the angiotensin part of the renin-angiotensin-aldosterone system.\n\nThe study treatment, finerenone, is expected to help control RAAS overactivation together with an ACEI or ARB.\n\nSo, the researchers in this study want to learn more about whether finerenone given in addition to either an ACEI or ARB can help their kidney function.\n\nThe main purpose of this study is to learn more about whether finerenone added to either ACEI or ARB can help reduce the amount of protein in the participants\' urine more than a placebo. A placebo looks like a treatment but does not have any medicine in it. Participants will also continue to receive their other medications.\n\nTo see how the treatment work, the doctors will take samples of the participants\' urine to measure their protein levels before and during taking treatment and after their last treatment. In addition, blood samples will be taken to monitor kidney function, electrolytes and the amount of finerenone in the blood as well as for other tests.\n\nThis study will include children with CKD and proteinuria aged from 6 months up to less than 18 years. The participants will take:\n\n* either finerenone or the placebo, in addition to\n* either ACEI or ARB, whichever they take as part of their normal treatment\n\nTwo visits are required up to 104 days, to check whether a child can take part in the treatment phase of the study. If participants qualify for the treatment phase, they will then undergo treatment for about 180 days. During this time, they will visit the study site at least 7 times. During these visits, the participants will:\n\n* have their blood pressure, heart rate, temperature, height and weight measured\n* have blood and urine samples taken\n* have physical examinations\n* have their heart examined by an electrocardiogram and echocardiography (a sonogram of the heart)\n* answer questions about their medication and whether they have any adverse events , or have their parents or guardians answer\n* answer questions about how they are feeling, or have their parents or guardians answer\n* answer question about how they like the study medication, or have their parents or guardians answer\n\nThe doctors will keep track of any adverse events. An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.\n\nThe doctors will check the participants\' health about 30 days after the participants take their last treatment.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '17 Years', 'minimumAge': '6 Months', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Participants must be 6 months to \\<18 years old at the time when the informed consent/assent is signed\n* Participants must have a clinical diagnosis of chronic kidney disease (CKD) at screening which is defined as\n\n * CKD stages 1-3 (eGFR ≥30 mL/min/1.73m\\^2) for children ≥1 year to \\<18 years of age or\n * a serum creatinine ≤ 0.40 mg/dL for infants 6 months to \\< 1 year of age and\n * severely increased proteinuria as defined by\n\n * Urinary protein-to-creatinine ratio (UPCR) of ≥ 0.50 g/g in participants ≥ 2 years with CKD stage 2 and 3 or\n * UPCR ≥ 1.0 g/g for patients \\< 2 years of age or ≥ 2 years of age and with CKD stage 1\n* Participants must have stable kidney function between screening and D0 defined as:\n\n * For participants with a creatinine of \\> 0.8 mg/dL at screening: no increase or decrease in eGFR by ≥ 20% at D0\n * For participants with a creatinine of ≤ 0.8 mg/dL at screening: no increase or decrease in creatinine ≥ 0.15 mg/dL at D0.\n* Treated with an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) at optimized doses defined as maximally tolerable doses within the recommended dose range according to guidelines on blood pressure management, unchanged for at least 30 days prior to screening\n* K+ ≤5.0 mmol/L for children ≥2 years of age at both screening and D0, and ≤5.3 mmol/L for children \\<2 years of age at both screening and D0\n\nExclusion Criteria:\n\n* Planned urological surgery expected to influence renal function\n* Children with hemolytic uremic syndrome (HUS) diagnosed ≤6 months prior to screening\n* Patients with nephrotic syndrome receiving albumin infusions within the last 6 months prior to screening\n* Patients who are candidates for renal transplantation, i.e., a kidney transplantation scheduled within the study time frame\n* Renal allograft in place\n* Bilateral renal artery stenosis\n* Acute kidney injury requiring dialysis within 6 months prior to screening\n* Systemic hypertension stage 2 in children ≥1 year of age defined according to guidelines on blood pressure management at screening or randomization\n* Systolic blood pressure (SBP) above 110 mmHg in infants 6 months to \\<1 year of age at screening or randomization\n* Systemic hypotension defined as a systolic blood pressure below the 5th percentile for age, sex and height at either screening or randomization but no lower than 80 mmHg (although for some participants the 5th percentile of SBP is \\< 80 mmHg they must be excluded if their SBP is \\<80 mmHg)\n* Participants with immune-mediated CKD using rituximab, cyclophosphamide, abatacept, or high-dose glucocorticoids, within \\<6 months prior to screening'}, 'identificationModule': {'nctId': 'NCT05196035', 'acronym': 'FIONA', 'briefTitle': 'A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bayer'}, 'officialTitle': 'A 6-month Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and PK/PD of an age-and Body Weight-adjusted Oral Finerenone Regimen, in Addition to an ACEI or ARB, for the Treatment of Children, 6 Months to <18 Years of Age, With Chronic Kidney Disease and Proteinuria', 'orgStudyIdInfo': {'id': '19920'}, 'secondaryIdInfos': [{'id': '2023-504884-17-00', 'type': 'REGISTRY', 'domain': 'CTIS (EU)'}, {'id': '2021-002071-19', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Finerenone (Kerendia, BAY94-8862)', 'description': 'Participants will receive finerenone treatment.', 'interventionNames': ['Drug: Finerenone (Kerendia, BAY94-8862)']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Participants will receive placebo to finerenone.', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Finerenone (Kerendia, BAY94-8862)', 'type': 'DRUG', 'description': 'Finerenone in different doses, treatment duration will be 180±7 days', 'armGroupLabels': ['Finerenone (Kerendia, BAY94-8862)']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo to finerenone, treatment duration will be 180±7 days', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85016', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'TERMINATED', 'country': 'United States', 'facility': "Phoenix Children's Hospital | Main - Transplant Department", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Cedars-Sinai Medical Center - Nephrology', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94304', 'city': 'Palo Alto', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Lucille Packard Children's Hospital Stanford - Pediatric Nephrology", 'geoPoint': {'lat': 37.44188, 'lon': -122.14302}}, {'zip': '92123', 'city': 'San Diego', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Rady Children's Hospital San Diego - Cardiology", 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'facility': "Children's National Medical Center - Nephrology", 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33021', 'city': 'Hollywood', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Memorial Transplant Institute - Pediatric Nephrology', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': "Emory University Hospital/Children's Healthcare of Atlanta - Nephrology", 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'facility': 'University of Iowa Health Care Medical Center - Nephrology', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '21287', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'facility': "The Charlotte R. Bloomberg Children's Center Building - Nephrology", 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02115', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': "Boston Children's Hospital - Main Campus - Nephrology", 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '64108', 'city': 'Kansas City', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Children's Mercy Hospital Kansas City - Nephrology", 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '45229', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension", 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '14013', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Cleveland Clinic | Pediatric Nephrology', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '43205', 'city': 'Columbus', 'state': 'Ohio', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'facility': "Nationwide Children's Hospital - Nephrology", 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '97239', 'city': 'Portland', 'state': 'Oregon', 'status': 'RECRUITING', 'country': 'United States', 'facility': "OHSU Doernbecher Children's Hospital - Neurology", 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'facility': "Children's Hospital of Philadelphia - Nephrology", 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '78207', 'city': 'San Antonio', 'state': 'Texas', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Univ of Texas Health Science Center | Nephrology Res Dept', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '84113', 'city': 'Salt Lake City', 'state': 'Utah', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Primary Children's Hospital", 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '98105', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': "Seattle Children's Hospital - Nephrology", 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': 'C1199ABB', 'city': 'Ciudad Autonoma de Buenos Aire', 'state': 'Ciudad Auton. de Buenos Aires', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Instituto Universitario Hospital Italiano de Buenos Aires | Hospital Italiano de Buenos Aires - Neurology Department'}, {'zip': 'C1425EFD', 'city': 'Ciudad Autonoma de Buenos Aire', 'state': 'Ciudad Auton. de Buenos Aires', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department'}, {'zip': 'D5700CGR', 'city': 'San Luis', 'state': 'San Luis Province', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Centro de Rehabilitacion Cardiovascular | San Luis, Argentina', 'geoPoint': {'lat': -33.2914, 'lon': -66.32467}}, {'zip': 'S3000', 'city': 'Santa Fe', 'state': 'Santa Fe Province', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina', 'geoPoint': {'lat': -31.64881, 'lon': -60.70868}}, {'zip': 'C1249ABN', 'city': 'Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'facility': 'Hospital de Pediatría Juan P. Garrahan', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1270', 'city': 'Buenos Aires', 'status': 'RECRUITING', 'country': 'Argentina', 'facility': 'Hospital General de Ninos Pedro de Elizalde | Nephrology Department', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '2145', 'city': 'Westmead', 'state': 'New South Wales', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'facility': "The Children's Hospital at Westmead", 'geoPoint': {'lat': -33.80383, 'lon': 150.98768}}, {'zip': '4101', 'city': 'South Brisbane', 'state': 'Queensland', 'status': 'RECRUITING', 'country': 'Australia', 'facility': "Queensland Children's Hospital", 'geoPoint': {'lat': -27.48034, 'lon': 153.02049}}, {'zip': '3168', 'city': 'Clayton', 'state': 'Victoria', 'status': 'COMPLETED', 'country': 'Australia', 'facility': "Monash Children's Hospital", 'geoPoint': {'lat': -37.91667, 'lon': 145.11667}}, {'zip': '3052', 'city': 'Parkville', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'facility': "Royal Children's Hospital Melbourne", 'geoPoint': {'lat': -37.78333, 'lon': 144.95}}, {'zip': '8036', 'city': 'Graz', 'state': 'Styria', 'status': 'RECRUITING', 'country': 'Austria', 'facility': 'Medizinische Univ Graz | Kinder & Jugendheilkunde', 'geoPoint': {'lat': 47.06733, 'lon': 15.44197}}, {'zip': '4020', 'city': 'Linz', 'state': 'Upper Austria', 'status': 'RECRUITING', 'country': 'Austria', 'facility': 'Kepler Universitätsklinikum Campus IV', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'zip': '5020', 'city': 'Salzburg', 'status': 'RECRUITING', 'country': 'Austria', 'facility': 'Uniklinikum Salzburg - Landeskrankenhaus', 'geoPoint': {'lat': 47.79941, 'lon': 13.04399}}, {'zip': '1090', 'city': 'Vienna', 'status': 'RECRUITING', 'country': 'Austria', 'facility': 'AKH Wien | Kinder & Jugendheilkunde, Kindernephrologie', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '1020', 'city': 'Bruxelles - Brussel', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'Huderf / Ukzkf'}, {'zip': '1200', 'city': 'Bruxelles - Brussel', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'CU Saint-Luc/UZ St-Luc'}, {'zip': '9000', 'city': 'Ghent', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'UZ Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'zip': '3000', 'city': 'Leuven', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'UZ Gasthuisberg - Pediatric Nephrology', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '4000', 'city': 'Liège', 'status': 'RECRUITING', 'country': 'Belgium', 'facility': 'CHC Montlégia - Pediatrics', 'geoPoint': {'lat': 50.63373, 'lon': 5.56749}}, {'zip': '30150-221', 'city': 'Belo Horizonte', 'state': 'Minas Gerais', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Santa Casa de Misericórdia de Belo Horizonte', 'geoPoint': {'lat': -19.92083, 'lon': -43.93778}}, {'zip': '80250-060', 'city': 'Curitiba', 'state': 'Paraná', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Pequeno Principe', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '14051-140', 'city': 'Ribeirão Preto/SP', 'state': 'São Paulo', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Hosp Clínicas Facult. Med. de Ribeirão Preto / USP'}, {'zip': '01227-200', 'city': 'São Paulo', 'state': 'São Paulo', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '13034-685', 'city': 'São Paulo', 'state': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '05403 000', 'city': 'São Paulo', 'status': 'NOT_YET_RECRUITING', 'country': 'Brazil', 'facility': 'Instituto da Crianca e do Adolescente', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '4002', 'city': 'Plovdiv', 'status': 'NOT_YET_RECRUITING', 'country': 'Bulgaria', 'facility': 'UMHAT Sveti Georgi', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '1606', 'city': 'Sofia', 'status': 'NOT_YET_RECRUITING', 'country': 'Bulgaria', 'facility': 'SHATPD "Prof. Ivan Mitev"', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '6003', 'city': 'Stara Zagora', 'status': 'NOT_YET_RECRUITING', 'country': 'Bulgaria', 'facility': 'MHAT prof. Stoyan Kirkovitch AD', 'geoPoint': {'lat': 42.43205, 'lon': 25.64262}}, {'zip': 'T3B 6A8', 'city': 'Calgary', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'facility': "Alberta Children's Hospital - Nephrology Clinic", 'geoPoint': {'lat': 51.05011, 'lon': -114.08529}}, {'zip': 'L8N 3Z5', 'city': 'Hamilton', 'state': 'Ontario', 'status': 'NOT_YET_RECRUITING', 'country': 'Canada', 'facility': "McMaster Children's Hospital", 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'M5G 1X8', 'city': 'Toronto', 'state': 'Ontario', 'status': 'NOT_YET_RECRUITING', 'country': 'Canada', 'facility': 'The Hospital for Sick Children (SickKids)', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'H3T 1C5', 'city': 'Montreal', 'state': 'Quebec', 'status': 'RECRUITING', 'country': 'Canada', 'facility': 'CHU Sainte-Justine', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': '128 08', 'city': 'Prague', 'status': 'RECRUITING', 'country': 'Czechia', 'facility': 'Všeobecná fakultní nemocnice v Praze', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '150 06', 'city': 'Prague', 'status': 'RECRUITING', 'country': 'Czechia', 'facility': 'Fakultní nemocnice v Motole', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '8200', 'city': 'Århus N', 'status': 'RECRUITING', 'country': 'Denmark', 'facility': 'Aarhus Universitetshospital - Børn og Unge'}, {'zip': '2100', 'city': 'Copenhagen', 'status': 'RECRUITING', 'country': 'Denmark', 'facility': 'Rigshospitalet - Børn og Unge', 'geoPoint': {'lat': 55.67594, 'lon': 12.56553}}, {'zip': '5000', 'city': 'Odense C', 'status': 'RECRUITING', 'country': 'Denmark', 'facility': 'Odense Universitetshospital - HC Andersen Børne og Ungehospital', 'geoPoint': {'lat': 55.40841, 'lon': 10.39538}}, {'zip': '290', 'city': 'Helsinki', 'status': 'RECRUITING', 'country': 'Finland', 'facility': "Helsinki University Hospital | Children's Hospital - Clinical Trial Unit, Nephrology Department", 'geoPoint': {'lat': 60.16952, 'lon': 24.93545}}, {'zip': '33521', 'city': 'Tampere', 'status': 'RECRUITING', 'country': 'Finland', 'facility': 'Tays Service Centre | Tampere University Hospital - Pediatric Early Phase Clinical Trials Unit', 'geoPoint': {'lat': 61.49911, 'lon': 23.78712}}, {'zip': '20520', 'city': 'Turku', 'status': 'RECRUITING', 'country': 'Finland', 'facility': 'Turun yliopistollinen keskussairaala', 'geoPoint': {'lat': 60.45148, 'lon': 22.26869}}, {'zip': '33076', 'city': 'Bordeaux', 'status': 'RECRUITING', 'country': 'France', 'facility': 'CHU bordeaux - Hopital Pellegrin', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'zip': '69677', 'city': 'Bron', 'status': 'RECRUITING', 'country': 'France', 'facility': 'CHU de Lyon - Hopital Femme Mère Enfant', 'geoPoint': {'lat': 45.73865, 'lon': 4.91303}}, {'zip': '34059', 'city': 'Montpellier', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Hopital Arnaud de Villeneuve CHU Montpellier', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'zip': '75019', 'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Hopital Robert Debre', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '67200', 'city': 'Strasbourg', 'status': 'RECRUITING', 'country': 'France', 'facility': 'CHU Strasbourg - Hopital Hautepierre', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '31059', 'city': 'Toulouse', 'status': 'RECRUITING', 'country': 'France', 'facility': 'Hôpital des Enfants', 'geoPoint': {'lat': 43.60426, 'lon': 1.44367}}, {'zip': '69115', 'city': 'Heidelberg', 'state': 'Baden-Wurttemberg', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Universitätsklinikum Heidelberg', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'zip': '91054', 'city': 'Erlangen', 'state': 'Bavaria', 'status': 'NOT_YET_RECRUITING', 'country': 'Germany', 'facility': 'Universitätsklinikum Erlangen', 'geoPoint': {'lat': 49.59099, 'lon': 11.00783}}, {'zip': '30625', 'city': 'Hanover', 'state': 'Lower Saxony', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Medizinische Hochschule Hannover (MHH)', 'geoPoint': {'lat': 52.37052, 'lon': 9.73322}}, {'zip': '53127', 'city': 'Bonn', 'state': 'North Rhine-Westphalia', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Kindernierenzentrum Bonn', 'geoPoint': {'lat': 50.73438, 'lon': 7.09549}}, {'zip': '45147', 'city': 'Essen', 'state': 'North Rhine-Westphalia', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Universitätsklinikum Essen', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '48149', 'city': 'Münster', 'state': 'North Rhine-Westphalia', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Universitätsklinikum Münster', 'geoPoint': {'lat': 51.96236, 'lon': 7.62571}}, {'zip': '13353', 'city': 'Berlin', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Charité / Pädiatrie', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '20246', 'city': 'Hamburg', 'status': 'RECRUITING', 'country': 'Germany', 'facility': 'Universitätsklinikum Hamburg Eppendorf (UKE)', 'geoPoint': {'lat': 53.55073, 'lon': 9.99302}}, {'zip': '11526', 'city': 'Athens', 'status': 'RECRUITING', 'country': 'Greece', 'facility': "Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department", 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '11527', 'city': 'Athens', 'status': 'RECRUITING', 'country': 'Greece', 'facility': "Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department", 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '711 10', 'city': 'Heraklion', 'status': 'RECRUITING', 'country': 'Greece', 'facility': 'University General Hospital of Heraklion - Department of Paediatrics', 'geoPoint': {'lat': 35.32787, 'lon': 25.14341}}, {'zip': '45500', 'city': 'Ioannina', 'status': 'RECRUITING', 'country': 'Greece', 'facility': 'Univ. General Hospital of Ioannina - Department of Paediatrics, Nephrology Unit', 'geoPoint': {'lat': 39.66341, 'lon': 20.85187}}, {'zip': '54642', 'city': 'Thessaloniki', 'status': 'RECRUITING', 'country': 'Greece', 'facility': "Hippokration General Hospital of Thessaloniki - 3rd Department of Paediatrics, Nephrology Unit'", 'geoPoint': {'lat': 40.64072, 'lon': 22.93493}}, {'zip': '1083', 'city': 'Budapest', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Semmelweis University', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4032', 'city': 'Debrecen', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Debreceni Egyetem Klinikai Kozpont', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'zip': '7623', 'city': 'Pécs', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'Pecsi Tudomanyegyetem Klinikai Kozpont', 'geoPoint': {'lat': 46.07617, 'lon': 18.22814}}, {'zip': '6720', 'city': 'Szeged', 'status': 'RECRUITING', 'country': 'Hungary', 'facility': 'SZTE ÁOK Szent Györgyi Albert Klinikai Kozpont', 'geoPoint': {'lat': 46.253, 'lon': 20.14824}}, {'zip': '380016', 'city': 'Ahmedabad', 'status': 'NOT_YET_RECRUITING', 'country': 'India', 'facility': 'Institute of Kidney Diseases and Research Center Gujarat University of Transplantation Sciences', 'geoPoint': {'lat': 23.02579, 'lon': 72.58727}}, {'zip': '560034', 'city': 'Bangalore', 'status': 'RECRUITING', 'country': 'India', 'facility': "St. John's National Academy of Health Sciences", 'geoPoint': {'lat': 12.97194, 'lon': 77.59369}}, {'zip': '160012', 'city': 'Chandigarh', 'status': 'NOT_YET_RECRUITING', 'country': 'India', 'facility': 'Post Graduate Institute of Medical Education and Research', 'geoPoint': {'lat': 30.73629, 'lon': 76.7884}}, {'zip': '110029', 'city': 'Delhi', 'status': 'NOT_YET_RECRUITING', 'country': 'India', 'facility': 'All India Institute of Medical Sciences (AIIMS) - New Delhi', 'geoPoint': {'lat': 28.65195, 'lon': 77.23149}}, {'zip': '700014', 'city': 'Kolkata', 'status': 'RECRUITING', 'country': 'India', 'facility': 'NRS Medical college', 'geoPoint': {'lat': 22.56263, 'lon': 88.36304}}, {'zip': '8410101', 'city': 'Beersheba', 'status': 'RECRUITING', 'country': 'Israel', 'facility': 'Clalit Health | Soroka Medical Center - Internal Medicine Department', 'geoPoint': {'lat': 31.25181, 'lon': 34.7913}}, {'zip': '9103102', 'city': 'Jerusalem', 'status': 'NOT_YET_RECRUITING', 'country': 'Israel', 'facility': "Wilf Children's Hospital Shaare Zedek Medical Center", 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'zip': '2210001', 'city': 'Nahariya', 'status': 'RECRUITING', 'country': 'Israel', 'facility': 'Health Corporation of Galilee Medical Center', 'geoPoint': {'lat': 33.00892, 'lon': 35.09814}}, {'zip': '4920235', 'city': 'Petah Tikva', 'status': 'RECRUITING', 'country': 'Israel', 'facility': "Clalit Health Services Schneider Children's Medical Center", 'geoPoint': {'lat': 32.08707, 'lon': 34.88747}}, {'zip': '6423906', 'city': 'Tel Aviv', 'status': 'RECRUITING', 'country': 'Israel', 'facility': "Dana-Dwek Children's Hospital", 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'zip': '40138', 'city': 'Bologna', 'state': 'Emilia-Romagna', 'status': 'RECRUITING', 'country': 'Italy', 'facility': "Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria", 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'zip': '00165', 'city': 'Rome', 'state': 'Lazio', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Ospedale Pediatrico Bambino Gesù - Nefrologia', 'geoPoint': {'lat': 41.89193, 'lon': 12.51133}}, {'zip': '16147', 'city': 'Genoa', 'state': 'Liguria', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene', 'geoPoint': {'lat': 44.40478, 'lon': 8.94439}}, {'zip': '20122', 'city': 'Milan', 'state': 'Lombardy', 'status': 'RECRUITING', 'country': 'Italy', 'facility': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene", 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'zip': '50139', 'city': 'Florence', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'zip': '10126', 'city': 'Torino', 'status': 'RECRUITING', 'country': 'Italy', 'facility': 'A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica', 'geoPoint': {'lat': 44.88856, 'lon': 11.99138}}, {'zip': 'LT-50161', 'city': 'Kaunas', 'status': 'RECRUITING', 'country': 'Lithuania', 'facility': 'Hospital of LT University of Health Sciences Kaunas Clinics', 'geoPoint': {'lat': 54.90156, 'lon': 23.90909}}, {'zip': 'LT-92140', 'city': 'Klaipėda', 'status': 'NOT_YET_RECRUITING', 'country': 'Lithuania', 'facility': "Klaipeda Children's Hospital", 'geoPoint': {'lat': 55.7068, 'lon': 21.13912}}, {'zip': 'LT-08406', 'city': 'Vilnius', 'status': 'RECRUITING', 'country': 'Lithuania', 'facility': "Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre", 'geoPoint': {'lat': 54.68916, 'lon': 25.2798}}, {'zip': '50300', 'city': 'Wilayah Persekutuan', 'state': 'Kuala Lumpur', 'status': 'NOT_YET_RECRUITING', 'country': 'Malaysia', 'facility': 'Hospital Tunku Azizah'}, {'zip': '70300', 'city': 'Seremban', 'state': 'Negeri Sembilan', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': "Hospital Tuanku Ja'afar", 'geoPoint': {'lat': 2.7297, 'lon': 101.9381}}, {'zip': '68100', 'city': 'Shah Alam', 'state': 'Selangor', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Hospital Selayang', 'geoPoint': {'lat': 3.08507, 'lon': 101.53281}}, {'zip': '47500', 'city': 'Subang Jaya', 'state': 'Selangor', 'status': 'NOT_YET_RECRUITING', 'country': 'Malaysia', 'facility': 'Sunway Medical Centre', 'geoPoint': {'lat': 3.04384, 'lon': 101.58062}}, {'zip': '16150', 'city': 'Kelantan', 'status': 'RECRUITING', 'country': 'Malaysia', 'facility': 'Hospital Universiti Sains Malaysia'}, {'zip': '20124', 'city': 'Aguascalientes', 'state': 'Agguascalientes', 'status': 'NOT_YET_RECRUITING', 'country': 'Mexico', 'facility': 'Sitio Alfredo Chew Wong | Aguascalientes, Mexico', 'geoPoint': {'lat': 21.88262, 'lon': -102.2843}}, {'zip': '11850', 'city': 'Mexico City', 'state': 'Mexico City', 'status': 'RECRUITING', 'country': 'Mexico', 'facility': 'Instituto Veracruzano en Investigación Clinica SC', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'zip': '6720', 'city': 'México D.F.', 'state': 'Mexico City', 'status': 'NOT_YET_RECRUITING', 'country': 'Mexico', 'facility': 'Hospital Infantil de México "Dr. Federico Gómez"'}, {'zip': '4530', 'city': 'México, D.F.', 'state': 'Mexico City', 'status': 'NOT_YET_RECRUITING', 'country': 'Mexico', 'facility': 'Instituto Nacional de Pediatría', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'zip': '64460', 'city': 'Nuevo León', 'state': 'Monterrey', 'status': 'NOT_YET_RECRUITING', 'country': 'Mexico', 'facility': 'Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia', 'geoPoint': {'lat': 32.4095, 'lon': -115.18896}}, {'zip': '56530.', 'city': 'Ixtapaluca', 'state': 'State of Mexico', 'status': 'WITHDRAWN', 'country': 'Mexico', 'facility': 'Hospital Regional de Alta Especialidad Ixtapaluca', 'geoPoint': {'lat': 19.31556, 'lon': -98.88284}}, {'zip': '9713 GZ', 'city': 'Groningen', 'status': 'RECRUITING', 'country': 'Netherlands', 'facility': 'Universitair Medisch Centrum Groningen', 'geoPoint': {'lat': 53.21917, 'lon': 6.56667}}, {'zip': '6525 GA', 'city': 'Nijmegen', 'status': 'NOT_YET_RECRUITING', 'country': 'Netherlands', 'facility': 'Universitair Medisch Centrum St. Radboud', 'geoPoint': {'lat': 51.8425, 'lon': 5.85278}}, {'zip': '3584 CX', 'city': 'Utrecht', 'status': 'RECRUITING', 'country': 'Netherlands', 'facility': 'University Medical Center Utrecht', 'geoPoint': {'lat': 52.09083, 'lon': 5.12222}}, {'zip': '15-274', 'city': 'Bialystok', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'zip': '80-952', 'city': 'Gdansk', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Uniwersyteckie Centrum Kliniczne', 'geoPoint': {'lat': 54.35227, 'lon': 18.64912}}, {'zip': '30-663', 'city': 'Krakow', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Uniwersytecki Szpital Dzieciecy w Krakowie', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'zip': '93-338', 'city': 'Lodz', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Instytut Centrum Zdrowia Matki Polki', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '02-091', 'city': 'Warsaw', 'status': 'NOT_YET_RECRUITING', 'country': 'Poland', 'facility': 'Dzieciecy Szpital Kliniczny im. Jozefa Brudzinskiego', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '04-730', 'city': 'Warsaw', 'status': 'RECRUITING', 'country': 'Poland', 'facility': 'Instytut "Pomnik - Centrum Zdrowia Dziecka"', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '50-556', 'city': 'Wroclaw', 'status': 'WITHDRAWN', 'country': 'Poland', 'facility': 'Uniwersytecki Szpital Kliniczny UM we Wroclawiu', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'zip': '1649-035', 'city': 'Missing', 'state': 'Lisbon District', 'status': 'NOT_YET_RECRUITING', 'country': 'Portugal', 'facility': 'Hospital Santa Maria | Centro de Investigacao Clinica'}, {'zip': '4710-243', 'city': 'Braga', 'status': 'NOT_YET_RECRUITING', 'country': 'Portugal', 'facility': 'Centro Clinico Academico Braga | Braga, Portugal', 'geoPoint': {'lat': 41.5514, 'lon': -8.42311}}, {'zip': '3000', 'city': 'Coimbra', 'status': 'NOT_YET_RECRUITING', 'country': 'Portugal', 'facility': 'Hospital Pediátrico de Coimbra I ULS Coimbra', 'geoPoint': {'lat': 40.20686, 'lon': -8.41996}}, {'zip': '4050-651', 'city': 'Porto', 'status': 'RECRUITING', 'country': 'Portugal', 'facility': 'Centro Hospitalar Universitario do Porto | Servico de Investigacao Clinica', 'geoPoint': {'lat': 41.1485, 'lon': -8.61097}}, {'zip': '1862', 'city': 'Soweto', 'state': 'Gauteng', 'status': 'NOT_YET_RECRUITING', 'country': 'South Africa', 'facility': 'Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit', 'geoPoint': {'lat': -26.26781, 'lon': 27.85849}}, {'zip': '41944', 'city': 'Daegu', 'state': "Daegu Gwang''yeogsi", 'status': 'RECRUITING', 'country': 'South Korea', 'facility': 'Kyungpook National University Hospital', 'geoPoint': {'lat': 35.87028, 'lon': 128.59111}}, {'zip': '13620', 'city': 'Seongnam-si', 'state': 'Gyeonggido', 'status': 'RECRUITING', 'country': 'South Korea', 'facility': 'Seoul National University Bundang Hospital', 'geoPoint': {'lat': 37.43861, 'lon': 127.13778}}, {'zip': '50612', 'city': 'Yangsan', 'state': 'Gyeongsangnam-do', 'status': 'RECRUITING', 'country': 'South Korea', 'facility': 'Pusan National University Yangsan Hospital', 'geoPoint': {'lat': 35.34199, 'lon': 129.03358}}, {'zip': '152-703', 'city': 'Seoul', 'state': 'Seoul Teugbyeolsi', 'status': 'RECRUITING', 'country': 'South Korea', 'facility': 'Korea University Guro Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '3080', 'city': 'Seoul', 'state': 'Seoul Teugbyeolsi', 'status': 'RECRUITING', 'country': 'South Korea', 'facility': 'Seoul National University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '08035', 'city': 'Barcelona', 'status': 'RECRUITING', 'country': 'Spain', 'facility': "Ciutat Sanitaria i Universitaria de la Vall d'Hebron", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '08950', 'city': 'Barcelona', 'status': 'RECRUITING', 'country': 'Spain', 'facility': 'Hospital de Sant Joan de Déu', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '28041', 'city': 'Madrid', 'status': 'RECRUITING', 'country': 'Spain', 'facility': 'H Univ. 12 de Octubre | Unidad Pediátrica Inv y EECC (UPIC)', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28046', 'city': 'Madrid', 'status': 'RECRUITING', 'country': 'Spain', 'facility': 'Hospital la Paz', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '29010', 'city': 'Málaga', 'status': 'RECRUITING', 'country': 'Spain', 'facility': 'Hospital Universitario Regional De Malaga - Nefrologia pediatrica', 'geoPoint': {'lat': 36.72016, 'lon': -4.42034}}, {'zip': '41013', 'city': 'Seville', 'status': 'RECRUITING', 'country': 'Spain', 'facility': 'Hospital Universitario Virgen Del Rocio S.L. - Nefrologia pediatrica', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '22185', 'city': 'Lund', 'status': 'RECRUITING', 'country': 'Sweden', 'facility': 'Skånes Universitetssjukhus Lund - Barnnefroenheten', 'geoPoint': {'lat': 55.70584, 'lon': 13.19321}}, {'zip': '141 86', 'city': 'Stockholm', 'status': 'RECRUITING', 'country': 'Sweden', 'facility': 'Karolinska University Hospital', 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'zip': '751 85', 'city': 'Uppsala', 'status': 'TERMINATED', 'country': 'Sweden', 'facility': 'Uppsala University Hospital', 'geoPoint': {'lat': 59.85882, 'lon': 17.63889}}, {'zip': '4056', 'city': 'Basel', 'state': 'Canton of Basel-City', 'status': 'RECRUITING', 'country': 'Switzerland', 'facility': 'Universitäts-Kinderspital UKBB', 'geoPoint': {'lat': 47.55839, 'lon': 7.57327}}, {'zip': '10121', 'city': 'Lausanne', 'state': 'Canton of Vaud', 'status': 'RECRUITING', 'country': 'Switzerland', 'facility': 'Centre Hospitalier Universitaire Vaudois (CHUV)', 'geoPoint': {'lat': 46.516, 'lon': 6.63282}}, {'zip': '1211', 'city': 'Geneva', 'status': 'RECRUITING', 'country': 'Switzerland', 'facility': 'Hopital des Enfants HUG', 'geoPoint': {'lat': 46.20222, 'lon': 6.14569}}, {'zip': '704', 'city': 'Tainan', 'state': 'TNN', 'status': 'NOT_YET_RECRUITING', 'country': 'Taiwan', 'facility': 'National Cheng Kung University Hospital', 'geoPoint': {'lat': 22.99083, 'lon': 120.21333}}, {'zip': '83301', 'city': 'Guishan', 'status': 'NOT_YET_RECRUITING', 'country': 'Taiwan', 'facility': 'Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch', 'geoPoint': {'lat': 24.99436, 'lon': 121.33672}}, {'zip': '813414', 'city': 'Kaohsiung City', 'status': 'NOT_YET_RECRUITING', 'country': 'Taiwan', 'facility': 'Kaohsiung Veterans General Hospital', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '100229', 'city': 'Taipei', 'status': 'RECRUITING', 'country': 'Taiwan', 'facility': 'National Taiwan University Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '10507', 'city': 'Taipei', 'status': 'NOT_YET_RECRUITING', 'country': 'Taiwan', 'facility': 'Chang Gung Memorial Hospital at Linkou', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '11217', 'city': 'Taipei', 'status': 'NOT_YET_RECRUITING', 'country': 'Taiwan', 'facility': 'Taipei Veterans General Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '01790', 'city': 'Adana', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Cukurova Univ. Tip. Fak. Balcali Hastanesi', 'geoPoint': {'lat': 36.98615, 'lon': 35.32531}}, {'zip': '6100', 'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Hacettepe Universitesi Tip Fakultesi', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '6490', 'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Baskent Universitesi Tip Fakultesi Hastanesi', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '6560', 'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Gazi Universitesi Tip Fakultesi', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '6800', 'city': 'Ankara', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '34093', 'city': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'zip': '34098', 'city': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'zip': '34899', 'city': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'facility': 'Marmara University Medical Faculty | Pediatric Nephrology', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'zip': 'B4 6NH', 'city': 'Birmingham', 'state': 'West Midlands', 'status': 'NOT_YET_RECRUITING', 'country': 'United Kingdom', 'facility': "Birmingham Children's Hospital", 'geoPoint': {'lat': 52.48142, 'lon': -1.89983}}, {'zip': 'G51 4TF', 'city': 'Glasgow', 'status': 'RECRUITING', 'country': 'United Kingdom', 'facility': 'NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility', 'geoPoint': {'lat': 55.86515, 'lon': -4.25763}}, {'zip': 'WC1N 3JH', 'city': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'facility': 'Great Ormond Street Hospital for Children NHS Foundation Trust | Great Ormond Street Hospital - Clinical Research Facility', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'M13 9WL', 'city': 'Manchester', 'status': 'RECRUITING', 'country': 'United Kingdom', 'facility': "Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility", 'geoPoint': {'lat': 53.48095, 'lon': -2.23743}}, {'zip': 'NG7 2UH', 'city': 'Nottingham', 'status': 'RECRUITING', 'country': 'United Kingdom', 'facility': 'Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility', 'geoPoint': {'lat': 52.9536, 'lon': -1.15047}}], 'centralContacts': [{'name': 'Bayer Clinical Trials Contact', 'role': 'CONTACT', 'email': 'clinical-trials-contact@bayer.com', 'phone': '(+) 1-888-84 22937'}, {'name': "For trial location information (Phone Menu Options '3' or '4')", 'role': 'CONTACT', 'phone': '(+)1-888-84 22937'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Availability of this study\'s data will later be determined according to Bayer\'s commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014.\n\nInterested researchers can use www.vivli.org to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the member section of the portal.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Bayer', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}