Ignite Creation Date:
2025-12-24 @ 10:23 PM
Ignite Modification Date:
2025-12-25 @ 7:55 PM
Study NCT ID:
NCT06722235
Status:
RECRUITING
Last Update Posted:
2025-12-18
First Post:
2024-12-05
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D016553', 'term': 'Purpura, Thrombocytopenic, Idiopathic'}, {'id': 'D013921', 'term': 'Thrombocytopenia'}, {'id': 'D001791', 'term': 'Blood Platelet Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D000095542', 'term': 'Cytopenia'}, {'id': 'D011693', 'term': 'Purpura'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}, {'id': 'D001327', 'term': 'Autoimmune Diseases'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D006470', 'term': 'Hemorrhage'}, {'id': 'D012877', 'term': 'Skin Manifestations'}, {'id': 'D011696', 'term': 'Purpura, Thrombocytopenic'}], 'ancestors': [{'id': 'D001778', 'term': 'Blood Coagulation Disorders'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D057049', 'term': 'Thrombotic Microangiopathies'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 171}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-02-27', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2027-12-28', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-16', 'studyFirstSubmitDate': '2024-12-05', 'studyFirstSubmitQcDate': '2024-12-05', 'lastUpdatePostDateStruct': {'date': '2025-12-18', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-12-09', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-12-28', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Percentage of Participants with Durable Platelet Response', 'timeFrame': 'Up to Week 24', 'description': 'Durable platelet response is defined as platelet count greater than or equal to (≥)50,000/microliter (μL) on at least 4 of the 6 weekly platelet measurements between Weeks 19 and 24.'}], 'secondaryOutcomes': [{'measure': 'Cumulative Number of Weeks with a Platelet Count of ≥50,000/μL', 'timeFrame': 'Up to Week 24', 'description': 'The cumulative number of weeks in which the platelet count is ≥50,000/μL through Week 24.'}, {'measure': 'Time to First Platelet Count ≥50,000/μL', 'timeFrame': 'Up to Week 24'}, {'measure': 'The Cumulative Number of Weeks with a Platelet Count of ≥30,000/μL', 'timeFrame': 'Up to Week 24', 'description': 'The cumulative number of weeks in which the platelet count is ≥30,000/μL, and at least doubled from baseline through Week 24.'}, {'measure': 'Percentage of Participants with Complete Platelet Response', 'timeFrame': 'Up to Week 24', 'description': 'Complete platelet response is defined as a platelet count ≥100,000/μL on at least 2 visits through Week 24.'}, {'measure': 'Percentage of Participants with Platelet Response at Week 16', 'timeFrame': 'Week 16', 'description': 'Platelet response is defined as a platelet count ≥50,000/μL before investigational medicinal product (IMP) administration at the Week 16 visit.'}, {'measure': 'Change from Baseline in the Symptoms Domain Score of the Immune Thrombocytopenia Patient Assessment Questionnaire (ITP-PAQ) at Weeks 16 and 24', 'timeFrame': 'Weeks 16 and 24', 'description': "ITP-PAQ is a 44-item participant reported outcome (PRO) measure that assesses disease-specific health-related quality of life (HRQoL) that includes 10 domains: Symptoms, Fatigue/Sleep, Physical Health - Bother, Physical Health - Activity, Emotional Health - Psychological, Emotional Health - Fear, Overall Quality of Life (QoL), Social Activity, Women's Reproductive Health (including Fertility subscale, and Menstrual Symptoms subscale), and Work. The 6-item symptoms domain is scored from 0 to 100, with higher scores representing improvement of symptoms."}, {'measure': 'Percentage of Participants Receiving Rescue Therapy', 'timeFrame': 'Up to Week 24'}, {'measure': 'Percentage of Participants with Bleeding Events', 'timeFrame': 'Up to Week 24', 'description': 'Bleeding events are defined as Grade ≥2 in the skin domain, or Grade ≥1 in the mucosal domain, or Grade ≥1 in the organ domain, in the immune thrombocytopenia-specific bleeding assessment tool (ITP-BAT) through Week 24.'}, {'measure': 'Serum Concentration of Mezagitamab During and After Intervention', 'timeFrame': 'Predose on Day 1 and at multiple time points post-dose up to Day 169'}, {'measure': 'Number of Participants with Anti-drug Antibodies (ADA)', 'timeFrame': 'Predose on Day 1 and at multiple time points post-dose up to Day 169'}, {'measure': 'Change in ADA Titers Over Time', 'timeFrame': 'Up to Day 169'}, {'measure': 'Number of Participants with Neutralizing ADA', 'timeFrame': 'Predose on Day 1 and at multiple time points post-dose up to Day 169'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Thrombocytopenia', 'TAK-079', 'Blood Platelet Disorders', 'Hematologic Diseases', 'Cytopenia', 'Purpura', 'Hemorrhagic Disorders', 'Autoimmune Diseases', 'Immune System Diseases', 'Hemorrhage', 'Skin Manifestations', 'Purpura, Thrombocytopenic, Idiopathic', 'Purpura, Thrombocytopenic'], 'conditions': ['Immune Thrombocytopenic Purpura (ITP)']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://clinicaltrials.takeda.com/study-detail/bcb48c3e8d9b4904??page=1&idFilter=TAK-079-3002', 'label': 'Click here for more information about this trial in easy-to-understand language, including a Plain Language Summary of the results if the trial has been completed.'}]}, 'descriptionModule': {'briefSummary': "Primary immune thrombocytopenia (ITP) is a condition where the immune system mistakenly destroys platelets, which are cells that help stop bleeding. This leads to a low number of platelets, making it easier to bruise or bleed. The main aim of this study is to learn whether mezagitamab, when given just under the skin (subcutaneously \\[SC\\]), is effective in keeping the platelet count of adults with ITP stable when compared to a placebo. A placebo looks like medicine but doesn't have any active ingredients in it.\n\nThe participants will be treated with mezagitamab for up to 6 months.\n\nDuring the study, participants will visit their study clinic several times.\n\nParticipants who complete the TAK-079-3002 study or do not have any response to study treatment by week 16 (according to study criteria) will be given the opportunity to participate in a continuation study to receive open label mezagitamab (if they are eligible and the site is able to open the continuation study)."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Key Inclusion Criteria:\n\n1. The participant has been diagnosed with ITP that has persisted for at least 12 months.\n2. The participant's diagnosis of ITP is supported by a prior response to an ITP therapy (not including a thrombopoietin receptor agonist \\[TPO-RA\\]), defined as having achieved a platelet count ≥50,000/μL.\n3. The participant has evidence of insufficient response or intolerance to at least 1 currently available first-line therapy for treatment of ITP (for example, corticosteroids), and at least 1 currently available second-line therapy for treatment of ITP (for example, TPO-RA, rituximab, fostamatinib, mycophenolate). Insufficient response to previous treatment is defined as failure to achieve a sustained platelet count of at least 50,000/μL or doubling of baseline platelet count after an appropriate course of prior ITP treatment. Intolerance is defined as a documented side effect causing discontinuation of the therapy.\n4. The participant has a mean platelet count of \\<30,000/μL.\n5. If the participant is receiving allowed standard-of-care treatment for ITP at screening, and continued use is intended, treatment may continue during the trial if the dose, and frequency have been stable for at least 4 weeks before receiving the first dose of IMP (i.e., Day 1), and are expected to remain stable throughout the trial.\n6. If the participant is an individual with potential for pregnancy, the participant is not pregnant as confirmed by negative human chorionic gonadotropin during screening, and before the first dose of trial intervention.\n\nKey Exclusion Criteria:\n\n1. The participant has secondary ITP.\n2. The participant has had any thrombotic or embolic event within 12 months before signing the informed consent form (ICF).\n3. The participant has had a splenectomy.\n4. The participant has active infection with hepatitis B virus, hepatitis C virus, or human immunodeficiency virus (HIV).\n5. History of malignancy (including myelodysplastic syndrome) within 5 years of signing the ICF, except for treated non-melanoma skin cancer or cervical carcinoma in situ.\n6. In the opinion of the investigator, the participant has a serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to this protocol.\n7. The participant has received anti-cluster of differentiation (CD)20 treatment within 12 months before screening, and either of the following applies:\n\n 1. The last dose was received within 6 months before screening.\n 2. The last dose was received between 6, and 12 months before screening, and the participant has a cluster of differentiation 19 positive (CD19+) count below the lower limit of normal.\n8. The participant has received any monoclonal or polyclonal antibody for immunomodulation within 6 months before Day 1.\n9. The participant has any prior exposure to mezagitamab or has been exposed to another investigational agent within 4 weeks or 5 half-lives, whichever is longer, before Day 1.\n10. The participant has used anticoagulants (e.g., vitamin K antagonists, direct oral anticoagulants) within 3 weeks prior to the first dose of trial treatment.\n11. The participant has received a live or live-attenuated vaccine within 4 weeks prior to the first dose of trial treatment or has any live or live-attenuated vaccine planned during the trial.\n12. The participant has used the following immunosuppressive agents as specified prior to the first dose of trial treatment: alkylating agents (e.g., cyclophosphamide) within 8 weeks, vinca alkaloids (e.g., vincristine) within 4 weeks, sulfones (e.g., dapsone) within 3 weeks, antiproliferative agents: (e.g., mycophenolate mofetil, and azathioprine) within 2 weeks, and calcineurin inhibitors: (e.g., cyclosporine) within 2 weeks.\n13. The participant has used intravenous immunoglobulin (IVIg), SC immunoglobulin, recombinant human thrombopoietin, anti-D immunoglobulin treatment, or efgartigimod within 4 weeks before signing the ICF or it is expected that any treatment for thrombocytopenia other than the participant's standard-of-care ITP therapy (e.g., rescue therapy, administration of blood products) may be used between screening, and Day 1.\n14. The participant has a history of severe allergic or anaphylactic reactions to recombinant proteins or excipients used in the mezagitamab/placebo formulation.\n\nOther protocol defined inclusion/exclusion criteria may apply."}, 'identificationModule': {'nctId': 'NCT06722235', 'briefTitle': 'A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia', 'organization': {'class': 'INDUSTRY', 'fullName': 'Takeda'}, 'officialTitle': 'A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy and Safety of Mezagitamab Subcutaneous Injection in Participants With Chronic Primary Immune Thrombocytopenia', 'orgStudyIdInfo': {'id': 'TAK-079-3002'}, 'secondaryIdInfos': [{'id': '2024-514401-54-00', 'type': 'CTIS'}, {'id': 'jRCT2031240667', 'type': 'REGISTRY', 'domain': 'jRCT'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Mezagitamab', 'description': 'Participants will receive mezagitamab injection, SC, once weekly (QW). They will receive 8 weekly doses, followed by 8 weekly doses off, and then receive 8 more weekly doses.', 'interventionNames': ['Drug: Mezagitamab']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Participants will receive mezagitamab placebo-matching injection, SC, QW. They will receive 8 weekly doses, followed by 8 weekly doses off, and then receive 8 more weekly doses.', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Mezagitamab', 'type': 'DRUG', 'otherNames': ['TAK-079'], 'description': 'Mezagitamab injection administered SC.', 'armGroupLabels': ['Mezagitamab']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Mezagitamab placebo-matching injection administered SC.', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Howard Liebman', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'USC Norris Comprehensive Cancer Center - Keck Medicine of USC', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '80218', 'city': 'Denver', 'state': 'Colorado', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Rocky Mountain Cancer Center', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '20007', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Catherine Broome', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Georgetown University Medical Center - Lombardi Comprehensive Cancer Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '30308', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Ana Antun', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Steven Lentz', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The University of Iowa', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Kamila Cisak', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University Of Louisville Brown Cancer Center', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'David Kuter', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Massachusetts General Hospital', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '01655', 'city': 'Worcester', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Daniel Winokur', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Massachusetts Chan Medical School', 'geoPoint': {'lat': 42.26259, 'lon': -71.80229}}, {'zip': '27710', 'city': 'Durham', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Ara Metjian', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Duke University Hospital', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '27837', 'city': 'Greenville', 'state': 'North Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Darla Liles', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'East Carolina University', 'geoPoint': {'lat': 35.61266, 'lon': -77.36635}}, {'zip': '97239', 'city': 'Portland', 'state': 'Oregon', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Joseph Shatzel', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Oregon Health & Science University', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Adam Cuker', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Perelman Center for Advanced Medicine (PCAM) Hospital of The University of Pennsylvania Penn Blood Disorders Program', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '19140', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Michael Bromberg', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Lewis Katz School of Medicine at Temple University', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Senthil Sukumar', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Baylor College of Medicine', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '23502', 'city': 'Norfolk', 'state': 'Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Bremer Celeste', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Virginia Oncology Associates', 'geoPoint': {'lat': 36.84681, 'lon': -76.28522}}, {'zip': '98109', 'city': 'Seattle', 'state': 'Washington', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Sandhya Panch', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Washingto', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '53226', 'city': 'Milwaukee', 'state': 'Wisconsin', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Lisa Kreuziger', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Versiti Wisconsin, Inc', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': '2605', 'city': 'Garran', 'state': 'Australian Capital Territory', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'phil.choi@act.gov.au', 'phone': '+61251248492'}, {'name': 'Philip Choi', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Canberra Hospital', 'geoPoint': {'lat': -35.34206, 'lon': 149.10846}}, {'zip': '2139', 'city': 'Concord', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'vivien.chen@health.nsw.gov.au', 'phone': '+610297676348'}, {'name': 'Vivien Chen', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Concord Repatriation General Hospital', 'geoPoint': {'lat': -33.84722, 'lon': 151.10381}}, {'zip': '2217', 'city': 'Kogarah', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'silvia.zheng@health.nsw.gov.au', 'phone': '+610291131111'}, {'name': 'Silvia Zheng', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'St George Hospital', 'geoPoint': {'lat': -33.9681, 'lon': 151.13564}}, {'zip': '2170', 'city': 'Liverpool', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Danny Hsu', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of New South Wales (UNSW) - Liverpool Hospital - Liverpool Cancer Therapy Centre', 'geoPoint': {'lat': -33.91938, 'lon': 150.92588}}, {'zip': '2145', 'city': 'Westmead', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'Jennifer.curnow@health.nsw.gov.au', 'phone': '+610288905200'}, {'name': 'Jennifer Curnow', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Westmead Hospital', 'geoPoint': {'lat': -33.80383, 'lon': 150.98768}}, {'zip': '3000', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Isaac Goncalves', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Peter MacCallum Cancer Centre', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '3004', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Zane Kaplan', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Monash University - Australian Centre for Blood Diseases (ACBD)', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '3005', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Huyen Tran', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Alfred Hospital', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '6150', 'city': 'Murdoch', 'state': 'Western Australia', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Dominic Pepperell', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Fiona Stanley Hospital', 'geoPoint': {'lat': -32.06987, 'lon': 115.83757}}, {'zip': '6005', 'city': 'West Perth', 'state': 'Western Australia', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'ross@pbi.org.au', 'phone': '+61892005300'}, {'name': 'Ross Baker', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Perth Blood Institute', 'geoPoint': {'lat': -31.94896, 'lon': 115.84199}}, {'zip': '1606', 'city': 'Sofia', 'state': 'Sofia-Grad', 'status': 'RECRUITING', 'country': 'Bulgaria', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'viktoriia1982@abv.bg', 'phone': '(359) 884-6741 x60'}, {'name': 'Viktoria Barbukova', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '4002', 'city': 'Plovdiv', 'status': 'NOT_YET_RECRUITING', 'country': 'Bulgaria', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'kasapunarova@yahoo.com', 'phone': '+359887860806'}, {'name': 'Katya Sapunarova', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medical Center "Fama Medical"', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '1431', 'city': 'Sofia', 'status': 'NOT_YET_RECRUITING', 'country': 'Bulgaria', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT'}, {'name': 'Atanas Radinoff', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UMHAT Sv. 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