Ignite Creation Date:
2025-12-24 @ 10:16 PM
Ignite Modification Date:
2025-12-29 @ 10:23 PM
Study NCT ID:
NCT06087835
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-19
First Post:
2023-10-04
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Philippines']}, 'conditionBrowseModule': {'meshes': [{'id': 'D007674', 'term': 'Kidney Diseases'}], 'ancestors': [{'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C511404', 'term': 'ZD4054'}, {'id': 'C529054', 'term': 'dapagliflozin'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1835}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2023-11-07', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2027-01-22', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-18', 'studyFirstSubmitDate': '2023-10-04', 'studyFirstSubmitQcDate': '2023-10-17', 'lastUpdatePostDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-10-18', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-01-22', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in eGFR from baseline', 'timeFrame': 'At month 24', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone to slow decline in kidney function'}], 'secondaryOutcomes': [{'measure': "Change in Urine Protein to Creatinine Ratio (UPCR) from baseline to each participant's mean level", 'timeFrame': 'Across the visits from Day 15 up to Month 24', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone in reducing proteinuria'}, {'measure': "Change in UACR from baseline to each participant's mean level", 'timeFrame': 'Across the visits from Day 15 up to Month 24', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone in reducing albuminuria'}, {'measure': 'Time to the first occurrence of any of the components of the renal composite endpoint of 40% sustained decline in eGFR or ESKD or renal death', 'timeFrame': 'Through study completion, approximately 43 months', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone in reducing the incidence of the renal composite endpoint of 40% sustained decline in eGFR or ESKD or renal death'}, {'measure': "Change in systolic blood pressure from baseline to each participant's mean level", 'timeFrame': 'Across the visits from Day 15 up to Month 24', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone in reducing systolic blood pressure'}, {'measure': "Proportion of participants achieving Urine Protein to Creatinine Ratio (UPCR) < 1000 mg/g and > 30% reduction from baseline for each participant's mean level", 'timeFrame': 'Across the visits from Day 15 up to Month 24', 'description': 'To determine whether zibotentan and dapagliflozin in fixed dose combination is superior to dapagliflozin alone, in reducing proteinuria, as measured by the proportion of participants achieving Urine Protein to Creatinine Ratio (UPCR) \\< 1000 mg/g and \\> 30% reduction from baseline'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Zibotentan', 'Nephrology', 'Dapagliflozin', 'Sodium-glucose co-transporter 2', 'sodium-glucose co-transporter 2 inhibitor', 'Kidney diseases', 'Endothelin antagonist', 'High Proteinuria'], 'conditions': ['Chronic Kidney Disease With High Proteinuria']}, 'referencesModule': {'references': [{'pmid': '39352861', 'type': 'DERIVED', 'citation': 'Smeijer JD, Wasehuus VS, Dhaun N, Gorriz JL, Soler MJ, Astrand M, Mercier AK, Greasley PJ, Ambery P, Heerspink HJL. Effects of Zibotentan Alone and in Combination with Dapagliflozin on Fluid Retention in Patients with CKD. J Am Soc Nephrol. 2024 Oct 1;35(10):1381-1390. doi: 10.1681/ASN.0000000000000436. Epub 2024 Jul 12.'}]}, 'descriptionModule': {'briefSummary': 'This is a Phase III, randomised, multicentre, double-blinded study to evaluate efficacy, safety and tolerability of treatment with zibotentan/dapagliflozin and dapagliflozin alone in participants with chronic kidney disease (CKD) and high proteinuria'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '95 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Participant must be ≥ 18 years of age and of legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.\n2. Diagnosis of CKD, defined as eGFR ≥ 20 and \\< 90 mL/min/1.73 m2 and UACR \\> 700 mg/g (\\> 79 mg/mmol) or UPCR \\> 1000 mg/g (\\> 113 mg/mmoL).\n3. All female participants must have a negative serum pregnancy test result at screening.\n4. Female participants must be either\n\n * not of child-bearing potential or\n * women of child bearing potential (WOCBP) using at least one highly effective birth control method for at least 3 months prior to first dose of study intervention\n5. Capable of giving signed informed consent\n6. Provision of signed informed consent prior to any study specific procedure.\n7. Provision of electronic informed consent prior to completion of the optional Study Participant Feedback Questionnaire (SPFQ).\n8. Provision of signed and dated written Optional Genomics Initiative Research Information and Consent Form prior to collection of samples for optional genomics imitative research that supports the Genomic Initiative.\n9. Receiving RAASi therapy (ACEi or ARB), and for the patient maximum tolerated labelled daily dose, that has been stable for at least 4 weeks.\n\nExclusion Criteria:\n\n1. Participants with NYHA class III or class IV Congestive HF at the time of enrolment.\n2. Participants hospitalised for HF during the last 6 month prior to screening.\n3. Evidence of rales or jugular venous distention on physical examination.\n4. Participants with type 1 diabetes mellitus.\n5. History of any life-threatening ventricular dysrhythmia (continuous or paroxysmal).\n6. Blood pressure above 160 mmHg systolic.\n7. Blood pressure below 90 mmHg systolic.\n8. Participants hospitalised for heart disease or cardiac procedures or for COVID-19 during the last 3 months prior to screening.\n9. History of solid organ transplantation or bone marrow transplant.\n10. History or ongoing allergy/hypersensitivity, as judged by the Investigator, to SGLT2i therapy (eg, dapagliflozin, canagliflozin, empagliflozin or other SGLT2 inhibitors) or Endothelin Receptor Antagonists (eg, ambrisentan, atrasentan, bosentan, or other).\n11. Any condition with a life expectancy of less than 2 years based on investigator´s clinical judgment.\n12. Malignancy within the past 5 years. Exceptions to this criterion include non-melanoma skin cancer and curatively treated cervical carcinoma in situ.\n13. Significant liver disease as judged by the investigator or severe hepatic impairment with AST or ALT \\> 3 × ULN; or total bilirubin \\> 2 × ULN at time of screening. An isolated increase in bilirubin in participants with known Gilbert's syndrome is not a reason for exclusion.\n14. Known blood-borne diseases.\n15. Clinically significant, unstable, or uncontrolled medical condition as assessed by the Investigator.\n16. Participants on renal replacement therapy or previous kidney transplant.\n17. Known history of drug or alcohol abuse within 12 months of screening.\n18. Participants on treatment with strong or moderate CYP3A4 inducer.\n19. Participants on systemic immunosuppression therapy other than stable maintenance therapy defined as prednisone 10 mg/day (or equivalent) or less, aziothioprine 100 mg/day or less; MMF 1000 mg/day or less for at least 3 months prior to Visit 1. Inhaled, nasal or dermatological steroids are also allowed.\n20. Participants treated or expecting to be treated with tolvaptan, any other ERAs, or budesonide (where used to treat IBD or IgAN).\n21. Participation in another clinical study with a study intervention administered in the last 3 months."}, 'identificationModule': {'nctId': 'NCT06087835', 'briefTitle': 'Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)', 'organization': {'class': 'INDUSTRY', 'fullName': 'AstraZeneca'}, 'officialTitle': 'A Phase III, Randomised, Multicentre, Double-blind Study to Evaluate the Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin Alone in Participants With Chronic Kidney Disease and High Proteinuria', 'orgStudyIdInfo': {'id': 'D4325C00010'}, 'secondaryIdInfos': [{'id': '2023-504124-26', 'type': 'REGISTRY', 'domain': 'EU CT number (CTIS)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Zibotentan/Dapagliflozin dose A or Zibotentan/Dapagliflozin dose B', 'description': 'Drug dose (dose A or B) are determined based on eGFR values. Participants will receive daily oral dose of zibotentan/dapagliflozin in fixed dose combination.', 'interventionNames': ['Drug: Zibotentan/Dapagliflozin']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Dapagliflozin alone', 'description': 'Participants will receive daily oral dose of dapagliflozin.', 'interventionNames': ['Drug: Dapagliflozin']}], 'interventions': [{'name': 'Zibotentan/Dapagliflozin', 'type': 'DRUG', 'description': 'Participants will receive zibotentan/dapagliflozin in fixed-dose combination as per the arms they are randomized to', 'armGroupLabels': ['Zibotentan/Dapagliflozin dose A or Zibotentan/Dapagliflozin dose B']}, {'name': 'Dapagliflozin', 'type': 'DRUG', 'description': 'Participants will receive dapagliflozin as per the arms they are randomized to', 'armGroupLabels': ['Dapagliflozin alone']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35805', 'city': 'Huntsville', 'state': 'Alabama', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.7304, 'lon': -86.58594}}, {'zip': '85375', 'city': 'Sun City West', 'state': 'Arizona', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.66198, 'lon': -112.34127}}, {'zip': '93309', 'city': 'Bakersfield', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 35.37329, 'lon': -119.01871}}, {'zip': '90255', 'city': 'Huntington Park', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.98168, 'lon': -118.22507}}, {'zip': '90720', 'city': 'Los Alamitos', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.80307, 'lon': -118.07256}}, {'zip': '90010', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '91324', 'city': 'Northridge', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.22834, 'lon': -118.53675}}, {'zip': '93036', 'city': 'Oxnard', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.1975, 'lon': -119.17705}}, {'zip': '94070', 'city': 'San Carlos', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 37.50716, 'lon': -122.26052}}, {'zip': '91773', 'city': 'San Dimas', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.10668, 'lon': -117.80673}}, {'zip': '91356', 'city': 'Tarzana', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.17334, 'lon': -118.55397}}, {'zip': '92392', 'city': 'Victorville', 'state': 'California', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.53611, 'lon': -117.29116}}, {'zip': '80002', 'city': 'Arvada', 'state': 'Colorado', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.80276, 'lon': -105.08748}}, {'zip': '80230', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '33435', 'city': 'Boynton Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '33016', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33024', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '34957', 'city': 'Jensen Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 27.25449, 'lon': -80.22977}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33165', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '30214', 'city': 'Fayetteville', 'state': 'Georgia', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.44873, 'lon': -84.45493}}, {'zip': '61822', 'city': 'Champaign', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.11642, 'lon': -88.24338}}, {'zip': '60616', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60521', 'city': 'Hinsdale', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.80086, 'lon': -87.93701}}, {'zip': '60042', 'city': 'Island Lake', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 42.27613, 'lon': -88.19203}}, {'zip': '60077', 'city': 'Skokie', 'state': 'Illinois', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 42.03336, 'lon': -87.73339}}, {'zip': '42101', 'city': 'Bowling Green', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.99032, 'lon': -86.4436}}, {'zip': '71101', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '20901', 'city': 'Silver Spring', 'state': 'Maryland', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.99067, 'lon': -77.02609}}, {'zip': '48504', 'city': 'Flint', 'state': 'Michigan', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 43.01253, 'lon': -83.68746}}, {'zip': '48532', 'city': 'Flint', 'state': 'Michigan', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 43.01253, 'lon': -83.68746}}, {'zip': '48098', 'city': 'Troy', 'state': 'Michigan', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 42.60559, 'lon': -83.14993}}, {'zip': '63376', 'city': 'City of Saint Peters', 'state': 'Missouri', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.80033, 'lon': -90.62651}}, {'zip': '12205', 'city': 'Albany', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 42.65258, 'lon': -73.75623}}, {'zip': '10940', 'city': 'Middletown', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.44593, 'lon': -74.42293}}, {'zip': '14127', 'city': 'Orchard Park', 'state': 'New York', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 42.76756, 'lon': -78.74392}}, {'zip': '27834', 'city': 'Greenville', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 35.61266, 'lon': -77.36635}}, {'zip': '28546', 'city': 'Jacksonville', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.75405, 'lon': -77.43024}}, {'zip': '28504', 'city': 'Kinston', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 35.26266, 'lon': -77.58164}}, {'zip': '28562', 'city': 'New Bern', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 35.10849, 'lon': -77.04411}}, {'zip': '28625', 'city': 'Statesville', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 35.78264, 'lon': -80.8873}}, {'zip': '28401', 'city': 'Wilmington', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.23556, 'lon': -77.94604}}, {'zip': '28412', 'city': 'Wilmington', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.23556, 'lon': -77.94604}}, {'zip': '27103', 'city': 'Winston-Salem', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.09986, 'lon': -80.24422}}, {'zip': '43537', 'city': 'Maumee', 'state': 'Ohio', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.56283, 'lon': -83.65382}}, {'zip': '19464', 'city': 'Pottstown', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.24537, 'lon': -75.64963}}, {'zip': '02915', 'city': 'East Providence', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 41.81371, 'lon': -71.37005}}, {'zip': '37660', 'city': 'Kingsport', 'state': 'Tennessee', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.54843, 'lon': -82.56182}}, {'zip': '76015', 'city': 'Arlington', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 32.73569, 'lon': -97.10807}}, {'zip': '78726', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '77004', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77099', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77584', 'city': 'Pearland', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.56357, 'lon': -95.28605}}, {'zip': '78204', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '78207', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '78212', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '77478', 'city': 'Sugar Land', 'state': 'Texas', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 29.61968, 'lon': -95.63495}}, {'zip': '84115', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '22311', 'city': 'Alexandria', 'state': 'Virginia', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.80484, 'lon': -77.04692}}, {'zip': '23606', 'city': 'Newport News', 'state': 'Virginia', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 36.98038, 'lon': -76.42975}}, {'zip': '98275', 'city': 'Mukilteo', 'state': 'Washington', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 47.94454, 'lon': -122.30458}}, {'zip': '99202', 'city': 'Spokane', 'state': 'Washington', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 47.65966, 'lon': -117.42908}}, {'zip': '1280', 'city': 'Ciudad de Buenos Aires', 'country': 'Argentina', 'facility': 'Research Site'}, {'zip': 'C1425AGC', 'city': 'Ciudad de Buenos Aires', 'country': 'Argentina', 'facility': 'Research Site'}, {'zip': '7600', 'city': 'Mar del Plata', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -38.00042, 'lon': -57.5562}}, {'zip': 'B7600', 'city': 'Mar del Plata', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -38.00042, 'lon': -57.5562}}, {'zip': 'S3000', 'city': 'Santa Fe', 'country': 'Argentina', 'facility': 'Research Site', 'geoPoint': {'lat': -31.64881, 'lon': -60.70868}}, {'zip': '2250', 'city': 'Gosford', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -33.4244, 'lon': 151.34399}}, {'zip': '4131', 'city': 'Meadowbrook', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -27.66401, 'lon': 153.14465}}, {'zip': '6000', 'city': 'Perth', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -31.95224, 'lon': 115.8614}}, {'zip': '3021', 'city': 'Reservoir', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -37.71667, 'lon': 145.0}}, {'zip': '3073', 'city': 'Reservoir', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -37.71667, 'lon': 145.0}}, {'zip': '4222', 'city': 'Southport', 'country': 'Australia', 'facility': 'Research Site', 'geoPoint': {'lat': -27.96724, 'lon': 153.39796}}, {'zip': '6800', 'city': 'Feldkirch', 'country': 'Austria', 'facility': 'Research Site', 'geoPoint': {'lat': 47.23306, 'lon': 9.6}}, {'zip': '1130', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Research Site', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '66073-005', 'city': 'Belém', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -1.45583, 'lon': -48.50444}}, {'zip': '18618-687', 'city': 'Botucatu', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -22.88583, 'lon': -48.445}}, {'zip': '89227-680', 'city': 'Joinville', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -26.30444, 'lon': -48.84556}}, {'zip': '15090-000', 'city': 'São José do Rio Preto', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -20.81972, 'lon': -49.37944}}, {'zip': '01228-200', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '04012-909', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '04038-031', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Research Site', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '9300', 'city': 'Dobrich', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 43.56491, 'lon': 27.83138}}, {'zip': '5800', 'city': 'Pleven', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 43.41791, 'lon': 24.61666}}, {'zip': '4000', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '4001', 'city': 'Plovdiv', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.15387, 'lon': 24.75001}}, {'zip': '1680', 'city': 'Sofia', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.69751, 'lon': 23.32415}}, {'zip': '6000', 'city': 'Stara Zagora', 'country': 'Bulgaria', 'facility': 'Research Site', 'geoPoint': {'lat': 42.43205, 'lon': 25.64262}}, {'zip': 'N6A 5A5', 'city': 'London', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Research Site', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'N2T 0C1', 'city': 'Waterloo', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Research Site', 'geoPoint': {'lat': 43.4668, 'lon': -80.51639}}, {'zip': 'J4V 2H1', 'city': 'Greenfield Park', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Research Site', 'geoPoint': {'lat': 45.48649, 'lon': -73.46223}}, {'zip': 'H4J 1C5', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Research Site', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': '014010', 'city': 'Baotou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 40.6516, 'lon': 109.84389}}, {'zip': '100029', 'city': 'Beijing', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '102218', 'city': 'Beijing', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '410013', 'city': 'Changsha', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '610000', 'city': 'Chengdu', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '610072', 'city': 'Chengdu', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '400010', 'city': 'Chongqing', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '618000', 'city': 'Deyang', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.13019, 'lon': 104.38198}}, {'zip': '528000', 'city': 'Foshan', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.02677, 'lon': 113.13148}}, {'zip': '510120', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510515', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '310014', 'city': 'Hangzhou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '421001', 'city': 'Hengyang', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 26.88946, 'lon': 112.61888}}, {'zip': '317000', 'city': 'Linhai', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 28.85535, 'lon': 121.1447}}, {'zip': '210009', 'city': 'Nanjing', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '210011', 'city': 'Nanjing', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '530022', 'city': 'Nanning', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '315010', 'city': 'Ningbo', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 29.87819, 'lon': 121.54945}}, {'zip': '337055', 'city': 'Pingxiang', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 27.61672, 'lon': 113.85353}}, {'zip': '200240', 'city': 'Shanghai', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '515041', 'city': 'Shantou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 23.35489, 'lon': 116.67876}}, {'zip': '518039', 'city': 'Shenzhen', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '518053', 'city': 'Shenzhen', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '325000', 'city': 'Wenzhou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 27.99942, 'lon': 120.66682}}, {'zip': '430010', 'city': 'Wuhan', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '214000', 'city': 'Wuxi', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '710077', 'city': "Xi'an", 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 34.25833, 'lon': 108.92861}}, {'zip': '361101', 'city': 'Xiamen', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'zip': '264000', 'city': 'Yantai', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 37.47649, 'lon': 121.44081}}, {'zip': '610500', 'city': 'Yibin', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 28.7593, 'lon': 104.63994}}, {'zip': '750004', 'city': 'Yinchuan', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 38.46806, 'lon': 106.27306}}, {'zip': '412007', 'city': 'Zhuzhou', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 27.83333, 'lon': 113.15}}, {'zip': '643000', 'city': 'Zigong', 'country': 'China', 'facility': 'Research Site', 'geoPoint': {'lat': 29.34162, 'lon': 104.77689}}, {'zip': '9100', 'city': 'Aalborg', 'country': 'Denmark', 'facility': 'Research Site', 'geoPoint': {'lat': 57.048, 'lon': 9.9187}}, {'zip': '8200', 'city': 'Aarhus', 'country': 'Denmark', 'facility': 'Research Site', 'geoPoint': {'lat': 56.15674, 'lon': 10.21076}}, {'zip': '2730', 'city': 'Herlev', 'country': 'Denmark', 'facility': 'Research Site', 'geoPoint': {'lat': 55.72366, 'lon': 12.43998}}, {'zip': '7400', 'city': 'Herning', 'country': 'Denmark', 'facility': 'Research Site', 'geoPoint': {'lat': 56.13615, 'lon': 8.97662}}, {'zip': '4000', 'city': 'Roskilde', 'country': 'Denmark', 'facility': 'Research Site', 'geoPoint': {'lat': 55.64152, 'lon': 12.08035}}, {'zip': '38700', 'city': 'La Tronche', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 45.20507, 'lon': 5.74629}}, {'zip': '68100', 'city': 'Mulhouse', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 47.75205, 'lon': 7.32866}}, {'zip': '06000', 'city': 'Nice', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 43.70313, 'lon': 7.26608}}, {'zip': '30000', 'city': 'Nîmes', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 43.83665, 'lon': 4.35788}}, {'zip': '76031', 'city': 'Rouen', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 49.44313, 'lon': 1.09932}}, {'zip': '42270', 'city': 'Saint-Priest-en-Jarez', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 45.4739, 'lon': 4.37678}}, {'zip': '67090', 'city': 'Strasbourg', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '37000', 'city': 'Tours', 'country': 'France', 'facility': 'Research Site', 'geoPoint': {'lat': 47.39484, 'lon': 0.70398}}, {'zip': '52074', 'city': 'Aachen', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 50.77664, 'lon': 6.08342}}, {'zip': '32545', 'city': 'Bad Oeynhausen', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 52.20699, 'lon': 8.80365}}, {'zip': '10117', 'city': 'Berlin', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '01279', 'city': 'Dresden', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 51.05089, 'lon': 13.73832}}, {'zip': '30625', 'city': 'Hanover', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 52.37052, 'lon': 9.73322}}, {'zip': '55131', 'city': 'Mainz', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 49.98185, 'lon': 8.28008}}, {'zip': '80336', 'city': 'München', 'country': 'Germany', 'facility': 'Research Site', 'geoPoint': {'lat': 51.60698, 'lon': 13.31243}}, {'zip': '560060', 'city': 'Bangalore', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 12.97194, 'lon': 77.59369}}, {'zip': '590010', 'city': 'Belagavi', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 15.85212, 'lon': 74.50447}}, {'zip': '110029', 'city': 'Delhi', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.65195, 'lon': 77.23149}}, {'zip': '387001', 'city': 'Nadiād', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 22.69385, 'lon': 72.86157}}, {'zip': '110017', 'city': 'New Delhi', 'country': 'India', 'facility': 'Research Site', 'geoPoint': {'lat': 28.62137, 'lon': 77.2148}}, {'zip': '78278', 'city': 'Ashkelon', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 31.66926, 'lon': 34.57149}}, {'zip': '3109601', 'city': 'Haifa', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '9372212', 'city': 'Jerusalem', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'zip': '44281', 'city': 'Kfar Saba', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 32.175, 'lon': 34.90694}}, {'zip': '22100', 'city': 'Nahariya', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 33.00892, 'lon': 35.09814}}, {'zip': '49372', 'city': 'Petah Tikva', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 32.08707, 'lon': 34.88747}}, {'zip': '52621', 'city': 'Ramat Gan', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 32.08227, 'lon': 34.81065}}, {'zip': '76100', 'city': 'Rehovot', 'country': 'Israel', 'facility': 'Research Site', 'geoPoint': {'lat': 31.89421, 'lon': 34.81199}}, {'zip': '24127', 'city': 'Bergamo', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'zip': '40138', 'city': 'Bologna', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'zip': '71100', 'city': 'Foggia', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 41.45845, 'lon': 15.55188}}, {'zip': '16132', 'city': 'Genoa', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.40478, 'lon': 8.94439}}, {'zip': '80138', 'city': 'Napoli', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'zip': '56124', 'city': 'Pisa', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 43.70853, 'lon': 10.4036}}, {'zip': '161', 'city': 'Roma', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '10126', 'city': 'Torino', 'country': 'Italy', 'facility': 'Research Site', 'geoPoint': {'lat': 44.88856, 'lon': 11.99138}}, {'zip': '103-0027', 'city': 'Chūōku', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.63867, 'lon': 130.67068}}, {'zip': '251-0041', 'city': 'Fujisawa-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '910-8526', 'city': 'Fukui-shi', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 36.06443, 'lon': 136.22257}}, {'zip': '810-0001', 'city': 'Fukuoka', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'zip': '810-8563', 'city': 'Fukuoka', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'zip': '819-0168', 'city': 'Fukuoka', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 33.6, 'lon': 130.41667}}, {'zip': '501-6061', 'city': 'Hashima-gun', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '247-0056', 'city': 'Kamakura-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '816-0864', 'city': 'Kasuga-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '332-0012', 'city': 'Kawaguchi-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '802-8555', 'city': 'Kitakyushu-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '806-8501', 'city': 'Kitakyusyu-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '400-8506', 'city': 'Kofu', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.66667, 'lon': 138.56667}}, {'zip': '830-0011', 'city': 'Kurume-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '830-8543', 'city': 'Kurume-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '525-8585', 'city': 'Kusatsu-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '607-8062', 'city': 'Kyoto', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.02107, 'lon': 135.75385}}, {'zip': '390-8510', 'city': 'Matsumoto-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '153-0061', 'city': 'Meguro-ku', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '108-0073', 'city': 'Minatoku', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 32.57237, 'lon': 130.59341}}, {'zip': '505-8510', 'city': 'Minokamo Shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '662-0918', 'city': 'Nishinomiya-Shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '662-0971', 'city': 'Nishinomiya-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '831-0016', 'city': 'Okawa-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '550-0006', 'city': 'Osaka', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.69379, 'lon': 135.50107}}, {'zip': '559-0012', 'city': 'Osaka', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.69379, 'lon': 135.50107}}, {'zip': '323-0022', 'city': 'Oyama-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '385-8558', 'city': 'Sakushu', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 43.52195, 'lon': 143.79507}}, {'zip': '003-0026', 'city': 'Sapporo', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'zip': '062-0931', 'city': 'Sapporo', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 43.06667, 'lon': 141.35}}, {'zip': '980-8574', 'city': 'Sendai', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 38.26667, 'lon': 140.86667}}, {'zip': '340-0015', 'city': 'Soka-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '760-0076', 'city': 'Takamatsu', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 34.33333, 'lon': 134.05}}, {'zip': '676-0812', 'city': 'Takasago-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '584-0082', 'city': 'Tondabayashi-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '302-0022', 'city': 'Toride-shi', 'country': 'Japan', 'facility': 'Research Site'}, {'zip': '279-0001', 'city': 'Urayasu', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 35.65879, 'lon': 139.90055}}, {'zip': '320-8580', 'city': 'Utsunomiya', 'country': 'Japan', 'facility': 'Research Site', 'geoPoint': {'lat': 36.56667, 'lon': 139.88333}}, {'zip': '5460', 'city': 'Alor Star', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 6.12104, 'lon': 100.36014}}, {'zip': '30990', 'city': 'Ipoh', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 4.5841, 'lon': 101.0829}}, {'zip': '88200', 'city': 'Kota Kinabalu', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 5.9749, 'lon': 116.0724}}, {'zip': '59100', 'city': 'Kuala Lumpur', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 3.1412, 'lon': 101.68653}}, {'zip': '70300', 'city': 'Seremban', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 2.7297, 'lon': 101.9381}}, {'zip': '32040', 'city': 'Seri Manjung', 'country': 'Malaysia', 'facility': 'Research Site', 'geoPoint': {'lat': 4.1987, 'lon': 100.67}}, {'zip': '82110', 'city': 'Mazatlán', 'country': 'Mexico', 'facility': 'Research Site', 'geoPoint': {'lat': 23.22163, 'lon': -106.41885}}, {'zip': '3813 TZ', 'city': 'Amersfoort', 'country': 'Netherlands', 'facility': 'Research Site', 'geoPoint': {'lat': 52.155, 'lon': 5.3875}}, {'zip': '4818 CK', 'city': 'Breda', 'country': 'Netherlands', 'facility': 'Research Site', 'geoPoint': {'lat': 51.58656, 'lon': 4.77596}}, {'zip': '3318 AT', 'city': 'Dordrecht', 'country': 'Netherlands', 'facility': 'Research Site', 'geoPoint': {'lat': 51.81, 'lon': 4.67361}}, {'zip': '8073', 'city': 'Bodø', 'country': 'Norway', 'facility': 'Research Site', 'geoPoint': {'lat': 67.28267, 'lon': 14.37513}}, {'zip': '1478', 'city': 'Lørenskog', 'country': 'Norway', 'facility': 'Research Site'}, {'zip': '0450', 'city': 'Oslo', 'country': 'Norway', 'facility': 'Research Site', 'geoPoint': {'lat': 59.91273, 'lon': 10.74609}}, {'zip': '4011', 'city': 'Stavanger', 'country': 'Norway', 'facility': 'Research Site', 'geoPoint': {'lat': 58.97005, 'lon': 5.73332}}, {'zip': '9019', 'city': 'Tromsø', 'country': 'Norway', 'facility': 'Research Site', 'geoPoint': {'lat': 69.6489, 'lon': 18.95508}}, {'zip': '32-500', 'city': 'Chrzanów', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.13546, 'lon': 19.40203}}, {'zip': '31-156', 'city': 'Krakow', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'zip': '31-501', 'city': 'Krakow', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'zip': '92-213', 'city': 'Lodz', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '60-354', 'city': 'Poznan', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'zip': '26-600', 'city': 'Radom', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 51.40253, 'lon': 21.14714}}, {'zip': '35-055', 'city': 'Rzeszów', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 50.04132, 'lon': 21.99901}}, {'zip': '70-111', 'city': 'Szczecin', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 53.42894, 'lon': 14.55302}}, {'zip': '03-291', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Research Site', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '984 01', 'city': 'Lučenec', 'country': 'Slovakia', 'facility': 'Research Site', 'geoPoint': {'lat': 48.33249, 'lon': 19.66708}}, {'zip': '080 01', 'city': 'Prešov', 'country': 'Slovakia', 'facility': 'Research Site', 'geoPoint': {'lat': 48.99923, 'lon': 21.2355}}, {'zip': '020 01', 'city': 'Púchov', 'country': 'Slovakia', 'facility': 'Research Site', 'geoPoint': {'lat': 49.12494, 'lon': 18.32597}}, {'zip': '048 01', 'city': 'Rožňava', 'country': 'Slovakia', 'facility': 'Research Site', 'geoPoint': {'lat': 48.66009, 'lon': 20.53758}}, {'zip': '07501', 'city': 'Trebišov', 'country': 'Slovakia', 'facility': 'Research Site', 'geoPoint': {'lat': 48.62858, 'lon': 21.71954}}, {'zip': '1501', 'city': 'Benoni', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -26.18848, 'lon': 28.32078}}, {'zip': '7925', 'city': 'Cape Town', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -33.92584, 'lon': 18.42322}}, {'zip': '4092', 'city': 'Chatsworth', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -33.54778, 'lon': 18.58201}}, {'zip': '4450', 'city': 'Durban', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -29.8579, 'lon': 31.0292}}, {'zip': '1827', 'city': 'Lenasia', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -26.32052, 'lon': 27.83564}}, {'zip': '1685', 'city': 'Midrand', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -25.976, 'lon': 28.118}}, {'zip': '7505', 'city': 'Parow', 'country': 'South Africa', 'facility': 'Research Site', 'geoPoint': {'lat': -33.89723, 'lon': 18.59992}}, {'zip': '15355', 'city': 'Ansan-si', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 37.32361, 'lon': 126.82194}}, {'zip': '49241', 'city': 'Busan', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 35.10168, 'lon': 129.03004}}, {'zip': '31151', 'city': 'Cheonan-si', 'country': 'South Korea', 'facility': 'Research Site'}, {'zip': '41944', 'city': 'Daegu', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 35.87028, 'lon': 128.59111}}, {'zip': '10380', 'city': 'Goyang-si', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 37.65639, 'lon': 126.835}}, {'zip': '06591', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '120-752', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '156-707', 'city': 'Seoul', 'country': 'South Korea', 'facility': 'Research Site', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '17007', 'city': 'Girona', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 41.98311, 'lon': 2.82493}}, {'zip': '08907', 'city': "L'Hospitalet de Llobregat", 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 41.35967, 'lon': 2.10028}}, {'zip': '27004', 'city': 'Lugo', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 43.00992, 'lon': -7.55602}}, {'zip': '28041', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28222', 'city': 'Majadahonda', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 40.47353, 'lon': -3.87182}}, {'zip': '41071', 'city': 'Seville', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '46010', 'city': 'Valencia', 'country': 'Spain', 'facility': 'Research Site', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}, {'zip': '413 46', 'city': 'Gothenburg', 'country': 'Sweden', 'facility': 'Research Site', 'geoPoint': {'lat': 57.70716, 'lon': 11.96679}}, {'zip': '581 85', 'city': 'Linköping', 'country': 'Sweden', 'facility': 'Research Site', 'geoPoint': {'lat': 58.41086, 'lon': 15.62157}}, {'zip': '79530', 'city': 'Rättvik', 'country': 'Sweden', 'facility': 'Research Site', 'geoPoint': {'lat': 60.88632, 'lon': 15.11787}}, {'zip': '141 86', 'city': 'Stockholm', 'country': 'Sweden', 'facility': 'Research Site', 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'zip': '751 85', 'city': 'Uppsala', 'country': 'Sweden', 'facility': 'Research Site', 'geoPoint': {'lat': 59.85882, 'lon': 17.63889}}, {'zip': '807', 'city': 'Kaohsiung City', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '833', 'city': 'Kaohsiung City', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 22.61626, 'lon': 120.31333}}, {'zip': '220', 'city': 'New Taipei City', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.06199, 'lon': 121.45703}}, {'zip': '40705', 'city': 'Taichung', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 24.1469, 'lon': 120.6839}}, {'zip': '710', 'city': 'Tainan', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 22.99083, 'lon': 120.21333}}, {'zip': '10002', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '110', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '11490', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}, {'zip': '333', 'city': 'Taoyuan District', 'country': 'Taiwan', 'facility': 'Research Site', 'geoPoint': {'lat': 24.9896, 'lon': 121.3187}}, {'zip': '10330', 'city': 'Bangkok', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.75398, 'lon': 100.50144}}, {'zip': '10700', 'city': 'Bangkok', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.75398, 'lon': 100.50144}}, {'zip': '50200', 'city': 'Chaingmai', 'country': 'Thailand', 'facility': 'Research Site'}, {'zip': '90110', 'city': 'Hat Yai', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 7.00836, 'lon': 100.47668}}, {'zip': '40002', 'city': 'Khon Kaen', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 16.44671, 'lon': 102.833}}, {'zip': '10400', 'city': 'Ratchathewi', 'country': 'Thailand', 'facility': 'Research Site', 'geoPoint': {'lat': 13.759, 'lon': 100.53358}}, {'zip': '54100', 'city': 'Adapazarı', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 40.78056, 'lon': 30.40333}}, {'zip': '06230', 'city': 'Ankara', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '16059', 'city': 'Bursa', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 40.19559, 'lon': 29.06013}}, {'zip': '03400', 'city': 'Dinar', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 38.065, 'lon': 30.16557}}, {'zip': '46040', 'city': 'Kahramanmaraş', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 37.5847, 'lon': 36.92641}}, {'zip': '38039', 'city': 'Kayseri', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 38.73222, 'lon': 35.48528}}, {'zip': '41380', 'city': 'Kocaeli', 'country': 'Turkey (Türkiye)', 'facility': 'Research Site', 'geoPoint': {'lat': 39.62497, 'lon': 27.51145}}, {'zip': 'CF14 4XW', 'city': 'Cardiff', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 51.48, 'lon': -3.18}}, {'zip': 'DD1 9SY', 'city': 'Dundee', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 56.46913, 'lon': -2.97489}}, {'zip': 'G51 4TF', 'city': 'Glasgow', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 55.86515, 'lon': -4.25763}}, {'zip': 'EC1A 2BE', 'city': 'London', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'NW3 2QG', 'city': 'London', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'SE5 9RJ', 'city': 'London', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'YO21 8HE', 'city': 'York', 'country': 'United Kingdom', 'facility': 'Research Site', 'geoPoint': {'lat': 53.95763, 'lon': -1.08271}}, {'zip': '180000', 'city': 'Haiphong', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 20.86481, 'lon': 106.68345}}, {'zip': '10000', 'city': 'Hanoi', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 21.0245, 'lon': 105.84117}}, {'zip': '700000', 'city': 'Ho Chi Minh City', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 10.82302, 'lon': 106.62965}}, {'zip': '70000', 'city': 'Ho Chi Minh City', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 10.82302, 'lon': 106.62965}}, {'city': 'Ho Chi Minh City', 'country': 'Vietnam', 'facility': 'Research Site', 'geoPoint': {'lat': 10.82302, 'lon': 106.62965}}]}, 'ipdSharingStatementModule': {'url': 'https://vivli.org/', 'infoTypes': ['STUDY_PROTOCOL', 'SAP'], 'timeFrame': 'AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at:\n\nhttps://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.', 'ipdSharing': 'YES', 'description': 'Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All requests will be evaluated as per the AZ disclosure commitment:\n\nhttps://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.\n\nYes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.', 'accessCriteria': 'When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level data in an approved sponsored tool. Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at:\n\nhttps://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'AstraZeneca', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}