Ignite Creation Date:
2025-12-24 @ 10:12 PM
Ignite Modification Date:
2026-01-01 @ 8:22 AM
Study NCT ID:
NCT01006135
Status:
COMPLETED
Last Update Posted:
2014-04-10
First Post:
2009-10-30
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Spiriva Observational Study Measuring Saint George's Respiratory Questionnaire (SGRQ) in Routine Medical Practice in Central & Eastern European Region
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Serbia']}, 'conditionBrowseModule': {'meshes': [{'id': 'D029424', 'term': 'Pulmonary Disease, Chronic Obstructive'}], 'ancestors': [{'id': 'D008173', 'term': 'Lung Diseases, Obstructive'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'clintriage.rdg@boehringer-ingelheim.com', 'phone': '1-800-243-0127', 'title': 'Boehringer Ingelheim Call Center', 'organization': 'Boehringer Ingelheim Pharmaceuticals'}, 'certainAgreement': {'otherDetails': 'Any publication of the result of this trial must be consistent with the Boehringer Ingelheim publication policy. The rights of the investigator and of the sponsor with regard to publication of the results of this trial are described in the investigator contract.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': '6 months', 'eventGroups': [{'id': 'EG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva', 'otherNumAtRisk': 4852, 'otherNumAffected': 0, 'seriousNumAtRisk': 4852, 'seriousNumAffected': 15}], 'seriousEvents': [{'term': 'Brain oedema', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Haemorrhagic stroke', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Somnolence', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Acute myocardial infarction', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Cardiac failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Cardiac failure acute', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Myocardial infarction', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Chronic obstructive pulmonary disease', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 5}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Acute respiratory failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Asthma', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Bronchopneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Dyspnoea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Lower respiratory tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Pneumonia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Pulmonary oedema', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Respiratory failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Tongue neoplasm malignant stage unspecified', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Rash generalised', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Skin and subcutaneous tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Death', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Pyrexia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Post procedural complication', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}, {'term': 'Radiation skin injury', 'stats': [{'groupId': 'EG000', 'numAtRisk': 4852, 'numAffected': 1}], 'organSystem': 'Injury, poisoning and procedural complications', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 14.1'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Mean Change of Total Saint George Respiratory Questionnaire (SGRQ) Score at the End of the Observational Period After 6 Months From Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4335', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'classes': [{'categories': [{'measurements': [{'value': '-21.73', 'spread': '19.09', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline and 6 months', 'description': 'The SGRQ ranges from 0 (no impairment of quality of life) to 100 (highest impairment of quality of life)', 'unitOfMeasure': 'Units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from the treated set (TS) who have evaluable SGRQ measurements at baseline and Visit 3 (6 months)'}, {'type': 'SECONDARY', 'title': 'Additional Bronchodilator or Inhaled Corticosteroids (ICS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4435', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'classes': [{'categories': [{'measurements': [{'value': '1146', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '6 months', 'description': 'Pulmonary medication from baseline to visit 3 (6 months)', 'unitOfMeasure': 'Number of participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from Full Analysis Set (FAS) which includes all patients from the TS who were assessed after administration of Spiriva, i.e. who have evaluable SGRQ measurements at visit 2 or visit 3.'}, {'type': 'SECONDARY', 'title': 'Compliance of Patients', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4435', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'classes': [{'categories': [{'measurements': [{'value': '3636', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '6 months', 'description': 'Patients are considered to be compliant if the difference of the number of days between visit 1 (baseline) and visit 3 (6months) and the number of actual taken capsules is less than 10.', 'unitOfMeasure': 'Number of participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients from FAS'}, {'type': 'SECONDARY', 'title': 'Patients With Any Adverse Events', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4852', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'classes': [{'categories': [{'measurements': [{'value': '182', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '6 months', 'unitOfMeasure': 'Number of participants', 'reportingStatus': 'POSTED', 'populationDescription': 'TS'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4852'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4712'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '140'}]}], 'dropWithdraws': [{'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '22'}]}, {'type': 'Protocol Violation', 'reasons': [{'groupId': 'FG000', 'numSubjects': '14'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '32'}]}, {'type': 'Other', 'reasons': [{'groupId': 'FG000', 'numSubjects': '72'}]}]}], 'preAssignmentDetails': 'Whilst 4854 patients were enrolled in the study, only 4852 of these entered and were included in the treated set, since two patients had no evidence of Spiriva administration.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '4852', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Patients Treated With Spiriva', 'description': 'Treatment with 18 mcg tiotropium inhalation capsules of Spiriva'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '62.6', 'spread': '9.8', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'description': 'There were only 4779 patients with a non-missing age.', 'unitOfMeasure': 'Years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex/Gender, Customized', 'classes': [{'title': 'Male', 'categories': [{'measurements': [{'value': '3433', 'groupId': 'BG000'}]}]}, {'title': 'Female', 'categories': [{'measurements': [{'value': '1391', 'groupId': 'BG000'}]}]}, {'title': 'Missing', 'categories': [{'measurements': [{'value': '28', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'Participants'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 4852}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2009-10'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-03', 'completionDateStruct': {'date': '2011-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-03-12', 'studyFirstSubmitDate': '2009-10-30', 'resultsFirstSubmitDate': '2012-06-02', 'studyFirstSubmitQcDate': '2009-10-30', 'lastUpdatePostDateStruct': {'date': '2014-04-10', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2012-06-02', 'studyFirstPostDateStruct': {'date': '2009-11-02', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2012-07-09', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Mean Change of Total Saint George Respiratory Questionnaire (SGRQ) Score at the End of the Observational Period After 6 Months From Baseline', 'timeFrame': 'Baseline and 6 months', 'description': 'The SGRQ ranges from 0 (no impairment of quality of life) to 100 (highest impairment of quality of life)'}], 'secondaryOutcomes': [{'measure': 'Additional Bronchodilator or Inhaled Corticosteroids (ICS)', 'timeFrame': '6 months', 'description': 'Pulmonary medication from baseline to visit 3 (6 months)'}, {'measure': 'Compliance of Patients', 'timeFrame': '6 months', 'description': 'Patients are considered to be compliant if the difference of the number of days between visit 1 (baseline) and visit 3 (6months) and the number of actual taken capsules is less than 10.'}, {'measure': 'Patients With Any Adverse Events', 'timeFrame': '6 months'}]}, 'conditionsModule': {'conditions': ['Pulmonary Disease, Chronic Obstructive']}, 'referencesModule': {'references': [{'pmid': '24159258', 'type': 'DERIVED', 'citation': 'Flezar M, Jahnz-Rozyk K, Enache G, Martynenko T, Kristufek P, Skrinjaric-Cincar S, Kadlecova P, Martinovic G. SOSPES: SPIRIVA(R) observational study measuring SGRQ score in routine medical practice in Central and Eastern Europe. Int J Chron Obstruct Pulmon Dis. 2013;8:483-92. doi: 10.2147/COPD.S45640. Epub 2013 Oct 9.'}]}, 'descriptionModule': {'briefSummary': 'The objective of this observational study is to collect and evaluate data on Health Related Quality of Life (HRQoL) of Spiriva delivered by HandiHaler, using disease specific SGRQ in the national samples of Central \\& Central European patients with varying severities of chronic obstructive pulmonary disease (COPD) in the real life setting over the 6 months.', 'detailedDescription': 'Study Design:\n\nan open-label, uncontrolled and single arm post-marketing surveillance study'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '40 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'patients', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion criteria:\n\n* 40 years and older male and female ambulatory outpatients.\n* Clinical diagnosis of Chronic Obstructive Lung Disease (COPD) (Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines: Forced expiratory Volume in one second (FEV1)/ Forced Vital Capacity (FVC) \\< 0.7 and FEV1 \\< 80% predicted).\n* Stable patient, without exacerbation for at least one month to the study.\n\nExclusion criteria:\n\n* Uncooperative patients as judged by the physician.\n* Patients that have any condition which, according to the participating physician's opinion, might decrease the chance of obtaining satisfactory data to achieve the objectives of the observation study.\n* Patients with any conditions excluded as per Country specific package insert.\n* Patients currently enrolled in another clinical trial which requires a change in medication for their respiratory problems."}, 'identificationModule': {'nctId': 'NCT01006135', 'briefTitle': "Spiriva Observational Study Measuring Saint George's Respiratory Questionnaire (SGRQ) in Routine Medical Practice in Central & Eastern European Region", 'organization': {'class': 'INDUSTRY', 'fullName': 'Boehringer Ingelheim'}, 'officialTitle': "Spiriva Observational Study Measuring Saint George's Respiratory Questionnaire (SGRQ) in Routine Medical Practice in Central & Eastern European Region", 'orgStudyIdInfo': {'id': '205.450'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'COPD patients'}]}, 'contactsLocationsModule': {'locations': [{'city': 'Drniš', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 1', 'geoPoint': {'lat': 43.8625, 'lon': 16.15556}}, {'city': 'Ivani? Grad-Zagreb', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 2'}, {'city': 'Karlovac', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 3', 'geoPoint': {'lat': 45.49167, 'lon': 15.55}}, {'city': 'Knin', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 4', 'geoPoint': {'lat': 44.04063, 'lon': 16.19662}}, {'city': 'Metkovi?', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 5'}, {'city': 'Osijek', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 6', 'geoPoint': {'lat': 45.55066, 'lon': 18.6942}}, {'city': 'Osijek', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 7', 'geoPoint': {'lat': 45.55066, 'lon': 18.6942}}, {'city': 'Petrinja-Sisak', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 8'}, {'city': 'Požega', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 9', 'geoPoint': {'lat': 45.34028, 'lon': 17.68528}}, {'city': 'Pula', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 10', 'geoPoint': {'lat': 44.86833, 'lon': 13.84806}}, {'city': 'Rijeka', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 11', 'geoPoint': {'lat': 45.32673, 'lon': 14.44241}}, {'city': 'Rijeka', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 12', 'geoPoint': {'lat': 45.32673, 'lon': 14.44241}}, {'city': 'Samobor', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 13', 'geoPoint': {'lat': 45.80306, 'lon': 15.71806}}, {'city': 'Senj', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 14', 'geoPoint': {'lat': 44.98944, 'lon': 14.90583}}, {'city': 'Slavonski Brod', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 16', 'geoPoint': {'lat': 45.16158, 'lon': 18.0163}}, {'city': 'Šibenik', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 15', 'geoPoint': {'lat': 43.73429, 'lon': 15.8942}}, {'city': 'Vinkovci', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 17', 'geoPoint': {'lat': 45.28833, 'lon': 18.80472}}, {'city': 'Virovitica', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 18', 'geoPoint': {'lat': 45.83448, 'lon': 17.38555}}, {'city': 'Vukovar', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 19', 'geoPoint': {'lat': 45.35161, 'lon': 19.00225}}, {'city': 'Zadar', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 20', 'geoPoint': {'lat': 44.11578, 'lon': 15.22514}}, {'city': 'Zagreb', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 21', 'geoPoint': {'lat': 45.81444, 'lon': 15.97798}}, {'city': 'Zagreb', 'country': 'Croatia', 'facility': 'Boehringer Ingelheim Investigational Site 22', 'geoPoint': {'lat': 45.81444, 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'Boehringer Ingelheim Investigational Site 30', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'city': 'Bialystok', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 31', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'city': 'Bialystok', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 32', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'city': 'Bialystok', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 33', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'city': 'Bialystok', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 34', 'geoPoint': {'lat': 53.13333, 'lon': 23.16433}}, {'city': 'Biała Prudnicka', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 26', 'geoPoint': {'lat': 50.38587, 'lon': 17.66035}}, {'city': 'Bielawa', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 35', 'geoPoint': {'lat': 50.69075, 'lon': 16.623}}, {'city': 'Bielawa', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 36', 'geoPoint': {'lat': 50.69075, 'lon': 16.623}}, {'city': 'Bielsk', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 37', 'geoPoint': {'lat': 52.6718, 'lon': 19.805}}, {'city': 'Bielsko-Biala', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 38', 'geoPoint': {'lat': 49.82245, 'lon': 19.04686}}, {'city': 'Biskupcu', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 39'}, {'city': 'Bochnia', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 40', 'geoPoint': {'lat': 49.96905, 'lon': 20.43028}}, {'city': 'Bolesław', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 41', 'geoPoint': {'lat': 50.29729, 'lon': 19.48073}}, {'city': 'Bolesławiec', 'country': 'Poland', 'facility': 'Boehringer Ingelheim Investigational Site 42', 'geoPoint': {'lat': 51.26418, 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