Ignite Creation Date:
2025-12-24 @ 10:08 PM
Ignite Modification Date:
2026-01-03 @ 5:53 AM
Study NCT ID:
NCT05943535
Status:
RECRUITING
Last Update Posted:
2025-12-23
First Post:
2023-07-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D017563', 'term': 'Lung Diseases, Interstitial'}], 'ancestors': [{'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C427248', 'term': 'treprostinil'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 698}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-10-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2027-11', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-22', 'studyFirstSubmitDate': '2023-07-05', 'studyFirstSubmitQcDate': '2023-07-05', 'lastUpdatePostDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-07-13', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-11', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in Absolute FVC from Baseline to Week 52', 'timeFrame': 'Baseline to Week 52', 'description': 'The FVC measurement indicates the amount of air a person can forcefully and quickly exhale after taking a deep breath.'}], 'secondaryOutcomes': [{'measure': 'Time to First Clinical Worsening', 'timeFrame': 'Baseline to Week 52', 'description': 'Clinical worsening is monitored from randomization until 1 of the following criteria are met: death (all causes), hospitalization due to a respiratory indication, or ≥10% relative decline in % predicted FVC.'}, {'measure': 'Time to First Acute Exacerbation of ILD', 'timeFrame': 'Baseline to Week 52', 'description': 'An exacerbation of ILD is defined as an acute, clinically significant, respiratory deterioration characterized by evidence of new widespread alveolar abnormality.'}, {'measure': 'Overall Survival at Week 52', 'timeFrame': 'Week 52', 'description': 'Vital status will be assessed for all subjects at Week 52, including those who discontinue the study prematurely or who withdraw consent.'}, {'measure': 'Change in % Predicted FVC from Baseline to Week 52', 'timeFrame': 'Baseline to Week 52', 'description': 'The FVC measurement indicates the amount of air a person can forcefully and quickly exhale after taking a deep breath. Percent predicted FVC is calculated based on factors such as race, sex, age, height, and weight.'}, {'measure': 'Change in K-BILD Questionnaire Score from Baseline to Week 52', 'timeFrame': 'Baseline to Week 52', 'description': 'The K-BILD is a self-administered, 15-item questionnaire validated for patients with ILD consisting of 3 domains (breathlessness and activities, psychological, and chest symptoms).'}, {'measure': 'Change in DLCO from Baseline to Week 52', 'timeFrame': 'Baseline to Week 52', 'description': 'The DLCO measurement measures how well oxygen moves from the lungs to the blood.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'keywords': ['Treprostinil', 'PPF', 'ILD'], 'conditions': ['Progressive Pulmonary Fibrosis', 'Interstitial Lung Disease']}, 'descriptionModule': {'briefSummary': 'Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.', 'detailedDescription': "Study RIN-PF-305 is a Phase 3, multinational, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of inhaled treprostinil in subjects with PPF over a 52-week period. Subjects will be randomly allocated 1:1 to receive inhaled treprostinil or placebo. All subjects will initiate inhaled treprostinil or placebo at a dose of 3 breaths administered 4 times daily (QID) and will titrate to a target dosing regimen of 12 breaths QID. Study drug doses may be titrated up as tolerated, until the target dose or maximum clinically tolerated dose is achieved. Once eligible, 6 Treatment Period visits to the clinic will be required at Weeks 4, 8, 16, 28, 40, and 52.\n\nEfficacy assessments include spirometry (forced vital capacity \\[FVC\\]), time to clinical worsening, time to first acute exacerbation of interstitial lung disease (ILD), overall survival, King's Brief Interstitial Lung Disease (K-BILD) questionnaire, plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration, supplemental oxygen use, and lung diffusion capacity (DLCO). Safety assessments include the development of adverse events (AEs)/serious adverse events (SAEs), vital signs, clinical laboratory parameters, and electrocardiogram (ECG) parameters.\n\nSubjects who complete the Week 52 Visit may be offered the opportunity to enter an open-label extension (OLE) study after completing the final study visit."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Subject gives voluntary informed consent to participate in the study.\n2. Subject is ≥18 years of age, inclusive, at the time of signing informed consent.\n3. Subject has radiological evidence of pulmonary fibrosis of \\>10% extent on an HRCT scan in the previous 12 months (confirmed by central review).\n4. Subject has a diagnosis of PPF (other than IPF) that fulfills at least 1 of the following criteria for progression within 24 months of screening despite standard treatment of ILD, as assessed by the Investigator:\n\n 1. Clinically significant decline in % predicted FVC based on ≥10% relative decline\n 2. Marginal decline in % predicted FVC based on ≥5% to \\<10% relative decline combined with worsening of respiratory symptoms\n 3. Marginal decline in % predicted FVC based on ≥5% to \\<10% relative decline combined with increasing extent of fibrotic changes on chest imaging\n 4. Worsening of respiratory symptoms as well as increasing extent of fibrotic changes on chest imaging\n5. FVC ≥45% predicted at Screening (confirmed by central review).\n6. Subjects must be on 1 of the following:\n\n 1. On nintedanib or pirfenidone for ≥90 days prior to Baseline and in the Investigator's opinion, are planning to continue treatment through the study\n 2. Not on treatment with nintedanib or pirfenidone for ≥90 days prior to Baseline and in the Investigator's opinion, not planning to initiate either treatment during the study.\n\n Concomitant use of both nintedanib and pirfenidone is not permitted.\n7. Subjects treated with immunosuppressive agents (eg, mycophenolate, methotrexate, azathioprine, oral corticosteroids, rituximab) need to be on treatment for at least 120 days prior to Baseline and, in the Investigator's clinical opinion, must be refractory to treatment.\n8. Women of childbearing potential must be non-pregnant (as confirmed by a urine pregnancy test at Screening and Baseline) and non-lactating, and will agree to do 1 of the following:\n\n 1. Abstain from intercourse (when it is in line with their preferred and usual lifestyle)\n 2. Use 2 medically acceptable, highly effective forms of contraception for the duration of the study, and at least 30 days after discontinuing study drug.\n\n i. Medically acceptable, highly effective forms of contraception can include approved hormonal contraceptives (oral, injectable, and implantable) and barrier methods (such as a condom or diaphragm) when used with a spermicide.\n\n Women who are successfully sterilized (including hysterectomy, bilateral salpingectomy, or bilateral oophorectomy) or postmenopausal (defined as amenorrhea for at least 12 consecutive months) are not considered to be of reproductive potential.\n9. Males with a partner of childbearing potential must agree to use a condom for the duration of treatment and for at least 48 hours after discontinuing study drug.\n10. In the opinion of the Investigator, the subject is able to communicate effectively with study personnel, and is considered reliable, willing, and likely to be cooperative with protocol requirements, including attending all study visits.\n\nExclusion Criteria:\n\n1. Subject is pregnant or lactating.\n2. Subject has primary obstructive airway physiology (forced expiratory volume in 1 second/FVC \\<0.70 at Screening) or greater extent of emphysema than fibrosis on HRCT (confirmed by central review).\n3. Subject has a diagnosis of IPF.\n4. Subject has shown intolerance or significant lack of efficacy to a prostacyclin or prostacyclin analogue that resulted in discontinuation or inability to effectively titrate that therapy.\n5. Subject has received any PAH-approved therapy, including prostacyclin therapy (epoprostenol, treprostinil, iloprost, or beraprost; except for acute vasoreactivity testing), IP receptor agonists (selexipag), endothelin receptor antagonists, phosphodiesterase type 5 inhibitors (PDE5-Is), soluble guanylate cyclase stimulators, or activin signaling inhibitors (sotatercept) within 60 days prior to Baseline. As needed use of a PDE5-I for erectile dysfunction is permitted, provided no doses are taken within 48 hours prior to any study-related efficacy assessments.\n6. Subject is receiving \\>10 L/min of oxygen supplementation by any mode of delivery at rest at Baseline.\n7. Exacerbation of ILD or active pulmonary or upper respiratory infection within 30 days prior to Baseline. Subjects must have completed any antibiotic or steroid regimens for treatment of the infection or acute exacerbation more than 30 days prior to Baseline to be eligible. If hospitalized for an acute exacerbation of ILD or a pulmonary or upper respiratory infection, subjects must have been discharged more than 90 days prior to Baseline to be eligible.\n8. Subject has uncontrolled cardiac disease, defined as myocardial infarction within 6 months prior to Baseline or unstable angina within 30 days prior to Baseline.\n9. Use of any other investigational drug/device or participation in any investigational study in which the subject received a medical intervention (ie, procedure, device, medication/supplement) within 30 days prior to Screening. Subjects participating in non-interventional, observational, or registry studies are eligible.\n10. Acute pulmonary embolism within 90 days prior to Baseline.\n11. In the opinion of the Investigator, the subject has any condition that would interfere with the interpretation of study assessments or would impair study participation or cooperation.\n12. In the opinion of the Investigator, life expectancy \\<12 months due to ILD or a concomitant illness.\n13. Subject has received nerandomilast within 60 days prior to Baseline."}, 'identificationModule': {'nctId': 'NCT05943535', 'briefTitle': 'Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)', 'organization': {'class': 'INDUSTRY', 'fullName': 'United Therapeutics'}, 'officialTitle': 'A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)', 'orgStudyIdInfo': {'id': 'RIN-PF-305'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Matching placebo inhaled using an ultrasonic nebulizer QID', 'interventionNames': ['Drug: Placebo', 'Device: Treprostinil Ultrasonic Nebulizer']}, {'type': 'EXPERIMENTAL', 'label': 'Inhaled Treprostinil', 'description': 'Treprostinil for inhalation solution (0.6 mg/mL) delivered via an ultrasonic nebulizer which emits a dose of approximately 6 mcg per breath. Inhaled QID and titrated up to a target of 12 breaths QID or until the subject reaches their maximum clinically tolerated dose.', 'interventionNames': ['Drug: Inhaled Treprostinil', 'Device: Treprostinil Ultrasonic Nebulizer']}], 'interventions': [{'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo administered QID', 'armGroupLabels': ['Placebo']}, {'name': 'Inhaled Treprostinil', 'type': 'DRUG', 'otherNames': ['Tyvaso'], 'description': 'Inhaled treprostinil (6 mcg/breath) administered QID', 'armGroupLabels': ['Inhaled Treprostinil']}, {'name': 'Treprostinil Ultrasonic Nebulizer', 'type': 'DEVICE', 'description': 'Treprostinil ultrasonic nebulizer which emits a dose of approximately 6 mcg per breath.', 'armGroupLabels': ['Inhaled Treprostinil', 'Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Melessia Wells', 'role': 'CONTACT', 'email': 'mrasheed@uabmc.edu', 'phone': '205-975-9332'}, {'name': 'Tejaswini Kulkarni, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UAB Lung Health Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85013', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Gabrielle Ambrose', 'role': 'CONTACT', 'email': 'gabrielle.ambrose@commonspirit.org', 'phone': '602-406-3825'}, {'name': 'Rajat Walia, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Norton Thoracic Institute', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90095', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Perez', 'role': 'CONTACT', 'email': 'jsperez@mednet.ucla.edu', 'phone': '310-825-5800'}, {'name': 'Stephen S Weigt, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Peter Morton Medical Building', 'geoPoint': {'lat': 34.05223, 'lon': 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'email': 'mswanson@paradigm-research.com', 'phone': '530-247-7049'}, {'name': 'Rafael Lupercio, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Paradigm Clinical Research', 'geoPoint': {'lat': 40.58654, 'lon': -122.39168}}, {'zip': '95817', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Natera', 'role': 'CONTACT', 'email': 'srnatera@ucdavis.edu', 'phone': '916-734-1820'}, {'name': 'Namita Sood, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UC Davis Health Medical Center', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '92108', 'city': 'San Diego', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Chery Bolovits', 'role': 'CONTACT', 'email': 'cbolovits@paradigm-research.com', 'phone': '858-274-4226'}, {'name': 'Daniel Jones, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Paradigm Clinical Research', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '94305', 'city': 'Stanford', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jannet Estrada', 'role': 'CONTACT', 'email': 'janestr@stanford.edu'}, {'name': 'Rishi Raj, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Stanford University Medical Center', 'geoPoint': {'lat': 37.42411, 'lon': -122.16608}}, {'zip': '20007', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Amen Hamed', 'role': 'CONTACT', 'email': 'amen.m.hamed@gunet.georgetown.edu', 'phone': '202-444-0895'}, {'name': 'Cristina Reichner, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Georgetown University Hospital', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer McWilliams', 'role': 'CONTACT', 'email': 'jennifer.mcwilliams@ascension.org', 'phone': '904-308-5764'}, {'name': 'Akram Shibani, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Ascension Medical Group St. Vincent's Lung Institute", 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32224', 'city': 'Jacksonville', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Inna Dawson', 'role': 'CONTACT', 'email': 'dawson.inna@mayo.edu', 'phone': '904-953-3855'}, {'name': 'Augustine S Lee, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33606', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Brenda Farlow', 'role': 'CONTACT', 'email': 'bfarlow@tgh.org', 'phone': '813-844-3430'}, {'name': 'Debabrata Bandyopadhyay, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'TGH/USF Center for Advanced Lung Disease and Lung Transplant', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '45227', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mitzi Near', 'role': 'CONTACT', 'email': 'mnear@emory.edu', 'phone': '404-712-9603'}, {'name': 'Srihari Veeraraghavan, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The Emory Clinic', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Aaron Gundersheimer', 'role': 'CONTACT', 'email': 'aaron.gundersheimer@northwestern.edu', 'phone': '312-503-7475'}, {'name': 'Bradford Bemiss, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwestern Memorial Hospital, Clinical Research Unit', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60612', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kimberly Saulsberry', 'role': 'CONTACT', 'email': 'Kimberly_P_Saulsberry@rush.edu', 'phone': '312-996-6275'}, {'name': 'Mark Yoder, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Rush University Medical Center Outpatient Pulmonary Clinic', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60612', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Hannah Carlson', 'role': 'CONTACT', 'email': 'hrc@uic.edu'}, {'name': 'Dustin Fraidenburg, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UI Health Hospital', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60153', 'city': 'Maywood', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Adriana Martinez', 'role': 'CONTACT', 'email': 'amartinez59@luc.edu', 'phone': '708-216-2057'}, {'name': 'Daniel Dilling, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Loyola University Medical Center', 'geoPoint': {'lat': 41.8792, 'lon': -87.84312}}, {'zip': '66160', 'city': 'Kansas City', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kimberly Lovell', 'role': 'CONTACT', 'email': 'klovell@kumc.edu', 'phone': '913-588-6067'}, {'name': 'Sahil Pandya, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Kansas Medical Center', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '45227', 'city': 'Lexington', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Srushan Shankara bhaktula', 'role': 'CONTACT', 'email': 'ssh486@uky.edu', 'phone': '859-562-0882'}, {'name': 'Parijat Sen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Kentucky', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Belica Graf', 'role': 'CONTACT', 'email': 'belica.graf@louisville.edu', 'phone': '502-852-3184'}, {'name': 'Mohamed A Saad, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Louisville Healthcare Outpatient Research Clinic', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '45227', 'city': 'New Orleans', 'state': 'Louisiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sandy Ditta', 'role': 'CONTACT', 'email': 'sditta@tulane.edu', 'phone': '504-988-4040'}, {'name': 'Joseph Lasky, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tulane Medical Center', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '21224', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Collins', 'role': 'CONTACT', 'email': 'shirsh1@jhmi.edu', 'phone': '410-550-2062'}, {'name': 'Mathew Lammi, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Johns Hopkins Asthma and Allergy Center', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '20904', 'city': 'Silver Spring', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Hernandez', 'role': 'CONTACT', 'email': 'jhernandez1@adventisthealthcare.com', 'phone': '240-637-5024'}, {'name': 'Jonathan Cohen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Adventist Healthcare White Oak Medical Center', 'geoPoint': {'lat': 38.99067, 'lon': -77.02609}}, {'zip': '02111', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mary Hays', 'role': 'CONTACT', 'email': 'Mary.M.Hays@tuftsmedicine.org', 'phone': '617-636-1334'}, {'name': 'Nicholas Hill, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tufts Medical Center', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Layla Rahimi', 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