Ignite Creation Date:
2025-12-24 @ 10:04 PM
Ignite Modification Date:
2025-12-28 @ 8:22 AM
Study NCT ID:
NCT05021835
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-02
First Post:
2021-08-19
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D051436', 'term': 'Renal Insufficiency, Chronic'}, {'id': 'D007249', 'term': 'Inflammation'}], 'ancestors': [{'id': 'D051437', 'term': 'Renal Insufficiency'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 6200}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2021-08-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2026-06-26', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-29', 'studyFirstSubmitDate': '2021-08-19', 'studyFirstSubmitQcDate': '2021-08-19', 'lastUpdatePostDateStruct': {'date': '2025-12-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2021-08-26', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-06-26', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months)', 'description': 'Months'}], 'secondaryOutcomes': [{'measure': 'Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months)', 'description': 'Months'}, {'measure': 'Number of heart failure hospitalisations or urgent heart failure visits or CV deaths', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months)', 'description': 'Count'}, {'measure': 'Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months)', 'description': 'Months'}, {'measure': 'Time to occurrence of all-cause mortality', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months)', 'description': 'Months'}, {'measure': 'Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint.', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Time to first occurrence of MI (fatal and non-fatal).', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Time to first occurrence of stroke (fatal and non-fatal).', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Time to first occurrence of coronary revascularisation', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Months'}, {'measure': 'Change in Urinary Abumin-to-Ceatinine ratio (UACR).', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months).', 'description': 'Percentage'}, {'measure': 'Change in eGFR (CKD-EPI))', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months)', 'description': 'mL/min/1.73 m\\^2'}, {'measure': 'Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'mL/min/1.73 m\\^2/ year'}, {'measure': 'Change in high-sensitivity C-reactive protein (hs-CRP)', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months', 'description': 'Percentage'}, {'measure': 'Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months)', 'description': 'Percentage'}, {'measure': 'Change in left ventricular ejection fraction (LVEF)', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months)', 'description': 'Percentage'}, {'measure': 'Number of events of atrial fibrillation', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Count'}, {'measure': 'Change in haemoglobin', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months)', 'description': 'Grams per deciliter (g/dL)'}, {'measure': 'Number of hospitalisations with infection as primary cause or death due to infection.', 'timeFrame': 'From randomisation (month 0) to end-of-study (up to 48 months).', 'description': 'Count'}, {'measure': 'Change in Short Form 36 (SF-36) Physical Component Score (PCS)', 'timeFrame': 'From randomisation (month 0) to 2 years (24 months)', 'description': 'Score on scale'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Cardiovascular Risk', 'Chronic Kidney Disease', 'Inflammation']}, 'referencesModule': {'references': [{'pmid': '41329869', 'type': 'DERIVED', 'citation': 'Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2025 Dec 2. doi: 10.2215/CJN.0000000968. Online ahead of print.'}, {'pmid': '40318255', 'type': 'DERIVED', 'citation': 'Mohammadnia N, van Broekhoven A, Bax WA, Eikelboom JW, Mosterd A, Fiolet ATL, Tijssen JGP, Thompson PL, de Kleijn DPV, Tsimikas S, Cornel JH, Yeang C, El Messaoudi S. Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort. Atherosclerosis. 2025 Jun;405:119211. doi: 10.1016/j.atherosclerosis.2025.119211. Epub 2025 Apr 26.'}]}, 'descriptionModule': {'briefSummary': 'This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.\n\nParticipants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same.\n\nZiltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe.\n\nParticipants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly.\n\nThe study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits.\n\nParticipants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram).\n\nWomen cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Chronic kidney disease defined by one of the below:\n\n 1. Estimated glomerular filtration rate (eGFR) greater than or equal to (\\>=) 15 and below 60 mL/min/1.73 m\\^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation)\n 2. Urinary albumin-to-creatinine ratio (UACR) \\>= 200 milligrams per gram (mg/g) and eGFR \\>= 60 mL/min/1.73 m2 (using the CKD-EPI creatinine equation)\n* Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligram per liter (mg/L)\n* Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:\n\n a) Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound.\n\n c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis).\n\nExclusion Criteria:\n\n* Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.\n* Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).\n* Planned coronary, carotid or peripheral artery revascularisation known on the day of randomisation (visit 2).\n* Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).'}, 'identificationModule': {'nctId': 'NCT05021835', 'acronym': 'ZEUS', 'briefTitle': 'ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation', 'organization': {'class': 'INDUSTRY', 'fullName': 'Novo Nordisk A/S'}, 'officialTitle': 'ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation', 'orgStudyIdInfo': {'id': 'EX6018-4758'}, 'secondaryIdInfos': [{'id': 'U1111-1259-3422', 'type': 'OTHER', 'domain': 'World Health Organization (WHO)'}, {'id': '2023-506926-35', 'type': 'OTHER', 'domain': 'European Medical Agency (EMA)'}, {'id': 'jRCT2021210033', 'type': 'REGISTRY', 'domain': 'JAPIC'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Ziltivekimab', 'description': 'Participants will receive Ziltivekimab B or Ziltivekimab C subcutaneously once monthly for up to 4 years.', 'interventionNames': ['Drug: Ziltivekimab B', 'Drug: Ziltivekimab C']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Participants will receive either placebo (Ziltivekimab B) or placebo (Ziltivekimab C) subcutaneously once monthly for up to 4 years.', 'interventionNames': ['Drug: Placebo (Ziltivekimab B)', 'Drug: Placebo (Ziltivekimab C)']}], 'interventions': [{'name': 'Ziltivekimab B', 'type': 'DRUG', 'description': 'Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.', 'armGroupLabels': ['Ziltivekimab']}, {'name': 'Ziltivekimab C', 'type': 'DRUG', 'description': 'Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.', 'armGroupLabels': ['Ziltivekimab']}, {'name': 'Placebo (Ziltivekimab B)', 'type': 'DRUG', 'description': 'Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.', 'armGroupLabels': ['Placebo']}, {'name': 'Placebo (Ziltivekimab C)', 'type': 'DRUG', 'description': 'Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Uni of Alabama at Birmingham', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '36106', 'city': 'Montgomery', 'state': 'Alabama', 'country': 'United States', 'facility': 'Chambliss Clinical Trials, LLC', 'geoPoint': {'lat': 32.36681, 'lon': -86.29997}}, {'zip': '85308', 'city': 'Glendale', 'state': 'Arizona', 'country': 'United States', 'facility': 'Lenzmeier Fam Med CCT Research', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '85206', 'city': 'Mesa', 'state': 'Arizona', 'country': 'United States', 'facility': 'Aventiv Research Inc.', 'geoPoint': {'lat': 33.42227, 'lon': -111.82264}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Univ of Arkansas Med Sciences', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '72143', 'city': 'Searcy', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Unity Health-Searcy Medical Center', 'geoPoint': {'lat': 35.25064, 'lon': -91.73625}}, {'zip': '90211', 'city': 'Beverly Hills', 'state': 'California', 'country': 'United States', 'facility': 'National Heart Institute Cal', 'geoPoint': {'lat': 34.07362, 'lon': -118.40036}}, {'zip': '91910', 'city': 'Chula Vista', 'state': 'California', 'country': 'United States', 'facility': 'California Inst Of Renal Res', 'geoPoint': {'lat': 32.64005, 'lon': -117.0842}}, {'zip': '91910', 'city': 'Chula Vista', 'state': 'California', 'country': 'United States', 'facility': 'California Institute of Renal Research #10', 'geoPoint': {'lat': 32.64005, 'lon': -117.0842}}, {'zip': '91723', 'city': 'Covina', 'state': 'California', 'country': 'United States', 'facility': 'Valley Clinical Trials', 'geoPoint': {'lat': 34.09001, 'lon': -117.89034}}, {'zip': '90255', 'city': 'Huntington Park', 'state': 'California', 'country': 'United States', 'facility': 'Valiance Clinical Research', 'geoPoint': {'lat': 33.98168, 'lon': -118.22507}}, {'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'Scripps Wht Diab Inst La Jolla', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '91942', 'city': 'La Mesa', 'state': 'California', 'country': 'United States', 'facility': 'Balboa Nephro Med Gr Inc LaMes', 'geoPoint': {'lat': 32.76783, 'lon': -117.02308}}, {'zip': '93534', 'city': 'Lancaster', 'state': 'California', 'country': 'United States', 'facility': 'First Valley Medical Group', 'geoPoint': {'lat': 34.69804, 'lon': -118.13674}}, {'zip': '92357', 'city': 'Loma Linda', 'state': 'California', 'country': 'United States', 'facility': 'VA Loma Linda Hlthcr Sys', 'geoPoint': {'lat': 34.04835, 'lon': -117.26115}}, {'zip': '90720', 'city': 'Los Alamitos', 'state': 'California', 'country': 'United States', 'facility': 'Pacific Clinical Studies', 'geoPoint': {'lat': 33.80307, 'lon': -118.07256}}, {'zip': '90010', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Angel City Research, Inc.', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90262', 'city': 'Lynwood', 'state': 'California', 'country': 'United States', 'facility': 'North America Research Institute', 'geoPoint': {'lat': 33.93029, 'lon': -118.21146}}, {'zip': '92663', 'city': 'Newport Beach', 'state': 'California', 'country': 'United States', 'facility': 'Hoag Medical Group', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '91325', 'city': 'Northridge', 'state': 'California', 'country': 'United States', 'facility': 'Valley Clinical Trials, Inc.', 'geoPoint': {'lat': 34.22834, 'lon': -118.53675}}, {'zip': '92262', 'city': 'Palm Springs', 'state': 'California', 'country': 'United States', 'facility': 'Desert Oasis Hlthcr Med Group', 'geoPoint': {'lat': 33.8303, 'lon': -116.54529}}, {'zip': '92503', 'city': 'Riverside', 'state': 'California', 'country': 'United States', 'facility': 'Riverside Nephrology Physicians', 'geoPoint': {'lat': 33.95335, 'lon': -117.39616}}, {'zip': '91773', 'city': 'San Dimas', 'state': 'California', 'country': 'United States', 'facility': 'N America Res Inst - San Dimas', 'geoPoint': {'lat': 34.10668, 'lon': -117.80673}}, {'zip': '90502', 'city': 'Torrance', 'state': 'California', 'country': 'United States', 'facility': 'Lundquist Inst-Biomed Innovtn', 'geoPoint': {'lat': 33.83585, 'lon': -118.34063}}, {'zip': '80204', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'Denver Health Outpatient Medical Center', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '06610', 'city': 'Bridgeport', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Bridgeport Hospital', 'geoPoint': {'lat': 41.17923, 'lon': -73.18945}}, {'zip': '06516', 'city': 'West Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'VA-Connecticut (VACHS)', 'geoPoint': {'lat': 41.27065, 'lon': -72.94705}}, {'zip': '20037', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'George Washington Uni Med', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33434', 'city': 'Boca Raton', 'state': 'Florida', 'country': 'United States', 'facility': 'Excel Med Ctr Clinical Trials', 'geoPoint': {'lat': 26.35869, 'lon': -80.0831}}, {'zip': '33756', 'city': 'Clearwater', 'state': 'Florida', 'country': 'United States', 'facility': 'Innovative Research of W FL', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33445', 'city': 'Delray Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Premier Cardiology', 'geoPoint': {'lat': 26.46146, 'lon': -80.07282}}, {'zip': '32003', 'city': 'Fleming Island', 'state': 'Florida', 'country': 'United States', 'facility': 'Northeast Research Institute', 'geoPoint': {'lat': 30.0933, 'lon': -81.71898}}, {'zip': '33312', 'city': 'Fort Lauderdale', 'state': 'Florida', 'country': 'United States', 'facility': 'Integrative Research Assoc Inc', 'geoPoint': {'lat': 26.12231, 'lon': -80.14338}}, {'zip': '33024', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': 'Elixia Pines', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '33024', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': 'Encore Medical Research LLC', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Northeast Research Institute', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32216', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Est Cst Inst for Rsrch,Jksnvil', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32258', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Baptist Heart Specialists', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33805', 'city': 'Lakeland', 'state': 'Florida', 'country': 'United States', 'facility': 'Clinical Research of Cent FL', 'geoPoint': {'lat': 28.03947, 'lon': -81.9498}}, {'zip': '33126', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Pharmax Research Clinic', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33130', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Life Spring Research', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33155', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Allied Biomedical Research', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'country': 'United States', 'facility': 'San Marcus Res Clin Miami Lakes', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '33027', 'city': 'Miramar', 'state': 'Florida', 'country': 'United States', 'facility': 'Office of Kenneth Blaze DO', 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