Ignite Creation Date:
2025-12-24 @ 10:00 PM
Ignite Modification Date:
2025-12-25 @ 7:37 PM
Study NCT ID:
NCT01429532
Status:
COMPLETED
Last Update Posted:
2014-07-11
First Post:
2011-09-04
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Outcomes of 3 Incision-size-dependent Phacoemulsification Systems
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D002386', 'term': 'Cataract'}], 'ancestors': [{'id': 'D007905', 'term': 'Lens Diseases'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D018918', 'term': 'Phacoemulsification'}], 'ancestors': [{'id': 'D002387', 'term': 'Cataract Extraction'}, {'id': 'D054140', 'term': 'Refractive Surgical Procedures'}, {'id': 'D013508', 'term': 'Ophthalmologic Surgical Procedures'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}, {'id': 'D059708', 'term': 'Ultrasonic Surgical Procedures'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'Reviewborad_SYsU@163.com', 'phone': '+86-20-87330341', 'title': 'Prof. Yizhi Liu', 'organization': 'SunYat-senU'}, 'certainAgreement': {'restrictionType': 'LTE60', 'piSponsorEmployee': True, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'description': 'Total Number of Participants at Risk for this Observational Study (e.g., serious and/or other \\[non-serious\\] adverse events were not collected/assessed).', 'eventGroups': [{'id': 'EG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system', 'otherNumAtRisk': 0, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system', 'otherNumAtRisk': 0, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system', 'otherNumAtRisk': 0, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Central Cornea Endothelial Cell Loss', 'denoms': [{'units': 'Participants', 'counts': [{'value': '40', 'groupId': 'OG000'}, {'value': '40', 'groupId': 'OG001'}, {'value': '40', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system'}, {'id': 'OG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system'}, {'id': 'OG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system'}], 'classes': [{'title': 'Post-op 1m', 'categories': [{'measurements': [{'value': '11.78', 'spread': '7.27', 'groupId': 'OG000'}, {'value': '13.03', 'spread': '8.33', 'groupId': 'OG001'}, {'value': '12.05', 'spread': '9.31', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 1 w', 'categories': [{'measurements': [{'value': '7.77', 'spread': '3.76', 'groupId': 'OG000'}, {'value': '9.35', 'spread': '4.69', 'groupId': 'OG001'}, {'value': '7.93', 'spread': '3.67', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 3 month', 'categories': [{'measurements': [{'value': '17.83', 'spread': '5.65', 'groupId': 'OG000'}, {'value': '18.08', 'spread': '7.93', 'groupId': 'OG001'}, {'value': '17.66', 'spread': '5.26', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'Central cornea endothelial cell loss was calculated on the basis of preoperative and postoperative endothelial cell density.', 'unitOfMeasure': '% of endothelial cell loss', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The SPSS software package (version 17.0, SPSS Inc, Chicago, IL, USA) was used for statistical analysis and sample size calculation. Mean ultrasound time (UST), surgical time, cumulative dissipated energy (CDE), total BSS volume, and SIA were compared using multifactor analysis of variance.'}, {'type': 'SECONDARY', 'title': 'Best-corrected Visual Acuity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '40', 'groupId': 'OG000'}, {'value': '40', 'groupId': 'OG001'}, {'value': '40', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system'}, {'id': 'OG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system'}, {'id': 'OG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system'}], 'classes': [{'title': 'Pre-op 1 day', 'categories': [{'measurements': [{'value': '0.16', 'spread': '0.10', 'groupId': 'OG000'}, {'value': '0.13', 'spread': '0.11', 'groupId': 'OG001'}, {'value': '0.15', 'spread': '0.11', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 1 day', 'categories': [{'measurements': [{'value': '0.66', 'spread': '0.27', 'groupId': 'OG000'}, {'value': '0.71', 'spread': '0.20', 'groupId': 'OG001'}, {'value': '0.73', 'spread': '0.23', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 1 month', 'categories': [{'measurements': [{'value': '0.89', 'spread': '0.20', 'groupId': 'OG000'}, {'value': '0.91', 'spread': '0.13', 'groupId': 'OG001'}, {'value': '0.88', 'spread': '0.14', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 3 months', 'categories': [{'measurements': [{'value': '0.98', 'spread': '0.11', 'groupId': 'OG000'}, {'value': '1.01', 'spread': '0.09', 'groupId': 'OG001'}, {'value': '0.98', 'spread': '0.10', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'The best-corrected visual acuity (BCVA) was measured, using an ETDRS chart and auto-refraction as refined by an ophthalmologist, preoperatively and at postoperative 1 day, 1 week, 1 month and 3 months.', 'unitOfMeasure': 'logMAR', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The SPSS software package (version 17.0, SPSS Inc, Chicago, IL, USA) was used for statistical analysis.'}, {'type': 'PRIMARY', 'title': 'Surgically Induced Astigmatism', 'denoms': [{'units': 'Participants', 'counts': [{'value': '40', 'groupId': 'OG000'}, {'value': '40', 'groupId': 'OG001'}, {'value': '40', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system'}, {'id': 'OG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system'}, {'id': 'OG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system'}], 'classes': [{'title': 'Post-op 1 day', 'categories': [{'measurements': [{'value': '1.2', 'spread': '0.32', 'groupId': 'OG000'}, {'value': '0.91', 'spread': '0.34', 'groupId': 'OG001'}, {'value': '0.951', 'spread': '0.28', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 1 week', 'categories': [{'measurements': [{'value': '0.61', 'spread': '0.24', 'groupId': 'OG000'}, {'value': '0.74', 'spread': '0.25', 'groupId': 'OG001'}, {'value': '0.79', 'spread': '0.23', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 1 month', 'categories': [{'measurements': [{'value': '0.4', 'spread': '0.21', 'groupId': 'OG000'}, {'value': '0.46', 'spread': '0.24', 'groupId': 'OG001'}, {'value': '0.75', 'spread': '0.31', 'groupId': 'OG002'}]}]}, {'title': 'Post-op 3 months', 'categories': [{'measurements': [{'value': '0.26', 'spread': '0.18', 'groupId': 'OG000'}, {'value': '0.31', 'spread': '0.19', 'groupId': 'OG001'}, {'value': '0.66', 'spread': '0.21', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'Corneal astigmatism was measured using an eye scanner (Pentacam; Oculus, Wetzlar, Germany), and the SIA was calculated at each postoperative visit using the following equation.', 'unitOfMeasure': 'Diopters', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system'}, {'id': 'FG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system'}, {'id': 'FG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '40'}, {'groupId': 'FG001', 'numSubjects': '40'}, {'groupId': 'FG002', 'numSubjects': '40'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '40'}, {'groupId': 'FG001', 'numSubjects': '40'}, {'groupId': 'FG002', 'numSubjects': '40'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'This prospective randomized study included 120 patients (120 eyes) with age-related cataract enrolled between July 2010 and January 2011 at the Zhong-shan Ophthalmic Center, Guangzhou, China.', 'preAssignmentDetails': 'Potential subjects with previous intraocular surgery, glaucoma, pseudoexfoliation, uveitis, high myopia and diabetes mellitus were excluded from participation in the study.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '40', 'groupId': 'BG000'}, {'value': '40', 'groupId': 'BG001'}, {'value': '40', 'groupId': 'BG002'}, {'value': '120', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system'}, {'id': 'BG001', 'title': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system'}, {'id': 'BG002', 'title': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '12', 'groupId': 'BG000'}, {'value': '12', 'groupId': 'BG001'}, {'value': '12', 'groupId': 'BG002'}, {'value': '36', 'groupId': 'BG003'}]}, {'title': '>=65 years', 'measurements': [{'value': '28', 'groupId': 'BG000'}, {'value': '28', 'groupId': 'BG001'}, {'value': '28', 'groupId': 'BG002'}, {'value': '84', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '73.95', 'spread': '6.05', 'groupId': 'BG000'}, {'value': '71.37', 'spread': '7.19', 'groupId': 'BG001'}, {'value': '72.48', 'spread': '6.15', 'groupId': 'BG002'}, {'value': '72.59', 'spread': '6.32', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '19', 'groupId': 'BG000'}, {'value': '22', 'groupId': 'BG001'}, {'value': '21', 'groupId': 'BG002'}, {'value': '62', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '21', 'groupId': 'BG000'}, {'value': '18', 'groupId': 'BG001'}, {'value': '19', 'groupId': 'BG002'}, {'value': '58', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'China', 'categories': [{'measurements': [{'value': '40', 'groupId': 'BG000'}, {'value': '40', 'groupId': 'BG001'}, {'value': '40', 'groupId': 'BG002'}, {'value': '120', 'groupId': 'BG003'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 120}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2010-07'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-06', 'completionDateStruct': {'date': '2011-05', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-06-06', 'studyFirstSubmitDate': '2011-09-04', 'resultsFirstSubmitDate': '2012-12-25', 'studyFirstSubmitQcDate': '2011-09-06', 'lastUpdatePostDateStruct': {'date': '2014-07-11', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2014-06-06', 'studyFirstPostDateStruct': {'date': '2011-09-07', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-07-11', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-05', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Central Cornea Endothelial Cell Loss', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'Central cornea endothelial cell loss was calculated on the basis of preoperative and postoperative endothelial cell density.'}, {'measure': 'Surgically Induced Astigmatism', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'Corneal astigmatism was measured using an eye scanner (Pentacam; Oculus, Wetzlar, Germany), and the SIA was calculated at each postoperative visit using the following equation.'}], 'secondaryOutcomes': [{'measure': 'Best-corrected Visual Acuity', 'timeFrame': 'post-operative week 1, post-operative month 1, and post-operative month 3', 'description': 'The best-corrected visual acuity (BCVA) was measured, using an ETDRS chart and auto-refraction as refined by an ophthalmologist, preoperatively and at postoperative 1 day, 1 week, 1 month and 3 months.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Cataract'], 'conditions': ['Cataract']}, 'referencesModule': {'references': [{'pmid': '16436926', 'type': 'BACKGROUND', 'citation': 'Weikert MP. Update on bimanual microincisional cataract surgery. Curr Opin Ophthalmol. 2006 Feb;17(1):62-7. doi: 10.1097/01.icu.0000193069.32369.e1.'}, {'pmid': '20494758', 'type': 'BACKGROUND', 'citation': 'Alio JL, Agdeppa MC, Rodriguez-Prats JL, Amparo F, Pinero DP. Factors influencing corneal biomechanical changes after microincision cataract surgery and standard coaxial phacoemulsification. J Cataract Refract Surg. 2010 Jun;36(6):890-7. doi: 10.1016/j.jcrs.2009.12.041.'}, {'pmid': '19251139', 'type': 'BACKGROUND', 'citation': 'Elkady B, Pinero D, Alio JL. Corneal incision quality: microincision cataract surgery versus microcoaxial phacoemulsification. J Cataract Refract Surg. 2009 Mar;35(3):466-74. doi: 10.1016/j.jcrs.2008.11.047.'}, {'pmid': '18939349', 'type': 'RESULT', 'citation': 'Liu Y, Jiang Y, Wu M, Liu Y, Zhang T. Bimanual microincision phacoemulsification in treating hard cataracts using different power modes. Clin Exp Ophthalmol. 2008 Jul;36(5):426-30.'}, {'pmid': '17276271', 'type': 'RESULT', 'citation': 'Liu Y, Zeng M, Liu X, Luo L, Yuan Z, Xia Y, Zeng Y. Torsional mode versus conventional ultrasound mode phacoemulsification: randomized comparative clinical study. J Cataract Refract Surg. 2007 Feb;33(2):287-92. doi: 10.1016/j.jcrs.2006.10.044.'}, {'pmid': '18567650', 'type': 'RESULT', 'citation': 'Zeng M, Liu X, Liu Y, Xia Y, Luo L, Yuan Z, Zeng Y, Liu Y. Torsional ultrasound modality for hard nucleus phacoemulsification cataract extraction. Br J Ophthalmol. 2008 Aug;92(8):1092-6. doi: 10.1136/bjo.2007.128504. Epub 2008 Jun 20.'}, {'pmid': '19878827', 'type': 'RESULT', 'citation': 'Wang Y, Xia Y, Zeng M, Liu X, Luo L, Chen B, Liu Y, Liu Y. Torsional ultrasound efficiency under different vacuum levels in different degrees of nuclear cataract. J Cataract Refract Surg. 2009 Nov;35(11):1941-5. doi: 10.1016/j.jcrs.2009.05.055.'}, {'pmid': '19548882', 'type': 'RESULT', 'citation': 'Xia Y, Liu X, Luo L, Zeng Y, Cai X, Zeng M, Liu Y. Early changes in clear cornea incision after phacoemulsification: an anterior segment optical coherence tomography study. Acta Ophthalmol. 2009 Nov;87(7):764-8. doi: 10.1111/j.1755-3768.2008.01333.x. Epub 2009 Jun 22.'}, {'pmid': '22310081', 'type': 'DERIVED', 'citation': 'Luo L, Lin H, He M, Congdon N, Yang Y, Liu Y. Clinical evaluation of three incision size-dependent phacoemulsification systems. Am J Ophthalmol. 2012 May;153(5):831-839.e2. doi: 10.1016/j.ajo.2011.10.034. Epub 2012 Feb 4.'}], 'seeAlsoLinks': [{'url': 'http://www.gzzoc.com', 'label': 'Home page of our investigation ophthalmic center'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to compare the outcomes of cataract surgery performed with three incision-size-dependent phacoemulsification systems (1.8, 2.2 and 3.0 mm).', 'detailedDescription': 'It is generally the case that smaller corneal cataract surgical incisions are associated with more rapid wound healing, more stable corneal biomechanical properties and less surgically induced astigmatism (SIA). With the development of phacoemulsification and foldable intraocular lenses (IOL) during recent decades, the size of clear corneal incisions has been reduced from 3.2-mm (coaxial small incision) to 1.4-mm (bimanual micro incision). Micro incision cataract surgery (MICS), including bimanual and micro coaxial phacoemulsification, has attracted much interest recently, due to its safety and ease of learning. However, the superiority of coaxial micro incision cataract surgery as compared conventional coaxial cataract surgery is still not certain, because micro incision phacoemulsification may result in longer ultrasound time (UST), the use of more ultrasonic power and consequently higher endothelial cell loss (ECL).\n\nIn our previous studies of the OZil Torsional phacoemulsification system (Infinity, Alcon), we reported that the safety and effectiveness of cataract surgery are influenced by many factors, including the blade used to create the incision, the phacoemulsification apparatus, and the IOL and mode of IOL delivery, which together constitute a surgical system, whose outcomes are restricted by the best performance of each component. Today, micro coaxial phacoemulsification is in wide use for cataract surgery, but the lower limits of incision size should be understood in the context of the various components of the surgical system.\n\nIn this study, we compared the safety and efficacy of three different incision-size-dependent phacoemulsification systems, 1.8, 2.2 and 3.0 mm, and evaluated the relationship between incision size and SIA.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '85 Years', 'minimumAge': '55 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'This prospective randomized study comprised 120 patients (120 eyes) with age-related cataract enrolled for surgeries between July 2010 and January 2011 at the Zhongshan Ophthalmic Center, Guangzhou, China.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* age between 55 and 85 years\n* the presence of nuclear or cortex-nuclear cataract, grades 2.0 to 4.0 (Lens Opacities Classification System III)\n* a transparent central cornea\n* pupil dilating to \\>= 7 mm at the time of preoperative examination\n* a preoperative central endothelial cell count of \\>= 1500 cells per square millimeter\n\nExclusion Criteria:\n\n* previous intraocular surgery\n* glaucoma\n* pseudoexfoliation\n* uveitis\n* high myopia\n* diabetes mellitus'}, 'identificationModule': {'nctId': 'NCT01429532', 'briefTitle': 'Outcomes of 3 Incision-size-dependent Phacoemulsification Systems', 'organization': {'class': 'OTHER', 'fullName': 'Sun Yat-sen University'}, 'officialTitle': 'Clinical Evaluation of Three Incision-size-dependent Phacoemulsification Systems', 'orgStudyIdInfo': {'id': 'CCPMOH2010-China2'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Group I', 'description': '1.8-mm-incision-size phacoemulsification system', 'interventionNames': ['Procedure: phacoemulsification']}, {'label': 'Group II', 'description': '2.2-mm-incision-size phacoemulsification system', 'interventionNames': ['Procedure: phacoemulsification']}, {'label': 'Group III', 'description': '3.0-mm-incision-size phacoemulsification system', 'interventionNames': ['Procedure: phacoemulsification']}], 'interventions': [{'name': 'phacoemulsification', 'type': 'PROCEDURE', 'otherNames': ['Three incision-size(1.8, 2.2 and 3.0 mm)'], 'description': 'Cataract surgery performed with three incision-size-dependent phacoemulsification systems (1.8, 2.2 and 3.0 mm)', 'armGroupLabels': ['Group I', 'Group II', 'Group III']}]}, 'contactsLocationsModule': {'locations': [{'zip': '510060', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'Zhongshan Ophthalmic Center, Sun Yat-sen U', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}], 'overallOfficials': [{'name': 'Yizhi Liu, M.D.,Ph.D.', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Sun Yat-sen University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Sun Yat-sen University', 'class': 'OTHER'}, 'collaborators': [{'name': 'Ministry of Health, China', 'class': 'OTHER_GOV'}, {'name': 'National Natural Science Foundation of China', 'class': 'OTHER_GOV'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Department of cataract, Zhongshan Ophthalmic Center', 'investigatorFullName': 'Haotian Lin', 'investigatorAffiliation': 'Sun Yat-sen University'}}}}