Ignite Creation Date:
2025-12-24 @ 9:59 PM
Ignite Modification Date:
2025-12-25 @ 7:37 PM
Study NCT ID:
NCT01524432
Status:
COMPLETED
Last Update Posted:
2013-04-02
First Post:
2012-01-18
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D014008', 'term': 'Tinea Pedis'}], 'ancestors': [{'id': 'D014005', 'term': 'Tinea'}, {'id': 'D003881', 'term': 'Dermatomycoses'}, {'id': 'D009181', 'term': 'Mycoses'}, {'id': 'D001423', 'term': 'Bacterial Infections and Mycoses'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D012874', 'term': 'Skin Diseases, Infectious'}, {'id': 'D005533', 'term': 'Foot Dermatoses'}, {'id': 'D005534', 'term': 'Foot Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D011537', 'term': 'Pruritus'}, {'id': 'D012877', 'term': 'Skin Manifestations'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D003022', 'term': 'Clotrimazole'}], 'ancestors': [{'id': 'D007093', 'term': 'Imidazoles'}, {'id': 'D001393', 'term': 'Azoles'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 42}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2012-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2013-03', 'completionDateStruct': {'date': '2012-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2013-03-31', 'studyFirstSubmitDate': '2012-01-18', 'studyFirstSubmitQcDate': '2012-02-01', 'lastUpdatePostDateStruct': {'date': '2013-04-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2012-02-02', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2012-05', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': '• Complete Cure', 'timeFrame': 'Day 44', 'description': 'Complete Cure is defined as a negative KOH and negative fungal culture and no evidence of clinical disease for each sign and symptom at Day 44.'}], 'secondaryOutcomes': [{'measure': 'Effective Treatment', 'timeFrame': 'Day 44', 'description': 'Effective Treatment defined as negative KOH, negative fungal culture, no or mild erythema and/or scaling with all other signs or symptoms being absent at Day 44.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Clotrimazole', 'Microcapsules'], 'conditions': ['Tinea Pedis']}, 'descriptionModule': {'briefSummary': "This is a study of hygienic socks with antifungal agent-loaded microcapsules for subjects with interdigital type tinea pedis (athlete's foot between the toes). This is a 6 week study which has a 2 week treatment period and a 4 week follow-up evaluation.", 'detailedDescription': "Tinea pedis (Athlete's Foot) is a common skin disease which affects a large number of the population. The development of hygienic socks through the microencapsulation technology have great potential to provide the convenient pharmacological treatment on one hand, and good moisture management which can reduce the microbial overgrowth on the other hand for patients with tinea pedis. The socks, therefore, reduce the effects of the skin disease on the quality of life."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Be at least 18 years of age and of either sex.\n* Subjects must have clinical evidence of interdigital tinea pedis of one or both feet characterized by: (i) moderate erythema, (ii) scaling and (iii) mild pruritis.\n* Have microscopic evidence (positive KOH) of the presence of fungi. Evaluable subjects must have a positive KOH and a fungal culture positive for a dermatophyte in the skin scrapings taken at the Baseline Visit. Subjects with a positive KOH may be entered into the study pending the results of the fungal culture\n* Be willing and able to give informed consent/assent or have their parent/guardian do so, if applicable.\n* Be willing and able to use the assigned study medication as directed and to commit to all follow-up visits for the duration of the study.\n* Be in good health and free of any disease or physical condition which might, in the Investigator's opinion, expose the subject to an unacceptable risk by study participation.\n* Females must be non-pregnant, non-lactating and not intending to become pregnant during the course of the study.\n\nExclusion Criteria:\n\n* Is pregnant, nursing or planning a pregnancy during the study.\n* Has used topical antifungals or topical corticosteroids on the feet within 4 weeks prior to the start of the study.\n* Has received systemic antifungal therapy within 4 weeks prior to the start of the study medication.\n* Has used systemic antibacterials or systemic corticosteroids within 4 weeks prior to the start of the study. Systemic corticosteroids do not include intranasal, inhaled, and ophthalmic corticosteroids used for the management of allergies, pulmonary disorders or other conditions.\n* Has a history of uncontrolled diabetes mellitus or is immunocompromised (due to disease, e.g., HIV, or medications).\n* Has concurrent tinea infection e.g. Tinea Versicolor, Tinea Cruris, Moccasin-type Tinea Pedis, etc. (in the opinion of the Investigator).\n* Onychomycosis, involving ≥ 20% of the area of either great toenail or involvement of more than five toenails in total.\n* Has any other skin disease which might interfere with the evaluation of tinea pedis.\n* Is currently enrolled in an investigational drug or device study.\n* Has received an investigational drug or treatment with an investigational device within 30 days prior to entering this study.\n* Is unreliable, including subjects with a history of drug or alcohol abuse.\n* Has known hypersensitivity to any of the components of the study medications."}, 'identificationModule': {'nctId': 'NCT01524432', 'briefTitle': 'Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis', 'organization': {'class': 'OTHER', 'fullName': 'The Hong Kong Polytechnic University'}, 'officialTitle': 'Phase III Study in Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis', 'orgStudyIdInfo': {'id': 'Mic_Clo_Terb'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Drug loaded microcapsules socks', 'description': 'Study medication', 'interventionNames': ['Drug: Anti-fungal agent (Clotrimazole) loaded microcapsules']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'No drug loaded microcapsules socks', 'description': 'Placebo medication', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Anti-fungal agent (Clotrimazole) loaded microcapsules', 'type': 'DRUG', 'otherNames': ['Anti-fungal agent loaded microcapsules'], 'description': 'Clotrimazole loaded microcapsules padded on socks and the patient should wear the socks every day for 2 weeks', 'armGroupLabels': ['Drug loaded microcapsules socks']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'No drug loaded microcapsules socks', 'armGroupLabels': ['No drug loaded microcapsules socks']}]}, 'contactsLocationsModule': {'locations': [{'zip': '00852', 'city': 'Kowloon', 'country': 'Hong Kong', 'facility': 'Institute of Textiles and Clothing, The Hong Kong Polytechnic University', 'geoPoint': {'lat': 22.31667, 'lon': 114.18333}}], 'overallOfficials': [{'name': 'Chun Wah M. Yuen', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Hong Kong PU'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Prof. Yuen Chun-Wah', 'class': 'OTHER'}, 'collaborators': [{'name': 'Dr. Cheung Hing Cheong Private Dermatology Clinic', 'class': 'UNKNOWN'}], 'responsibleParty': {'type': 'SPONSOR_INVESTIGATOR', 'investigatorTitle': 'Professor', 'investigatorFullName': 'Prof. Yuen Chun-Wah', 'investigatorAffiliation': 'The Hong Kong Polytechnic University'}}}}