Ignite Creation Date:
2025-12-24 @ 1:17 PM
Ignite Modification Date:
2025-12-25 @ 9:52 PM
Study NCT ID:
NCT01369095
Status:
COMPLETED
Last Update Posted:
2015-10-12
First Post:
2011-06-07
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Brazil', 'Germany']}, 'conditionBrowseModule': {'meshes': [{'id': 'D003863', 'term': 'Depression'}], 'ancestors': [{'id': 'D001526', 'term': 'Behavioral Symptoms'}, {'id': 'D001519', 'term': 'Behavior'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000068736', 'term': 'Duloxetine Hydrochloride'}, {'id': 'D000089983', 'term': 'Escitalopram'}, {'id': 'C000594001', 'term': '6-(2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyridazin-3-amine'}], 'ancestors': [{'id': 'D013876', 'term': 'Thiophenes'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D011437', 'term': 'Propylamines'}, {'id': 'D000588', 'term': 'Amines'}, {'id': 'D009570', 'term': 'Nitriles'}, {'id': 'D001572', 'term': 'Benzofurans'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 976}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2011-07'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2015-09', 'dispFirstSubmitDate': '2015-09-23', 'completionDateStruct': {'date': '2013-05', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2015-09-23', 'studyFirstSubmitDate': '2011-06-07', 'dispFirstSubmitQcDate': '2015-09-23', 'studyFirstSubmitQcDate': '2011-06-07', 'dispFirstPostDateStruct': {'date': '2015-10-12', 'type': 'ESTIMATED'}, 'lastUpdatePostDateStruct': {'date': '2015-10-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-06-08', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-05', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change from baseline to endpoint in the Montgomery Asberg Depression Rating Scale (MADRS) total score', 'timeFrame': 'Week 13'}], 'secondaryOutcomes': [{'measure': 'Change from baseline to endpoint in mean Sheehan Disability Scale (SDS) score.', 'timeFrame': 'Week 13'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'conditions': ['Depression']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://www.bms.com/studyconnect/Pages/home.aspx', 'label': 'BMS clinical trial educational resource'}, {'url': 'http://www.bms.com/clinical_trials/Pages/Investigator_Inquiry_form.aspx', 'label': 'Investigator Inquiry form'}]}, 'descriptionModule': {'briefSummary': 'The purpose of the study is to evaluate the efficacy of study drug (BMS-820836) as compared with continued Duloxetine/Escitalopram in the treatment of patients with treatment resistant depression (TRD).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Men and women of age 18-65 years (Argentina minimum age will be 24 years of age)\n* Patients must be able to understand the nature of the study, agree to comply with the prescribed dosage regimens, report for regularly scheduled office visits, and communicate to study personnel about adverse events and concomitant medication use.\n* Patients with a diagnosis of Major Depressive Disorder, currently experiencing a Major Depressive Episode, as defined by Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition (Text Revision)\\[DSM IV TR\\] criteria. The current depressive episode must be \\> 8 weeks in duration and \\< 3 years duration.\n* In the current Major depressive disorder (MDD) episode, patients should report a history of inadequate response to 1-3 adequate trials of antidepressant treatment.\n* Patients must have a 17-item Hamilton Depression Rating Scale (HAM-D17) total score ≥ 18 at Screening and Baseline.\n\nExclusion Criteria:\n\n* Patients who report an inadequate response (less than 50% reduction in depressive symptom severity) to more than three adequate trials of antidepressant treatments during the current depressive episode.\n* Patients who have failed Duloxetine and Escitalopram at an adequate dose and for an adequate duration in their current episode.'}, 'identificationModule': {'nctId': 'NCT01369095', 'briefTitle': 'Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bristol-Myers Squibb'}, 'officialTitle': 'A Multicenter, Randomized, Double-Blind, Active Controlled, Comparative, Fixed-Dose, Dose Response Study of the Efficacy and Safety of BMS-820836 in Patients With Treatment Resistant Major Depression (TRD).', 'orgStudyIdInfo': {'id': 'CN162-007'}, 'secondaryIdInfos': [{'id': '2011-000778-71', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Arm 1: Duloxetine / Escitalopram + BMS-820836 placebo', 'interventionNames': ['Drug: Duloxetine', 'Drug: Escitalopram', 'Drug: BMS-820836 Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'Arm 2: BMS-820836 (0.25 mg) + BMS-820836 placebo', 'interventionNames': ['Drug: BMS-820836 Placebo', 'Drug: BMS-820836']}, {'type': 'EXPERIMENTAL', 'label': 'Arm 3: BMS-820836 (0.50 mg) + BMS-820836 placebo', 'interventionNames': ['Drug: BMS-820836 Placebo', 'Drug: BMS-820836']}, {'type': 'EXPERIMENTAL', 'label': 'Arm 4: BMS-820836 (1.0 mg) + BMS-820836 placebo', 'interventionNames': ['Drug: BMS-820836 Placebo', 'Drug: BMS-820836']}, {'type': 'EXPERIMENTAL', 'label': 'Arm 5: BMS-820836 (2.0 mg) + BMS-820836 placebo', 'interventionNames': ['Drug: BMS-820836 Placebo', 'Drug: BMS-820836']}], 'interventions': [{'name': 'Duloxetine', 'type': 'DRUG', 'otherNames': ['Cymbalta'], 'description': 'Capsule, Oral, 30-60mg/day, once daily, 7 weeks (Phase B), 7weeks (Phase C\\&D)', 'armGroupLabels': ['Arm 1: Duloxetine / Escitalopram + BMS-820836 placebo']}, {'name': 'Escitalopram', 'type': 'DRUG', 'otherNames': ['Lexapro'], 'description': 'Capsule, Oral, 10-20 mg/day, once daily, 7 weeks (Phase B), 7 weeks (Phase C\\&D)', 'armGroupLabels': ['Arm 1: Duloxetine / Escitalopram + BMS-820836 placebo']}, {'name': 'BMS-820836 Placebo', 'type': 'DRUG', 'description': 'Tablet, Oral, 0.0mg, once daily, 13 weeks (Phase B\\&C)', 'armGroupLabels': ['Arm 1: Duloxetine / Escitalopram + BMS-820836 placebo', 'Arm 2: BMS-820836 (0.25 mg) + BMS-820836 placebo', 'Arm 3: BMS-820836 (0.50 mg) + BMS-820836 placebo', 'Arm 4: BMS-820836 (1.0 mg) + BMS-820836 placebo', 'Arm 5: BMS-820836 (2.0 mg) + BMS-820836 placebo']}, {'name': 'BMS-820836', 'type': 'DRUG', 'description': 'Tablet, Oral, 0.25mg, once daily, 6 weeks (Phase C)', 'armGroupLabels': ['Arm 2: BMS-820836 (0.25 mg) + BMS-820836 placebo']}, {'name': 'BMS-820836', 'type': 'DRUG', 'description': 'Tablet, Oral, 0.5 mg, once daily, 6 weeks (Phase C)', 'armGroupLabels': ['Arm 3: BMS-820836 (0.50 mg) + BMS-820836 placebo']}, {'name': 'BMS-820836', 'type': 'DRUG', 'description': 'Tablet, Oral, 1.0 mg, once daily, 6 weeks (Phase C)', 'armGroupLabels': ['Arm 4: BMS-820836 (1.0 mg) + BMS-820836 placebo']}, {'name': 'BMS-820836', 'type': 'DRUG', 'description': 'Tablet, Oral, 2.0 mg, once daily, 6 weeks (Phase C)', 'armGroupLabels': ['Arm 5: BMS-820836 (2.0 mg) + BMS-820836 placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35226', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Birmingham Psychiatry Pharmaceutical Studies, Inc.', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '72223', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Arkansas Psychiatric Clinic Clinical Research Trials, P.A.', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '91710', 'city': 'Chino', 'state': 'California', 'country': 'United States', 'facility': 'Catalina Research Institute, Llc', 'geoPoint': {'lat': 34.01223, 'lon': -117.68894}}, {'zip': '91206', 'city': 'Glendale', 'state': 'California', 'country': 'United States', 'facility': 'Behavioral Research Specialists, Llc', 'geoPoint': {'lat': 34.14251, 'lon': -118.25508}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'country': 'United States', 'facility': 'Pacific Clinical Research Medical Group', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '92374', 'city': 'Redlands', 'state': 'California', 'country': 'United States', 'facility': 'Anderson Clinical Research', 'geoPoint': {'lat': 34.05557, 'lon': -117.18254}}, {'zip': '92108', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Affiliated Research Institute', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92123', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Artemis Institute For Clinical Research', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92123', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Sharp Mesa Vista Hospital', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '80209', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'Western Affiliated Research Institute', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '06416', 'city': 'Cromwell', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Connecticut Clinical Research', 'geoPoint': {'lat': 41.5951, 'lon': -72.64537}}, {'zip': '34601', 'city': 'Brooksville', 'state': 'Florida', 'country': 'United States', 'facility': 'Meridien Research', 'geoPoint': {'lat': 28.55554, 'lon': -82.38991}}, {'zip': '33912', 'city': 'Fort Myers', 'state': 'Florida', 'country': 'United States', 'facility': 'Gulfcoast Clinical Research Center', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32256', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Amit Vijapura', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33613', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'Stedman Clinical Trials', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33407', 'city': 'West Palm Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Janus Center For Psychiatric Research', 'geoPoint': {'lat': 26.71534, 'lon': -80.05337}}, {'zip': '30306', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60640', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Uptown Research Institute, Llc', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '47802', 'city': 'Terre Haute', 'state': 'Indiana', 'country': 'United States', 'facility': 'Clinco', 'geoPoint': {'lat': 39.4667, 'lon': -87.41391}}, {'zip': '66206', 'city': 'Prairie Village', 'state': 'Kansas', 'country': 'United States', 'facility': 'Clinical Trials Technology, Inc', 'geoPoint': {'lat': 38.99167, 'lon': -94.63357}}, {'zip': '71104', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Ert', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '02478', 'city': 'Belmont', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Mclean Hospital', 'geoPoint': {'lat': 42.39593, 'lon': -71.17867}}, {'zip': '08755', 'city': 'Toms River', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Bio Behavioral Health', 'geoPoint': {'lat': 39.95373, 'lon': -74.19792}}, {'zip': '87109', 'city': 'Albuquerque', 'state': 'New Mexico', 'country': 'United States', 'facility': 'Albuquerque Neuroscience, Inc.', 'geoPoint': {'lat': 35.08449, 'lon': -106.65114}}, {'zip': '11366', 'city': 'Fresh Meadows', 'state': 'New York', 'country': 'United States', 'facility': 'Comprehensive Clinical Development, Inc', 'geoPoint': {'lat': 40.73482, 'lon': -73.79347}}, {'zip': '10549', 'city': 'Mount Kisco', 'state': 'New York', 'country': 'United States', 'facility': 'Bioscience Research, Llc', 'geoPoint': {'lat': 41.20426, 'lon': -73.72708}}, {'zip': '10003', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Village Clinical Research, Inc.', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '44122', 'city': 'Beachwood', 'state': 'Ohio', 'country': 'United States', 'facility': 'Northcoast Clinical Trials, Inc', 'geoPoint': {'lat': 41.4645, 'lon': -81.50873}}, {'zip': '45215', 'city': 'Cincinnati', 'state': 'Ohio', 'country': 'United States', 'facility': 'Patient Priority Clinical Sites, Llc', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '43623', 'city': 'Toledo', 'state': 'Ohio', 'country': 'United States', 'facility': 'Neurology & Neuroscience Center Of Ohio', 'geoPoint': {'lat': 41.66394, 'lon': -83.55521}}, {'zip': '19063', 'city': 'Media', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Suburban Research Associates', 'geoPoint': {'lat': 39.91678, 'lon': -75.38769}}, {'zip': '19403', 'city': 'Norristown', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Keystone Clinical Studies, Llc', 'geoPoint': {'lat': 40.1215, 'lon': -75.3399}}, {'zip': '15219', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Ert', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '15219', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Neuropsychiatric Research Center Of Orange County', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '15219', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Northwest Clinical Research Center', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '02865', 'city': 'Lincoln', 'state': 'Rhode Island', 'country': 'United States', 'facility': 'Lincoln Research', 'geoPoint': {'lat': 41.92111, 'lon': -71.435}}, {'zip': '78731', 'city': 'Austin', 'state': 'Texas', 'country': 'United States', 'facility': 'Future Search Trials', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '75231', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'Futuresearch Trials Of Dallas', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '75115', 'city': 'DeSoto', 'state': 'Texas', 'country': 'United States', 'facility': 'Insite Clinical Research', 'geoPoint': {'lat': 32.58986, 'lon': -96.85695}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Ben Taub General Hospital', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '76309', 'city': 'Wichita Falls', 'state': 'Texas', 'country': 'United States', 'facility': 'Grayline Clinical Drug Trials', 'geoPoint': {'lat': 33.91371, 'lon': -98.49339}}, {'zip': '84015', 'city': 'Clinton', 'state': 'Utah', 'country': 'United States', 'facility': 'Ericksen Research And Development', 'geoPoint': {'lat': 41.13967, 'lon': -112.0505}}, {'zip': '84107', 'city': 'Murray', 'state': 'Utah', 'country': 'United States', 'facility': 'Clinical Methods Llc', 'geoPoint': {'lat': 40.66689, 'lon': -111.88799}}, {'zip': '05091', 'city': 'Woodstock', 'state': 'Vermont', 'country': 'United States', 'facility': 'Neuropsychiatric Associates', 'geoPoint': {'lat': 43.62424, 'lon': -72.51843}}, {'zip': '20170', 'city': 'Herndon', 'state': 'Virginia', 'country': 'United States', 'facility': 'Neuroscience, Inc', 'geoPoint': {'lat': 38.96955, 'lon': -77.3861}}, {'zip': '23219', 'city': 'Richmond', 'state': 'Virginia', 'country': 'United States', 'facility': 'Virginia Commonwealth University', 'geoPoint': {'lat': 37.55376, 'lon': -77.46026}}, {'zip': '98104', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Summit Research Network (Seattle) Llc', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '53562', 'city': 'Middleton', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Dean Foundation For Health Research & Education', 'geoPoint': {'lat': 43.09722, 'lon': -89.50429}}, {'zip': '1405', 'city': 'Caba', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Local Institution'}, {'zip': '1425', 'city': 'Caba', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Local Institution'}, {'zip': '1900', 'city': 'La Plata', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Local Institution', 'geoPoint': {'lat': -34.92126, 'lon': -57.95442}}, {'zip': '5000', 'city': 'Córdoba', 'state': 'Córdoba Province', 'country': 'Argentina', 'facility': 'Local Institution', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': '5003', 'city': 'Córdoba', 'state': 'Córdoba Province', 'country': 'Argentina', 'facility': 'Local Institution', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': '5500', 'city': 'Mendoza', 'state': 'Mendoza Province', 'country': 'Argentina', 'facility': 'Local Institution', 'geoPoint': {'lat': -32.88946, 'lon': -68.84582}}, {'zip': '4000', 'city': 'Brisbane', 'state': 'Queensland', 'country': 'Australia', 'facility': 'Local Institution', 'geoPoint': {'lat': -27.46794, 'lon': 153.02809}}, {'zip': '5112', 'city': 'Adelaide', 'state': 'South Australia', 'country': 'Australia', 'facility': 'Local Institution', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '3084', 'city': 'Heidelberg', 'state': 'Victoria', 'country': 'Australia', 'facility': 'Local Institution', 'geoPoint': {'lat': -37.75, 'lon': 145.06667}}, {'zip': '6009', 'city': 'Nedlands', 'state': 'Western Australia', 'country': 'Australia', 'facility': 'Local Institution', 'geoPoint': {'lat': -31.98184, 'lon': 115.8073}}, {'zip': '1010', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Local Institution', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '1090', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Local Institution', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': 'V6Z 2L4', 'city': 'Vancouver', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 49.24966, 'lon': -123.11934}}, {'zip': 'E2A 4X7', 'city': 'Bathurst', 'state': 'New Brunswick', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 47.61814, 'lon': -65.65112}}, {'zip': 'K1Z 7K4', 'city': 'Ottawa', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 45.41117, 'lon': -75.69812}}, {'zip': 'M4W 2N4', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'H1N 3V2', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'H2R 1V6', 'city': 'Montreal', 'state': 'Quebec', 'country': 'Canada', 'facility': 'Local Institution', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': '34295', 'city': 'Montpellier', 'state': 'France', 'country': 'France', 'facility': 'Local Institution', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'zip': '39100', 'city': 'Dole', 'country': 'France', 'facility': 'Local Institution', 'geoPoint': {'lat': 47.09225, 'lon': 5.48966}}, {'zip': '59500', 'city': 'Douai', 'country': 'France', 'facility': 'Local Institution', 'geoPoint': {'lat': 50.37069, 'lon': 3.07922}}, {'zip': '78990', 'city': 'Élancourt', 'country': 'France', 'facility': 'Local Institution', 'geoPoint': {'lat': 48.78421, 'lon': 1.9552}}, {'zip': '175003', 'city': 'Jonzac', 'country': 'France', 'facility': 'Local Institution', 'geoPoint': {'lat': 45.44636, 'lon': -0.43485}}, {'zip': '517 507', 'city': 'Tirupati', 'state': 'Andhra Pradesh', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 13.63551, 'lon': 79.41989}}, {'zip': '530002', 'city': 'Visakhapatnam', 'state': 'Andhra Pradesh', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 17.68009, 'lon': 83.20161}}, {'zip': '380 006', 'city': 'Ahmedabad', 'state': 'Gujarat', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 23.02579, 'lon': 72.58727}}, {'zip': '400012', 'city': 'Mumbai', 'state': 'Maharashtra', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 19.07283, 'lon': 72.88261}}, {'zip': '411004', 'city': 'Pune', 'state': 'Maharashtra', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 18.51957, 'lon': 73.85535}}, {'zip': '226006', 'city': 'Lucknow', 'state': 'Uttar Pradesh', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 26.83928, 'lon': 80.92313}}, {'zip': '600116', 'city': 'Chennai', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 13.08784, 'lon': 80.27847}}, {'zip': '411030', 'city': 'Pune', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 18.51957, 'lon': 73.85535}}, {'zip': '211 005', 'city': 'Varanasi', 'country': 'India', 'facility': 'Local Institution', 'geoPoint': {'lat': 25.31668, 'lon': 83.01041}}, {'zip': '56126', 'city': 'Pisa', 'country': 'Italy', 'facility': 'Local Institution', 'geoPoint': {'lat': 43.70853, 'lon': 10.4036}}, {'zip': '00168', 'city': 'Roma', 'country': 'Italy', 'facility': 'Local Institution', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': '53100', 'city': 'Siena', 'country': 'Italy', 'facility': 'Local Institution', 'geoPoint': {'lat': 43.31822, 'lon': 11.33064}}, {'zip': '00731', 'city': 'Ponce', 'country': 'Puerto Rico', 'facility': 'Local Institution', 'geoPoint': {'lat': 18.01031, 'lon': -66.62398}}, {'zip': '0002', 'city': 'Pretoria', 'state': 'Gauteng', 'country': 'South Africa', 'facility': 'Local Institution', 'geoPoint': {'lat': -25.74486, 'lon': 28.18783}}, {'zip': '0181', 'city': 'Pretoria', 'state': 'Gauteng', 'country': 'South Africa', 'facility': 'Local Institution', 'geoPoint': {'lat': -25.74486, 'lon': 28.18783}}, {'zip': '0187', 'city': 'Pretoria', 'state': 'Gauteng', 'country': 'South Africa', 'facility': 'Local Institution', 'geoPoint': {'lat': -25.74486, 'lon': 28.18783}}, {'zip': '3630', 'city': 'Durban', 'state': 'KwaZulu-Natal', 'country': 'South Africa', 'facility': 'Local Institution', 'geoPoint': {'lat': -29.8579, 'lon': 31.0292}}, {'zip': '08003', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Local Institution', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '08025', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Local Institution', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': 'W6 8RP', 'city': 'London', 'state': 'Greater London', 'country': 'United Kingdom', 'facility': 'Local Institution', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'zip': 'HA8 0AD', 'city': 'Edgware', 'state': 'Middlesex', 'country': 'United Kingdom', 'facility': 'Local Institution', 'geoPoint': {'lat': 51.6128, 'lon': -0.27539}}, {'zip': 'B23 6DW', 'city': 'Birmingham', 'state': 'West Midlands', 'country': 'United Kingdom', 'facility': 'Local Institution', 'geoPoint': {'lat': 52.48142, 'lon': -1.89983}}], 'overallOfficials': [{'name': 'Bristol-Myers Squibb', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Bristol-Myers Squibb'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Bristol-Myers Squibb', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}