Ignite Creation Date:
2025-12-24 @ 9:49 PM
Ignite Modification Date:
2025-12-25 @ 7:27 PM
Study NCT ID:
NCT05987332
Status:
RECRUITING
Last Update Posted:
2025-11-07
First Post:
2023-07-12
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000098943', 'term': 'Uveal Melanoma'}, {'id': 'D008545', 'term': 'Melanoma'}], 'ancestors': [{'id': 'D018358', 'term': 'Neuroendocrine Tumors'}, {'id': 'D017599', 'term': 'Neuroectodermal Tumors'}, {'id': 'D009373', 'term': 'Neoplasms, Germ Cell and Embryonal'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009380', 'term': 'Neoplasms, Nerve Tissue'}, {'id': 'D018326', 'term': 'Nevi and Melanomas'}, {'id': 'D014604', 'term': 'Uveal Neoplasms'}, {'id': 'D005134', 'term': 'Eye Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D005128', 'term': 'Eye Diseases'}, {'id': 'D014603', 'term': 'Uveal Diseases'}, {'id': 'D012878', 'term': 'Skin Neoplasms'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077547', 'term': 'Crizotinib'}, {'id': 'C582435', 'term': 'pembrolizumab'}, {'id': 'D000074324', 'term': 'Ipilimumab'}, {'id': 'D000077594', 'term': 'Nivolumab'}, {'id': 'D003606', 'term': 'Dacarbazine'}], 'ancestors': [{'id': 'D010880', 'term': 'Piperidines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D000631', 'term': 'Aminopyridines'}, {'id': 'D011725', 'term': 'Pyridines'}, {'id': 'D061067', 'term': 'Antibodies, Monoclonal, Humanized'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D014226', 'term': 'Triazenes'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D007093', 'term': 'Imidazoles'}, {'id': 'D001393', 'term': 'Azoles'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SEQUENTIAL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 420}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-10-31', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-03', 'completionDateStruct': {'date': '2028-01-15', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-06', 'studyFirstSubmitDate': '2023-07-12', 'studyFirstSubmitQcDate': '2023-08-03', 'lastUpdatePostDateStruct': {'date': '2025-11-07', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-08-14', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-01-15', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': "Progression-Free Survival (PFS) by blinded independent central review (BICR) of IDE196 + Crizotinib compared to investigator's choice of treatment", 'timeFrame': 'Approximately 2 years', 'description': 'PFS per RECIST 1.1'}, {'measure': "Overall Survival (OS) of IDE196 + Crizotinib compared to investigator's choice of treatment", 'timeFrame': 'Approximately 4 years', 'description': 'OS from randomization to date of death due to any cause'}], 'secondaryOutcomes': [{'measure': 'Safety of IDE196 + Crizotinib: Incidence of Adverse Events', 'timeFrame': 'Approximately 2 years', 'description': 'Treatment emergent adverse events will be summarized by all AEs, all Grade 3-4-5 AEs, all treatment related AEs, all AEs leading to study drug modifications or discontinuations, all SAEs as measured by CTCAE V5.0'}, {'measure': 'Phase 2a: Dose exposure response of IDE196', 'timeFrame': 'Approximately 5 months', 'description': 'Dose-exposure-response of IDE196 as measured by concentration of IDE196 in plasma'}, {'measure': 'Phase 2a: Dose exposure response of Crizotinib', 'timeFrame': 'Approximately 5 months', 'description': 'Dose-exposure-response of Crizotinib as measured by concentration of Crizotinib in plasma'}, {'measure': "Progression-Free Survival (PFS) per Investigator of IDE196 + Crizotinib compared to investigator's choice of treatment", 'timeFrame': 'Approximately 2 years', 'description': 'PFS per RECIST 1.1'}, {'measure': "Objective Response Rate (ORR) per BICR and Investigator assessment of IDE196 + Crizotinib compared to investigator's choice of treatment", 'timeFrame': 'Approximately 2 years', 'description': 'ORR per RECIST 1.1'}, {'measure': "Duration of Response (DOR) per BICR and Investigator assessment of IDE196 + Crizotinib compared to investigator's choice of treatment", 'timeFrame': 'Approximately 2 years', 'description': 'DOR per RECIST 1.1'}, {'measure': 'Change from baseline over time and between treatment arms in EORTC QLQ-C30', 'timeFrame': 'Approximately 2 years', 'description': 'Global health status and quality of life will be assessed using the EORTC QLQ-C30 questionnaire. The score range for the EORTC QLQ-C30 is from 0 to 100, with higher scores indicating better functioning and better global health status and health-related quality of life. A positive change indicates improvement.'}, {'measure': 'Change from baseline over time and between treatment arms in EuroQoL (EQ)-5D-5L scores', 'timeFrame': 'Approximately 2 years', 'description': 'General health status will be assessed using the EQ-5D,5L questionnaire, which includes five dimensions (5D): mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has 3 scoring levels, where 1 indicates a better health state (no problems) and 3 indicates a worse health state. A positive change indicates improvement.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['IDE196', 'Darovasertib', 'Protein Kinase C', 'Metastatic Uveal Melanoma', 'Melanoma', 'Ocular Oncology', 'Ophthalmology', 'Crizotinib', 'Ocular melanoma'], 'conditions': ['Metastatic Uveal Melanoma']}, 'descriptionModule': {'briefSummary': "This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A\\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).", 'detailedDescription': "This study is designed as a multi-stage Phase 2 study within a Phase 3 study to evaluate the safety, tolerability, pharmacokinetics, dose-exposure relationship, and anti-tumor activity of IDE196 in combination with crizotinib compared to the comparator arm of investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).\n\nThe Phase 2a dose optimization stage will evaluate two doses of IDE196 in combination with crizotinib compared to the comparator arm. Participants will be randomized to the three treatment arms. At the point of optimal IDE196 + crizotinib dose selection, the other dose arm will be dropped with discontinuation of enrollment to that arm. Participants receiving the IDE196 dose (in combination with crizotinib) that is not selected, will be offered the choice to remain on the same dose or change to the chosen optimal dose.\n\nThe optimal dose will be chosen to complete the Phase 2b portion. The Phase 2b part of the study will continue to enroll the chosen combination dose of IDE196 + crizotinib compared with the comparator arm. Participants will be randomized to the two treatment arms.\n\nThe Phase 3 part of the study will continue to enroll the chosen combination dose of IDE196 + crizotinib compared with the comparator arm. Participants will be randomized to the two treatment arms."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Histological or cytological confirmed Metastatic Uveal Melanoma\n* HLA-A\\*02:01 negative\n* No prior systemic therapy in the metastatic or advanced setting or regional or liver-directed therapy. Ablations or surgical resection of oligometastatic disease, and neoadjuvant or adjuvant therapy is allowed\n* Measurable disease per RECIST 1.1\n* Able to be safely administered and absorb study therapy\n* ECOG performance status 0 or 1\n* Life expectancy of ≥3 months\n* Adequate organ function\n\nExclusion Criteria:\n\n* Previous treatment with a PKC inhibitor (including prior treatment with IDE196), an inhibitor directly targeting MET, or an inhibitor directly targeting GNAQ/11\n* Concurrent malignant disease\n* AEs from prior anti-cancer therapy that have not resolved to Grade ≤1\n* Symptomatic or untreated central nervous system (CNS) metastases, or CNS metastases that require corticosteroids\n* High risk of syncope\n* Known AIDS related illness or active Hep B/C\n* Active adrenal insufficiency, active colitis, or active inflammatory bowel disease\n* History of interstitial lung disease, active pneumonitis, or history of pneumonitis\n* Active infection requiring systemic antibiotic therapy\n* Use of hematopoietic colony-stimulating factors (CSF) prior to start of study drug\n* Females who are pregnant or breastfeeding\n* History of severe hypersensitivity reactions (eg, anaphylaxis) to other biologic drugs or monoclonal antibodies\n* Contraindication for treatment with investigator's choice therapies as per applicable labelling\n* History of stroke within the last 6 months of the first dose of study drug\n* Has any other condition that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the opinion of the investigator, would make the participant inappropriate for entry into the study, including institutionalization on the basis of an official or court order"}, 'identificationModule': {'nctId': 'NCT05987332', 'briefTitle': 'IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma', 'organization': {'class': 'INDUSTRY', 'fullName': 'IDEAYA Biosciences'}, 'officialTitle': "IDE196 (Darovasertib) in Combination With Crizotinib Versus Investigator's Choice of Treatment as First-line Therapy in HLA-A2 Negative Metastatic Uveal Melanoma (DAR-UM-2)", 'orgStudyIdInfo': {'id': 'IDE196-002'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Phase 2a Dose Optimization of IDE196 + crizotinib', 'description': 'Multiple doses of IDE196 will be tested in combination with fixed dose of crizotinib to identify the optimal combination dose.', 'interventionNames': ['Drug: IDE196', 'Drug: Crizotinib']}, {'type': 'EXPERIMENTAL', 'label': 'Phase 2b / 3 Chosen Combination dose of IDE196 + crizotinib', 'description': 'Chosen combination dose of IDE196 + crizotinib will be tested in additional participants.', 'interventionNames': ['Drug: IDE196', 'Drug: Crizotinib']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Phase 2a / 2b / 3 Comparator Arm', 'description': "Participants will receive investigator's choice of Pembrolizumab, Ipilimumab + Nivolumab, or Dacarbazine.", 'interventionNames': ['Drug: Pembrolizumab', 'Drug: Ipilimumab', 'Drug: Nivolumab', 'Drug: Dacarbazine']}], 'interventions': [{'name': 'IDE196', 'type': 'DRUG', 'otherNames': ['Darovasertib'], 'description': 'Dosed orally, twice daily', 'armGroupLabels': ['Phase 2a Dose Optimization of IDE196 + crizotinib', 'Phase 2b / 3 Chosen Combination dose of IDE196 + crizotinib']}, {'name': 'Crizotinib', 'type': 'DRUG', 'otherNames': ['XALKORI'], 'description': 'Dosed orally, twice daily', 'armGroupLabels': ['Phase 2a Dose Optimization of IDE196 + crizotinib', 'Phase 2b / 3 Chosen Combination dose of IDE196 + crizotinib']}, {'name': 'Pembrolizumab', 'type': 'DRUG', 'otherNames': ['Keytruda'], 'description': 'IV administration every 3 weeks', 'armGroupLabels': ['Phase 2a / 2b / 3 Comparator Arm']}, {'name': 'Ipilimumab', 'type': 'DRUG', 'otherNames': ['Yervoy'], 'description': 'IV administration every 3 weeks for 4 Cycles', 'armGroupLabels': ['Phase 2a / 2b / 3 Comparator Arm']}, {'name': 'Nivolumab', 'type': 'DRUG', 'otherNames': ['Opdivo'], 'description': 'IV administration every 3 Weeks for 4 Cycles, thereafter every 4 Weeks maintenance', 'armGroupLabels': ['Phase 2a / 2b / 3 Comparator Arm']}, {'name': 'Dacarbazine', 'type': 'DRUG', 'otherNames': ['DTIC-Dome'], 'description': 'IV administration every 3 Weeks', 'armGroupLabels': ['Phase 2a / 2b / 3 Comparator Arm']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85258', 'city': 'Scottsdale', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Oncology Clinical Trials Nurse Navigator', 'role': 'CONTACT', 'email': 'clinicaltrials@honorhealth.com', 'phone': '480-323-1791'}, {'role': 'CONTACT', 'phone': '833-354-6667'}], 'facility': 'Honor Health', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '92093', 'city': 'La Jolla', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': "Katie O'Neil, BA", 'role': 'CONTACT', 'email': 'croneil@health.ucsd.edu', 'phone': '858-822-5354'}, {'name': 'Jazelle Molina', 'role': 'CONTACT', 'email': 'jgmolina@health.ucsd.edu', 'phone': '858-822-5354'}], 'facility': 'Moores Cancer Center', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '90024', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Adyel Annelus', 'role': 'CONTACT', 'email': 'aannelus@mednet.ucla.edu', 'phone': '310-794-4955'}, {'name': 'Elizabeth Seja', 'role': 'CONTACT', 'email': 'eseja@mednet.ucla.edu', 'phone': '310-794-6892'}], 'facility': 'UCLA Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90025', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Saba Mukarram', 'role': 'CONTACT', 'email': 'smukarram@theangelesclinic.org', 'phone': '310-231-2181'}], 'facility': 'The Angeles Clinic and Research Institute', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Denise Fortun', 'role': 'CONTACT', 'email': 'denise.fortun@sutterhealth.org', 'phone': '415-600-1775'}, {'name': 'CPMC Clinical Research Group', 'role': 'CONTACT', 'email': 'clinicalresearch@sutterhealth.org'}], 'facility': 'California Pacific Medical Center (CPMC)', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94143', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sonia Contreras Martinez, BSN', 'role': 'CONTACT', 'email': 'sonia.contrerasmartinez@ucsf.edu', 'phone': '415-514-6427'}], 'facility': 'University of California San Francisco', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Mayer, BA', 'role': 'CONTACT', 'email': 'sara.j.mayer@cuanschutz.edu', 'phone': '303-724-5056'}, {'name': 'Victoria Mayer, VA', 'role': 'CONTACT', 'email': 'victoria.nuanes@cuanschutz.edu', 'phone': '303-724-9807'}], 'facility': 'University of Colorado Cancer Center', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80218', 'city': 'Denver', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'SCRI Front Desk', 'role': 'CONTACT', 'email': 'cann.ddudenvergeneral@sarahcannon.com', 'phone': '720-754-2610'}], 'facility': 'SCRI at HealthONE', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '33136', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'CRSCutaneous@miami.edu'}], 'facility': 'University of Miami Sylvester Comprehensive Cancer Center', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33612', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nikhil Khushalani, MD', 'role': 'CONTACT', 'email': 'Nikhil.khushalani@moffitt.org', 'phone': '813-745-3437'}, {'name': 'Leticia Tetteh, BSN', 'role': 'CONTACT', 'email': 'Leticia.tetteh@moffitt.org', 'phone': '813-745-4617'}], 'facility': 'Moffitt Cancer Center', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Central Research Department', 'role': 'CONTACT', 'email': 'clinicaltrials@northside.com', 'phone': '404-303-3355'}], 'facility': 'Northside Hospital Atlanta', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mohammed Milhelm, MBBS', 'role': 'CONTACT', 'email': 'mohammed-milhelm@uiowa.edu', 'phone': '319-356-2324'}], 'facility': 'University of Iowa', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kamaneh Montazeri, MD', 'role': 'CONTACT', 'email': 'kmontazeri@mgh.harvard.edu', 'phone': '617-724-4000'}, {'name': 'Ryan Sullivan, MD', 'role': 'CONTACT', 'email': 'rsullivan7@mgh.harvard.edu', 'phone': '6177245197'}], 'facility': 'Massachusetts General Hospital', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Rizwan Haq', 'role': 'CONTACT', 'email': 'rizwan_haq@dfci.harvard.edu', 'phone': '617-632-6168'}, {'name': 'Linnea Drew', 'role': 'CONTACT', 'email': 'linneam_drew@dfci.harvard.edu', 'phone': '617-632-6705'}], 'facility': 'Dana Farber Cancer Institute', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '49546', 'city': 'Grand Rapids', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'The Cancer and Hematology Centers', 'role': 'CONTACT', 'email': 'ClinicalTrials@chcwm.com', 'phone': '616-954-5550'}, {'name': 'Jessica Miller, RN', 'role': 'CONTACT', 'email': 'Jmiller@chcwm.com', 'phone': '616-954-5550', 'phoneExt': '1651'}], 'facility': 'The Cancer and Hematology Centers', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '55337', 'city': 'Burnsville', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kayla McDonald', 'role': 'CONTACT', 'email': 'kayla.mcdonald1@usoncology.com', 'phone': '763-712-2128'}], 'facility': 'Minnesota Oncology Hematology, P.A.', 'geoPoint': {'lat': 44.76774, 'lon': -93.27772}}, {'zip': '55905', 'city': 'Rochester', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Referral Office', 'role': 'CONTACT', 'email': 'mayocliniccancerstudies@mayo.edu', 'phone': '855-776-0015'}], 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'zip': '63110', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Amer Alyasiry, MHS', 'role': 'CONTACT', 'email': 'aalyasiry@wustl.edu', 'phone': '314-600-4605'}, {'name': 'Tyler Klein', 'role': 'CONTACT', 'email': 'kleint@wustl.edu', 'phone': '314-273-3072'}], 'facility': 'Washington University School of Medicine', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '14263', 'city': 'Buffalo', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Benjamin Switzer, DO', 'role': 'CONTACT', 'email': 'benjamin.switzer@rosewellpark.org', 'phone': '716-845-7668'}, {'name': 'igor Puzanov, MD', 'role': 'CONTACT', 'email': 'igor.puzanov@roswellpark.org', 'phone': '716-845-7505'}], 'facility': 'Roswell Park Cancer Institute', 'geoPoint': {'lat': 42.88645, 'lon': -78.87837}}, {'zip': '11030', 'city': 'Manhasset', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Shaheer Khan, MD', 'role': 'CONTACT', 'email': 'skhan137@northwell.edu'}, {'name': 'Tracy Green, BS', 'role': 'CONTACT', 'email': 'tgreen22@northwell.edu'}], 'facility': 'Northwell Health', 'geoPoint': {'lat': 40.79788, 'lon': -73.69957}}, {'zip': '10065', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alexander Shoushtari, MD', 'role': 'CONTACT', 'email': 'shoushta@mskcc.org', 'phone': '646-888-4161'}, {'name': 'James Smithy, MD', 'role': 'CONTACT', 'email': 'smithyj@mskcc.org', 'phone': '929-623-0275'}], 'facility': 'Memorial Sloan Kettering Cancer Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '27710', 'city': 'Durham', 'state': 'North Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Carol Ann Wiggs, BSN', 'role': 'CONTACT', 'email': 'carolann.wiggs@duke.edu', 'phone': '919-684-0281'}, {'name': 'Emily Bolch', 'role': 'CONTACT', 'email': 'emily.bolch@duke.edu', 'phone': '919-668-6359'}], 'facility': 'Duke University Health System', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '45267', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'cancer@uchealth.com', 'phone': '513-584-7698'}], 'facility': 'University of Cincinnati', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '44195', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Lucy Kennedy, MD', 'role': 'CONTACT', 'phone': '866-223-8100'}], 'facility': 'The Cleveland Clinic Foundation', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '19107', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 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