Ignite Creation Date:
2025-12-24 @ 9:48 PM
Ignite Modification Date:
2025-12-29 @ 10:43 PM
Study NCT ID:
NCT00037232
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2002-05-16
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Failure Time Methods for Family Disease Studies
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D003327', 'term': 'Coronary Disease'}], 'ancestors': [{'id': 'D017202', 'term': 'Myocardial Ischemia'}, {'id': 'D014652', 'term': 'Vascular Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL'}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2001-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2005-05', 'completionDateStruct': {'date': '2005-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2016-03-15', 'studyFirstSubmitDate': '2002-05-16', 'studyFirstSubmitQcDate': '2002-05-16', 'lastUpdatePostDateStruct': {'date': '2016-03-16', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2002-05-17', 'type': 'ESTIMATED'}}, 'conditionsModule': {'conditions': ['Heart Diseases', 'Cardiovascular Diseases', 'Coronary Disease']}, 'referencesModule': {'references': [{'pmid': '12071409', 'type': 'BACKGROUND', 'citation': 'Glidden DV. Robust inference for event probabilities with non-Markov event data. Biometrics. 2002 Jun;58(2):361-8. doi: 10.1111/j.0006-341x.2002.00361.x.'}, {'pmid': '12008987', 'type': 'BACKGROUND', 'citation': 'St Jeor ST, Perumean-Chaney S, Sigman-Grant M, Williams C, Foreyt J. Family-based interventions for the treatment of childhood obesity. J Am Diet Assoc. 2002 May;102(5):640-4. doi: 10.1016/s0002-8223(02)90146-x. No abstract available.'}, {'pmid': '12548672', 'type': 'BACKGROUND', 'citation': 'Glidden DV, Liang KY, Chiu YF, Pulver AE. Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases. Genet Epidemiol. 2003 Feb;24(2):107-17. doi: 10.1002/gepi.10215.'}, {'pmid': '12384971', 'type': 'BACKGROUND', 'citation': 'Glidden DV, Liang KY. Ascertainment adjustment in complex diseases. Genet Epidemiol. 2002 Oct;23(3):201-8. doi: 10.1002/gepi.10204.'}, {'pmid': '14748034', 'type': 'BACKGROUND', 'citation': 'Glidden DV, Vittinghoff E. Modelling clustered survival data from multicentre clinical trials. Stat Med. 2004 Feb 15;23(3):369-88. doi: 10.1002/sim.1599.'}]}, 'descriptionModule': {'briefSummary': 'To develop statistical methodologies to study genetic and environmental factors in cardiovascular disease, using age at onset data from population-based family studies of disease incidence.', 'detailedDescription': 'BACKGROUND:\n\nIn the study of chronic diseases, both environmental and genetic factors can be influential. In highly common diseases, such as coronary heart disease, genetic effects may be more influential in determining the age of onset of the disease than in determining whether or not one gets the disease. When sufficient information is available, family studies can help localize possible disease genes on the human chromosome through genetic linkage analysis, and familial aggregation of disease can help separate the effects of inheritance, environment and lifestyle on the risk of disease.\n\nDESIGN NARRATIVE:\n\nThe study developed: (1) a general strategy for evaluating the fit of parametric dependence models for familial clustering of ages at disease-onset; (2) a computationally simple method for genetic linkage analysis of age at onset data; (3) application and illustration of recently developed additive frailty models for complex familial dependence structures. Method (1) was applied to a family study of cardiovascular disease and a twin study of appendectomy. Method (2) was applied to ongoing genetic studies conducted at the University of California at San Francisco. Method (3) was applied to a family study of coronary heart disease in Western Australia. Well-documented, user-friendly programs were developed and made publicly available.\n\nThe study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'maximumAge': '100 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'No eligibility criteria'}, 'identificationModule': {'nctId': 'NCT00037232', 'briefTitle': 'Failure Time Methods for Family Disease Studies', 'organization': {'class': 'NIH', 'fullName': 'National Heart, Lung, and Blood Institute (NHLBI)'}, 'orgStudyIdInfo': {'id': '1140'}, 'secondaryIdInfos': [{'id': 'R01HL065411', 'link': 'https://reporter.nih.gov/quickSearch/R01HL065411', 'type': 'NIH'}]}, 'contactsLocationsModule': {'overallOfficials': [{'name': 'David Glidden', 'affiliation': 'University of California at San Francisco'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Heart, Lung, and Blood Institute (NHLBI)', 'class': 'NIH'}}}}