Ignite Creation Date:
2025-12-24 @ 9:43 PM
Ignite Modification Date:
2025-12-25 @ 7:24 PM
Study NCT ID:
NCT06105632
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-16
First Post:
2023-10-24
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Chile', 'Switzerland']}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'D012008', 'term': 'Recurrence'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077267', 'term': 'Fulvestrant'}, {'id': 'D000068338', 'term': 'Everolimus'}, {'id': 'C056516', 'term': 'exemestane'}], 'ancestors': [{'id': 'D004958', 'term': 'Estradiol'}, {'id': 'D004963', 'term': 'Estrenes'}, {'id': 'D004962', 'term': 'Estranes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D045166', 'term': 'Estradiol Congeners'}, {'id': 'D012739', 'term': 'Gonadal Steroid Hormones'}, {'id': 'D042341', 'term': 'Gonadal Hormones'}, {'id': 'D006728', 'term': 'Hormones'}, {'id': 'D006730', 'term': 'Hormones, Hormone Substitutes, and Hormone Antagonists'}, {'id': 'D020123', 'term': 'Sirolimus'}, {'id': 'D018942', 'term': 'Macrolides'}, {'id': 'D007783', 'term': 'Lactones'}, {'id': 'D009930', 'term': 'Organic Chemicals'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 333}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-01-09', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-01-21', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-14', 'studyFirstSubmitDate': '2023-10-24', 'studyFirstSubmitQcDate': '2023-10-24', 'lastUpdatePostDateStruct': {'date': '2025-12-16', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-10-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-03-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-Free Survival (PFS) progression, as determined by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1', 'timeFrame': 'From Initiation up to 2 years'}], 'secondaryOutcomes': [{'measure': 'Overall Survival (OS)', 'timeFrame': 'Time from the date of randomization to the date of death due to any cause up to approximately 3 years'}, {'measure': 'OR by investigator per RECIST v1.1', 'timeFrame': 'Time From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death whichever occurs first (up to approximately 2 years)'}, {'measure': 'Duration of Response (DOR) as defined by investigator per RECIST v1.1', 'timeFrame': 'From the date of the first objective response (every 8 weeks during the first 48 weeks and then every 12 week) up to approximately 2 years.'}, {'measure': 'Number of Participants With Clinical Benefit Response (CBR) by investigator per RECIST v1.1', 'timeFrame': 'From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) up to approximately 2 years'}, {'measure': 'Number or Patients with Adverse Events (AEs) by Type', 'timeFrame': 'From screening until 28 days after the last dose, to approximately 3 years'}, {'measure': 'Number or Patients with AEs by Incidence', 'timeFrame': 'From screening until 28 days after the last dose, to approximately 3 years'}, {'measure': 'Number or Patients with AEs by Seriousness', 'timeFrame': 'From screening until 28 days after the last dose, to approximately 3 years'}, {'measure': 'Number or Patients with AEs by relationship to study interventions', 'timeFrame': 'From screening until 28 days after the last dose, to approximately 3 years'}, {'measure': 'Number of Participants With Abnormal Electrocardiogram (ECG)', 'timeFrame': 'From baseline to approximately 2 years'}, {'measure': 'Number of Participants With Laboratory Test Abnormalities', 'timeFrame': 'From screening until 28 days after the last dose to approximately 2 years'}, {'measure': 'EQ-5D-5L', 'timeFrame': 'Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days.'}, {'measure': 'EORTC QLQ', 'timeFrame': 'Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days.'}, {'measure': 'EORTC QLQ Breast Cancer Module 23 (BR23)', 'timeFrame': 'Screening Days 1, 15 of Cycle 1 and 2, Day 1 of Cycles 3-6, then Day 1 of every other subsequent Cycle starting with Cycle 8 (eg, Cycles 8, 10, 12, etc) and EoT. Each Cycle is 28 days.'}, {'measure': 'Ctrough of PF-07220060', 'timeFrame': 'Cycle 1 (Day 15), Cycle 2 (Day 1), and Cycle 3 (Day 1). Each Cycle is 28 days'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Estrogen receptor positive [ER(+)]', 'Human epidermal growth factor receptor 2 negative [HER(-)]', 'ER(+)/HER2(-)', 'Advanced Breast Cancer', 'Breast tumor', 'Breast cancer', 'fulvestrant', 'everolimus', 'exemestane', 'Partial Response+ (PR+)', 'Metastatic breast cancer', 'Hormone Therapy', 'Hormone positive breast cancer', 'Recurrent breast cancer', 'HR+', 'HER2-negative', 'Relapse', 'Recurrent', 'Second line treatment.'], 'conditions': ['Advanced or Metastatic Breast Cancer']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://pmiform.com/clinical-trial-info-request?StudyID=C4391022', 'label': 'To obtain contact information for a study center near you, click here.'}]}, 'descriptionModule': {'briefSummary': "The purpose of this study is to learn about the safety and how effective the study medicine (PF-07220060) plus fulvestrant is compared to the study doctor's choice of treatment in people with advanced or metastatic breast cancer. Advanced cancer is the one that is unlikely to be cured or taken care of with treatment. Metastatic cancer is the one that has spread to other parts of the body.\n\nThis study is seeking female and male participants who:\n\n* are 18 years of age or older;\n* are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative;\n* have advanced or metastatic breast cancer after taking other treatments before this study;\n* have not taken or need to take medications that are not allowed by the study protocol;\n* do not have any medical or mental conditions that may increase the risk of study participation.\n\nHalf of the participants will take PF-07220060 two times daily by mouth along with fulvestrant. Fulvestrant will be given as a shot into the muscle. The other half will take the study doctor's choice of treatment which can either be:\n\n* Fulvestrant alone taken as shot into the muscle.\n* Everolimus along with exemestane taken once daily by mouth.\n\nThis study will compare the experiences of participants receiving the study medicine plus fulvestrant to those who are receiving the study doctor's choice of treatment. This will help decide if the study medicine is safe and effective.\n\nParticipants will receive study treatment and/or will be in the study until:\n\n* imaging scans (such as an MRI and/or CT) show that their cancer is getting worse.\n* the study doctor thinks the participant is no longer benefitting from the study medicine.\n* has side effects that become too severe. A side effect is a reaction (expected or unexpected) to a medicine or treatment you take.\n* the participant chooses to stop taking part."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Histological confirmation of breast cancer with evidence of locally advanced or metastatic disease, which is not amenable to surgical resection or radiation therapy with curative intent.\n* Documented estrogen receptor (ER) and/or progesterone receptor (PR)- positive tumor\n* Documented HER2-negative tumor\n* Able to provide a sufficient amount of representative formalin fixed, paraffin embedded (FFPE) tumor tissue specimen.\n* Must have received CDK4/6i plus NSAI defined per study protocol. There must be documented PD during or after CDK4/6i treatment.\n* Measurable disease or non-measurable bone only disease as defined by RECIST version 1.1.\n* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤2.\n\nExclusion Criteria:\n\n* Any medical or psychiatric condition that may increase the risk of study participation or make the participant inappropriate for the study.\n* In visceral crisis at risk of immediately life-threatening complications in the short term.\n* Known active uncontrolled or symptomatic central nervous system metastases, carcinomatous meningitis, or leptomeningeal disease.\n* Prior treatment with any of the following:\n* Everolimus or investigational anti-cancer agents in any setting\n* Prior chemotherapy in the advanced setting\n* Radiation within 2 weeks of randomization\n* Current use or anticipated need for any prohibited food, supplements or concomitant medication(s) (ie, other anti-cancer therapies, other endocrine therapies, growth factors, chronic systemic corticosteroids, strong cytochrome P450 3A4/5 \\[CYP3A4/5\\] or uridine 5' diphosphate-glucuronosyltransferase 2B7 \\[UGT2B7\\] inhibitors and inducers, direct oral anticoagulants, proton pump inhibitors).\n* Inadequate renal function, hepatic dysfunction, or hematologic abnormalities."}, 'identificationModule': {'nctId': 'NCT06105632', 'briefTitle': 'A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment', 'organization': {'class': 'INDUSTRY', 'fullName': 'Pfizer'}, 'officialTitle': "AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER PHASE 2 STUDY OF PF-07220060 PLUS FULVESTRANT COMPARED TO INVESTIGATOR'S CHOICE OF THERAPY IN PARTICIPANTS AT LEAST 18 YEARS OF AGE WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED/METASTATIC BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR CDK 4/6 INHIBITOR-BASED THERAPY (FOURLIGHT-1)", 'orgStudyIdInfo': {'id': 'C4391022'}, 'secondaryIdInfos': [{'id': '2023-506487-13-00', 'type': 'REGISTRY', 'domain': 'CTIS (EU)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm A', 'description': 'PF-07220060 to be taken by mouth as a tablet in combination with fulvestrant (a solution for injection)', 'interventionNames': ['Drug: PF-07220060 CDK4 inhibitor', 'Drug: Fulvestrant']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm B', 'description': "Investigator's choice of therapy of either:\n\n* Fulvestrant alone (a solution for injection), or\n* Everolimus in combination with exemestane, both a tablet to be taken by mouth.", 'interventionNames': ['Drug: Fulvestrant', 'Drug: Everolimus', 'Drug: Exemestane']}], 'interventions': [{'name': 'PF-07220060 CDK4 inhibitor', 'type': 'DRUG', 'description': 'Experimental', 'armGroupLabels': ['Arm A']}, {'name': 'Fulvestrant', 'type': 'DRUG', 'description': 'Experimental and Active comparator', 'armGroupLabels': ['Arm A', 'Arm B']}, {'name': 'Everolimus', 'type': 'DRUG', 'description': 'Active Comparator', 'armGroupLabels': ['Arm B']}, {'name': 'Exemestane', 'type': 'DRUG', 'description': 'Active Comparator', 'armGroupLabels': ['Arm B']}]}, 'contactsLocationsModule': {'locations': [{'zip': '94702', 'city': 'Berkeley', 'state': 'California', 'country': 'United States', 'facility': 'UCSF - John Muir Health Cancer Center Berkeley', 'geoPoint': {'lat': 37.87159, 'lon': -122.27275}}, {'zip': '94538', 'city': 'Fremont', 'state': 'California', 'country': 'United States', 'facility': 'Washington Hospital Healthcare System', 'geoPoint': {'lat': 37.54827, 'lon': -121.98857}}, {'zip': '92618', 'city': 'Irvine', 'state': 'California', 'country': 'United States', 'facility': 'Hoag Health Center Irvine', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '92618', 'city': 'Irvine', 'state': 'California', 'country': 'United States', 'facility': 'Hoag Hospital Irvine', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '92253', 'city': 'La Quinta', 'state': 'California', 'country': 'United States', 'facility': 'Eisenhower George and Julia Argyros Health Center', 'geoPoint': {'lat': 33.66336, 'lon': -116.31001}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Keck Hospital of USC', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Los Angeles General Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'USC/Norris Comprehensive Cancer Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92663', 'city': 'Newport Beach', 'state': 'California', 'country': 'United States', 'facility': 'Hoag Memorial Hospital Presbyterian', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '92262', 'city': 'Palm Springs', 'state': 'California', 'country': 'United States', 'facility': 'Eisenhower Health Center at South Palm Canyon', 'geoPoint': {'lat': 33.8303, 'lon': -116.54529}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'country': 'United States', 'facility': 'Keck Medical Center of USC Pasadena', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '92270', 'city': 'Rancho Mirage', 'state': 'California', 'country': 'United States', 'facility': 'Eisenhower Medical Center', 'geoPoint': {'lat': 33.73974, 'lon': -116.41279}}, {'zip': '94110', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'Zuckerberg San Francisco General Hospital and Trauma Center', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'UCSF Medical Center at Mission Bay', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94402', 'city': 'San Mateo', 'state': 'California', 'country': 'United States', 'facility': 'UCSF Cancer Center San Mateo', 'geoPoint': {'lat': 37.56299, 'lon': -122.32553}}, {'zip': '06606', 'city': 'Bridgeport', 'state': 'Connecticut', 'country': 'United States', 'facility': "Saint Vincent's Medical Center (SVMC)", 'geoPoint': {'lat': 41.17923, 'lon': -73.18945}}, {'zip': '06810', 'city': 'Danbury', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Danbury Hospital', 'geoPoint': {'lat': 41.39482, 'lon': -73.45401}}, {'zip': '06102', 'city': 'Hartford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Hartford Hospital (HH)', 'geoPoint': {'lat': 41.76371, 'lon': -72.68509}}, {'zip': '06451', 'city': 'Meriden', 'state': 'Connecticut', 'country': 'United States', 'facility': 'MidState Medical Center (MMC)', 'geoPoint': {'lat': 41.53815, 'lon': -72.80704}}, {'zip': '06053', 'city': 'New Britain', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Hartford Healthcare', 'geoPoint': {'lat': 41.66121, 'lon': -72.77954}}, {'zip': '06856', 'city': 'Norwalk', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Norwalk Hospital', 'geoPoint': {'lat': 41.1176, 'lon': -73.4079}}, {'zip': '06062', 'city': 'Plainville', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Medical Arts Center', 'geoPoint': {'lat': 41.67454, 'lon': -72.85816}}, {'zip': '20007', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'Georgetown University Medical Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'MedStar Washington Hospital Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Northwestern Memorial Hospital', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60625', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'NorthShore University HealthSystem', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60201', 'city': 'Evanston', 'state': 'Illinois', 'country': 'United States', 'facility': 'NorthShore University HealthSystem', 'geoPoint': {'lat': 42.04114, 'lon': -87.69006}}, {'zip': '60026', 'city': 'Glenview', 'state': 'Illinois', 'country': 'United States', 'facility': 'NorthShore University HealthSystem', 'geoPoint': {'lat': 42.06975, 'lon': -87.78784}}, {'zip': '60035', 'city': 'Highland Park', 'state': 'Illinois', 'country': 'United States', 'facility': 'NorthShore University HealthSystem', 'geoPoint': {'lat': 42.18169, 'lon': -87.80034}}, {'zip': '59101', 'city': 'Billings', 'state': 'Montana', 'country': 'United States', 'facility': 'Intermountain 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'53215', 'city': 'Milwaukee', 'state': 'Wisconsin', 'country': 'United States', 'facility': "Aurora St Luke's Medical Center", 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': '53066', 'city': 'Summit', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Aurora Medical Center - Summit'}, {'zip': '53226', 'city': 'Wauwatosa', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Aurora Cancer Care', 'geoPoint': {'lat': 43.04946, 'lon': -88.00759}}, {'zip': 'C1061', 'city': 'Buenos Aires', 'state': 'Buenos Aires F.D.', 'country': 'Argentina', 'facility': 'CIPREC', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'C1015ABO', 'city': 'CABA', 'state': 'Buenos Aires F.D.', 'country': 'Argentina', 'facility': 'Organizacion Medica de Investigacion'}, {'zip': 'C1125ABD', 'city': 'CABA', 'state': 'Buenos Aires F.D.', 'country': 'Argentina', 'facility': 'Fundación Cenit Para La Investigación En Neurociencias'}, {'zip': 'R8500ACE', 'city': 'Viedma', 'state': 'Río Negro Province', 'country': 'Argentina', 'facility': 'Clinica Viedma S. A', 'geoPoint': {'lat': -40.81519, 'lon': -63.0004}}, {'zip': 'S2000KZE', 'city': 'Rosario', 'state': 'Santa Fe Province', 'country': 'Argentina', 'facility': 'Instituto de Oncología de Rosario', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': '4000', 'city': 'San Miguel de Tucumán', 'state': 'Tucumán Province', 'country': 'Argentina', 'facility': 'Centro Para la Atención Integral del Paciente Oncologico (CAIPO)', 'geoPoint': {'lat': -26.81601, 'lon': -65.21051}}, {'zip': 'C1056ABI', 'city': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Centro de Investigaciones Metabólicas (CINME)', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': 'X5004FHP', 'city': 'Córdoba', 'country': 'Argentina', 'facility': 'Clínica Universitaria Reina Fabiola', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': 'F5300COE', 'city': 'La Rioja', 'country': 'Argentina', 'facility': 'Fundación CORI para la Investigación y Prevención del Cáncer', 'geoPoint': {'lat': -29.41328, 'lon': -66.85637}}, {'zip': '5400', 'city': 'San Juan', 'country': 'Argentina', 'facility': 'COE (Centro Oncológico de Excelencia)', 'geoPoint': {'lat': -31.53726, 'lon': -68.52568}}, {'zip': '4200', 'city': 'Santiago del Estero', 'country': 'Argentina', 'facility': 'Sanatorio Norte', 'geoPoint': {'lat': -27.80047, 'lon': -64.26285}}, {'zip': '2109', 'city': 'North Ryde', 'state': 'New South Wales', 'country': 'Australia', 'facility': 'Macquarie University', 'geoPoint': {'lat': -33.79677, 'lon': 151.12436}}, {'zip': '4812', 'city': 'Rosslea', 'state': 'Queensland', 'country': 'Australia', 'facility': 'Icon Cancer Centre Townsville', 'geoPoint': {'lat': -19.29871, 'lon': 146.79824}}, {'zip': '50070-480', 'city': 'Recife', 'state': 'Pernambuco', 'country': 'Brazil', 'facility': "Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco", 'geoPoint': {'lat': -8.05389, 'lon': -34.88111}}, {'zip': '59062-000', 'city': 'Natal', 'state': 'Rio Grande do Norte', 'country': 'Brazil', 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