Ignite Creation Date:
2025-12-24 @ 9:42 PM
Ignite Modification Date:
2026-01-03 @ 9:25 PM
Study NCT ID:
NCT02843932
Status:
TERMINATED
Last Update Posted:
2020-11-18
First Post:
2015-05-12
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Subjective Perception of Motor Control During Psychogenic Disorders
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D013001', 'term': 'Somatoform Disorders'}], 'ancestors': [{'id': 'D001523', 'term': 'Mental Disorders'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 14}}, 'statusModule': {'whyStopped': 'recruitment difficulties', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2015-05-13', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-11', 'completionDateStruct': {'date': '2019-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2020-11-16', 'studyFirstSubmitDate': '2015-05-12', 'studyFirstSubmitQcDate': '2016-07-22', 'lastUpdatePostDateStruct': {'date': '2020-11-18', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2016-07-26', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2019-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Familiarization with the joystick.', 'timeFrame': '30 minutes', 'description': 'HHSC-JOY-I from Current Designs. They are asked to trace a straight line.'}, {'measure': 'Brain MRI', 'timeFrame': 'One hour and a half'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Somatoform', 'Psychogenic'], 'conditions': ['Somatoform Disorders']}, 'referencesModule': {'references': [{'pmid': '11058820', 'type': 'BACKGROUND', 'citation': 'Desmurget M, Grafton S. Forward modeling allows feedback control for fast reaching movements. Trends Cogn Sci. 2000 Nov 1;4(11):423-431. doi: 10.1016/s1364-6613(00)01537-0.'}, {'pmid': '7569931', 'type': 'BACKGROUND', 'citation': 'Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880-2. doi: 10.1126/science.7569931.'}, {'pmid': '11240283', 'type': 'BACKGROUND', 'citation': 'Sabes PN. The planning and control of reaching movements. Curr Opin Neurobiol. 2000 Dec;10(6):740-6. doi: 10.1016/s0959-4388(00)00149-5.'}, {'pmid': '6286035', 'type': 'BACKGROUND', 'citation': 'Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain. 1982 Sep;105 (Pt 3):515-42. doi: 10.1093/brain/105.3.515.'}, {'pmid': '1822314', 'type': 'BACKGROUND', 'citation': 'Ghez C, Hening W, Gordon J. Organization of voluntary movement. Curr Opin Neurobiol. 1991 Dec;1(4):664-71. doi: 10.1016/s0959-4388(05)80046-7.'}, {'pmid': '12217180', 'type': 'BACKGROUND', 'citation': 'van Beers RJ, Baraduc P, Wolpert DM. Role of uncertainty in sensorimotor control. Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1137-45. doi: 10.1098/rstb.2002.1101.'}, {'pmid': '9842759', 'type': 'BACKGROUND', 'citation': 'Fourneret P, Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133-40. doi: 10.1016/s0028-3932(98)00006-2.'}, {'pmid': '15548505', 'type': 'BACKGROUND', 'citation': 'Carson AJ, Stone J, Warlow C, Sharpe M. Patients whom neurologists find difficult to help. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1776-8. doi: 10.1136/jnnp.2003.032169.'}, {'pmid': '11353724', 'type': 'BACKGROUND', 'citation': 'Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001 Jun;124(Pt 6):1077-90. doi: 10.1093/brain/124.6.1077.'}, {'pmid': '19450695', 'type': 'BACKGROUND', 'citation': 'Cojan Y, Waber L, Carruzzo A, Vuilleumier P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 2009 Sep;47(3):1026-37. doi: 10.1016/j.neuroimage.2009.05.023. Epub 2009 May 18.'}, {'type': 'BACKGROUND', 'citation': 'Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis'}, {'type': 'BACKGROUND', 'citation': 'Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011'}, {'pmid': '18387583', 'type': 'BACKGROUND', 'citation': 'de Lange FP, Roelofs K, Toni I. Motor imagery: a window into the mechanisms and alterations of the motor system. Cortex. 2008 May;44(5):494-506. doi: 10.1016/j.cortex.2007.09.002. Epub 2007 Dec 23.'}, {'pmid': '12039604', 'type': 'BACKGROUND', 'citation': 'Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002 Jun 1;6(6):237-242. doi: 10.1016/s1364-6613(02)01907-1.'}, {'pmid': '17367826', 'type': 'BACKGROUND', 'citation': 'de Lange FP, Roelofs K, Toni I. Increased self-monitoring during imagined movements in conversion paralysis. Neuropsychologia. 2007 May 15;45(9):2051-8. doi: 10.1016/j.neuropsychologia.2007.02.002. Epub 2007 Feb 11.'}, {'pmid': '10385576', 'type': 'BACKGROUND', 'citation': 'Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5. doi: 10.1006/nimg.1999.0439.'}, {'pmid': '15718216', 'type': 'BACKGROUND', 'citation': 'Stone J, Carson A, Sharpe M. Functional symptoms in neurology: management. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1(Suppl 1):i13-21. doi: 10.1136/jnnp.2004.061663. No abstract available.'}]}, 'descriptionModule': {'briefSummary': "The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.\n\nThe Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.\n\nSubjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.", 'detailedDescription': 'New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Signed informed consent\n* Medical exam médical done before study participation\n* Between 18 and 65 years\n* Right-handed persons\n* Conversion disorder based on DSM IV-R criterias\n* Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)\n\nExclusion Criteria:\n\n* Subjects included in a clinical and/or therapeutic exeprimentation in progress\n* People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia\n* Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale\n* History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.\n* Alcohol ingestion\n* Pregnant, parturient or breastfeeding women\n* All other categories of protected persons"}, 'identificationModule': {'nctId': 'NCT02843932', 'acronym': 'PERCMO-TNF', 'briefTitle': 'Subjective Perception of Motor Control During Psychogenic Disorders', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital, Grenoble'}, 'officialTitle': 'Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.', 'orgStudyIdInfo': {'id': '38RC14.120*'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Psychogenic disorders', 'description': 'Psychogenic movement disorders and seizures', 'interventionNames': ['Other: functional brain MRI']}], 'interventions': [{'name': 'functional brain MRI', 'type': 'OTHER', 'description': 'functional imagery during motor-perception tasks', 'armGroupLabels': ['Psychogenic disorders']}]}, 'contactsLocationsModule': {'locations': [{'zip': '38043', 'city': 'Grenoble', 'country': 'France', 'facility': 'Chu Grenoble', 'geoPoint': {'lat': 45.17869, 'lon': 5.71479}}], 'overallOfficials': [{'name': 'Tiphaine Montagnon', 'role': 'STUDY_CHAIR', 'affiliation': 'DRCI, CHU GRENOBLE, FRANCE'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University Hospital, Grenoble', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}