Ignite Creation Date:
2025-12-24 @ 9:36 PM
Ignite Modification Date:
2025-12-30 @ 9:55 PM
Study NCT ID:
NCT02550132
Status:
COMPLETED
Last Update Posted:
2016-02-05
First Post:
2015-09-08
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D020393', 'term': 'Manipulation, Spinal'}, {'id': 'D026201', 'term': 'Musculoskeletal Manipulations'}], 'ancestors': [{'id': 'D026741', 'term': 'Physical Therapy Modalities'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D012046', 'term': 'Rehabilitation'}, {'id': 'D000529', 'term': 'Complementary Therapies'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'martin.descarreaux@uqtr.ca', 'phone': '18193765011', 'title': 'Dr Martin Descarreaux DC, PhD', 'phoneExt': '3791', 'organization': 'Université du Québec à Trois-Rivières'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'Adverse event were collected during the 45 min experimental session', 'description': 'Participants were invited to express their pain or discomfort during the experimental session.', 'eventGroups': [{'id': 'EG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.', 'otherNumAtRisk': 25, 'otherNumAffected': 0, 'seriousNumAtRisk': 25, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Left T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.72', 'spread': '0.68', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '2.83', 'spread': '0.30', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.03', 'spread': '0.35', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.51', 'spread': '0.84', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.75', 'spread': '0.76', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.12', 'spread': '0.50', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.13', 'spread': '0.33', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.46', 'spread': '0.41', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.92', 'spread': '0.91', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.03', 'spread': '0.52', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.40', 'spread': '0.40', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.57', 'spread': '0.55', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.17', 'spread': '0.53', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Left T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.80', 'spread': '0.88', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T6 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.87', 'spread': '0.64', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Right T8 Normalized Root Mean Square (RMS) Value', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.79', 'spread': '0.49', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.', 'unitOfMeasure': 'ratio', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.81', 'spread': '0.04', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.01', 'spread': '0.03', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.76', 'spread': '0.04', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.18', 'spread': '0.07', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.32', 'spread': '0.06', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.10', 'spread': '0.05', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.48', 'spread': '0.06', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.69', 'spread': '0.05', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.40', 'spread': '0.05', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.74', 'spread': '0.09', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.40', 'spread': '0.08', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.70', 'spread': '0.07', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter', 'unitOfMeasure': 'cm', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '25'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '25'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '25', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '24.76', 'spread': '3.8', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '10', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '15', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Canada', 'categories': [{'measurements': [{'value': '25', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 25}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2013-06'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2016-01', 'completionDateStruct': {'date': '2014-06', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2016-01-06', 'studyFirstSubmitDate': '2015-09-08', 'resultsFirstSubmitDate': '2015-12-02', 'studyFirstSubmitQcDate': '2015-09-14', 'lastUpdatePostDateStruct': {'date': '2016-02-05', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2016-01-06', 'studyFirstPostDateStruct': {'date': '2015-09-15', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2016-02-05', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2014-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Left T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Left T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T6 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Right T8 Normalized Root Mean Square (RMS) Value', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Normalized amplitude (RMS) of surface electromyography response. The normalisation was achieved by dividing the obtained RMS by the RMS value before thrust application.'}, {'measure': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'timeFrame': 'During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'timeFrame': 'During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'timeFrame': 'During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Sixth Thoracic Vertebra', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Seventh Thoracic Vertebra', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}, {'measure': 'Vertebral Displacement of the Eighth Thoracic Vertebra', 'timeFrame': 'During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset', 'description': 'Absolute posterior to anterior vertebral displacement during the spinal manipulation in centimeter'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['electromyography', 'biomechanical phenomena', 'dose-response relationship', 'musculoskeletal manipulations', 'spinal manipulation'], 'conditions': ['Spinal Manipulation']}, 'referencesModule': {'references': [{'pmid': '27249939', 'type': 'DERIVED', 'citation': 'Nougarou F, Page I, Loranger M, Dugas C, Descarreaux M. Neuromechanical response to spinal manipulation therapy: effects of a constant rate of force application. BMC Complement Altern Med. 2016 Jun 2;16:161. doi: 10.1186/s12906-016-1153-6.'}]}, 'descriptionModule': {'briefSummary': 'The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.', 'detailedDescription': 'Although there are indirect evidences that the rate of force application modulates neuromuscular responses to spinal manipulation therapy (SMT) through peak force or thrust duration modulations, such an assumption remains to be confirmed. Therefore, the objective of the present study was to determine if different SMT force-time profiles where a constant rate of force application would be maintained (through the modulation of the peak force and the time to peak force) lead to similar neuromechanical responses. Based on the available data relative to the effect of SMT biomechanical parameters modulation, it was hypothesized that neuromuscular responses would be similar across SMT force-time profiles, while vertebral displacements would increase as SMT peak force increases.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '50 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Healthy adult\n\nExclusion Criteria:\n\n* Thoracic or lumbar pain\n* History of back trauma or surgery\n* Severe osteoarthritis\n* Inflammatory arthritis\n* Vascular conditions\n* Contraindication to the use of SMT'}, 'identificationModule': {'nctId': 'NCT02550132', 'briefTitle': 'The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy', 'organization': {'class': 'OTHER', 'fullName': 'Université du Québec à Trois-Rivières'}, 'officialTitle': 'Neuromechanical Response to Spinal Manipulation Therapy: Effects of a Constant Rate of Force Application', 'orgStudyIdInfo': {'id': 'UQTR-2013-SMTrate'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Participants', 'description': 'All volunteers will participate in an experimental session. Participants will be delivered four different spinal manipulations (SMT) at T7 with a rate of force application of about 2200 Newtons/seconds and a preload force of 25 Newtons (N). SMTs will differed in their time to peak force (ms) and peak force (N), respectively fixed as follow for each applied SMT: (1)57 ms / 150 N, (2)80 ms / 200 N, (3)102 ms / 250 N and (4)125 ms / 300 N.', 'interventionNames': ['Procedure: Spinal manipulation', 'Device: Apparatus used to deliver spinal manipulations']}], 'interventions': [{'name': 'Spinal manipulation', 'type': 'PROCEDURE', 'otherNames': ['Manual therapy'], 'description': 'Participants will lie down during the 45-minute experimental session. Vertebral displacements (cm) and muscle response amplitude (RMS value) will be recorded through kinematic markers (on T6, T7 and T8 spinous processes) and surface electromyography electrodes (on the left and right erector spinae at T6 and T8 vertebra level). Each SMT (4 per participant) will be delivered at T7 transverse processes by an apparatus. Responses during the thrust phase (duration equal to twice the time to peak force) and after the thrust (1,5s duration) will be compared between SMTs.', 'armGroupLabels': ['Participants']}, {'name': 'Apparatus used to deliver spinal manipulations', 'type': 'DEVICE', 'description': 'An apparatus using a servo-controlled linear actuator motor (Linear Motor Series P01-48x360, LinMot Inc., Switzerland) will be used to deliver spinal manipulations.', 'armGroupLabels': ['Participants']}]}, 'contactsLocationsModule': {'overallOfficials': [{'name': 'Martin Descarreaux, DC, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Université du Québec à Trois-Rivières'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Université du Québec à Trois-Rivières', 'class': 'OTHER'}, 'collaborators': [{'name': 'Fondation Chiropratique du Québec', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Dr Martin Descarreaux DC, PhD', 'investigatorFullName': 'Martin Descarreaux', 'investigatorAffiliation': 'Université du Québec à Trois-Rivières'}}}}