Ignite Creation Date:
2025-12-24 @ 9:29 PM
Ignite Modification Date:
2025-12-28 @ 3:20 PM
Study NCT ID:
NCT07011732
Status:
RECRUITING
Last Update Posted:
2025-12-16
First Post:
2025-06-02
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Puerto Rico']}, 'conditionBrowseModule': {'meshes': [{'id': 'D000544', 'term': 'Alzheimer Disease'}], 'ancestors': [{'id': 'D003704', 'term': 'Dementia'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D024801', 'term': 'Tauopathies'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D019965', 'term': 'Neurocognitive Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C075257', 'term': 'xanomeline'}, {'id': 'C003330', 'term': 'trospium chloride'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 352}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-07-10', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-12-08', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-10', 'studyFirstSubmitDate': '2025-06-02', 'studyFirstSubmitQcDate': '2025-06-02', 'lastUpdatePostDateStruct': {'date': '2025-12-16', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-06-10', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-11-24', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change from baseline on the Cohen-Mansfield Agitation Inventory-International Psychogeriatric Association (CMAI-IPA) total score at Week 14', 'timeFrame': 'At Week 14'}], 'secondaryOutcomes': [{'measure': 'Change from baseline on the Clinical Global Impressions-Severity (CGI-S) at Week 14', 'timeFrame': 'At Week 14'}, {'measure': 'Change from baseline on the CMAI-IPA Domains at Week 14', 'timeFrame': 'At Week 14'}, {'measure': 'Change from baseline on the CMAI Total Score at Week 14', 'timeFrame': 'At Week 14'}, {'measure': 'Number of participants with Occurrence of Response at Week 14', 'timeFrame': 'At Week 14', 'description': 'As determined by CMAI-IPA changes of at least 30%, 40%, and 50% from baseline'}, {'measure': 'Change from baseline on the Neuropsychiatric Inventory/Neuropsychiatric Inventory -Nursing Home (NPI/NPI-NH) Total Score at Week 14', 'timeFrame': 'At Week 14'}, {'measure': 'Number of participants with Adverse Events (AEs)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with Treatment Emergent AEs (TEAEs)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with Serious AEs (SAEs)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with AEs leading to study drug withdrawal', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of deaths', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with AEs of Special Interest (AESIs)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Barnes Akathisia Rating Scale (BARS)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Abnormal Involuntary Movement Scale (AIMS)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Body Weight', 'timeFrame': 'Up to Week 18'}, {'measure': 'Body Mass Index (BMI)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with vital sign abnormalities', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with clinical laboratory abnormalities', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with electrocardiogram (ECG) abnormalities', 'timeFrame': 'Up to Week 18'}, {'measure': 'Number of participants with suicidal ideation as assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS)', 'timeFrame': 'Up to Week 18'}, {'measure': 'Severity of benign prostatic hyperplasia in male participants as assessed by International Prostate Symptom Score (IPSS)', 'timeFrame': 'Up to Week 18'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Alzheimer Disease']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html', 'label': 'BMS Clinical Trial Information'}, {'url': 'https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT07011732.html', 'label': 'BMS Clinical Trial Patient Recruiting'}]}, 'descriptionModule': {'briefSummary': "The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '90 Years', 'minimumAge': '55 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria\n\n\\- A diagnosis of Alzheimer's disease (AD) in accordance with the 2024 Alzheimer's Association criteria with one of the following confirmations of AD pathology: i) Historical evidence of AD diagnosis with amyloid positron emission tomography (PET), Aβ42/40 ratio in CSF, pTau181/Aβ42 ratio in CSF or pTau217/Aβ42 ratio in plasma using an Health Authority (HA)-authorized diagnostic assay.\n\nii) If no historical evidence available: A. A plasma biomarker will be assessed for eligibility if allowed per regulatory requirements. The test cutoff(s) will be based on diagnostic use approval.\n\nB. If a plasma biomarker assay cannot be used or if the assay result is inconclusive, conduct one the following:\n\n* Amyloid PET.\n* Aβ42/40 ratio or pTau181/Aβ42 ratio in CSF using an HA-authorized diagnostic assay.\n\n * Mini-Mental State Examination (MMSE) score of 5 to 22, inclusive, at Screening (Visit 1).\n * Have one identified caregiver who should have sufficient contact (approximately 10 hours a week or more) and is willing to:\n\n i) Attend all visits and report on participant's status. ii) Oversee participant compliance with medication and study procedures. iii) Participate in the study assessments and provide informed consent to participate in the study.\n * History of agitation that meets the International Psychogeriatric Association (IPA) consensus definition for agitation in cognitive disorders with onset at least two weeks prior to Screening (Visit 1).\n * AD participants are required to have NPI/NPI-NH Agitation/Aggression score ≥ 4 at Screening (Visit 1) and Baseline (Visit 2).\n * CGI-S ≥ 4, as related to agitation, at Screening (Visit 1) and Baseline (Visit 2).\n * At least 1 of the following 3 criteria must be established from the CMAI-IPA at Screening (Visit 1) and Baseline (Visit 2; CMAI-IPA Physical/Verbal Aggression Positivity):\n\n i) 1 or more aggressive behaviors occurring at least several times per week. ii) 2 or more aggressive behaviors occurring at least once or twice per week. iii) 3 or more aggressive behaviors occurring less than once per week.\n\nExclusion Criteria\n\n\\- Medical Conditions: i) Agitation symptoms that are primarily attributable to a condition other than the AD causing the dementia.\n\nii) History of bipolar disorder, schizophrenia, or schizoaffective disorder. iii) History of (or at high risk for) urinary retention, gastric retention, or narrow-angle glaucoma as evaluated by the Investigator.\n\niv) Risk of suicidal behavior during the study as determined by the Investigator's clinical assessment and/or C-SSR.\n\n\\- Prior/Concomitant Therapy: i) Recent history of receiving monoamine oxidase inhibitors, anticonvulsants (eg, lamotrigine, divalproex), mood stabilizers (eg, lithium), tricyclic antidepressants (eg, imipramine, desipramine), or any other psychoactive medications except for as needed anxiolytics (eg, lorazepam).\n\nA. Selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors taken at a stable dose for at least 8 weeks prior to Screening (Visit 1) may be permitted.\n\nB. Mirtazapine or trazodone may be used as a hypnotic if started at least 8 weeks prior to Screening (Visit 1).\n\n\\- Other protocol-defined Inclusion/Exclusion criteria apply."}, 'identificationModule': {'nctId': 'NCT07011732', 'briefTitle': "A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)", 'organization': {'class': 'INDUSTRY', 'fullName': 'Bristol-Myers Squibb'}, 'officialTitle': "A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease", 'orgStudyIdInfo': {'id': 'CN012-0023'}, 'secondaryIdInfos': [{'id': '2025-520613-31', 'type': 'OTHER', 'domain': 'EU CTR'}, {'id': 'U1111-1316-5745', 'type': 'OTHER', 'domain': 'WHO'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'KarXT + KarX-EC', 'interventionNames': ['Drug: Xanomeline/Trospium Chloride Capsule', 'Drug: Xanomeline Enteric Capsule']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Xanomeline/Trospium Chloride Capsule', 'type': 'DRUG', 'otherNames': ['KarXT', 'BMS-986510'], 'description': 'Specified dose on specified days', 'armGroupLabels': ['KarXT + KarX-EC']}, {'name': 'Xanomeline Enteric Capsule', 'type': 'DRUG', 'otherNames': ['KarX-EC', 'BMS-986519'], 'description': 'Specified dose on specified days', 'armGroupLabels': ['KarXT + KarX-EC']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85258', 'city': 'Scottsdale', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nida Laurin, Site 1619', 'role': 'CONTACT', 'phone': '480-290-1547'}], 'facility': 'Imaging Endpoints', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '92805', 'city': 'Anaheim', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Steven Macina, Site 1657', 'role': 'CONTACT', 'phone': '714-999-6688'}], 'facility': 'Advanced Research Center (ARC) - Anaheim', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '92037', 'city': 'La Jolla', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Janne Nissinen, Site 1637', 'role': 'CONTACT'}], 'facility': 'Kaizen Brain Center', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '91767', 'city': 'Pomona', 'state': 'California', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1662', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1662', 'geoPoint': {'lat': 34.05529, 'lon': -117.75228}}, {'zip': '90505', 'city': 'Torrance', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marina Raikhel, Site 1639', 'role': 'CONTACT', 'phone': '310-373-8120'}], 'facility': 'Torrance Clinical Research', 'geoPoint': {'lat': 33.83585, 'lon': -118.34063}}, {'zip': '94596', 'city': 'Walnut Creek', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ira Glick, Site 1651', 'role': 'CONTACT', 'phone': '925-298-5147'}], 'facility': 'Sunwise Clinical Research', 'geoPoint': {'lat': 37.90631, 'lon': -122.06496}}, {'zip': '80907', 'city': 'Colorado Springs', 'state': 'Colorado', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 1630', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '32751', 'city': 'Maitland', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1622', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1622', 'geoPoint': {'lat': 28.62778, 'lon': -81.36312}}, {'zip': '32751', 'city': 'Maitland', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1631', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1631', 'geoPoint': {'lat': 28.62778, 'lon': -81.36312}}, {'zip': '33122', 'city': 'Miami', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1602', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1602', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33135', 'city': 'Miami', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1618', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1618', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33166', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jorge Jorge, Site 1609', 'role': 'CONTACT', 'phone': '786-681-4959'}], 'facility': 'Hope Research Network - Miami', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33186', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jorge Betancourt, MD, Site 1604', 'role': 'CONTACT', 'phone': '786-616-9853'}], 'facility': 'Nuovida Research Center', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '34471', 'city': 'Ocala', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1608', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1608', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '32807', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Eric Carbonell, Site 1635', 'role': 'CONTACT', 'phone': '407-440-4493'}], 'facility': 'Combined Research Orlando (CRO)', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32127', 'city': 'Port Orange', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alexander White, Site 1612', 'role': 'CONTACT', 'phone': '386-304-7070'}], 'facility': 'Progressive Medical Research', 'geoPoint': {'lat': 29.13832, 'lon': -80.99561}}, {'zip': '31406', 'city': 'Savannah', 'state': 'Georgia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1661', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1661', 'geoPoint': {'lat': 32.08354, 'lon': -81.09983}}, {'zip': '70072', 'city': 'Marrero', 'state': 'Louisiana', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1655', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1655', 'geoPoint': {'lat': 29.89937, 'lon': -90.10035}}, {'zip': '20877', 'city': 'Gaithersburg', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Elia Acevedo Diaz, Site 1636', 'role': 'CONTACT', 'phone': '301-251-4702'}], 'facility': 'CBH Health', 'geoPoint': {'lat': 39.14344, 'lon': -77.20137}}, {'zip': '02035-1309', 'city': 'Foxborough', 'state': 'Massachusetts', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1663', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1663', 'geoPoint': {'lat': 42.06538, 'lon': -71.24783}}, {'zip': '02459', 'city': 'Newton', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Paul Solomon, Site 1638', 'role': 'CONTACT', 'phone': '413-281-0577'}], 'facility': 'Boston Center for Memory', 'geoPoint': {'lat': 42.33704, 'lon': -71.20922}}, {'zip': '02747', 'city': 'South Dartmouth', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Simon Desjardins, Site 1642', 'role': 'CONTACT'}], 'facility': 'Mayflower Clinical Research', 'geoPoint': {'lat': 41.59177, 'lon': -70.94115}}, {'zip': '01151', 'city': 'Springfield', 'state': 'Massachusetts', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1660', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1660', 'geoPoint': {'lat': 42.10148, 'lon': -72.58981}}, {'zip': '48302', 'city': 'Bloomfield Hills', 'state': 'Michigan', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1665', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1665', 'geoPoint': {'lat': 42.58364, 'lon': -83.24549}}, {'zip': '48085', 'city': 'Troy', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jay Sandberg, Site 1620', 'role': 'CONTACT', 'phone': '248-687-7412'}], 'facility': 'Oakland Medical Research', 'geoPoint': {'lat': 42.60559, 'lon': -83.14993}}, {'zip': '89119', 'city': 'Las Vegas', 'state': 'Nevada', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jelena Kunovac, Site 1649', 'role': 'CONTACT', 'phone': '760-758-2222'}], 'facility': 'Redbird Research', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '07748', 'city': 'Middletown', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Matthew Davis, Site 1647', 'role': 'CONTACT', 'phone': '585-288-0893'}], 'facility': 'Patient First MD', 'geoPoint': {'lat': 40.39428, 'lon': -74.11709}}, {'zip': '08540', 'city': 'Princeton', 'state': 'New Jersey', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1664', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1664', 'geoPoint': {'lat': 40.34872, 'lon': -74.65905}}, {'zip': '11096', 'city': 'Inwood', 'state': 'New York', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1610', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1610', 'geoPoint': {'lat': 40.86566, 'lon': -73.9268}}, {'zip': '12553', 'city': 'New Windsor', 'state': 'New York', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1656', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1656', 'geoPoint': {'lat': 41.47676, 'lon': -74.02375}}, {'zip': '11598-1739', 'city': 'Woodmere', 'state': 'New York', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 1645', 'geoPoint': {'lat': 40.63205, 'lon': -73.71263}}, {'zip': '11598-1739', 'city': 'Woodmere', 'state': 'New York', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1658', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1658', 'geoPoint': {'lat': 40.63205, 'lon': -73.71263}}, {'zip': '28112', 'city': 'Monroe', 'state': 'North Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1601', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1601', 'geoPoint': {'lat': 34.98543, 'lon': -80.54951}}, {'zip': '45459', 'city': 'Centerville', 'state': 'Ohio', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1659', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1659', 'geoPoint': {'lat': 39.62839, 'lon': -84.15938}}, {'zip': '74136', 'city': 'Tulsa', 'state': 'Oklahoma', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sarah Land, Site 1640', 'role': 'CONTACT', 'phone': '918-645-5400'}], 'facility': 'Central States Research', 'geoPoint': {'lat': 36.15398, 'lon': -95.99277}}, {'zip': '29205', 'city': 'Columbia', 'state': 'South Carolina', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 1652', 'geoPoint': {'lat': 34.00071, 'lon': -81.03481}}, {'zip': '29205', 'city': 'Columbia', 'state': 'South Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1653', 'role': 'CONTACT'}], 'facility': 'Local Institution - 1653', 'geoPoint': {'lat': 34.00071, 'lon': -81.03481}}, {'zip': '79912', 'city': 'El Paso', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Aamr Herekar, Site 1643', 'role': 'CONTACT', 'phone': '505-903-1715'}], 'facility': 'Advanced Neurology Epilepsy and Sleep Center', 'geoPoint': {'lat': 31.75872, 'lon': -106.48693}}, {'zip': '84107', 'city': 'Salt Lake City', 'state': 'Utah', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Albert Jarvi, Site 1641', 'role': 'CONTACT', 'phone': '801-288-0607'}], 'facility': 'Wasatch Clinical Research, LLC', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '05201-9810', 'city': 'Bennington', 'state': 'Vermont', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 1646', 'role': 'CONTACT'}], 'facility': 'Local Institution - 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