Ignite Creation Date:
2025-12-24 @ 9:22 PM
Ignite Modification Date:
2025-12-28 @ 9:48 PM
Study NCT ID:
NCT00631904
Status:
COMPLETED
Last Update Posted:
2011-09-02
First Post:
2008-02-29
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 150}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2005-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2011-08', 'completionDateStruct': {'date': '2011-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2011-08-31', 'studyFirstSubmitDate': '2008-02-29', 'studyFirstSubmitQcDate': '2008-03-07', 'lastUpdatePostDateStruct': {'date': '2011-09-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2008-03-10', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-03', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Any change greater than 1 volt at a pulse width of 0.5 ms in a pacemaker lead 12 months from an MRI scan', 'timeFrame': '12 months'}], 'secondaryOutcomes': [{'measure': 'Cardiac troponin-I, creatine kinase, MB fraction, and myoglobin levels within the first 12 hours following the scans.', 'timeFrame': '12 hours'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Pacemaker'], 'conditions': ['Cardiovascular Disease']}, 'referencesModule': {'references': [{'pmid': '3946261', 'type': 'BACKGROUND', 'citation': 'Erlebacher JA, Cahill PT, Pannizzo F, Knowles RJ. Effect of magnetic resonance imaging on DDD pacemakers. Am J Cardiol. 1986 Feb 15;57(6):437-40. doi: 10.1016/0002-9149(86)90768-x.'}, {'pmid': '10831713', 'type': 'BACKGROUND', 'citation': 'Sommer T, Vahlhaus C, Lauck G, von Smekal A, Reinke M, Hofer U, Block W, Traber F, Schneider C, Gieseke J, Jung W, Schild H. MR imaging and cardiac pacemakers: in-vitro evaluation and in-vivo studies in 51 patients at 0.5 T. Radiology. 2000 Jun;215(3):869-79. doi: 10.1148/radiology.215.3.r00jn08869.'}, {'pmid': '9888762', 'type': 'BACKGROUND', 'citation': "Shellock FG, O'Neil M, Ivans V, Kelly D, O'Connor M, Toay L, Crues JV. Cardiac pacemakers and implantable cardioverter defibrillators are unaffected by operation of an extremity MR imaging system. AJR Am J Roentgenol. 1999 Jan;172(1):165-70. doi: 10.2214/ajr.172.1.9888762."}, {'pmid': '15277324', 'type': 'BACKGROUND', 'citation': 'Roguin A, Zviman MM, Meininger GR, Rodrigues ER, Dickfeld TM, Bluemke DA, Lardo A, Berger RD, Calkins H, Halperin HR. Modern pacemaker and implantable cardioverter/defibrillator systems can be magnetic resonance imaging safe: in vitro and in vivo assessment of safety and function at 1.5 T. Circulation. 2004 Aug 3;110(5):475-82. doi: 10.1161/01.CIR.0000137121.28722.33. Epub 2004 Jul 26.'}, {'pmid': '16966586', 'type': 'BACKGROUND', 'citation': 'Nazarian S, Roguin A, Zviman MM, Lardo AC, Dickfeld TL, Calkins H, Weiss RG, Berger RD, Bluemke DA, Halperin HR. Clinical utility and safety of a protocol for noncardiac and cardiac magnetic resonance imaging of patients with permanent pacemakers and implantable-cardioverter defibrillators at 1.5 tesla. Circulation. 2006 Sep 19;114(12):1277-84. doi: 10.1161/CIRCULATIONAHA.105.607655. Epub 2006 Sep 11.'}, {'pmid': '16221260', 'type': 'BACKGROUND', 'citation': 'Gimbel JR, Bailey SM, Tchou PJ, Ruggieri PM, Wilkoff BL. Strategies for the safe magnetic resonance imaging of pacemaker-dependent patients. Pacing Clin Electrophysiol. 2005 Oct;28(10):1041-6. doi: 10.1111/j.1540-8159.2005.00230.x.'}, {'pmid': '3655146', 'type': 'BACKGROUND', 'citation': 'Hayes DL, Holmes DR Jr, Gray JE. Effect of 1.5 tesla nuclear magnetic resonance imaging scanner on implanted permanent pacemakers. J Am Coll Cardiol. 1987 Oct;10(4):782-6. doi: 10.1016/s0735-1097(87)80270-x.'}, {'pmid': '11231696', 'type': 'BACKGROUND', 'citation': 'Goldschlager N, Epstein A, Friedman P, Gang E, Krol R, Olshansky B; North American Society of Pacing and Electrophysiology (NASPE) Practice Guideline Committee. Environmental and drug effects on patients with pacemakers and implantable cardioverter/defibrillators: a practical guide to patient treatment. Arch Intern Med. 2001 Mar 12;161(5):649-55. doi: 10.1001/archinte.161.5.649. No abstract available.'}, {'pmid': '15063447', 'type': 'BACKGROUND', 'citation': 'Martin ET, Coman JA, Shellock FG, Pulling CC, Fair R, Jenkins K. Magnetic resonance imaging and cardiac pacemaker safety at 1.5-Tesla. J Am Coll Cardiol. 2004 Apr 7;43(7):1315-24. doi: 10.1016/j.jacc.2003.12.016.'}, {'pmid': '6205375', 'type': 'BACKGROUND', 'citation': 'Fetter J, Aram G, Holmes DR Jr, Gray JE, Hayes DL. The effects of nuclear magnetic resonance imagers on external and implantable pulse generators. Pacing Clin Electrophysiol. 1984 Jul;7(4):720-7. doi: 10.1111/j.1540-8159.1984.tb05602.x.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to monitor and follow non-pacemaker dependent patients with implanted permanent pacemakers, who undergo medically required Magnetic Resonance Imaging (MRI) scans.\n\nPatients with pacemakers are currently excluded from obtaining MRI scans. MRI scanning is now the imaging of choice for a number of neurological, vascular, or musculoskeletal conditions.\n\nData suggests that patients with pacemakers, when properly monitored, can safely undergo MRI scanning, though the largest published study to date consists of 54 patients, and no long term follow-up has been published.\n\nThough MRI cardiac scanning has been demonstrated to produce local tissue heating at the pacemaker lead tip, the long term effect of tissue heating on lead stability is unclear.\n\nThis study will evaluate patients with permanent pacemakers undergoing medically indicated MRI scanning.\n\nPatients will be followed for one year at 3, 6, and 12 months. Data collected will evaluate change in pacing thresholds over time as well as cardiac troponin I, creatinine kinase MB function, and myoglobin levels within the first 12 hours following the scans, side effects, symptoms, the need to make pacemaker program changes, and possible artifacts created by the pacemaker on the MRI scan.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Permanent pacemaker or implantable cardioverter-defibrillator (ICD) implanted for at least 6 weeks.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Permanent pacemaker or ICD implanted for at least 6 weeks\n* Referred for medically indicated MRI\n* Age greater or equal to 18 years old\n\nExclusion Criteria:\n\n* ICD market released before 2001 including GDT Ventak-AV, GDT MINI-II, GDT MINI-IV, GDT MINI-III, GDT Prizm-2 MDT GEM-I series\n* Epicardial coronary sinus lead or subcutaneous array\n* Unable to program all leads to bipolar configuration\n* Pacemaker Dependent\n* Device has reached elective replacement or end of life\n* Other usual contraindications to MRI scanning\n* The use of inotropic pharmacological agents, such as dobutamine, during the MRI'}, 'identificationModule': {'nctId': 'NCT00631904', 'briefTitle': "St. Mary's Duluth Clinic (SMDC) Pacemaker Magnetic Resonance Imaging (MRI) Study", 'organization': {'class': 'OTHER', 'fullName': 'Essentia Health'}, 'officialTitle': 'SMDC Pacemaker-MRI Cohort Study', 'orgStudyIdInfo': {'id': '010503'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Single Observation', 'description': 'Patients with permanent pacemakers undergoing medically indicated MRI scanning.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '55805', 'city': 'Duluth', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Essentia Health', 'geoPoint': {'lat': 46.78327, 'lon': -92.10658}}], 'overallOfficials': [{'name': 'Michael Mollerus, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Essentia Health'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Essentia Health', 'class': 'OTHER'}, 'responsibleParty': {'oldNameTitle': 'Michael Mollerus, MD', 'oldOrganization': 'Essentia Health'}}}}