Ignite Creation Date:
2025-12-24 @ 9:19 PM
Ignite Modification Date:
2026-02-24 @ 5:03 PM
Study NCT ID:
NCT04970004
Status:
WITHDRAWN
Last Update Posted:
2022-05-12
First Post:
2021-07-16
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study in Adult and Pediatric Patients With HSCT-TMA
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D057049', 'term': 'Thrombotic Microangiopathies'}], 'ancestors': [{'id': 'D013921', 'term': 'Thrombocytopenia'}, {'id': 'D001791', 'term': 'Blood Platelet Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D000095542', 'term': 'Cytopenia'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'CASE_ONLY'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 0}, 'patientRegistry': False}, 'statusModule': {'whyStopped': 'Sponsor decision to not proceed.', 'overallStatus': 'WITHDRAWN', 'startDateStruct': {'date': '2021-07-12', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-05', 'completionDateStruct': {'date': '2022-04-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2022-05-09', 'studyFirstSubmitDate': '2021-07-16', 'studyFirstSubmitQcDate': '2021-07-16', 'lastUpdatePostDateStruct': {'date': '2022-05-12', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2021-07-21', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-04-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Proportion of patients achieving TMA Response', 'timeFrame': 'During the 26-week period after HSCT-TMA diagnosis', 'description': 'TMA Response is defined as platelet count ≥ 50,000/mm\\^3, lactate dehydrogenase \\< 1.5 upper limit of normal, absence of schistocytes (if present at baseline), and increase in eGFR ≥ 30% from baseline or discontinuation of dialysis (for patients on dialysis at baseline)'}], 'secondaryOutcomes': [{'measure': 'Proportion of patients achieving TMA response', 'timeFrame': 'During the 52-week period after HSCT-TMA diagnosis'}, {'measure': 'Changes in individual components of TMA response', 'timeFrame': 'From baseline to 26 weeks and to 52 weeks after HSCT-TMA diagnosis', 'description': 'Platelets, lactate dehydrogenase, eGFR, chronic kidney disease stage, dialysis status'}, {'measure': 'Overall survival', 'timeFrame': 'At 26 weeks and 52 weeks after HSCT-TMA diagnosis'}, {'measure': 'Nonrelapse mortality', 'timeFrame': 'At 26 weeks and 52 weeks after HSCT-TMA diagnosis', 'description': 'Death due to any cause during the study, with the exception of death due to underlying disease progression or relapse'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Hematopoietic Stem Cell Transplant', 'Transplant-associated TMA', 'Thrombotic Microangiopathy (TMA)'], 'conditions': ['Stem Cell Transplant Complications', 'Thrombotic Microangiopathies']}, 'descriptionModule': {'briefSummary': 'This is an observational, retrospective study designed to assess outcomes in patients diagnosed with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) who were not treated with complement component (C5) inhibitor therapy. Data required to evaluate study outcomes will be abstracted from the medical records of all patients who meet study eligibility criteria.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '1 Month', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Adult and pediatric patients who were diagnosed with TMA within 6 months after a HSCT procedure', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Body weight ≥ 5 kg at the time of HSCT-TMA diagnosis\n* Documented TMA diagnosis within 6 months from the HSCT\n* Evidence of renal dysfunction\n* Presence of hypertension\n\nExclusion Criteria:\n\n* History or presence of familial or acquired 'a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13' (ADAMTS13) deficiency (activity \\< 5%)\n* Shiga toxin-related hemolytic uremic syndrome (ST-HUS)\n* Positive direct Coombs test\n* Diagnosis of disseminated intravascular coagulation\n* History or presence of bone marrow/graft failure\n* Diagnosis of veno-occlusive disease\n* Received a complement inhibitor (eg, eculizumab) post-HSCT through 12 months post TMA diagnosis"}, 'identificationModule': {'nctId': 'NCT04970004', 'briefTitle': 'Study in Adult and Pediatric Patients With HSCT-TMA', 'organization': {'class': 'INDUSTRY', 'fullName': 'Alexion Pharmaceuticals, Inc.'}, 'officialTitle': 'A Retrospective Observational Study of Adult and Pediatric Patients With Thrombotic Microangiopathy (TMA) After Hematopoietic Stem Cell Transplant (HSCT)', 'orgStudyIdInfo': {'id': 'ALX-TMA-501'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Patients Diagnosed with HSCT-TMA', 'interventionNames': ['Other: No intervention']}], 'interventions': [{'name': 'No intervention', 'type': 'OTHER', 'description': 'No study intervention will be administered as part of this study.', 'armGroupLabels': ['Patients Diagnosed with HSCT-TMA']}]}, 'contactsLocationsModule': {'locations': [{'zip': '84112', 'city': 'Salt Lake City', 'state': 'Utah', 'country': 'United States', 'facility': 'Clinical Trial Site', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Alexion Pharmaceuticals, Inc.', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}