Ignite Creation Date:
2025-12-24 @ 9:16 PM
Ignite Modification Date:
2026-01-06 @ 8:16 PM
Study NCT ID:
NCT03101904
Status:
COMPLETED
Last Update Posted:
2025-02-26
First Post:
2016-03-10
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000860', 'term': 'Hypoxia'}], 'ancestors': [{'id': 'D012818', 'term': 'Signs and Symptoms, Respiratory'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'j.h.macdonald@bangor.ac.uk', 'phone': '+44 1248 38', 'title': 'Dr Jamie Hugo Macdonald', 'phoneExt': '3272', 'organization': 'Bangor Univeristy'}, 'certainAgreement': {'piSponsorEmployee': True, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'Adverse even data was collected throughout participant involvement in the study. Adverse even data was collected 2 hours and 48 hours after each laboratory visit.', 'eventGroups': [{'id': 'EG000', 'title': 'Nitrate', 'description': 'Participants consumed a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).', 'otherNumAtRisk': 23, 'deathsNumAtRisk': 23, 'otherNumAffected': 1, 'seriousNumAtRisk': 23, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Placebo', 'description': 'Participants consumed a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).', 'otherNumAtRisk': 20, 'deathsNumAtRisk': 20, 'otherNumAffected': 0, 'seriousNumAtRisk': 20, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Chest Pain', 'notes': 'Possible inter-costal muscle strain or pericarditis.', 'stats': [{'groupId': 'EG000', 'numAtRisk': 23, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 20, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Acute Mountain Sickness (AMS-C) as Assessed by the Environmental Symptoms Questionnaire.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Nitrate', 'description': 'Participants consumed a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}, {'id': 'OG001', 'title': 'Placebo', 'description': 'Participants consumed a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}], 'classes': [{'categories': [{'measurements': [{'value': '0.36', 'spread': '0.09', 'groupId': 'OG000'}, {'value': '0.21', 'spread': '0.04', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Measured on the fifth day of supplementation with a six-hour exposure to hypoxia', 'description': 'Acute Cerebral Mountain Sickness score (AMS-C) calculated from the 11-item Environmental Symptoms Questionnaire (ESQ; Sampson et al., 1994). Participants rate the severity of each item from zero to five, and the ratings were multiplied by their factorial loadings and summed.\n\nUnabbreviated scale title: Acute Cerebral Mountain Sickness Abbreviated title: AMS-C Unit of measure: Scores on a scale Minimum value: 0 Maximum value: 5 Interpretation: Higher scores mean a worse outcome', 'unitOfMeasure': 'scores on a scale', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Hypoxic Exercise Performance as Assessed by Time to Exhaustion at 80% of Hypoxic V̇O2max Reserve.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '15', 'groupId': 'OG000'}, {'value': '15', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Nitrate', 'description': 'Participants consumed a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}, {'id': 'OG001', 'title': 'Placebo', 'description': 'Participants consumed a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}], 'classes': [{'categories': [{'measurements': [{'value': '666', 'spread': '206', 'groupId': 'OG000'}, {'value': '656', 'spread': '184', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Measured on the sixth day of supplementation', 'description': 'On day six of each supplementation protocol, participants completed a time to exhaustion test at 80% of their hypoxic V̇O2max reserve in acute hypoxia (FiO2 14.1%, equivalent 3225 m). Maximal exercise performance is defined as time to exhaustion (TTE) determined by the time from onset of test to task failure (volitional exhaustion or inability to maintain treadmill speed).', 'unitOfMeasure': 'seconds', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Five participants did not complete the TTE on day 6 because of injury or technical reasons, e.g., cramp or tripping while on the treadmill, and one of these was also removed from analyses relating to RPE on day 5 because of failure to use the RPE scale consistently.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Nitrate First, Then Placebo', 'description': 'Participants will consume a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\n10 day wash out.\n\nFollowing a minimum of ten days wash out, participants will then consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}, {'id': 'FG001', 'title': 'Placebo First, Then Nitrate', 'description': 'Participants will consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\n10 day wash out.\n\nFollowing a minimum of ten days wash out, participants will then consume a daily beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}], 'periods': [{'title': 'First Intervention (6 Days)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'Baseline Bloods (Day 1)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'AMS Trial (Day 5)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'Performance Trial (Day 6)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}, {'title': 'Wash Out (10 Days)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '13'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '0'}]}], 'dropWithdraws': [{'type': 'Adverse Event', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '0'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '2'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}, {'title': 'Second Intervention (6 Days)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'Baseline Bloods (Day 1)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'AMS Trial (Day 5)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'Performance Trial (Day 6)', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '10'}, {'groupId': 'FG001', 'numSubjects': '10'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}], 'preAssignmentDetails': '1. Participants completed a baseline demographics visit including the following assessments:\n\n * Age\n * Height\n * Body mass\n * Blood pressure\n * Haemoglobin\n * Normoxic VO2max (maximal exercise) test\n2. Participants then completed a minimum 48 h wash out\n3. Participants completed a hypoxic VO2max test at 14.1% O2'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Nitrate First, Then Placebo', 'description': 'Participants consumed a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\n10 day wash out\n\nAfter a minimum 10-day wash-out, participants consumed a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}, {'id': 'BG001', 'title': 'Placebo First, Then Nitrate', 'description': 'Participants consumed a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\n10 day wash out\n\nAfter a minimum 10-day wash-out, participants consumed a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}], 'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '21', 'spread': '4', 'groupId': 'BG000'}, {'value': '22', 'spread': '4', 'groupId': 'BG001'}, {'value': '22', 'spread': '4', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Female', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race and Ethnicity Not Collected', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Race and Ethnicity were not collected from any participant.'}, {'title': 'Maximal Aerobic Capacity', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '23', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '53', 'spread': '6', 'groupId': 'BG000'}, {'value': '50', 'spread': '6', 'groupId': 'BG001'}, {'value': '51', 'spread': '6', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'ml/kg/min', 'dispersionType': 'STANDARD_DEVIATION'}], 'populationDescription': 'Analysis population is different from overall number because it does not include the 3 participants that did not complete the study.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2015-10-15', 'size': 209692, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_000.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2020-04-28T06:32', 'hasProtocol': False}, {'date': '2016-07-25', 'size': 292920, 'label': 'Informed Consent Form', 'hasIcf': True, 'hasSap': False, 'filename': 'ICF_001.pdf', 'typeAbbrev': 'ICF', 'uploadDate': '2020-04-28T05:21', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 23}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2016-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-02', 'completionDateStruct': {'date': '2017-01-10', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-02-05', 'studyFirstSubmitDate': '2016-03-10', 'resultsFirstSubmitDate': '2017-05-04', 'studyFirstSubmitQcDate': '2017-03-30', 'lastUpdatePostDateStruct': {'date': '2025-02-26', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2025-02-05', 'studyFirstPostDateStruct': {'date': '2017-04-05', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2025-02-26', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2017-01-09', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Acute Mountain Sickness (AMS-C) as Assessed by the Environmental Symptoms Questionnaire.', 'timeFrame': 'Measured on the fifth day of supplementation with a six-hour exposure to hypoxia', 'description': 'Acute Cerebral Mountain Sickness score (AMS-C) calculated from the 11-item Environmental Symptoms Questionnaire (ESQ; Sampson et al., 1994). Participants rate the severity of each item from zero to five, and the ratings were multiplied by their factorial loadings and summed.\n\nUnabbreviated scale title: Acute Cerebral Mountain Sickness Abbreviated title: AMS-C Unit of measure: Scores on a scale Minimum value: 0 Maximum value: 5 Interpretation: Higher scores mean a worse outcome'}], 'secondaryOutcomes': [{'measure': 'Hypoxic Exercise Performance as Assessed by Time to Exhaustion at 80% of Hypoxic V̇O2max Reserve.', 'timeFrame': 'Measured on the sixth day of supplementation', 'description': 'On day six of each supplementation protocol, participants completed a time to exhaustion test at 80% of their hypoxic V̇O2max reserve in acute hypoxia (FiO2 14.1%, equivalent 3225 m). Maximal exercise performance is defined as time to exhaustion (TTE) determined by the time from onset of test to task failure (volitional exhaustion or inability to maintain treadmill speed).'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Hypoxia']}, 'referencesModule': {'references': [{'type': 'RESULT', 'citation': 'Sampson JB, Kobrick JL, Johnson RF. Measurement of subjective reactions to extreme environments: the Environmental Symptoms Questionnaire. Military Psychology. 1994; 6(4):215-233. doi: 10.1207/s15327876mp0604_2'}]}, 'descriptionModule': {'briefSummary': 'The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment. It is hypothesized that beetroot supplementation will decrease acute mountain sickness and increase exercise performance.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Women only: Regular menstrual cycle or post-menopausal\n\nExclusion Criteria:\n\n* Stayed at altitude above 2500m in the last 6 months\n* Traveled to altitude above 2500m in the last 2 months\n* Unable to give informed consent\n* Unstable medical condition.'}, 'identificationModule': {'nctId': 'NCT03101904', 'briefTitle': 'The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia', 'organization': {'class': 'OTHER', 'fullName': 'Bangor University'}, 'officialTitle': 'The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia', 'orgStudyIdInfo': {'id': 'Jan 27 2016'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Nitrate then Placebo', 'description': 'Participants will consume a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\nFollowing a minimum of ten days wash out, participants will then consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).', 'interventionNames': ['Dietary Supplement: Beetroot Juice', 'Dietary Supplement: Placebo']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo then Nitrate', 'description': 'Participants will consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).\n\nFollowing a minimum of ten days wash out, participants will then consume a daily beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).', 'interventionNames': ['Dietary Supplement: Beetroot Juice', 'Dietary Supplement: Placebo']}], 'interventions': [{'name': 'Beetroot Juice', 'type': 'DIETARY_SUPPLEMENT', 'otherNames': ['Nitrate-rich beetroot juice'], 'armGroupLabels': ['Nitrate then Placebo', 'Placebo then Nitrate']}, {'name': 'Placebo', 'type': 'DIETARY_SUPPLEMENT', 'otherNames': ['Nitrate-depleted beetroot juice'], 'armGroupLabels': ['Nitrate then Placebo', 'Placebo then Nitrate']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'LL57 2PZ', 'city': 'Bangor', 'state': 'Gwynedd', 'country': 'United Kingdom', 'facility': 'School of Sport, Health and Exercise Sciences, Bangor University', 'geoPoint': {'lat': 54.66079, 'lon': -5.66802}}], 'overallOfficials': [{'name': 'Jamie H Macdonald, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Bangor University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Bangor University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}