Ignite Creation Date:
2025-12-24 @ 9:16 PM
Ignite Modification Date:
2026-01-04 @ 12:58 PM
Study NCT ID:
NCT06418204
Status:
RECRUITING
Last Update Posted:
2025-12-11
First Post:
2024-05-08
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D002289', 'term': 'Carcinoma, Non-Small-Cell Lung'}, {'id': 'D008545', 'term': 'Melanoma'}, {'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}, {'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D018358', 'term': 'Neuroendocrine Tumors'}, {'id': 'D017599', 'term': 'Neuroectodermal Tumors'}, {'id': 'D009373', 'term': 'Neoplasms, Germ Cell and Embryonal'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009380', 'term': 'Neoplasms, Nerve Tissue'}, {'id': 'D018326', 'term': 'Nevi and Melanomas'}, {'id': 'D012878', 'term': 'Skin Neoplasms'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': "About one tablespoon (15mL) of blood will be collected from a vein in the participant's arm at 3 different time points."}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2000}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-01-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-08', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-05', 'studyFirstSubmitDate': '2024-05-08', 'studyFirstSubmitQcDate': '2024-05-15', 'lastUpdatePostDateStruct': {'date': '2025-12-11', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-05-17', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-08', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Cancer-related symptoms', 'timeFrame': 'Baseline and re-assessed monthly up to 12 months post-enrollment', 'description': 'Will use the National Cancer Institute Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events to measure cancer-related symptoms. Will examine the longitudinal relationship between cannabis and/or cannabinoid use and the likelihood of exhibiting individual symptoms using three-level GLMMs to account for the nested data. The investigators will model continuous measures (e.g., symptom severity) using a linear generalized linear mixed-effects models (GLMM) and the prevalence of symptoms or moderate to severe symptoms using a logistic GLMM. Cannabis and/or cannabinoid use at each monthly assessment will be included as a time-varying covariate and an interaction with time will be included to assess its impact on symptoms over time. Analyses will consider dichotomous definitions of use (yes/no past month), frequency of use (# days in the past month) as well as mode of administration, dose/potency, and cannabinoid type.'}], 'secondaryOutcomes': [{'measure': 'Cannabis and Cannabinoid Use from Cannabis Engagement Assessment', 'timeFrame': 'Baseline and re-assessed monthly up to 12 months post-enrollment', 'description': 'Cannabis and cannabinoid use will be measured monthly using items from the Cannabis Engagement Assessment (CEA). The CEA contains 30 questions that assess the quantity, frequency of use, and method of consumption for dried cannabis products (excluding edibles), cannabis concentrates, and edible products in the previous 30 days. Two additional sections assess other factors associated with cannabis use and history of use. Estimates of consumption can be calculated from responses, with a lower limit of 0 and no upper limit. Higher values represent higher consumption in that month.'}, {'measure': 'Cannabis and Cannabinoid Use from the International Cannabis Policy Study survey', 'timeFrame': 'Baseline and re-assessed monthly up to 12 months post-enrollment', 'description': 'Cannabis and cannabinoid use will be measured monthly using items from the International Cannabis Policy Study (ICPS) survey. The ICPS surveys provide a comprehensive assessment of cannabis use, includes detailed patterns of consumption, purchasing, adverse outcomes, as well as attitudes and beliefs towards cannabis. Results from this survey will help quantify amount of cannabis use, if any.'}, {'measure': 'Cannabis and Cannabinoid Perceived Benefits and Harms', 'timeFrame': 'Baseline and re-assessed monthly up to 12 months post-enrollment', 'description': 'The NCI Cannabis Core Measures survey will be used to ask cannabis and cannabinoid users each month whether they think cannabis or cannabinoid use worsened or improved their symptoms. Using the NCI Cannabis Core Measures survey, the investigators will ask cannabis and cannabinoid users each month whether they think cannabis or cannabinoid use worsened or improved their symptoms. The investigators will define this as a nominal outcome where 0=no change; 1=worsened quite a bit or somewhat worsened, and 2=somewhat improved or improved quite a bit.'}, {'measure': 'Cannabis and Cannabinoid Adverse Effects', 'timeFrame': 'Baseline and re-assessed monthly up to 12 months post-enrollment', 'description': 'The Adverse Reactions Scale will be used to ask cannabis and cannabinoid users each month whether they have experienced a checklist of potential adverse reactions. The investigators will participants using cannabis and/or cannabinoids each month whether they have experienced a checklist of potential adverse reactions. These are defined as presence or absence of the adverse effect. The investigators will also consider the frequency of time they experience the effect (% of time they experience the effect when consuming cannabis or cannabinoids) and the severity of the effect (0 = Not at all distressing; 1 = Mildly distressing; 2 = Moderately distressing; 3 = Quite distressing 4 = Severely distressing) as continuous measures.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Breast Carcinoma', 'Colorectal Carcinoma', 'Lung Non-Small Cell Carcinoma', 'Melanoma', 'Non-Hodgkin Lymphoma']}, 'descriptionModule': {'briefSummary': 'This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed therapies with chemotherapy and/or (immune checkpoint inhibitors) ICIs.', 'detailedDescription': 'The objective of this study is to examine the association between cannabis and/or cannabinoid use and cancer-related symptoms assessed monthly for one year in adults newly diagnosed with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer who are planning or recently started to receive one or more systemic cancer directed therapies with chemotherapy and/or immune check point inhibitors (ICIs) targeting PD-1, PD-L1 or CTLA-4.\n\nParticipants complete surveys and have their medical records reviewed on study.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed therapies with chemotherapy and/or immune checkpoint inhibitors (ICIs)', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer (e.g. adenocarcinoma, squamous cell carcinoma, large cell carcinoma, adenosquamous cell carcinoma, and not otherwise specified).\n* Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of Cycle 2 treatment.\n* Participants must be able to comprehend English or Spanish (for survey completion).\n* Participants must have a working email address and be must be willing to complete surveys online. This can be completed at home, in the clinic or other location.\n* Completion of the confidential Self-Reported Screening Survey and receipt of a screening result - eligible for enrollment.\n* Participant must reside in the United States, officially determined per patient report on Self-reported Screening Survey\n* In the treating provider's opinion, the participant should have a life expectancy of \\>=6 months. Participants in hospice are not eligible.\n\nOptional Sub-study (available at select sites only):\n\n* Must be willing to participate in both the main study and the sub-study at the Wake Forest University Comprehensive Cancer Center (WF CCC) and Virginia Commonwealth University (VCU).\n* Must be receiving treatment at the WF CCC and VCU.\n* Must be diagnosed with non-small cell lung cancer.\n* Must be planning to receive paclitaxel as part of their chemotherapy in conjunction with Immune Checkpoint Inhibitor (ICIs) PD-1, PD-L1 or CTLA-4.\n\nExclusion Criteria:\n\n* Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms.\n* Participants with known pregnancy.\n* Participant received systemic therapy treatment for prior cancer(s) including chemotherapy, immunotherapy, targeted therapy, and hormonal therapy.\n* Participants enrolled in hospice.\n\nOptional Substudy (available at select sites only):\n\n* Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed.\n* Participants with a history of HIV, hepatitis B or hepatitis C."}, 'identificationModule': {'nctId': 'NCT06418204', 'acronym': 'COSMIC', 'briefTitle': 'Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics', 'organization': {'class': 'OTHER', 'fullName': 'Wake Forest University Health Sciences'}, 'officialTitle': 'Complementary Options for Symptom Management In Cancer (COSMIC): Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics', 'orgStudyIdInfo': {'id': 'IRB00122898'}, 'secondaryIdInfos': [{'id': 'NCI-2024-03314', 'type': 'OTHER', 'domain': 'NCI Trial Identifier'}, {'id': 'WF2304-A172401', 'type': 'OTHER', 'domain': 'Lead Organization Identifier'}, {'id': '5UG1CA189824', 'link': 'https://reporter.nih.gov/quickSearch/5UG1CA189824', 'type': 'NIH'}, {'id': '1U01CA286813', 'link': 'https://reporter.nih.gov/quickSearch/1U01CA286813', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Observational', 'description': 'Participants complete surveys and have their medical records reviewed on study.', 'interventionNames': ['Other: Non-interventional Study']}], 'interventions': [{'name': 'Non-interventional Study', 'type': 'OTHER', 'description': 'Non-interventional study', 'armGroupLabels': ['Observational']}]}, 'contactsLocationsModule': {'locations': [{'zip': '99701', 'city': 'Fairbanks', 'state': 'Alaska', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Veronica.Stevenson@foundationhealth.org', 'phone': '907-458-3043'}, {'name': 'Nicholas J DiBella', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Fairbanks Memorial Hospital', 'geoPoint': {'lat': 64.83778, 'lon': -147.71639}}, {'zip': '86401', 'city': 'Kingman', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'research@sncrf.org', 'phone': '702-384-0013'}, {'name': 'Khawaja S Jahangir', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kingman Regional Medical Center', 'geoPoint': {'lat': 35.18944, 'lon': -114.05301}}, {'zip': '85004', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Cancer Center at Saint Joseph's", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '72903', 'city': 'Fort Smith', 'state': 'Arkansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '800-378-9373'}, {'name': 'Jay W Carlson', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy Hospital Fort Smith', 'geoPoint': {'lat': 35.38592, 'lon': -94.39855}}, {'zip': '72401', 'city': 'Jonesboro', 'state': 'Arkansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '870-936-7066'}, {'name': 'Alyssa D Throckmorton', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro', 'geoPoint': {'lat': 35.8423, 'lon': -90.70428}}, {'zip': '94531', 'city': 'Antioch', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Deer Valley Medical Center', 'geoPoint': {'lat': 38.00492, 'lon': -121.80579}}, {'zip': '93420', 'city': 'Arroyo Grande', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mission Hope Medical Oncology - Arroyo Grande', 'geoPoint': {'lat': 35.11859, 'lon': -120.59073}}, {'zip': '93420', 'city': 'Arroyo Grande', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'research@sncrf.org', 'phone': '702-384-0013'}, {'name': 'Khawaja S Jahangir', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'PCR Oncology', 'geoPoint': {'lat': 35.11859, 'lon': -120.59073}}, {'zip': '95608', 'city': 'Carmichael', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy Cancer Center - Carmichael', 'geoPoint': {'lat': 38.61713, 'lon': -121.32828}}, {'zip': '95608', 'city': 'Carmichael', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'OncologyResearch@DignityHealth.org', 'phone': '916-556-3301'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy San Juan Medical Center', 'geoPoint': {'lat': 38.61713, 'lon': -121.32828}}, {'zip': '94568', 'city': 'Dublin', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente Dublin', 'geoPoint': {'lat': 37.70215, 'lon': -121.93579}}, {'zip': '95758', 'city': 'Elk Grove', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy Cancer Center - Elk Grove', 'geoPoint': {'lat': 38.4088, 'lon': -121.37162}}, {'zip': '94538', 'city': 'Fremont', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yuspov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Fremont', 'geoPoint': {'lat': 37.54827, 'lon': -121.98857}}, {'zip': '93720', 'city': 'Fresno', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '833-574-2273'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente Fresno Orchard Plaza', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '93720', 'city': 'Fresno', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Fresno', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '93720', 'city': 'Fresno', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'medresearch@samc.com', 'phone': '559-450-7790'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Saint Agnes Medical Center', 'geoPoint': {'lat': 36.74773, 'lon': -119.77237}}, {'zip': '94553-3156', 'city': 'Martinez', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '925-957-5400'}, {'name': 'Lilli X Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Contra Costa Regional Medical Center', 'geoPoint': {'lat': 38.01937, 'lon': -122.13413}}, {'zip': '94553', 'city': 'Martinez', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '925-957-5400'}, {'name': 'Lili X Wang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Contra Costa Regional Medical Center', 'geoPoint': {'lat': 38.01937, 'lon': -122.13413}}, {'zip': '95356', 'city': 'Modesto', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Modesto', 'geoPoint': {'lat': 37.6391, 'lon': -120.99688}}, {'zip': '94611', 'city': 'Oakland', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Oakland', 'geoPoint': {'lat': 37.80437, 'lon': -122.2708}}, {'zip': '94063', 'city': 'Redwood City', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente- Marshall Medical Offices', 'geoPoint': {'lat': 37.48522, 'lon': -122.23635}}, {'zip': '94801', 'city': 'Richmond', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Richmond', 'geoPoint': {'lat': 37.93576, 'lon': -122.34775}}, {'zip': '95765', 'city': 'Rocklin', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy Cancer Center - Rocklin', 'geoPoint': {'lat': 38.79073, 'lon': -121.23578}}, {'zip': '95661', 'city': 'Roseville', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-Roseville', 'geoPoint': {'lat': 38.75212, 'lon': -121.28801}}, {'zip': '95814', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente Downtown Commons', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '95816', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ResearchInstituteInquiries@CommonSpirit.org', 'phone': '720-874-1881'}, {'name': 'Shahzad Siddique', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mercy Cancer Center - Sacramento', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '95823', 'city': 'Sacramento', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-South Sacramento', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya Greyz-Yusupov', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kaiser Permanente-San Francisco', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '95119', 'city': 'San Jose', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'Kpoct@kp.org', 'phone': '877-642-4691'}, {'name': 'Natalya 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{'zip': '53227', 'city': 'West Allis', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'ncorp@aurora.org', 'phone': '414-302-2304'}, {'name': 'Sigrun Hallmeyer', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Aurora West Allis Medical Center', 'geoPoint': {'lat': 43.01668, 'lon': -88.00703}}, {'zip': '54476', 'city': 'Weston', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'oncology.clinical.trials@marshfieldresearch.org', 'phone': '800-782-8581', 'phoneExt': '94457'}, {'name': 'Laura M Lauer', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Marshfield Medical Center - Weston', 'geoPoint': {'lat': 44.8908, 'lon': -89.54762}}, {'zip': '54494', 'city': 'Wisconsin Rapids', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'phone': '715-422-7718'}, {'name': 'Andrew J Huang', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Aspirus Cancer Care - Wisconsin Rapids', 'geoPoint': {'lat': 44.38358, 'lon': -89.81735}}, {'zip': '54494', 'city': 'Wisconsin Rapids', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'role': 'CONTACT', 'email': 'oncology.clinical.trials@marshfieldresearch.org', 'phone': '800-782-8581'}, {'name': 'Laura M Lauer', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Marshfield Clinic - Wisconsin Rapids Center', 'geoPoint': {'lat': 44.38358, 'lon': -89.81735}}], 'centralContacts': [{'name': 'Karen Craver', 'role': 'CONTACT', 'email': 'NCORP@wfusm.edu', 'phone': '336-716-0891'}], 'overallOfficials': [{'name': 'Glenn Lesser, MD', 'role': 'STUDY_CHAIR', 'affiliation': 'Wake Forest University Health Sciences'}]}, 'ipdSharingStatementModule': {'url': 'http://nctn-data-archive.nci.nih.gov/', 'timeFrame': '6 months after publication for a 2 year duration', 'ipdSharing': 'YES', 'description': 'Wake Forest NCORP Research Base is committed to following the NIH Statement on Sharing Research Data (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-032.html). 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