Ignite Creation Date:
2025-12-24 @ 1:06 PM
Ignite Modification Date:
2025-12-28 @ 8:22 PM
Study NCT ID:
NCT06233461
Status:
RECRUITING
Last Update Posted:
2025-12-17
First Post:
2024-01-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Spain']}, 'conditionBrowseModule': {'meshes': [{'id': 'D003424', 'term': 'Crohn Disease'}], 'ancestors': [{'id': 'D015212', 'term': 'Inflammatory Bowel Diseases'}, {'id': 'D005759', 'term': 'Gastroenteritis'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 268}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-03-05', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2027-07-23', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-11', 'studyFirstSubmitDate': '2024-01-23', 'studyFirstSubmitQcDate': '2024-01-23', 'lastUpdatePostDateStruct': {'date': '2025-12-17', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-01-31', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-09-18', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': "Percentage of Participants With Endoscopic Response Based on Simple Endoscopic Score for Crohn's Disease (SES-CD) at Week 12", 'timeFrame': 'Week 12', 'description': 'Endoscopic response is defined by decrease in SES-CD \\>50% from baseline (or for participants with isolated ileal disease, SES-CD \\<=4 or at least a 2-point reduction from baseline). SES-CD evaluates 4 endoscopic variables (the intestinal surface affected by ulcers, the intestinal surface affected by other inflammatory lesions, the presence of ulcers, and the presence of narrowing).'}], 'secondaryOutcomes': [{'measure': "Percentage of Participants Achieving Clinical Remission Based on the Crohn's Disease Activity Index (CDAI) at Week 12", 'timeFrame': 'Week 12', 'description': 'Clinical remission is defined as a CDAI score of \\<150 points.'}, {'measure': 'Percentage of Participants With a Clinical Response Based on the CDAI at Week 12', 'timeFrame': 'Week 12', 'description': 'Clinical response is defined as \\>=100-point decrease from Baseline in CDAI score.'}, {'measure': 'Percentage of Participants Achieving Endoscopic Remission Based on SES-CD at Week 12.', 'timeFrame': 'Week 12', 'description': 'Endoscopic remission as per SES-CD is defined as SES-CD score \\<=4 or \\<=2 for ileal disease, no subscore \\>1.'}, {'measure': 'Percentage of Participants Achieving Clinical Remission in 2-item Patient-reported Outcome Measure (PRO2) at Week 12', 'timeFrame': 'Week 12', 'description': 'Clinical remission based on PRO2 is defined as average daily liquid or very soft stool frequency (SF) score \\<=2.8 and not worse than baseline and average daily abdominal pain (AP) score \\<=1 and not worse than baseline.'}, {'measure': 'Percentage of Participants With a Clinical Response in PRO2 at Week 12', 'timeFrame': 'Week 12', 'description': 'Clinical response based on PRO2 is defined as \\>=30% decrease in average daily very soft or liquid stools and/ or \\>=30% decrease in average AP from baseline.'}, {'measure': 'Percentage of Participants With no Bowel Urgency at Week 12', 'timeFrame': 'Week 12', 'description': 'Bowel urgency is assessed using a 1-item daily patient diary that asks participants to indicate if they had an urgent bowel movement (when they felt the need to rush to the toilet to avoid an accident) in the past 24 hours. Response options, "Yes" or "No" will be coded as numeric values.'}, {'measure': 'Percentage of Participants With Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score >=170 at Week 12', 'timeFrame': 'Week 12', 'description': 'The IBDQ is a 32-item questionnaire that measures 4 dimensions: bowel function, emotional status, systemic symptoms, and social function. Within dimensions, each question will be assessed on a 7-point Likert scale. Each domain score is the sum of 8 responses each ranging from 1 to 7, where 1 indicates worst function and 7 the best. The total score ranges from 32 to 224, with higher scores representing better quality of life.'}, {'measure': 'Change from Baseline in Health-related Quality of Life (HRQoL) as per IBDQ Total Score at Week 12', 'timeFrame': 'Baseline to Week 12', 'description': 'The IBDQ is a 32-item questionnaire that measures 4 dimensions: bowel function, emotional status, systemic symptoms, and social function. Within dimensions, each question will be assessed on a 7-point Likert scale. Each domain score is the sum of 8 responses each ranging from 1 to 7, where 1 indicates worst function and 7 the best. The total score ranges from 32 to 224, with higher scores representing better quality of life.'}, {'measure': 'Change from Baseline in Fatigue as per Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Score at Week 12', 'timeFrame': 'Baseline to Week 12', 'description': 'FACIT-Fatigue questionnaire contains 13 fatigue-related questions. The responses to the 13 items on the FACIT-Fatigue questionnaire are each measured on a 5-point Likert scale, where 0=Not at all, 1=A little bit, 2=Somewhat, 3=Quite a bit and 4=Very much. The total score ranges from 0 to 52. High scores represent less fatigue.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Drug Therapy', 'Latitude CD, Latitude Research Program'], 'conditions': ["Crohn's Disease"]}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://clinicaltrials.takeda.com/study-detail/6b7fad105d7b4f53?idFilter=%5B%22TAK-279-CD-2001%22%5D', 'label': 'To obtain more information about this study, click this link'}]}, 'descriptionModule': {'briefSummary': "Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate medical problems. An endoscopy will be used to check the bowel for inflammation.\n\nThe participants will be treated with TAK-279 for 52 weeks (1 year).\n\nDuring the study, participants will visit their study clinic 15 times.", 'detailedDescription': "The drug being tested in this study is TAK-279. TAK-279 is being tested to treat participants with moderately to severely active Crohn's disease. The study will look at the efficacy and safety of TAK-279.\n\nThe study will enroll approximately 268 participants. During the Induction Period participants will be randomly assigned to one of the following treatment groups in a ratio of 1:1:1:1 to receive TAK-279 or placebo which will remain undisclosed to the participant and study doctor during the study (unless there is an urgent medical need):\n\n1. TAK-279 Dose 1\n2. TAK-279 Dose 2\n3. TAK-279 Dose 3\n4. Placebo\n\nThis multi-center trial will be conducted globally. The overall study duration is approximately 60 weeks including a 4-week safety follow-up period."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Male or female aged 18-75 years old with diagnosis of CD for at least 30 days. In South Korea, the age requirement for adult participants is \\>=19 years of age.\n2. Confirmed diagnosis of moderately to severely active CD assessed by SES-CD and CDAI.\n3. Participants must have had an inadequate response to, loss of response to, or intolerance to at least one or more conventional, biologic, or advanced therapy for CD.\n\nExclusion Criteria:\n\n1. Participants with indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, radiation colitis, and diverticular disease associated with colitis, and/or ulcerative colitis.\n2. Have complications of CD that might require surgery during the study.\n3. Participants with a current ostomy.\n4. Participants who have failed 3 or more classes of advanced therapies.'}, 'identificationModule': {'nctId': 'NCT06233461', 'briefTitle': "A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease", 'organization': {'class': 'INDUSTRY', 'fullName': 'Takeda'}, 'officialTitle': "A Phase 2b, Multicenter, Randomized, Double-Blind Induction, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Oral TAK-279 in Subjects With Moderately to Severely Active Crohn's Disease", 'orgStudyIdInfo': {'id': 'TAK-279-CD-2001'}, 'secondaryIdInfos': [{'id': '2023-506704-14-00', 'type': 'CTIS', 'domain': 'Abbreviated EU CT Number'}, {'id': 'jRCT2051240050', 'type': 'REGISTRY', 'domain': 'jRCT'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'TAK-279 Dose 1', 'description': 'Participants will be randomized to receive TAK-279 Dose 1 capsules with TAK-279 placebo-matching capsule orally.', 'interventionNames': ['Drug: TAK-279', 'Drug: Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'TAK-279 Dose 2', 'description': 'Participants will be randomized to receive TAK-279 Dose 2 capsules with TAK-279 placebo-matching capsule orally.', 'interventionNames': ['Drug: TAK-279', 'Drug: Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'TAK-279 Dose 3', 'description': 'Participants will be randomized to receive TAK-279 Dose 3 capsules orally.', 'interventionNames': ['Drug: TAK-279']}, {'type': 'EXPERIMENTAL', 'label': 'Placebo', 'description': 'Participants will be randomized to receive TAK-279 placebo-matching capsules orally.', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'TAK-279', 'type': 'DRUG', 'otherNames': ['Zasocitinib'], 'description': 'TAK-279 capsules.', 'armGroupLabels': ['TAK-279 Dose 1', 'TAK-279 Dose 2', 'TAK-279 Dose 3']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'TAK-279 placebo-matching capsules.', 'armGroupLabels': ['Placebo', 'TAK-279 Dose 1', 'TAK-279 Dose 2']}]}, 'contactsLocationsModule': {'locations': [{'zip': '90067', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'Nicholas.Karyotakis@cshs.org'}, {'name': 'Nicholas Karyotakis', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'GastroIntestinal BioSciences', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92563', 'city': 'Murrieta', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'drhongpi@unitedmd.com', 'phone': '951-566-5229'}, {'name': 'John Hong', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'United Medical Doctors', 'geoPoint': {'lat': 33.55391, 'lon': -117.21392}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'rfearn@hs.uci.edu', 'phone': '714-456-5694'}, {'name': 'Robert Fearn', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'UCI Health', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '33762', 'city': 'Clearwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'lmweiss@gastrofl.com', 'phone': '727-347-0005'}, {'name': 'Lawrence Michael Weiss', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'West Central Gastroenterology, LLP, d/b/a/ Gastro Florida', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33813', 'city': 'Lakeland', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'nausaf@auzmer.com', 'phone': '208-346-8900'}, {'name': 'Niaz Ausaf', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Auzmer Research', 'geoPoint': {'lat': 28.03947, 'lon': -81.9498}}, {'zip': '33016', 'city': 'Miami Lakes', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'lucky@wellnessclinicalresearch.com', 'phone': '786-483-7856'}, {'name': 'Lucky Flores', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Wellness Clinical Research', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '34102', 'city': 'Naples', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'rphillips212@comcast.net', 'phone': '239-649-1336'}, {'name': 'Raymond Phillips', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'GI PROS, Inc.', 'geoPoint': {'lat': 26.14234, 'lon': -81.79596}}, {'zip': '33612', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'msrosari@usf.edu'}, {'name': 'Michelle Rosario', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'USF Health Morsani Center for Advanced Healthcare', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'heba.iskandar@emoryhealthcare.org'}, {'name': 'Heba Iskandar', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Emory University Hospital, The Emory Clinic', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30033', 'city': 'Decatur', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'dbrausher@acgaec.com', 'phone': '404-512-3280'}, {'name': 'David Rausher', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Atlanta Center For Gastroenterology, P.C.', 'geoPoint': {'lat': 33.77483, 'lon': -84.29631}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'steven-polyak@uiowa.edu', 'phone': '319-384-6336'}, {'name': 'Steven Polyak', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'The University of Iowa Hospitals & Clinics', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'gerald.dryden@louisville.edu', 'phone': '502-852-6991'}, {'name': 'Gerald Dryden', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University Of Louisville', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '21061', 'city': 'Glen Burnie', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'konwueme@woodholmegi.com', 'phone': '410-863-4899'}, {'name': 'Kenolisa Onwueme', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Woodholme Gastroenterology Associates', 'geoPoint': {'lat': 39.16261, 'lon': -76.62469}}, {'zip': '64068', 'city': 'Liberty', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'c.bartalos@bvlresearch.com'}, {'name': 'Christopher Bartalos', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'BVL Clinical Research', 'geoPoint': {'lat': 39.24611, 'lon': -94.41912}}, {'zip': '89128', 'city': 'Las Vegas', 'state': 'Nevada', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'cstone@nevadagastro.com', 'phone': '702-750-0000'}, {'name': 'Christian Stone', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Las Vegas Medical Research', 'geoPoint': {'lat': 36.17497, 'lon': -115.13722}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'adam.steinlauf@mssm.edu', 'phone': '917-538-2158'}, {'name': 'Adam Steinlauf', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH)', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '14609', 'city': 'Rochester', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'jgoldstein@rcrclinical.com', 'phone': '585-329-9644'}, {'name': 'Jonathan Goldstein', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Rochester Clinical Research', 'geoPoint': {'lat': 43.15478, 'lon': -77.61556}}, {'zip': '44060', 'city': 'Mentor', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'kfriedenberg@thectnx.com', 'phone': '440-205-1225'}, {'name': 'Keith Friedenberg', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Great Lakes Gastroenterology Research, LLC', 'geoPoint': {'lat': 41.66616, 'lon': -81.33955}}, {'zip': '02904', 'city': 'Providence', 'state': 'Rhode Island', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'lisa.mueller@gialliance.com'}, {'name': 'Lisa Mueller', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University Gastroenterology Providence', 'geoPoint': {'lat': 41.82399, 'lon': -71.41283}}, {'zip': '29615', 'city': 'Greenville', 'state': 'South Carolina', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'mbarnesmd@gastroassociates.com', 'phone': '910-488-3857'}, {'name': 'Matthew Barnes', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Gastroenterology Associates, PA', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '77401', 'city': 'Bellaire', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'sana@novelresearch.net', 'phone': '281-491-9779'}, {'name': 'Moazzam Sana', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Novel Research, LLC', 'geoPoint': {'lat': 29.70579, 'lon': -95.45883}}, {'zip': '75246', 'city': 'Dallas', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'bkahn@tddctx.com'}, {'name': 'Ben Kahn', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'TDDC - Baylor University Medical Center Gaston Ave', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '76104', 'city': 'Fort Worth', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'kgutta@gastront.com', 'phone': '817-870-7300'}, {'name': 'Kumar Gutta', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance', 'geoPoint': {'lat': 32.72541, 'lon': -97.32085}}, {'zip': '76063', 'city': 'Mansfield', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'moustafa.youssef@dhat.com'}, {'name': 'Moustafa Youssef', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'TDDC dba Alliance Research', 'geoPoint': {'lat': 32.56319, 'lon': -97.14168}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'js_bull@yahoo.com', 'phone': '210-581-2812'}, {'name': 'Jeff Bullock', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Southern Star Research Institute, LLC', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '75701', 'city': 'Tyler', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'aarond@tylerri.com', 'phone': '903-630-6211'}, {'name': 'George Duvall', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Tyler Research Institute, LLC', 'geoPoint': {'lat': 32.35126, 'lon': -95.30106}}, {'zip': '98195', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'scottl@medicine.washington.edu', 'phone': '206-543-3500'}, {'name': 'Scott Lee', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Washington Medical Center', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '2139', 'city': 'Sydney', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'rupert.leong@health.nsw.gov.au', 'phone': '297676111'}, {'name': 'Rupert Leong', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Concord Repatriation General Hospital', 'geoPoint': {'lat': -33.86785, 'lon': 151.20732}}, {'zip': '4101', 'city': 'South Brisbane', 'state': 'Queensland', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'jakob.begun@mater.uq.edu.au', 'phone': '731638196'}, {'name': 'Jakob Begun', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mater Cancer Care Centre-Mater Health Services', 'geoPoint': {'lat': -27.48034, 'lon': 153.02049}}, {'zip': '5042', 'city': 'Bedford Park', 'state': 'South Australia', 'status': 'NOT_YET_RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'reme.mountifield@sa.gov.au', 'phone': '882044964'}, {'name': 'Reme Mountifield', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Flinders Medical Centre', 'geoPoint': {'lat': -35.02204, 'lon': 138.56815}}, {'zip': '5011', 'city': 'Woodville', 'state': 'South Australia', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Site Contact', 'role': 'CONTACT', 'email': 'robvbryant@gmail.com', 'phone': 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