Ignite Creation Date:
2025-12-24 @ 9:11 PM
Ignite Modification Date:
2026-04-04 @ 6:45 AM
Study NCT ID:
NCT03607604
Status:
UNKNOWN
Last Update Posted:
2020-08-19
First Post:
2018-06-26
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003922', 'term': 'Diabetes Mellitus, Type 1'}, {'id': 'D003924', 'term': 'Diabetes Mellitus, Type 2'}, {'id': 'C562772', 'term': 'Mason-Type Diabetes'}, {'id': 'D003920', 'term': 'Diabetes Mellitus'}], 'ancestors': [{'id': 'D044882', 'term': 'Glucose Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D001327', 'term': 'Autoimmune Diseases'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D059014', 'term': 'High-Throughput Nucleotide Sequencing'}], 'ancestors': [{'id': 'D017421', 'term': 'Sequence Analysis'}, {'id': 'D005821', 'term': 'Genetic Techniques'}, {'id': 'D008919', 'term': 'Investigative Techniques'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'DNA will be extracted from collected blood samples for genetic analysis (suspected MODY cases)'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 778}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2015-04-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-08', 'completionDateStruct': {'date': '2021-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2020-08-18', 'studyFirstSubmitDate': '2018-06-26', 'studyFirstSubmitQcDate': '2018-07-22', 'lastUpdatePostDateStruct': {'date': '2020-08-19', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2018-07-31', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2021-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Urinary C-peptide Creatinine Ratio (UCPCR)', 'timeFrame': '2 hours post-prandial', 'description': 'Measuring UCPCR in our study cohort and testing if a cutoff of 0.7nmol/mmol in children and 0.2nmol/mmol in adults will apply to our population of interest (ie UAE population).'}], 'secondaryOutcomes': [{'measure': 'Receiver operating characteristic (ROC) curve', 'timeFrame': 'through study completion, an average of 1 year', 'description': 'Using receiver operating characteristic (ROC) curves to identify the optimal UCPCR cut-off for discriminating diabetes subtypes in our study population.'}, {'measure': 'Genetic analysis', 'timeFrame': 'through study completion, an average of 2 year', 'description': 'Confirming our UCPCR results through genetic analysis of the samples.'}, {'measure': 'Positive genetic result analysis', 'timeFrame': 'through study completion, an average of 2 year', 'description': 'Validating positive genetic test results by performing mutational analysis on the parents of the patient.'}, {'measure': 'Novel MODY genes and mutations', 'timeFrame': 'through study completion, an average of 2 year', 'description': 'Identifying novel MODY genes and/or mutations in the study population through next generation sequencing methodologies'}, {'measure': 'UCPCR measurements', 'timeFrame': 'through study completion, an average of 2 year', 'description': 'Conducting UCPCR measurements for patients who have been clinically and genetically diagnosed with MODY. This will assist us in confirming the cutoff values for MODY diagnosis.'}, {'measure': 'Prevalence of MODY', 'timeFrame': 'through study completion, an average of 2 year', 'description': 'Estimating the background prevalence of MODY in diabetes patients in the Emirates of Abu Dhabi.'}]}, 'conditionsModule': {'keywords': ['MODY', 'Diabetes Mellitus', 'UCPCR', 'Monogenic Diabetes'], 'conditions': ['Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Maturity-onset Diabetes of the Young']}, 'descriptionModule': {'briefSummary': 'The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients with type 1 diabetes and MODY in the UAE population.', 'detailedDescription': 'Urinary C-peptide creatinine ratio (UCPCR) is a non invasive measure of endogenous insulin secretion and has been shown to be effective in identifying Maturity Onset Diabetes of the Young (MODY) from Type 1 Diabetes in adults and paediatric population. Here in the UAE, diabetes prevalence is at 18.9% of the general population and patients are medically treated according to their diabetes type. Currently identification of patients with MODY poses multiple challenges and in some instances results in wrongful diagnosis and treatment of the patients. Most commonly, patients are treated as having type 1 diabetes and given unnecessary insulin injections.\n\nMaking correct diabetes diagnosis is pivotal for appropriate disease management. Currently, a set of criteria including age of onset of diabetes (\\<30 years), BMI\\<25kg/m2 and absence of islet-cell and GAD auto-antibodies are applied in order to identify potential Maturity Onset Diabetes of the Young (MODY) patients. This has to be followed by genetic testing before final diagnosis is made. Although the set criteria increase the probability of identifying MODY patients, fully discriminating between MODY and type 1 diabetes can still be difficult. As such, some MODY patients (e.g. with mutations in HNF1A or HNF4A genes) are wrongfully treated with insulin when sulphonylureas would be efficient enough for management of their diabetes.\n\nThis study will consists of three groups; patients who are autoantibody negative (divided into patients with potential MODY and patients with type 2 diabetes), patients diagnosed with type 1 diabetes and patients who do not have diabetes at the time of recruitment (selected randomly and will include patients with other diagnoses such as IFG and/or IGT). All groups will consist of paediatric patients (≤18 years of age) and adult patients (age of onset of diabetes ≤ 30 years).\n\nThe scientific aims of the study are:\n\n* Validating UCPCR as an in-house test that can potentially be used for clinical purposes.\n* Measuring UCPCR in the study cohort and testing if a cutoff of 0.7nmol/mmol in children and 0.2nmol/mmol in adults will apply to population of interest (ie UAE population).\n* Using operating characteristic curves to identify the optimal UCPCR cut-off for discriminating diabetes subtypes in.\n* Confirming the UCPCR results through genetic analysis of the samples.\n* Validating positive genetic test results by performing mutational analysis on the parents of the patient.\n* Potentially identifying novel MODY mutations in the study population.\n* conducting UCPCR measurements for patients who have been clinically and genetically diagnosed with MODY. This will assist the investigators in confirming the cutoff values for MODY diagnosis.\n* Successfully estimating the background prevalence of MODY in diabetes patients in the Emirates of Abu Dhabi.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Patients attending Imperial College London Diabetes Centre, UAE.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* patients with age and age of diabetes onset of \\<18 years\n* patients with age of ≥18 years and age of diabetes onset of ≤30 years\n\nExclusion Criteria:\n\n\\- patients with age of ≥18 years and age of diabetes onset of \\>30 years'}, 'identificationModule': {'nctId': 'NCT03607604', 'briefTitle': 'Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE', 'organization': {'class': 'OTHER', 'fullName': 'Imperial College London Diabetes Centre'}, 'officialTitle': 'Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE', 'orgStudyIdInfo': {'id': 'IREC018'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Autoantibody Negative', 'description': 'Patients who are autoantibody negative (could potentially be either MODY or type 2 diabetes patients)\n\nSuspected MODY patients will be candidates for next generation sequencing (NGS)', 'interventionNames': ['Genetic: Next generation sequencing (NGS)']}, {'label': 'Diabetes Mellitus, Type 1', 'description': 'Patients diagnosed with type 1 diabetes mellitus\n\nPatients with positive UCPCR and negative autoantibodies results will be suspected with MODY and will be candidates for next generation sequencing (NGS)', 'interventionNames': ['Genetic: Next generation sequencing (NGS)']}, {'label': 'Non Diabetic', 'description': 'Individuals not diagnosed with any type of diabetes (but could be diagnosed with IFG and/or IGT)'}], 'interventions': [{'name': 'Next generation sequencing (NGS)', 'type': 'GENETIC', 'otherNames': ['NGS panel', 'Whole exome/genome sequencing (WES/WGS)'], 'description': 'Patients will be tested for known MODY genes with specific focus on HNF1A, GCK and HNF4A genes. Furthermore, gene panel testing may be performed for any known diabetes genes.If the results are negative, WES/WGS will be performed in patients suspected of having MODY for identification of novel MODY mutations.', 'armGroupLabels': ['Autoantibody Negative', 'Diabetes Mellitus, Type 1']}]}, 'contactsLocationsModule': {'locations': [{'zip': '48338', 'city': 'Abu Dhabi', 'country': 'United Arab Emirates', 'facility': 'Imperial College London Diabetes Centre', 'geoPoint': {'lat': 24.45118, 'lon': 54.39696}}], 'overallOfficials': [{'name': 'Nader Lessan, MBBS FRCP MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Imperial College London Diabetes Centre'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Imperial College London Diabetes Centre', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}