Ignite Creation Date:
2025-12-24 @ 9:09 PM
Ignite Modification Date:
2025-12-28 @ 6:51 PM
Study NCT ID:
NCT00049504
Status:
COMPLETED
Last Update Posted:
2017-05-17
First Post:
2002-11-12
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015465', 'term': 'Leukemia, Myeloid, Accelerated Phase'}, {'id': 'D000013', 'term': 'Congenital Abnormalities'}, {'id': 'D054391', 'term': 'Lymphoma, Extranodal NK-T-Cell'}, {'id': 'D017728', 'term': 'Lymphoma, Large-Cell, Anaplastic'}, {'id': 'D007119', 'term': 'Immunoblastic Lymphadenopathy'}, {'id': 'D002051', 'term': 'Burkitt Lymphoma'}, {'id': 'D019337', 'term': 'Hematologic Neoplasms'}, {'id': 'D064090', 'term': 'Intraocular Lymphoma'}, {'id': 'D018442', 'term': 'Lymphoma, B-Cell, Marginal Zone'}, {'id': 'D016411', 'term': 'Lymphoma, T-Cell, Peripheral'}, {'id': 'D016403', 'term': 'Lymphoma, Large B-Cell, Diffuse'}, {'id': 'D008228', 'term': 'Lymphoma, Non-Hodgkin'}, {'id': 'D006689', 'term': 'Hodgkin Disease'}, {'id': 'D016400', 'term': 'Lymphoma, Large-Cell, Immunoblastic'}, {'id': 'D054198', 'term': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma'}, {'id': 'D054218', 'term': 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma'}, {'id': 'D054739', 'term': 'Dendritic Cell Sarcoma, Interdigitating'}, {'id': 'D016410', 'term': 'Lymphoma, T-Cell, Cutaneous'}, {'id': 'D008224', 'term': 'Lymphoma, Follicular'}, {'id': 'D020522', 'term': 'Lymphoma, Mantle-Cell'}, {'id': 'D009182', 'term': 'Mycosis Fungoides'}, {'id': 'D012751', 'term': 'Sezary Syndrome'}, {'id': 'D015451', 'term': 'Leukemia, Lymphocytic, Chronic, B-Cell'}, {'id': 'D012008', 'term': 'Recurrence'}, {'id': 'D009101', 'term': 'Multiple Myeloma'}, {'id': 'D008258', 'term': 'Waldenstrom Macroglobulinemia'}], 'ancestors': [{'id': 'D015464', 'term': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive'}, {'id': 'D007951', 'term': 'Leukemia, Myeloid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009196', 'term': 'Myeloproliferative Disorders'}, {'id': 'D001855', 'term': 'Bone Marrow Diseases'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D009358', 'term': 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities'}, {'id': 'D016399', 'term': 'Lymphoma, T-Cell'}, {'id': 'D008223', 'term': 'Lymphoma'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D000072281', 'term': 'Lymphadenopathy'}, {'id': 'D020031', 'term': 'Epstein-Barr Virus Infections'}, {'id': 'D006566', 'term': 'Herpesviridae Infections'}, {'id': 'D004266', 'term': 'DNA Virus Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D014412', 'term': 'Tumor Virus Infections'}, {'id': 'D016393', 'term': 'Lymphoma, B-Cell'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D005134', 'term': 'Eye Neoplasms'}, {'id': 'D007945', 'term': 'Leukemia, Lymphoid'}, {'id': 'D015620', 'term': 'Histiocytic Disorders, Malignant'}, {'id': 'D015614', 'term': 'Histiocytosis'}, {'id': 'D015448', 'term': 'Leukemia, B-Cell'}, {'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D003520', 'term': 'Cyclophosphamide'}, {'id': 'C042382', 'term': 'fludarabine phosphate'}, {'id': 'D016559', 'term': 'Tacrolimus'}, {'id': 'D009173', 'term': 'Mycophenolic Acid'}, {'id': 'D016133', 'term': 'Polymerase Chain Reaction'}, {'id': 'D017404', 'term': 'In Situ Hybridization, Fluorescence'}, {'id': 'D054458', 'term': 'Amplified Fragment Length Polymorphism Analysis'}, {'id': 'D020869', 'term': 'Gene Expression Profiling'}, {'id': 'D014916', 'term': 'Whole-Body Irradiation'}, {'id': 'D014180', 'term': 'Transplantation'}], 'ancestors': [{'id': 'D010752', 'term': 'Phosphoramide Mustards'}, {'id': 'D009588', 'term': 'Nitrogen Mustard Compounds'}, {'id': 'D009150', 'term': 'Mustard Compounds'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D063088', 'term': 'Phosphoramides'}, {'id': 'D009943', 'term': 'Organophosphorus Compounds'}, {'id': 'D018942', 'term': 'Macrolides'}, {'id': 'D007783', 'term': 'Lactones'}, {'id': 'D002208', 'term': 'Caproates'}, {'id': 'D000144', 'term': 'Acids, Acyclic'}, {'id': 'D002264', 'term': 'Carboxylic Acids'}, {'id': 'D005227', 'term': 'Fatty Acids'}, {'id': 'D008055', 'term': 'Lipids'}, {'id': 'D021141', 'term': 'Nucleic Acid Amplification Techniques'}, {'id': 'D005821', 'term': 'Genetic Techniques'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D017403', 'term': 'In Situ Hybridization'}, {'id': 'D013194', 'term': 'Staining and Labeling'}, {'id': 'D016591', 'term': 'Histocytological Preparation Techniques'}, {'id': 'D003584', 'term': 'Cytological Techniques'}, {'id': 'D019411', 'term': 'Clinical Laboratory Techniques'}, {'id': 'D019937', 'term': 'Diagnostic Techniques and Procedures'}, {'id': 'D003933', 'term': 'Diagnosis'}, {'id': 'D006652', 'term': 'Histological Techniques'}, {'id': 'D020732', 'term': 'Cytogenetic Analysis'}, {'id': 'D009693', 'term': 'Nucleic Acid Hybridization'}, {'id': 'D016172', 'term': 'DNA Fingerprinting'}, {'id': 'D011878', 'term': 'Radiotherapy'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'rsalit@fredhutch.gov', 'phone': '206-667-1317', 'title': 'Rachel Salit', 'organization': 'Fred Hutchinson Cancer Research Center'}, 'certainAgreement': {'piSponsorEmployee': True}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.', 'otherNumAtRisk': 55, 'deathsNumAtRisk': 55, 'otherNumAffected': 55, 'seriousNumAtRisk': 55, 'deathsNumAffected': 30, 'seriousNumAffected': 11}], 'otherEvents': [{'term': 'Invasive Fungal Infection', 'notes': 'Proven or probable invasive fungal infections', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 6}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'CMV reactivation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 34, 'numAffected': 27}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Recurrent or progressive malignancy', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 22}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'seriousEvents': [{'term': 'Bacterial infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 7}], 'organSystem': 'Infections and infestations', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Graft-versus-host disease', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 2}], 'organSystem': 'Immune system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Secondary myeloid malignancy', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 1}], 'organSystem': 'Blood and lymphatic system disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}, {'term': 'Diffuse alveolar hemorrhage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 55, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Donor Engraftment (Chimerism)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '36', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.'}], 'classes': [{'categories': [{'measurements': [{'value': '34', 'groupId': 'OG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'At day +84 after transplantation', 'description': 'Defined by the detection of at least 50% donor derived T-cells (CD3+), as a proportion of the total T-cell population', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients receiving haploidentical transplant who had T cell chimerism tested at day +84'}, {'type': 'PRIMARY', 'title': 'Incidence of Grades III-IV Acute GVHD', 'denoms': [{'units': 'Participants', 'counts': [{'value': '55', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.'}], 'classes': [{'categories': [{'measurements': [{'value': '4', 'groupId': 'OG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'At any time within 200 days after transplantation', 'description': 'Grade III GVHD represents moderate severity. Grade IV GVHD represents extreme severity', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Non-relapse-related Mortality', 'denoms': [{'units': 'Participants', 'counts': [{'value': '55', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.'}], 'classes': [{'categories': [{'measurements': [{'value': '12', 'groupId': 'OG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 200 days after transplantation', 'description': 'Number of deaths without progression or recurrence of malignant disease', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '55'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '55'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '55', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Treatment (Nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '40', 'groupId': 'BG000', 'lowerLimit': '18', 'upperLimit': '73'}]}]}], 'paramType': 'MEDIAN', 'unitOfMeasure': 'years', 'dispersionType': 'FULL_RANGE'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '21', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '34', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '3', 'groupId': 'BG000'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '49', 'groupId': 'BG000'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '3', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Asian', 'measurements': [{'value': '3', 'groupId': 'BG000'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Black or African American', 'measurements': [{'value': '5', 'groupId': 'BG000'}]}, {'title': 'White', 'measurements': [{'value': '41', 'groupId': 'BG000'}]}, {'title': 'More than one race', 'measurements': [{'value': '3', 'groupId': 'BG000'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '3', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '55', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 53}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2002-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-04', 'completionDateStruct': {'date': '2014-02', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2017-04-10', 'studyFirstSubmitDate': '2002-11-12', 'resultsFirstSubmitDate': '2017-04-10', 'studyFirstSubmitQcDate': '2003-01-26', 'lastUpdatePostDateStruct': {'date': '2017-05-17', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2017-04-10', 'studyFirstPostDateStruct': {'date': '2003-01-27', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2017-05-17', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2011-03', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Donor Engraftment (Chimerism)', 'timeFrame': 'At day +84 after transplantation', 'description': 'Defined by the detection of at least 50% donor derived T-cells (CD3+), as a proportion of the total T-cell population'}, {'measure': 'Incidence of Grades III-IV Acute GVHD', 'timeFrame': 'At any time within 200 days after transplantation', 'description': 'Grade III GVHD represents moderate severity. Grade IV GVHD represents extreme severity'}, {'measure': 'Non-relapse-related Mortality', 'timeFrame': 'Up to 200 days after transplantation', 'description': 'Number of deaths without progression or recurrence of malignant disease'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Accelerated Phase Chronic Myelogenous Leukemia', 'Adult Acute Lymphoblastic Leukemia in Remission', 'Adult Acute Myeloid Leukemia in Remission', 'Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities', 'Adult Acute Myeloid Leukemia With Del(5q)', 'Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)', 'Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)', 'Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)', 'Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)', 'Adult Nasal Type Extranodal NK/T-cell Lymphoma', 'Anaplastic Large Cell Lymphoma', 'Angioimmunoblastic T-cell Lymphoma', 'Childhood Acute Lymphoblastic Leukemia in Remission', 'Childhood Acute Myeloid Leukemia in Remission', 'Childhood Burkitt Lymphoma', 'Childhood Chronic Myelogenous Leukemia', 'Childhood Myelodysplastic Syndromes', 'Childhood Nasal Type Extranodal NK/T-cell Lymphoma', 'Cutaneous B-cell Non-Hodgkin Lymphoma', 'de Novo Myelodysplastic Syndromes', 'Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue', 'Hematopoietic/Lymphoid Cancer', 'Hepatosplenic T-cell Lymphoma', 'Intraocular Lymphoma', 'Nodal Marginal Zone B-cell Lymphoma', 'Peripheral T-cell Lymphoma', 'Post-transplant Lymphoproliferative Disorder', 'Previously Treated Myelodysplastic Syndromes', 'Recurrent Adult Burkitt Lymphoma', 'Recurrent Adult Diffuse Large Cell Lymphoma', 'Recurrent Adult Diffuse Mixed Cell Lymphoma', 'Recurrent Adult Diffuse Small Cleaved Cell Lymphoma', 'Recurrent Adult Grade III Lymphomatoid Granulomatosis', 'Recurrent Adult Hodgkin Lymphoma', 'Recurrent Adult Immunoblastic Large Cell Lymphoma', 'Recurrent Adult Lymphoblastic Lymphoma', 'Recurrent Adult T-cell Leukemia/Lymphoma', 'Recurrent Childhood Anaplastic Large Cell Lymphoma', 'Recurrent Childhood Grade III Lymphomatoid Granulomatosis', 'Recurrent Childhood Large Cell Lymphoma', 'Recurrent Childhood Lymphoblastic Lymphoma', 'Recurrent Childhood Small Noncleaved Cell Lymphoma', 'Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma', 'Recurrent Grade 1 Follicular Lymphoma', 'Recurrent Grade 2 Follicular Lymphoma', 'Recurrent Grade 3 Follicular Lymphoma', 'Recurrent Mantle Cell Lymphoma', 'Recurrent Marginal Zone Lymphoma', 'Recurrent Mycosis Fungoides/Sezary Syndrome', 'Recurrent Small Lymphocytic Lymphoma', 'Recurrent/Refractory Childhood Hodgkin Lymphoma', 'Refractory Chronic Lymphocytic Leukemia', 'Refractory Multiple Myeloma', 'Relapsing Chronic Myelogenous Leukemia', 'Secondary Myelodysplastic Syndromes', 'Small Intestine Lymphoma', 'Splenic Marginal Zone Lymphoma', 'Stage II Multiple Myeloma', 'Stage III Adult Burkitt Lymphoma', 'Stage III Adult Diffuse Large Cell Lymphoma', 'Stage III Adult Diffuse Mixed Cell Lymphoma', 'Stage III Adult Diffuse Small Cleaved Cell Lymphoma', 'Stage III Adult Hodgkin Lymphoma', 'Stage III Adult Immunoblastic Large Cell Lymphoma', 'Stage III Adult Lymphoblastic Lymphoma', 'Stage III Adult T-cell Leukemia/Lymphoma', 'Stage III Childhood Hodgkin Lymphoma', 'Stage III Chronic Lymphocytic Leukemia', 'Stage III Cutaneous T-cell Non-Hodgkin Lymphoma', 'Stage III Grade 1 Follicular Lymphoma', 'Stage III Grade 2 Follicular Lymphoma', 'Stage III Grade 3 Follicular Lymphoma', 'Stage III Mantle Cell Lymphoma', 'Stage III Marginal Zone Lymphoma', 'Stage III Multiple Myeloma', 'Stage III Mycosis Fungoides/Sezary Syndrome', 'Stage III Small Lymphocytic Lymphoma', 'Stage IV Adult Burkitt Lymphoma', 'Stage IV Adult Diffuse Large Cell Lymphoma', 'Stage IV Adult Diffuse Mixed Cell Lymphoma', 'Stage IV Adult Diffuse Small Cleaved Cell Lymphoma', 'Stage IV Adult Hodgkin Lymphoma', 'Stage IV Adult Immunoblastic Large Cell Lymphoma', 'Stage IV Adult Lymphoblastic Lymphoma', 'Stage IV Adult T-cell Leukemia/Lymphoma', 'Stage IV Childhood Hodgkin Lymphoma', 'Stage IV Chronic Lymphocytic Leukemia', 'Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma', 'Stage IV Grade 1 Follicular Lymphoma', 'Stage IV Grade 2 Follicular Lymphoma', 'Stage IV Grade 3 Follicular Lymphoma', 'Stage IV Mantle Cell Lymphoma', 'Stage IV Marginal Zone Lymphoma', 'Stage IV Mycosis Fungoides/Sezary Syndrome', 'Stage IV Small Lymphocytic Lymphoma', 'Testicular Lymphoma', 'Waldenström Macroglobulinemia']}, 'descriptionModule': {'briefSummary': "This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide, tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone marrow transplant works in treating patients with high-risk hematologic cancer. Giving low doses of chemotherapy, such as fludarabine phosphate and cyclophosphamide, and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells by stopping them from dividing or killing them. Giving cyclophosphamide after transplant may also stop the patient's immune system from rejecting the donor's bone marrow stem cells. The donated stem cells may replace the patient's immune system cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus and mycophenolate mofetil after the transplant may stop this from happening", 'detailedDescription': 'OBJECTIVES:\n\nI. To determine if engraftment can be achieved safely in patients with high-risk hematologic malignancies who undergo non-myeloablative bone marrow transplantation (BMT) from human leukocyte antigen (HLA)-haploidentical donors.\n\nOUTLINE:\n\nNONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate intravenously (IV) over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus orally (PO), once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.\n\nTreatment continues in the absence of disease progression or unacceptable toxicity.\n\nAfter completion of study treatment, patients are followed up at 6 months and then annually thereafter.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Chronic myeloid leukemia (CML) in accelerated phase (AP)\n* Acute myeloid leukemia (AML) with high-risk cytogenetics \\[del(5q)/-5, del(7q)/-7, abnormal 3q, 9q, 11q, 20q, 21q, 17p, t(6:9), t(9;22), complex karyotypes (\\>= 3 abnormalities)\\] in complete remission (CR)1\n* AML \\>= CR2; patients should have \\< 5% marrow blasts at the time of transplant\n* High-risk ALL defined as: CR1 with high-risk cytogenetics; t(9;22), t(4;11), or hypodiploid (\\< 45 chromosomes) for pediatric patients; t(9;22), t(8;14), t(4;11), t(1;19) for adult patients; \\> 4 wk to achieve CR1; \\>= CR2 (patients should have \\< 5% marrow blasts at the time of transplant)\n* Myelodysplastic syndromes (MDS) (\\>int-1 per IPSS) after \\>= 1 prior cycle of induction chemotherapy; should have \\< 5% marrow blasts at the time of transplant\n* Multiple myeloma (MM) Stage II or III patients who have progressed after an initial response to chemotherapy or autologous hematopoietic stem cell transplantation (HSCT) or MM patients with refractory disease who may benefit from tandem autologous-nonmyeloablative allogeneic transplant\n* Chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL) or Hodgkin's Disease (HD) who are ineligible for autologous HSCT or who have resistant/refractory disease and who may benefit from tandem autologous nonmyeloablative allogeneic transplant\n* Patients who have received a prior allogeneic HSCT and who have either rejected their grafts or who have become tolerant of their grafts with no active graft-versus-host disease (GvHD) requiring immunosuppressive therapy\n* DONOR: Related donors who are identical for one HLA haplotype and mismatched at the HLA-A, -B, -C or DRB1 loci of the unshared haplotype with the exception of single HLA-A, -B or -C allele mismatches\n\nExclusion Criteria:\n\n* Cross-match positive with donor\n* Patients with suitably matched related or unrelated donors\n* Patients with conventional transplant options (a conventional transplant should be the priority for eligible patients =\\< 50 yr of age who have a related donor mismatched for a single HLA-A, -B or DRB1 antigen)\n* Central nervous system (CNS) involvement with disease refractory to intrathecal chemotherapy\n* Presence of active, serious infection (e.g., mucormycosis, uncontrolled aspergillosis, tuberculosis)\n* Karnofsky Performance Status \\< 60 for adult patients\n* Lansky-Play Performance Score \\< 60 for pediatric patients\n* Left ventricular ejection fraction \\< 35%\n* Diffusing capacity of the lung for carbon monoxide (DLCO) \\< 35% and/or receiving supplemental continuous oxygen\n* Liver abnormalities: fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, alcoholic hepatitis, esophageal varices, hepatic encephalopathy, uncorrectable hepatic synthetic dysfunction as evidenced by prolongation of the prothrombin time, ascites related to portal hypertension, bacterial or fungal liver abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin \\> 3 mg/dL or symptomatic biliary disease\n* Human immunodeficiency virus (HIV)-positive patients\n* Women of childbearing potential who are pregnant (beta-HCG+) or breast feeding\n* Fertile men and women unwilling to use contraceptives during and for 12 months post-transplant\n* Life expectancy severely limited by diseases other than malignancy\n* DONOR: Donor-recipient pairs in which the HLA-mismatch is only in the HVG direction\n* DONOR: Cross-match positive with recipient"}, 'identificationModule': {'nctId': 'NCT00049504', 'briefTitle': 'Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Fred Hutchinson Cancer Center'}, 'officialTitle': 'Nonmyeloablative Hematopoietic Stem Cell Transplantation for Patients With High-Risk Hematologic Malignancies Using Related, HLA-Haploidentical Donors: A Phase II Trial of Combined Immunosuppression Before and After Transplantation', 'orgStudyIdInfo': {'id': '1667.00'}, 'secondaryIdInfos': [{'id': 'NCI-2010-00166', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Treatment (nonmyeloablative HSCT)', 'description': 'NONMYELOABLATIVE CONDITIONING: Patients receive fludarabine phosphate IV over 1 hour on days -6 to -2 and cyclophosphamide IV over 1 hour on days -6 and -5. Patients undergo total body irradiation on day -1.\n\nTRANSPLANTATION: Patients undergo BMT, from an HLA-haploidentical donor, on day 0.\n\nPOST-TRANSPLANT IMMUNOSUPPRESSION: Patients receive cyclophosphamide IV over 1 hour on day 3.\n\nGRAFT-VERSUS-HOST DISEASE PROPHYLAXIS: Patients receive tacrolimus IV over 1-2 hours and then tacrolimus PO, once tolerated, on days 4-180, with taper on day 86 in the absence of graft-versus-host disease. Patients also receive mycophenolate mofetil PO three times daily on days 4-35.', 'interventionNames': ['Drug: cyclophosphamide', 'Drug: fludarabine phosphate', 'Drug: tacrolimus', 'Drug: mycophenolate mofetil', 'Genetic: polymerase chain reaction', 'Genetic: fluorescence in situ hybridization', 'Genetic: polymorphism analysis', 'Genetic: gene expression analysis', 'Radiation: total-body irradiation', 'Procedure: allogeneic bone marrow transplantation', 'Procedure: allogeneic hematopoietic stem cell transplantation']}], 'interventions': [{'name': 'cyclophosphamide', 'type': 'DRUG', 'otherNames': ['CPM', 'CTX', 'Cytoxan', 'Endoxan', 'Endoxana'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'fludarabine phosphate', 'type': 'DRUG', 'otherNames': ['2-F-ara-AMP', 'Beneflur', 'Fludara'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'tacrolimus', 'type': 'DRUG', 'otherNames': ['FK 506', 'Prograf'], 'description': 'Given IV or orally', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'mycophenolate mofetil', 'type': 'DRUG', 'otherNames': ['Cellcept', 'MMF'], 'description': 'Given orally', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'polymerase chain reaction', 'type': 'GENETIC', 'otherNames': ['PCR'], 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'fluorescence in situ hybridization', 'type': 'GENETIC', 'otherNames': ['fluorescence in situ hybridization (FISH)'], 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'polymorphism analysis', 'type': 'GENETIC', 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'gene expression analysis', 'type': 'GENETIC', 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'total-body irradiation', 'type': 'RADIATION', 'otherNames': ['TBI'], 'description': 'Undergo total-body irradiation', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'allogeneic bone marrow transplantation', 'type': 'PROCEDURE', 'otherNames': ['bone marrow therapy, allogeneic', 'bone marrow therapy, allogenic', 'transplantation, allogeneic bone marrow', 'transplantation, allogenic bone marrow'], 'description': 'Undergo haploidentical hematopoietic bone marrow transplantation', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}, {'name': 'allogeneic hematopoietic stem cell transplantation', 'type': 'PROCEDURE', 'description': 'Undergo haploidentical hematopoietic bone marrow transplantation', 'armGroupLabels': ['Treatment (nonmyeloablative HSCT)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '98109', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}], 'overallOfficials': [{'name': "Paul O'Donnell", 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Individual patient data is protected by HIPAA at each participant organization.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Fred Hutchinson Cancer Center', 'class': 'OTHER'}, 'collaborators': [{'name': 'National Cancer Institute (NCI)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}