Ignite Creation Date:
2025-12-24 @ 9:06 PM
Ignite Modification Date:
2026-02-20 @ 1:34 PM
Study NCT ID:
NCT00537004
Status:
RECRUITING
Last Update Posted:
2025-01-27
First Post:
2007-09-26
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Language in Primary Progressive Aphasia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D018888', 'term': 'Aphasia, Primary Progressive'}, {'id': 'D057180', 'term': 'Frontotemporal Dementia'}, {'id': 'D057178', 'term': 'Primary Progressive Nonfluent Aphasia'}, {'id': 'D001037', 'term': 'Aphasia'}, {'id': 'D057174', 'term': 'Frontotemporal Lobar Degeneration'}], 'ancestors': [{'id': 'D003704', 'term': 'Dementia'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D013064', 'term': 'Speech Disorders'}, {'id': 'D007806', 'term': 'Language Disorders'}, {'id': 'D003147', 'term': 'Communication Disorders'}, {'id': 'D019954', 'term': 'Neurobehavioral Manifestations'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D019965', 'term': 'Neurocognitive Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}, {'id': 'D057177', 'term': 'TDP-43 Proteinopathies'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D057165', 'term': 'Proteostasis Deficiencies'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 500}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2007-05', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-01', 'completionDateStruct': {'date': '2027-04', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-23', 'studyFirstSubmitDate': '2007-09-26', 'studyFirstSubmitQcDate': '2007-09-26', 'lastUpdatePostDateStruct': {'date': '2025-01-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2007-09-28', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2027-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Neuropsychological variables', 'timeFrame': 'Immediately after testing and at two years post-testing'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['primary progressive aphasia', 'frontotemporal dementia', 'semantic dementia', 'progressive nonfluent aphasia', 'progressive aphasia', 'frontotemporal lobar degeneration'], 'conditions': ['Primary Progressive Aphasia']}, 'referencesModule': {'references': [{'pmid': '7114808', 'type': 'BACKGROUND', 'citation': 'Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607.'}, {'pmid': '2252450', 'type': 'BACKGROUND', 'citation': 'Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. 1990 Dec;47(12):1329-35. doi: 10.1001/archneur.1990.00530120075013.'}, {'pmid': '33441454', 'type': 'DERIVED', 'citation': 'Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ. Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia. Neurology. 2021 Feb 9;96(6):e916-e925. doi: 10.1212/WNL.0000000000011397. Epub 2021 Jan 13.'}], 'seeAlsoLinks': [{'url': 'https://www.brain.northwestern.edu/join/index.html', 'label': 'PPA Research at Northwestern University'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.', 'detailedDescription': 'The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.\n\nDuring the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.\n\nFor participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': "Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.", 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Diagnosis of primary progressive aphasia\n* Right-handed\n* Native English speaker\n* Visual acuity of 20/30 corrected\n* Adequate hearing to follow conversation\n* Safe for an MRI scan\n\nExclusion Criteria:\n\n* Left-handedness\n* Claustrophobia\n* Presence of significant medical illness that initially or in the future could interfere with continued participation in the study'}, 'identificationModule': {'nctId': 'NCT00537004', 'briefTitle': 'Language in Primary Progressive Aphasia', 'organization': {'class': 'OTHER', 'fullName': 'Northwestern University'}, 'officialTitle': 'Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia', 'orgStudyIdInfo': {'id': 'IA0125'}, 'secondaryIdInfos': [{'id': 'R01AG077444', 'link': 'https://reporter.nih.gov/quickSearch/R01AG077444', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'PPA (Primary Progressive Aphasia)', 'description': 'Individuals with primary progressive aphasia'}, {'label': 'Control', 'description': 'Individuals with no diagnosis of any type of dementia'}]}, 'contactsLocationsModule': {'locations': [{'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Seyi Adeolu', 'role': 'CONTACT', 'email': 'PPA.Research@northwestern.edu', 'phone': '312-503-2398'}, {'name': 'M.-Marsel Mesulam, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northwestern University', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}], 'centralContacts': [{'name': 'Elizabeth A Haynes', 'role': 'CONTACT', 'email': 'PPA.Research@northwestern.edu', 'phone': '312-503-2398'}], 'overallOfficials': [{'name': 'Marsel Mesulam, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Northwestern University Feinberg School of Medicine'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Northwestern University', 'class': 'OTHER'}, 'collaborators': [{'name': 'National Institute on Aging (NIA)', 'class': 'NIH'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': "Director, Mesulam Center for Cognitive Neurology and Alzheimer's Disease", 'investigatorFullName': 'Marsel Mesulam', 'investigatorAffiliation': 'Northwestern University'}}}}