Ignite Creation Date:
2025-12-24 @ 8:01 PM
Ignite Modification Date:
2026-01-01 @ 5:42 PM
Study NCT ID:
NCT03992404
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-12-19
First Post:
2019-06-18
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Australia', 'Norway']}, 'conditionBrowseModule': {'meshes': [{'id': 'D000070642', 'term': 'Brain Injuries, Traumatic'}], 'ancestors': [{'id': 'D001930', 'term': 'Brain Injuries'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D006259', 'term': 'Craniocerebral Trauma'}, {'id': 'D020196', 'term': 'Trauma, Nervous System'}, {'id': 'D014947', 'term': 'Wounds and Injuries'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C545476', 'term': 'incobotulinumtoxinA'}, {'id': 'D019274', 'term': 'Botulinum Toxins, Type A'}], 'ancestors': [{'id': 'D001905', 'term': 'Botulinum Toxins'}, {'id': 'D008666', 'term': 'Metalloendopeptidases'}, {'id': 'D010450', 'term': 'Endopeptidases'}, {'id': 'D010447', 'term': 'Peptide Hydrolases'}, {'id': 'D006867', 'term': 'Hydrolases'}, {'id': 'D004798', 'term': 'Enzymes'}, {'id': 'D045762', 'term': 'Enzymes and Coenzymes'}, {'id': 'D045726', 'term': 'Metalloproteases'}, {'id': 'D001426', 'term': 'Bacterial Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D001427', 'term': 'Bacterial Toxins'}, {'id': 'D014118', 'term': 'Toxins, Biological'}, {'id': 'D001685', 'term': 'Biological Factors'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 603}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2019-09-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2027-04', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-18', 'studyFirstSubmitDate': '2019-06-18', 'studyFirstSubmitQcDate': '2019-06-18', 'lastUpdatePostDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2019-06-20', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-06-19', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change from baseline in derived Modified Ashworth Scale-Bohannon (MAS) ankle score (knee extended) at weeks 4 to 6', 'timeFrame': 'Baseline to week 4-6', 'description': 'The MAS is a 6-grade scale'}, {'measure': 'Co-Primary: Global Impression of Change Scale (GICS) assessed by physician at Week 4 to 6', 'timeFrame': 'Week 4-6', 'description': 'The GICS s a 9-grade scale'}, {'measure': 'Occurrence of treatment emergent adverse events [TEAEs] in the Main Period', 'timeFrame': 'Baseline to week 12'}], 'secondaryOutcomes': [{'measure': 'Change from Study Baseline in Goal Attainment Scale [GAS] at Week 6', 'timeFrame': 'Baseline to week 6', 'description': 'The GAS is a 6-grade scale'}, {'measure': 'Global Impression of Change Scale (GICS) assessed by the study subject at Week 4 to 6', 'timeFrame': 'Week 4-6', 'description': 'The GICS s a 9-grade scale'}, {'measure': 'Global Impression of Change Scale (GICS) assessed by the caregiver at Week 4 to 6', 'timeFrame': 'Week 4-6', 'description': 'The GICS s a 9-grade scale'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to determine whether a single treatment with administration of 400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of lower limb spasticity caused by stroke or traumatic brain injury (Main Period). Participants will be assigned to the treatment groups by chance and neither the participants nor the research staff who interact with them will know the allocation.\n\nThe following 4 to 5 treatment cycles will investigate the safety and tolerability of treatment with NT 201 (botulinum toxin) when administered in doses between 400 and 800 Units (Open Label Extension Period). All participants will receive the treatment and the dose will depend on whether only lower limb spasticity or combined upper and lower limb spasticity are treated.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '85 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Female or male subject ≥ 18 years and ≤ 85 years at screening\n* Diagnosis of lower limb spasticity with or without upper limb spasticity of the same body side caused by stroke or traumatic brain injury\n* Disabling ankle flexor spasticity presenting as pes equinus or pes equinovarus\n* Modified Ashworth Scale-Bohannon \\[MAS\\] score of 2 or 3 points in the ankle plantar flexor of the target lower limb (supine position, knee extended)\n* Minimum passive range of motion in ankle of the target lower limb (supine position, knee extended): 10°dorsiflexion and 20°plantarflexion\n* At least 4 months since last botulinum neurotoxin \\[BoNT\\] injection for treatment of spasticity or any other condition\n* For subjects receiving anticoagulation therapy, the investigator confirms and documents that the subject has an:\n* Activated partial thromboplastin time \\[aPTT\\] ≤ 80 seconds (subjects on dabigatran or other direct thrombin inhibitors) or\n* International normalized ratio \\[INR\\] value of ≤ 2.5 (subjects on coumarins or other anticoagulants monitored by INR)\n\nExclusion Criteria:\n\n* Generalized disorders of muscle activity (e.g. myasthenia gravis, Lambert Eaton syndrome, amyotrophic lateral sclerosis) or any other significant peripheral neuromuscular dysfunction which might interfere with the study\n* Bilateral lower limb paresis/paralysis/spasticity or tetraparesis/paralysis/spasticity\n* Body weight \\< 50 kg\n* Severe atrophy of the target limb muscles\n* Previous, ongoing or planned treatments of spasticity with intrathecal baclofen\n* Previous, ongoing, or planned treatments of spasticity in the target lower limb with any of the following procedures: Surgical Intervention; Alcohol or phenol block; Muscle afferent block\n* Physiotherapy or use of orthoses or splints at the target limb initiated less than 4 weeks before screening or expected to change during the double blind phase of the study\n* Current or planned treatment with parenterally administered drugs that interfere with neuromuscular transmission (e.g. intrathecal baclofen, tubocurarine type muscle relaxants used in anesthesia), or local anesthetics in the treated region within 2 weeks prior to screening\n* Infection or inflammation at the injection sites\n* Subjects with presence or history of aspiration pneumonia, recurrent lower respiratory tract infections, or compromised respiratory function as per investigator's clinical judgment\n* Pregnancy (as verified by a positive pregnancy test) or breast feeding"}, 'identificationModule': {'nctId': 'NCT03992404', 'acronym': 'PATTERN', 'briefTitle': 'Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury', 'organization': {'class': 'INDUSTRY', 'fullName': 'Merz Pharmaceuticals GmbH'}, 'officialTitle': 'Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Investigate the Efficacy and Safety of NT 201 in the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury in Adult Subjects, Followed by an Open Label Extension With or Without Combined Upper Limb Treatment', 'orgStudyIdInfo': {'id': 'M602011014'}, 'secondaryIdInfos': [{'id': '2018-001639-35', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'NT 201 (IncobotulinumtoxinA, Xeomin)', 'description': 'Main Period (1 treatment cycle): subjects to receive intramuscular injection of NT 201 (400 units) into muscles of the lower limb.\n\nOpen Label Extension Period (4-5 treatment cycles): subjects to receive intramuscular injection of NT 201 (up to 800 units) into muscles of the lower limb and upper limb, if indicated.', 'interventionNames': ['Drug: NT 201']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Main Period (1 treatment cycle): subjects to receive intramuscular placebo injection into muscles of the lower limb.\n\nOpen Label Extension Period (4-5 treatment cycles): subjects to receive intramuscular injection of NT 201 (up to 800 units) into muscles of the lower limb and upper limb, if indicated.', 'interventionNames': ['Drug: NT 201', 'Drug: Placebo']}], 'interventions': [{'name': 'NT 201', 'type': 'DRUG', 'otherNames': ['IncobotulinumtoxinA', 'Incobotulinumtoxin A', 'Xeomin', 'Botulinum toxin type A (150 kiloDalton), free from complexing proteins'], 'description': 'Active ingredient: Clostridium Botulinum neurotoxin Type A free from complexing proteins. Solution for injection prepared by reconstitution of powder with 0.9% Sodium Chloride (NaCl).', 'armGroupLabels': ['NT 201 (IncobotulinumtoxinA, Xeomin)', 'Placebo']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Solution for injection prepared by reconstitution of powder with 0.9% Sodium Chloride (NaCl).', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Physical Medicine and Rehabilitation at University of Alabama at Birmingham; Merz investigational site #0010479', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'University of Arkansas for Medical Sciences, Merz investigational site #0010481', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '90242', 'city': 'Downey', 'state': 'California', 'country': 'United States', 'facility': 'Rancho Research Institute at Rancho Los Amigos National Rehabilitation Center; Merz investigational site #0010184', 'geoPoint': {'lat': 33.94001, 'lon': -118.13257}}, {'zip': '06905', 'city': 'Stamford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'New England institute for clinical research; Merz Investigational Site #0010441', 'geoPoint': {'lat': 41.05343, 'lon': -73.53873}}, {'zip': '34209', 'city': 'Brandenton', 'state': 'Florida', 'country': 'United States', 'facility': 'Nova Clinical Research, Merz investigational site #0010474'}, {'zip': '72204', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Brooks Rehabilitation Clinical Integration and Research, Merz investigational site #0010483', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '34239', 'city': 'Sarasota', 'state': 'Florida', 'country': 'United States', 'facility': 'Sarasota Memorial Health Care System, Rehabilitation Medicine, Merz investigational site #0010478', 'geoPoint': {'lat': 27.33643, 'lon': -82.53065}}, {'zip': '02035', 'city': 'Foxborough', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Neurology Center of New England P.C., Merz investigative site #0010476', 'geoPoint': {'lat': 42.06538, 'lon': -71.24783}}, {'zip': '65203', 'city': 'Columbia', 'state': 'Missouri', 'country': 'United States', 'facility': 'Howard A. Rusk Rehabilitation Center; Merz investigational site #0010283', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '10029', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Icahn School of Medicine at Mount Sinai, Neurology Department, Merz Investigational Site #0010191', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10065', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Weill Cornell Medical Center, Department of Rehabilitation Medicine; Merz Investigational Site #0010440', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '15213', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pittsburgh Medical Center, Physical Medicine & Rehabiliation, Merz Investigational Site #0010211', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '75390-9055', 'city': 'Dallas', 'state': 'Texas', 'country': 'United States', 'facility': 'UT Southwestern Medical Center, Department of Physical Medicine & Rehabilitation, Merz investigational site #0010082', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'University of Texas Health Science Center McGovern, Medical School Department of PM&R; merz investigational site #0010183', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '53226', 'city': 'Milwaukee', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Medical College of Wisconsin,Department of PM&R, Merz Investigational Site #0010237', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': '1020', 'city': 'Brussels', 'country': 'Belgium', 'facility': 'CHU Brugmann Neurology; Merz investigational site #0320015', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '1200', 'city': 'Brussels', 'country': 'Belgium', 'facility': 'UCL Bruxelles, Physical Medicine & Rehabilitation Department, Merz Investigational Site #0320013', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'zip': '3212', 'city': 'Pellenberg', 'country': 'Belgium', 'facility': 'UZ Leuven Pellenberg campus; Merz investigational site #0320014', 'geoPoint': {'lat': 50.87245, 'lon': 4.79394}}, {'zip': '5530', 'city': 'Yvoir', 'country': 'Belgium', 'facility': 'UCL Mont Godinne, Physical Medicine & Rehabilitation Department; Merz Investigational Site #0320008', 'geoPoint': {'lat': 50.3279, 'lon': 4.88059}}, {'zip': 'T5G 0B7', 'city': 'Edmonton', 'country': 'Canada', 'facility': 'Glenrose Rehabilitation Hospital, Merz investigational site #0010195', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'zip': '61500', 'city': 'Brno', 'country': 'Czechia', 'facility': 'Neurology and Physiotherapy Skopalikova, Merz Investigational Site #4200049', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'zip': '708 52', 'city': 'Ostrava', 'country': 'Czechia', 'facility': 'University Hospital Ostrava; Neurology Departement, Merz investigational site #4200024', 'geoPoint': {'lat': 49.83465, 'lon': 18.28204}}, {'zip': '530 03', 'city': 'Pardubice', 'country': 'Czechia', 'facility': 'Pardubice Regional Hospital; Merz investigational site #4200025', 'geoPoint': {'lat': 50.04075, 'lon': 15.77659}}, {'zip': '92380', 'city': 'Garches', 'country': 'France', 'facility': 'Raymond Poincaré University Hospital, Service de MPR Pôle Handicap-Rééducation, Merz Investigational site #00330018', 'geoPoint': {'lat': 48.84226, 'lon': 2.18232}}, {'zip': '59000', 'city': 'Lille', 'country': 'France', 'facility': 'CHU Lille/Hôpital Swynghedauw; investigational site # 0330045', 'geoPoint': {'lat': 50.63391, 'lon': 3.05512}}, {'zip': '35000', 'city': 'Rennes', 'country': 'France', 'facility': 'Pôle Saint-Hélier; Merz investigational site #0330024', 'geoPoint': {'lat': 48.11109, 'lon': -1.67431}}, {'zip': '67000', 'city': 'Strasbourg', 'country': 'France', 'facility': 'Institut Universitaire de Readaptation Clemenceau, Physical Medicine / Rehabilitation Medecine, Merz Investigational site # 0330063', 'geoPoint': {'lat': 48.58392, 'lon': 7.74553}}, {'zip': '31059', 'city': 'Toulouse', 'country': 'France', 'facility': 'Rangueil Hospital-University Hospital Center (CHU) of Toulouse, Médecine physique et de réadaptation, Merz investigational site #0330025', 'geoPoint': {'lat': 43.60426, 'lon': 1.44367}}, {'zip': '52074', 'city': 'Aachen', 'country': 'Germany', 'facility': 'Uniklinik RWTH Aachen, Neurologie, Merz Investigational Site #0490191', 'geoPoint': {'lat': 50.77664, 'lon': 6.08342}}, {'zip': '10627', 'city': 'Berlin', 'country': 'Germany', 'facility': 'Neurologie Bewegt; Merz Investigational site #0490378', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'zip': '53127', 'city': 'Bonn', 'country': 'Germany', 'facility': 'University of Bonn Medical Center, Department of Neurodegenerative disease, Merz investigational site #0490390', 'geoPoint': {'lat': 50.73438, 'lon': 7.09549}}, {'zip': '40225', 'city': 'Düsseldorf', 'country': 'Germany', 'facility': 'Heinrich Heine University Duesseldorf, Department of Neurology; Merz Investigational Site #0490071', 'geoPoint': {'lat': 51.22172, 'lon': 6.77616}}, {'zip': '20246', 'city': 'Hamburg', 'country': 'Germany', 'facility': 'Universitätsklinikum Hamburg-Eppendorf, Merz Investigational site #0490079', 'geoPoint': {'lat': 53.55073, 'lon': 9.99302}}, {'zip': '65191', 'city': 'Wiesbaden', 'country': 'Germany', 'facility': 'DKD HELIOS Medical Center, Fachbereich Neurologie, Merz Investigational Site #0490081', 'geoPoint': {'lat': 50.08601, 'lon': 8.24435}}, {'zip': '97080', 'city': 'Würzburg', 'country': 'Germany', 'facility': 'Neurologische Klinik und Poliklinik des Universitätsklinikums Würzburg, Merz Investigational Site #0490302', 'geoPoint': {'lat': 49.79391, 'lon': 9.95121}}, {'zip': '9024', 'city': 'Győr', 'country': 'Hungary', 'facility': 'Petz Hospital, Neurology, Merz Investigational Site #0360010', 'geoPoint': {'lat': 47.68333, 'lon': 17.63512}}, {'zip': '4600', 'city': 'Kisvárda', 'country': 'Hungary', 'facility': 'St.Damjan Hospital, Kisvarda; Merz investigational site #0360019', 'geoPoint': {'lat': 48.21667, 'lon': 22.08333}}, {'zip': '6725', 'city': 'Szeged', 'country': 'Hungary', 'facility': 'University of Szeged, Department of Neurology, Merz investigational site #0360008', 'geoPoint': {'lat': 46.253, 'lon': 20.14824}}, {'zip': '71122', 'city': 'Foggia', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Ospedali Riuniti Di Foggia; Merz Investigational Site #0390018', 'geoPoint': {'lat': 41.45845, 'lon': 15.55188}}, {'zip': '16132', 'city': 'Genova', 'country': 'Italy', 'facility': 'IRCCS Ospedale Policlinico S. Martino, U.O.Complessa Riabilitazione e Rieducazione Funzionale; Merz investigational site #0390020', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'zip': '28100', 'city': 'Novara', 'country': 'Italy', 'facility': 'Ospedale Maggiore della Carita, Dipartimento di Medicina fisica e Riabilitativa, Merz Investigational Site #0390017', 'geoPoint': {'lat': 45.44694, 'lon': 8.62118}}, {'zip': '04019', 'city': 'Terracina', 'country': 'Italy', 'facility': 'Ospedale Alfredo Fiorini, UOSD Neurologia Universitaria; Merz Investigational site #0390022', 'geoPoint': {'lat': 41.29174, 'lon': 13.24359}}, {'zip': '40-097', 'city': 'Katowice', 'country': 'Poland', 'facility': 'Specjalistyczna Praktyka Lekarska Dr. n. med Stanisław Ochudło, Merz Investigational Site #0480077', 'geoPoint': {'lat': 50.2597, 'lon': 19.02173}}, {'zip': '30-539', 'city': 'Krakow', 'country': 'Poland', 'facility': 'Specjalistyczne Gabinety Sp z o.o., Merz Investigational Site #0480059', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'zip': '90-640', 'city': 'Lodz', 'country': 'Poland', 'facility': 'NeuroKlinika Gabinet Lekarski Prof Andrzej Bogucki, Merz Investigational Site #0480101', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'zip': '20-582', 'city': 'Lublin', 'country': 'Poland', 'facility': 'Indywidualna Praktyka Lekarska dr. hab. Med. Anna Szczepanska-Szerej, Merz Investigational Site #0480096', 'geoPoint': {'lat': 51.25058, 'lon': 22.57009}}, {'zip': '01-518', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Filia 7 Centrum Kompleksowej Rehabilitacji Sp. z o.o., Merz Investigational Site #0480100', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '02-121', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Projekt Samodzielni Sp z o.o., Merz Investigational Site #0480099', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '02-957', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Instytut Psychiatrii i Neurologii, II Klinika Neurologiczna, Merz Investigational Site #0480023', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '03-242', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Mazowiecki Szpital Brodnowski, Merz investigational site #0480064', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '50-305', 'city': 'Wroclaw', 'country': 'Poland', 'facility': 'Neuryt Diagnostyka I Terapia Neurologiczna, Merz investigational site #0480106', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'zip': '660049', 'city': 'Krasnoyarsk', 'country': 'Russia', 'facility': 'Federal State Budgetary Educational Institution of Higher Education "Krasnoyarsk State Medical University n.a. Professor V.F. 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