Ignite Creation Date:
2025-12-24 @ 8:00 PM
Ignite Modification Date:
2025-12-27 @ 6:06 AM
Study NCT ID:
NCT04624204
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-07-02
First Post:
2020-11-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D055752', 'term': 'Small Cell Lung Carcinoma'}, {'id': 'C565324', 'term': 'Parkinson Disease 4, Autosomal Dominant Lewy Body'}], 'ancestors': [{'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C582435', 'term': 'pembrolizumab'}, {'id': 'D012965', 'term': 'Sodium Chloride'}, {'id': 'C531550', 'term': 'olaparib'}, {'id': 'C494814', 'term': 'BID protein, human'}, {'id': 'D005047', 'term': 'Etoposide'}, {'id': 'D010984', 'term': 'Platinum'}], 'ancestors': [{'id': 'D002712', 'term': 'Chlorides'}, {'id': 'D006851', 'term': 'Hydrochloric Acid'}, {'id': 'D017606', 'term': 'Chlorine Compounds'}, {'id': 'D007287', 'term': 'Inorganic Chemicals'}, {'id': 'D017670', 'term': 'Sodium Compounds'}, {'id': 'D011034', 'term': 'Podophyllotoxin'}, {'id': 'D013764', 'term': 'Tetrahydronaphthalenes'}, {'id': 'D009281', 'term': 'Naphthalenes'}, {'id': 'D011084', 'term': 'Polycyclic Aromatic Hydrocarbons'}, {'id': 'D006841', 'term': 'Hydrocarbons, Aromatic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D005960', 'term': 'Glucosides'}, {'id': 'D006027', 'term': 'Glycosides'}, {'id': 'D002241', 'term': 'Carbohydrates'}, {'id': 'D019216', 'term': 'Metals, Heavy'}, {'id': 'D004602', 'term': 'Elements'}, {'id': 'D028561', 'term': 'Transition Elements'}, {'id': 'D008670', 'term': 'Metals'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 672}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2020-12-08', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-06', 'completionDateStruct': {'date': '2027-10-28', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-06-27', 'studyFirstSubmitDate': '2020-11-05', 'studyFirstSubmitQcDate': '2020-11-05', 'lastUpdatePostDateStruct': {'date': '2025-07-02', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2020-11-10', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-10-28', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-free Survival Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1); the time from randomization to progression or death due to any cause, whichever occurs first', 'timeFrame': 'Up to approximately 59 months', 'description': 'Progression-free Survival (PFS) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) is the time from randomization to progression or death due to any cause, whichever occurs first.'}, {'measure': 'Overall Survival: the time from randomization to death due to any cause', 'timeFrame': 'Up to approximately 82 months', 'description': 'Overall Survival (OS) is the time from randomization to death due to any cause.'}], 'secondaryOutcomes': [{'measure': 'Number of Participants Experiencing an Adverse Events (AEs)', 'timeFrame': 'Up to approximately 82 months', 'description': 'An AE is defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study.'}, {'measure': 'Number of Participants Discontinuing Study Treatment Due to Adverse Events (AEs)', 'timeFrame': 'Up to approximately 82 months', 'description': 'An AE is defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study.'}, {'measure': 'Objective Response (OR): Complete Response (CR) or Partial Response (PR)', 'timeFrame': 'Up to approximately 82 months', 'description': 'Percentage of participants in the analysis population who have a best overall response of either confirmed CR or a PR per RECIST 1.1.'}, {'measure': 'Duration of Response (DOR): the time from the earliest date of first documented evidence of confirmed CR or PR until the earliest date of disease progression or death from any cause, whichever comes first', 'timeFrame': 'Up to approximately 82 months', 'description': 'DOR is the time from the earliest date of first documented evidence of confirmed CR or PR until the earliest date of disease progression or death from any cause, whichever comes first.'}, {'measure': 'Change from Baseline at Cycle 1 in European Organization for Research and Treatment (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) Global Health Status / Quality of Life (Items 29 & 30) Scale Score', 'timeFrame': 'Baseline and 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to the question "How would you rate your overall health during the past week?" are scored on a 7-point scale (1= Very poor to 7=Excellent). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better overall health status. The change from baseline in EORTC QLQ-C30 Items 29 and 30 scores will be presented.'}, {'measure': 'Change from Baseline at Cycle 1 in EORTC Quality of Life Questionnaire Lung Cancer Module 13 (QLQ-LC13) Cough (Item 1) Scale Score', 'timeFrame': 'Baseline and 82 months post randomization', 'description': 'The EORTC QLQ-LC13 is a lung cancer specific supplemental questionnaire used in combination with the EORTC QLQC30 questionnaire. Participant responses to the question "How much did you cough?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. The change from baseline in EORTC QLQ-LC13 cough (Item 1) score will be presented.'}, {'measure': 'Change from Baseline at Cycle 1 in EORTC QLQ-LC13 Chest Pain (Item 10) Scale Score', 'timeFrame': 'Baseline and 82 months post randomization', 'description': 'The EORTC QLQ-LC13 is a lung cancer-specific supplemental questionnaire used in combination with the EORTC QLQC30 questionnaire. Participant responses to the question "How was your chest pain?" are scored on a 4 point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. The change from baseline in EORTC QLQ-LC13 chest pain (Item 10) score will be presented.'}, {'measure': 'Change from Baseline at Cycle 1 in EORTC QLQ-C30 Dyspnea (Item 8) Scale Score', 'timeFrame': 'Baseline and 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to the question "Were you short of breath?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. The change from baseline in EORTC QLQ-LC13 dyspnea (Item 8) score will be presented.'}, {'measure': 'Change from Baseline at Cycle 1 in EORTC QLQ-C30 Physical Functioning (Items 1 to 5) Scale Score', 'timeFrame': 'Baseline and 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to 5 questions about their physical functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better quality of life. The change from baseline in Physical Functioning (EORTC QLQ-C30 Items 1-5) score will be presented.'}, {'measure': 'Time to True Deterioration (TTD) in EORTC QLQ-C30 Global Health Status / Quality of Life (Items 29 & 30) Scale Score', 'timeFrame': 'Up to approximately 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to the question "How would you rate your overall health during the past week?" are scored on a 7-point scale (1= Very poor to 7=Excellent). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better overall health status. TTD was defined as the time from baseline (at randomization) to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in EORTC QLQ-C30 Items 29 and 30 scale scores.'}, {'measure': 'Time to True Deterioration (TTD) in Cough (LC13/Item 1) Scale Score', 'timeFrame': 'Up to approximately 82 months post randomization', 'description': 'The EORTC QLQ-LC13 is a lung cancer-specific supplemental questionnaire used in combination with the EORTC QLQC30 questionnaire. Participant responses to the question "How much did you cough?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. TTD was defined as the time from baseline (at randomization) to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in cough EORTC QLQLC13 cough (Item 1) scale score.'}, {'measure': 'Time to True Deterioration (TTD) in Chest Pain (LC13/Item 10) Scale Score', 'timeFrame': 'Up to approximately 82 months post randomization', 'description': 'The EORTC QLQ-LC13 is a lung cancer-specific supplemental questionnaire used in combination with the EORTC QLQC30 questionnaire. Participant responses to the question "How was your chest pain?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. TTD was defined as the time from baseline (at randomization) to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in EORTC QLQ-LC13 chest pain (Item 10) scale score.'}, {'measure': 'Time to True Deterioration (TTD) in EORTC QLQ-C30 Dyspnea (Item 8) Scale Score', 'timeFrame': 'Up to approximately 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to the question "Were you short of breath?" are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A lower score indicates a better outcome. TTD was defined as the time from baseline (at randomization) to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in EORTC QLQ-C30 dyspnea (Item 8) scale score.'}, {'measure': 'Time to True Deterioration (TTD) in EORTC QLQ-C30 Physical Functioning (Items 1 to 5) Scale Score', 'timeFrame': 'Up to approximately 82 months post randomization', 'description': 'The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to 5 questions about their physical functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better quality of life. TTD was defined as the time from baseline (at randomization) to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in EORTC QLQ-C30 physical functioning (Items 1 to 5) scale scores.'}, {'measure': 'Objective Response (OR, according to RECIST 1.1 by BICR) assessed by programmed cell death ligand 1 (PD-L1) expression levels', 'timeFrame': 'Up to approximately 82 months', 'description': 'Percentage of participants in the analysis population who have a best overall response of either confirmed CR or a PR per RECIST 1.1, analyzed by programmed cell death ligand 1 (PD-L1) expression levels.'}, {'measure': 'Duration of Response (DOR, according to RECIST 1.1 by BICR) assessed by programmed cell death ligand 1 (PD-L1) expression levels', 'timeFrame': 'Up to approximately 82 months', 'description': 'DOR is the time from the earliest date of first documented evidence of confirmed CR or PR until the earliest date of disease progression or death from any cause, whichever comes first, analyzed by programmed cell death ligand 1 (PD-L1) expression levels.'}, {'measure': 'Progression-free Survival (PFS, according to RECIST 1.1 by BICR) assessed by programmed cell death ligand 1 (PD-L1) expression levels', 'timeFrame': 'Up to approximately 59 months', 'description': 'Progression-free Survival Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1); the time from randomization to progression or death due to any cause, whichever occurs first, analyzed by programmed cell death ligand 1 (PD-L1) expression levels.'}, {'measure': 'Overall Survival (OS) assessed by programmed cell death ligand 1 (PD-L1) expression levels', 'timeFrame': 'Up to approximately 82 months', 'description': 'Overall Survival: the time from randomization to death due to any cause, analyzed by programmed cell death ligand 1 (PD-L1) expression levels.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Programmed Cell Death-1 (PD1, PD-1)', 'Programmed Death-Ligand 1 (PDL1, PD-L1)', 'Pembrolizumab', 'Olaparib'], 'conditions': ['Small Cell Lung Cancer']}, 'referencesModule': {'references': [{'pmid': '35613997', 'type': 'DERIVED', 'citation': 'Rimner A, Lai WV, Califano R, Jabbour SK, Rudin CM, Faivre-Finn C, Cho BC, Kato T, Yu J, Chafin W, Yu L, Zhao B, Byers L. Rationale and Design of the Phase 3 KEYLYNK-013 Study of Pembrolizumab With Concurrent Chemoradiotherapy Followed by Pembrolizumab With or Without Olaparib for Limited-Stage Small-Cell Lung Cancer. Clin Lung Cancer. 2022 Jul;23(5):e325-e329. doi: 10.1016/j.cllc.2022.04.005. Epub 2022 Apr 29.'}], 'seeAlsoLinks': [{'url': 'https://www.merckclinicaltrials.com/', 'label': 'Merck Clinical Trials Information'}, {'url': 'https://msd.trialsummaries.com/Study/StudyDetails?id=26265&tenant=MT_MSD_9011', 'label': 'Plain Language Summary'}]}, 'descriptionModule': {'briefSummary': 'Researchers are looking for new ways to treat Limited-Stage Small Cell Lung Cancer (LS-SCLC), a type of lung cancer that has not spread from the lung to other parts of the body. The purpose of this study is to learn if pembrolizumab and olaparib, when given with chemotherapy and radiation treatment (CRT), can be effective in treating LS-SCLC. The researchers want to know if participants who receive CRT and pembrolizumab, with or without olaparib, have a longer overall survival compared to participants who only receive CRT.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Has pathologically (histologically or cytologically) confirmed Small Cell Lung Cancer (SCLC).\n\n Note: Note: Participants with histology showing a mixed tumor with small cell and non-small cell elements are not eligible.\n2. Has Limited-Stage SCLC (Stage I-III, by AJCC 8th Edition Cancer Staging), and can be safely treated with definitive radiation doses.\n3. Has no evidence of metastatic disease by whole body positron emission tomography /computed tomography (PET/CT scan), CT or magnetic resonance imaging (MRI) scans\n4. Has at least 1 lesion that meets the criteria for being measurable, as defined by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)\n5. Has not received prior treatment (chemotherapy or radiotherapy or surgery resection) of LS-SCLC.\n6. Is not expected to require tumor resection during the course of the study.\n7. Must submit a pre-treatment tumor tissue sample (formalin-fixed, paraffin embedded blocks are preferred to slides) including cytologic sample, if tissue sample unavailable.\n8. Has Eastern Cooperative Oncology Group (ECOG) Performance score 0 or 1 assessed within 7 days prior to the first administration of study intervention.\n9. Has a life expectancy of at least 6 months.\n10. Has adequate organ function.\n11. Male and female participants who are not pregnant and of childbearing potential must follow contraceptive guidance during the treatment period and for the time needed to eliminate each study intervention.\n12. Male and female participants who are at least 18 years of age at the time of signing the information consent.\n13. Male participants must refrain from donating sperm during the treatment period and for the time needed to eliminate each study intervention.\n14. Abstains from breastfeeding during the study intervention period and for at least the following period after the last study intervention:\n\n * Pembrolizumab: 120 days\n * Olaparib: 7 days\n\nExclusion Criteria:\n\n1. Has history, current diagnosis, or features suggestive of myelodysplastic syndrome/ acute myeloid leukemia (MDS/AML).\n2. Has received prior therapy with an anti-programmed cell death 1 (anti-PD-1), anti-programmed cell death ligand 1 (anti-PDL1), or anti- programmed cell death ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or coinhibitory T-cell receptor\n3. Has received prior therapy with olaparib or with any other polyadenosine 5'diphosphoribose (polyADP ribose) polymerization (PARP) inhibitor.\n4. Had major surgery \\<4 weeks prior to the first dose of study intervention (except for placement of vascular access).\n5. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study intervention.\n6. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study intervention.\n7. Has a known additional malignancy that is progressing or has required active treatment within the past 5 years. Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, or carcinoma in situ (e.g., breast carcinoma, cervical cancer in situ) that have undergone potentially curative therapy are not excluded.\n8. Has severe hypersensitivity (≥ Grade 3) to study intervention and/or any of its excipients.\n9. Has an active autoimmune disease that has required systemic treatment in past 2 years\n10. Has a history of (non-infectious) pneumonitis/interstitial lung disease that requires steroids\n11. Has an active infection requiring systemic therapy.\n12. Has a known history of human immunodeficiency virus (HIV) infection or Hepatitis B or known active Hepatitis C virus infection."}, 'identificationModule': {'nctId': 'NCT04624204', 'briefTitle': 'Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Merck Sharp & Dohme LLC'}, 'officialTitle': 'A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib (MK-7339), Compared to Concurrent Chemoradiation Therapy Alone in Participants With Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC)', 'orgStudyIdInfo': {'id': '7339-013'}, 'secondaryIdInfos': [{'id': 'MK-7339-013', 'type': 'OTHER', 'domain': 'MSD Protocol Number'}, {'id': 'jRCT2031200296', 'type': 'REGISTRY', 'domain': 'jRCT'}, {'id': '2023-504959-27-00', 'type': 'REGISTRY', 'domain': 'EU CT'}, {'id': 'U1111-1290-4870', 'type': 'REGISTRY', 'domain': 'UTN'}, {'id': '2019-003616-31', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Group A - Pembrolizumab 200 mg', 'description': 'Participants will receive 4 cycles of standard-of-care chemotherapy (etoposide/platinum) plus pembrolizumab 200 mg every 3 weeks (Q3W) concurrently with standard thoracic radiotherapy, followed by 9 cycles of pembrolizumab 400 mg every 6 weeks (Q6W) plus olaparib matching placebo twice daily (BID) for 12 months or until specific discontinuation criteria are met.', 'interventionNames': ['Biological: Pembrolizumab 200 mg', 'Biological: Pembrolizumab 400 mg', 'Drug: Olaparib matching placebo', 'Drug: Etoposide 100 mg/m^2', "Drug: Platinum, investigator's choice", 'Radiation: Standard Thoracic Radiotherapy', 'Radiation: Prophylactic Cranial Irradiation (PCI)']}, {'type': 'EXPERIMENTAL', 'label': 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID', 'description': 'Participants will receive 4 cycles of standard-of-care chemotherapy (etoposide/platinum) plus pembrolizumab 200 mg Q3W concurrently with standard thoracic radiotherapy, followed by 9 cycles of pembrolizumab 400 mg Q6W plus olaparib 300 mg BID for 12 months or until specific discontinuation criteria are met.', 'interventionNames': ['Biological: Pembrolizumab 200 mg', 'Biological: Pembrolizumab 400 mg', 'Drug: Olaparib 300 mg BID', 'Drug: Etoposide 100 mg/m^2', "Drug: Platinum, investigator's choice", 'Radiation: Standard Thoracic Radiotherapy', 'Radiation: Prophylactic Cranial Irradiation (PCI)']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Group C (Pembrolizumab and Olaparib Matching Placebos)', 'description': 'Participants will receive 4 cycles of standard-of-care chemotherapy (etoposide/platinum) plus pembrolizumab placebo (saline) Q3W concurrently with standard thoracic radiotherapy, followed by 9 cycles of pembrolizumab placebo (saline) Q6W plus olaparib matching placebo for 12 months or until specific discontinuation criteria are met.', 'interventionNames': ['Drug: Pembrolizumab placebo (saline)', 'Drug: Olaparib matching placebo', 'Drug: Etoposide 100 mg/m^2', "Drug: Platinum, investigator's choice", 'Radiation: Standard Thoracic Radiotherapy', 'Radiation: Prophylactic Cranial Irradiation (PCI)']}], 'interventions': [{'name': 'Pembrolizumab 200 mg', 'type': 'BIOLOGICAL', 'otherNames': ['MK-3475', 'KEYTRUDA®'], 'description': 'Pembrolizumab 200 mg Q3W', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID']}, {'name': 'Pembrolizumab 400 mg', 'type': 'BIOLOGICAL', 'otherNames': ['MK-3475', 'KEYTRUDA®'], 'description': 'Pembrolizumab 400 mg Q6W', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID']}, {'name': 'Pembrolizumab placebo (saline)', 'type': 'DRUG', 'description': 'Pembrolizumab placebo (saline) Q3W', 'armGroupLabels': ['Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': 'Pembrolizumab placebo (saline)', 'type': 'DRUG', 'description': 'Pembrolizumab placebo (saline) Q6W', 'armGroupLabels': ['Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': 'Olaparib 300 mg BID', 'type': 'DRUG', 'otherNames': ['MK-7339', 'LYNPARZA®'], 'description': 'Olaparib 300 mg twice daily (BID)', 'armGroupLabels': ['Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID']}, {'name': 'Olaparib matching placebo', 'type': 'DRUG', 'description': 'Olaparib matching placebo BID', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': 'Etoposide 100 mg/m^2', 'type': 'DRUG', 'description': 'Etoposide 100 mg/m\\^2 intravenous (IV) Q3W, Day 1-3', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID', 'Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': "Platinum, investigator's choice", 'type': 'DRUG', 'description': 'Carboplatin titrated to an area under the plasma drug concentration time curve (AUC) of 5 mg/mL/min IV Q3W OR Cisplatin 75 mg/m\\^2 IV Q3W on Day 1 of each cycle', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID', 'Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': 'Standard Thoracic Radiotherapy', 'type': 'RADIATION', 'description': 'Standard Thoracic Radiotherapy', 'armGroupLabels': ['Group A - Pembrolizumab 200 mg', 'Group B - Pembrolizumab 200 mg plus Olaparib 300 mg BID', 'Group C (Pembrolizumab and Olaparib Matching Placebos)']}, {'name': 'Prophylactic Cranial Irradiation (PCI)', 'type': 'RADIATION', 'description': 'PCI will be strongly recommended for participants who achieve CR or PR after completion of chemoradiation treatment.', 'armGroupLabels': ['Group A - 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