Ignite Creation Date:
2025-12-24 @ 7:58 PM
Ignite Modification Date:
2025-12-25 @ 5:32 PM
Study NCT ID:
NCT01346904
Status:
UNKNOWN
Last Update Posted:
2011-05-03
First Post:
2011-05-02
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
a 3.0T Magnetic Resonance Imaging Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D005902', 'term': 'Glaucoma, Open-Angle'}], 'ancestors': [{'id': 'D005901', 'term': 'Glaucoma'}, {'id': 'D009798', 'term': 'Ocular Hypertension'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 200}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2011-05'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2011-05', 'completionDateStruct': {'date': '2012-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2011-05-02', 'studyFirstSubmitDate': '2011-05-02', 'studyFirstSubmitQcDate': '2011-05-02', 'lastUpdatePostDateStruct': {'date': '2011-05-03', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-05-03', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2012-12', 'type': 'ESTIMATED'}}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'conditions': ['Primary Open Angle Glaucoma']}, 'descriptionModule': {'briefSummary': 'Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'All subjects recruited from the Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Clinical ophthalmic assessments including measurement of visual acuities, intraocular pressure, slit-lamp microscopes and funduscopes examinations, cup-to-dick ratio (CDR) evaluation, visual field test \\[Octopus 101 Automated Perimeter, Haag-streit, Switzerland. Program G2\\], optical coherence tomography for retinal nerve fiber layer thickness(RNFLT) around the optic disk\\[Stratus OCT，Carl Zeiss Meditec, Dublin, CA .Scan Type :Fast RNFLT 3.4, Scan Length: 10.87mm\\].', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of \\>0.2)\n* matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )\n\nExclusion Criteria:\n\n* optic neuropathy\n* neurological disorder\n* other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.'}, 'identificationModule': {'nctId': 'NCT01346904', 'briefTitle': 'a 3.0T Magnetic Resonance Imaging Study', 'organization': {'class': 'OTHER', 'fullName': 'Huazhong University of Science and Technology'}, 'officialTitle': 'The Central Nerve System Injury in Patients With Primary Open Angle Glaucoma', 'orgStudyIdInfo': {'id': 'POAG3243'}}, 'contactsLocationsModule': {'overallOfficials': [{'name': 'HONG ZHANG, PHD', 'role': 'STUDY_CHAIR', 'affiliation': 'Tongji Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Huazhong University of Science and Technology', 'class': 'OTHER'}, 'collaborators': [{'name': 'Sun Yat-sen University', 'class': 'OTHER'}], 'responsibleParty': {'oldNameTitle': 'HONG ZHANG', 'oldOrganization': 'Department of Opthalmology ,Tongji Hospital'}}}}