Ignite Creation Date:
2025-12-24 @ 7:33 PM
Ignite Modification Date:
2025-12-29 @ 3:39 AM
Study NCT ID:
NCT04844203
Status:
RECRUITING
Last Update Posted:
2024-01-03
First Post:
2021-04-09
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Prevalence of Orthostatic Tremor in Patients With Unsteadiness
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D014202', 'term': 'Tremor'}], 'ancestors': [{'id': 'D020820', 'term': 'Dyskinesias'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 100}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2021-04-27', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-01', 'completionDateStruct': {'date': '2024-04', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-01-01', 'studyFirstSubmitDate': '2021-04-09', 'studyFirstSubmitQcDate': '2021-04-09', 'lastUpdatePostDateStruct': {'date': '2024-01-03', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2021-04-14', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Prevalence of orthostatic tremor (OT', 'timeFrame': 'Day 0', 'description': 'Prevalence of OT (95% confidence interval) in patients complaining of postural instability and referred for ENMG'}], 'secondaryOutcomes': [{'measure': 'Inflammatory Neuropathy Cause and Treatment (INCAT) Sensory Sum Score (ISS) simplified', 'timeFrame': 'Day 0', 'description': 'The ISS ranges from 0 (normal sensation) to 20 (most severe sensory deficit) and is composed of the summation of the following sensation evaluations : pinprick arm grade (range 0-4) ; vibration arm grade (range 0-4) ; pinprick leg grade (range 0-4); vibration leg grade (range 0-4): two-point discrimination grade (range 0-4)'}, {'measure': 'Medical Research Council (MRC) score', 'timeFrame': 'Day 0', 'description': 'The MRC score grades muscle power on a scale of 0 (no detectable contraction) to 5 (normal force, comparable to the healthy side)'}, {'measure': 'Overall Neuropathy Limitations Scale (ONLS) score', 'timeFrame': 'Day 0', 'description': 'The ONLS score is be completed by adding the total of the Arm disability scale score (0-5) and Leg disability scale score (0-7) yielding a total score of 0-12 (higher score indicates higher disability)'}, {'measure': 'Rasch-built Overall Disability Scale (R-ODS) score', 'timeFrame': 'Day 0', 'description': 'R-ODS scale comprising 24 items evaluates the ability to perform daily activities. The answers are rated on a scale of 0 to 48 (with 0 being very poor and 48 being best performance)'}, {'measure': 'OT frequency', 'timeFrame': 'Day 0', 'description': 'OT frequency in Hz'}, {'measure': 'Motor unit number index (MUNIX)', 'timeFrame': 'Day 0', 'description': 'MUNIX is a method for assessment of number of motor units using the compound muscle action potential (CMAP) and surface electromyographic interference pattern (SIP).'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Electroneuromyography', 'Polygraphy', 'Unsteadiness', 'Tremor', 'Anti-MAG neuropathy', 'Chronic demyelinating inflammatory neuropathy'], 'conditions': ['Orthostatic Tremor', 'Neuropathy']}, 'descriptionModule': {'briefSummary': 'Clinical presentation of orthostatic tremor (OT) may be misleading and simply perceived by a postural instability such as in several peripheral neuropathies. In addition, peripheral neuropathies represent the leading cause of pathologies associated with OT. Among patients referred for an electroneuromyogram (ENMG) for peripheral neuropathy and presenting with postural unsteadiness, OT assessment will be systematically performed. Demographic, clinical and polygraphy characteristics of these patients will be analyzed and prevalence of OT in the general population of peripheral neuropathies will be assessed.', 'detailedDescription': 'Among patients who will be referred for ENMG and exploration of a neuropathy, orthostatic tremor will be investigated systematically.\n\nMain objective and primary endpoint:\n\n* To estimate the prevalence of OT with its 95% confidence interval in the population of patients defined above\n* Presence of OT confirmed by surface EMG (polygraphy) in patients with standing instability referred for ENMG.\n\nSecondary objectives and end points\n\n* Determine the demographic, clinical, electrophysiological characteristics of patients with OT; Estimate the prevalence of peripheral neuropathy in patients with OT; Duration of symptoms; Correlation with quantitative neuropathy scores (ISS, MRC, ONLS, R-ODS)\n* Age, sex, clinical parameters: symptoms reported by the patient (instability, tremor, weakness, pain, falls), duration, current medications, ISS score, MRC score, ONLS score, R-ODS score) and electrophysiological parameters (mean frequency of OT in Hertz, MUNIX score (number of motor units in the anterior tibialis, calculated by software on the ENMG machine).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Any patient referred to the Clinical physiology Department for an ENMG (investigation of the neuropathy)', 'eligibilityCriteria': "Inclusion Criteria:\n\n* Age ≥ 18 years old\n* All patients complaining of instability when standing up and referred for an ENMG\n* Patient informed and having expressed his non-opposition to participating in the research\n\nExclusion Criteria:\n\n* Patient's refusal to participate in the study\n* Impossibility to stand\n* No affiliation to health insurance\n* Patients under a legal protection measure or unable to express their will\n* Patient under the State Medical Assistance (AME)\n* Patient under 18 years old\n* Pregnant women, parturients and breast-feeding mothers"}, 'identificationModule': {'nctId': 'NCT04844203', 'acronym': 'EMG-SOT', 'briefTitle': 'Prevalence of Orthostatic Tremor in Patients With Unsteadiness', 'organization': {'class': 'OTHER', 'fullName': 'Assistance Publique - Hôpitaux de Paris'}, 'officialTitle': 'Prevalence of Orthostatic Tremor by Surface Electromyographic Recording in Patients Reporting Unsteadiness', 'orgStudyIdInfo': {'id': 'APHP191089'}, 'secondaryIdInfos': [{'id': '2019-A02976-51', 'type': 'REGISTRY', 'domain': 'IDRCB'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Patients with unsteadiness', 'description': 'Patients with unsteadiness referred for an ENMG', 'interventionNames': ['Diagnostic Test: Polygraphy with surface electrodes']}], 'interventions': [{'name': 'Polygraphy with surface electrodes', 'type': 'DIAGNOSTIC_TEST', 'description': 'Patients referred for ENMG to the Clinical Physiology Department and complaining of postural unsteadiness will undergo a polygraphy recording using surface electrodes (Natus Medical Incorporated), performed at the end of ENMG', 'armGroupLabels': ['Patients with unsteadiness']}]}, 'contactsLocationsModule': {'locations': [{'zip': '75010', 'city': 'Paris', 'status': 'RECRUITING', 'country': 'France', 'contacts': [{'name': 'Nathalie KUBIS, MD, PhD', 'role': 'CONTACT', 'email': 'nathalie.kubis@aphp.fr', 'phone': '+33149958108'}, {'name': 'Pierre LOZERON, MD, PhD', 'role': 'CONTACT', 'email': 'pierre.lozeron@aphp.fr', 'phone': '+33149958076'}], 'facility': 'APHP Lariboisière Hospital, Clinical Physiology Department', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}], 'centralContacts': [{'name': 'Nathalie KUBIS, MD, PhD', 'role': 'CONTACT', 'email': 'nathalie.kubis@aphp.fr', 'phone': '+33149958108'}, {'name': 'Pierre LOZERON, MD, PhD', 'role': 'CONTACT', 'email': 'pierre.lozeron@aphp.fr', 'phone': '+33149958076'}], 'overallOfficials': [{'name': 'Nathalie KUBIS, MD, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'APHP, Lariboisière Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Assistance Publique - Hôpitaux de Paris', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}