Ignite Creation Date:
2025-12-24 @ 7:15 PM
Ignite Modification Date:
2025-12-25 @ 4:52 PM
Study NCT ID:
NCT03462303
Status:
COMPLETED
Last Update Posted:
2018-09-11
First Post:
2018-02-20
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Modulation of Cognitive Flexibility by Tyrosine Depletion and Transcranial Direct Current Stimulation
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2018-02-28', 'size': 57284, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_000.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2018-02-28T07:09', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'BASIC_SCIENCE', 'interventionModel': 'FACTORIAL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 36}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2018-02-12', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-09', 'completionDateStruct': {'date': '2018-06-30', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2018-09-10', 'studyFirstSubmitDate': '2018-02-20', 'studyFirstSubmitQcDate': '2018-03-08', 'lastUpdatePostDateStruct': {'date': '2018-09-11', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2018-03-12', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-06-30', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change in cognitive flexibility performance', 'timeFrame': 'Measured over 5 hours four times.1st measurement taken at baseline (i.e. time 0). 2nd measurement taken 120 minutes after measurement 1. 3rd measurement taken 220 minutes after measurement 1. 4th measurement taken 270 minutes after measurement 1.', 'description': 'Measured using Wisconsin Card Sorting Test'}, {'measure': 'Change in cognitive flexibility performance', 'timeFrame': 'Measured over 5 hours. 1st measurement taken at baseline (i.e. time 0). 2nd measurement taken 120 minutes after measurement 1. 3rd measurement taken 220 minutes after measurement 1. 4th measurement taken 270 minutes after measurement 1.', 'description': 'Measured using Probabilistic Reversal Learning'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Cognitive Flexibility']}, 'descriptionModule': {'briefSummary': 'The dorsolateral prefrontal cortex (dlPFC) and dopamine (DA) have been implicated in the control of cognitive flexibility. However, while a great deal of what it is know regarding a causative relationship between cognitive flexibility and its neuronal underpinning comes from animal studies, human data have largely been correlational (i.e. imaging investigations). In a recent study, the current research group examined whether putative increases in dopamine levels through tyrosine administration and blockage of these by cathodal (i.e. inhibitory) transcranial direct current stimulation (tDCS) of the dlPFC could be causally related to cognitive flexibility as measured by task switching and reversal learning.\n\nThe next step involves finding a way of lowering dopamine concentrations while anodal (i.e. excitatory) stimulation of the dlPFC is applied and cognitive flexibility measured. One experimental approach to reduce global DA synthesis and transmission is through acute phenylalanine and tyrosine depletion (APTD). This dietary intervention involves the administration of an amino-acid mixture lacking in tyrosine and phenylalanine, which can be used to selectively lower DA synthesis in humans.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '30 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Either male or female\n* You are aged between 18 and 30 years\n* You are in good health\n* You agree to fast overnight prior to testing\n\nExclusion Criteria:\n\n* Are suffering from cardiac, hepatic, renal, or neurological disorders\n* Damaged or diseased skin on your face and scalp, or a sensitive scalp\n* A history of alcohol or drug addiction, or severe psychiatric illness\n* Are in drug treatment which may lower seizure threshold (i.e. epilepsy)\n* You are pregnant\n* Slept less than 6 hours prior to coming to the lab\n* Suffer from phenylketonuria\n* A history of or current experience of migraine or headaches\n* A history of or current use of antidepressants\n* A history of or current use of tyrosine supplements\n* Consume more than five beverages containing caffeine per day'}, 'identificationModule': {'nctId': 'NCT03462303', 'briefTitle': 'Modulation of Cognitive Flexibility by Tyrosine Depletion and Transcranial Direct Current Stimulation', 'organization': {'class': 'OTHER', 'fullName': 'Sheffield Hallam University'}, 'officialTitle': 'Modulation of Cognitive Flexibility by Tyrosine Depletion and Transcranial Direct Current Stimulation', 'orgStudyIdInfo': {'id': 'SheffieldHallamAquili2018'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'tDCS sham + balanced drink', 'interventionNames': ['Combination Product: Sham tDCS and balanced drink']}, {'type': 'EXPERIMENTAL', 'label': 'tDCS sham + tyrosine depleted drink', 'interventionNames': ['Combination Product: Sham tDCS and tyrosine depleted drink']}, {'type': 'EXPERIMENTAL', 'label': 'tDCS anodal + balanced drink', 'interventionNames': ['Combination Product: Anodal tDCS and balanced drink']}, {'type': 'EXPERIMENTAL', 'label': 'tDCS anodal +tyrosine depleted drink', 'interventionNames': ['Combination Product: Anodal tDCS and tyrosine depleted drink']}], 'interventions': [{'name': 'Sham tDCS and tyrosine depleted drink', 'type': 'COMBINATION_PRODUCT', 'description': 'Transcranial direct current stimulation (sham) of the dlPFC in combination with a tyrosine and phenylalanine free product.', 'armGroupLabels': ['tDCS sham + tyrosine depleted drink']}, {'name': 'Anodal tDCS and tyrosine depleted drink', 'type': 'COMBINATION_PRODUCT', 'description': 'Transcranial direct current stimulation (anodal) of the dlPFC in combination with a tyrosine and phenylalanine free product.', 'armGroupLabels': ['tDCS anodal +tyrosine depleted drink']}, {'name': 'Sham tDCS and balanced drink', 'type': 'COMBINATION_PRODUCT', 'description': 'Transcranial direct current stimulation (sham) of the dlPFC in combination with a drink containing both tyrosine and phenylalanine.', 'armGroupLabels': ['tDCS sham + balanced drink']}, {'name': 'Anodal tDCS and balanced drink', 'type': 'COMBINATION_PRODUCT', 'description': 'Transcranial direct current stimulation (anodal) of the dlPFC in combination with a drink containing both tyrosine and phenylalanine.', 'armGroupLabels': ['tDCS anodal + balanced drink']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'S10 2BQ', 'city': 'Sheffield', 'state': 'South Yorkshire', 'country': 'United Kingdom', 'facility': 'Department of Psychology labs', 'geoPoint': {'lat': 53.38297, 'lon': -1.4659}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Sheffield Hallam University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}