Ignite Creation Date:
2025-12-24 @ 7:13 PM
Ignite Modification Date:
2025-12-30 @ 3:29 PM
Study NCT ID:
NCT00745303
Status:
COMPLETED
Last Update Posted:
2008-09-03
First Post:
2008-09-01
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': 'Blood sample obtained from each subject was withdrawn for the quantitative measurements of total cholesterol (TC), high-density lipoprotein--cholesterol (HDL-C), high-density lipoprotein--cholesterol (LDL-C), triglyceride (TG), fasting blood sugar (FBS), and uric acid (UA). The immunoenzymometric assays for the quantitative measurement of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the serum were also performed on the blood sample from each subject.'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 50}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2002-05'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-09', 'completionDateStruct': {'date': '2004-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2008-09-01', 'studyFirstSubmitDate': '2008-09-01', 'studyFirstSubmitQcDate': '2008-09-01', 'lastUpdatePostDateStruct': {'date': '2008-09-03', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2008-09-03', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2003-05', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'TCC training for 3 months can improve the pulmonary function, glucose availability and lipid profile, and increase the cytokines production and vagal modulation in aged subjects.', 'timeFrame': '3 months'}], 'secondaryOutcomes': [{'measure': 'Other effects of TCC observed', 'timeFrame': '3 months'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Tai Chi Chuan; Lipid; Cytokine'], 'conditions': ['Healthy Subjects']}, 'referencesModule': {'references': [{'pmid': '14652490', 'type': 'RESULT', 'citation': 'Lu WA, Kuo CD. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc. 2003 Dec;35(12):1972-6. doi: 10.1249/01.MSS.0000099242.10669.F7.'}]}, 'descriptionModule': {'briefSummary': 'Since Tai Chi Chuan (TCC) training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects.', 'detailedDescription': 'Tai Chi Chuan (TCC) is a traditional Oriental conditioning exercise or calisthenics that is believed by many people around the world to be good for the health. The frequently claimed reason for this merit of TCC is that it can improve the cardiopulmonary function and immunity of the subject who practice it continuously. TCC has been shown to delay the decline of aerobic power, improve the cardiopulmonary function, balance and strength of the subjects. One study has demonstrated that TCC could reduce tension, anxiety, and mood disturbance. However, few studies have examined the effect of TCC on the blood lipid profile and immunity of the TCC practitioners. Another study reported that 12-week programme of regular TCC exercise enhanced functional mobility, personal health expectations, and regulatory T cell function. It has also been shown that an appropriate combination of TCC exercise program with diabetic medication might improve both glucose metabolism and immunity in type 2 diabetic patients. Since TCC training has been shown to be beneficial to the cardiopulmonary function of the subject, TCC may also have an effect on the blood lipid profile and immunity of the subjects. We hypothesize that TCC might have a beneficial effect on the pulmonary function, autonomic nervous modulation, lipid profile, and cytokines production in the aged subjects. Thus, the aim of this study was to examine whether or not TCC have these effects in the aged subjects.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '50 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Healthy aged subjects', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* All subjects included in this study had normal lifestyles, and were capable of daily activities without limitations.\n\nExclusion Criteria:\n\n* Subjects who had major cardiopulmonary disease or were on regular medicine for diabetes mellitus, hypertension, renal or liver disease were not included in the study.'}, 'identificationModule': {'nctId': 'NCT00745303', 'briefTitle': 'Effect of Tai Chi Chuan on Autonomic Nervous Modulation in Aged Subjects', 'organization': {'class': 'OTHER_GOV', 'fullName': 'Taipei Veterans General Hospital, Taiwan'}, 'officialTitle': 'Effect of Tai Chi Chuan on Autonomic Nervous Modulation, Blood Lipid and Cytokines Production in Aged Subjects', 'orgStudyIdInfo': {'id': 'VGH91-365-1'}}, 'armsInterventionsModule': {'armGroups': [{'label': '1', 'description': 'Subjects in this group received TCC training for 3 months', 'interventionNames': ['Procedure: Tai Chi Cuan']}, {'label': '2', 'description': 'Subjects in this group received no TCC training within 3 months'}], 'interventions': [{'name': 'Tai Chi Cuan', 'type': 'PROCEDURE', 'otherNames': ["Yang's Tai Chi Cuan"], 'description': 'Tai Chi Cuan training for 3 months', 'armGroupLabels': ['1']}]}, 'contactsLocationsModule': {'locations': [{'zip': '112', 'city': 'Taipei', 'country': 'Taiwan', 'facility': 'Taipei Veterans General Hospital', 'geoPoint': {'lat': 25.05306, 'lon': 121.52639}}], 'overallOfficials': [{'name': 'Cheng-Deng Kuo, MD,PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Taipei Veterans General Hospital, Taiwan'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Taipei Veterans General Hospital, Taiwan', 'class': 'OTHER_GOV'}, 'collaborators': [{'name': 'National Science and Technology Council, Taiwan', 'class': 'OTHER_GOV'}], 'responsibleParty': {'oldNameTitle': 'Cho-yu Chan, MD', 'oldOrganization': 'Taipei Veterans General Hospital'}}}}