Ignite Creation Date:
2025-12-24 @ 6:50 PM
Ignite Modification Date:
2026-01-01 @ 10:38 PM
Study NCT ID:
NCT01652157
Status:
TERMINATED
Last Update Posted:
2021-03-22
First Post:
2012-07-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Long-term Study in US Cystic Fibrosis Patients Receiving Digestive Enzyme Supplements to Assess Narrowing of the Large Intestine Causing Adverse Intestinal Symptoms (Fibrosing Colonopathy)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010188', 'term': 'Exocrine Pancreatic Insufficiency'}], 'ancestors': [{'id': 'D010182', 'term': 'Pancreatic Diseases'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D020799', 'term': 'Pancrelipase'}], 'ancestors': [{'id': 'D008049', 'term': 'Lipase'}, {'id': 'D002265', 'term': 'Carboxylic Ester Hydrolases'}, {'id': 'D004950', 'term': 'Esterases'}, {'id': 'D006867', 'term': 'Hydrolases'}, {'id': 'D004798', 'term': 'Enzymes'}, {'id': 'D045762', 'term': 'Enzymes and Coenzymes'}, {'id': 'D010184', 'term': 'Pancreatic Extracts'}, {'id': 'D014020', 'term': 'Tissue Extracts'}, {'id': 'D045424', 'term': 'Complex Mixtures'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 17}}, 'statusModule': {'whyStopped': 'Strategic considerations', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2012-07-31', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2021-03', 'completionDateStruct': {'date': '2020-04-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2021-03-18', 'studyFirstSubmitDate': '2012-07-25', 'studyFirstSubmitQcDate': '2012-07-25', 'lastUpdatePostDateStruct': {'date': '2021-03-22', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2012-07-27', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2020-04-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving ZENPEP', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving ULTRESA', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving PERTZYE.', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving CREON', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving PANCREAZE', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients not receiving pancreatic enzyme therapy.', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}, {'measure': 'Incidence rate of fibrosing colonopathy confirmed by an independent adjudication panel in patients receiving non-sponsor pancreatic enzyme replacement therapy', 'timeFrame': 'up to 10 years', 'description': 'Fibrosing colonopathy is confirmed by an independent adjudication panel based on prospectively defined criteria.'}], 'secondaryOutcomes': [{'measure': 'Odds ratio (95% confidence interval) to quantify the association between possible risk factors and confirmed fibrosing colonopathy', 'timeFrame': 'up to 10 years', 'description': 'Potential risk factors include demographics, medical history, and concurrent medications, including daily dosage and length of specific pancreatic enzyme replacement therapy.'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['prospective', 'observational', 'pancreatic insufficiency', 'pancreatic enzyme replacement therapy', 'fibrosing colonopathy', 'patients with cystic fibrosis'], 'conditions': ['Fibrosing Colonopathy']}, 'referencesModule': {'references': [{'pmid': '37880023', 'type': 'DERIVED', 'citation': 'Chiuve SE, Fife D, Leitz G, Peterson C, Campbell NM, Rennig A, Rodrigues L Jr, Decktor D, Dowd C, Marshall BC, Borowitz D. Incidence of fibrosing colonopathy with pancreatic enzyme replacement therapy in patients with cystic fibrosis. J Cyst Fibros. 2023 Nov;22(6):1017-1023. doi: 10.1016/j.jcf.2023.08.013. Epub 2023 Oct 23.'}]}, 'descriptionModule': {'briefSummary': 'This is a long-term study in cystic fibrosis patients who are participating in the Cystic Fibrosis Patient Registry to assess the occurrence and risk factors for a rare bowel disorder called fibrosing colonopathy (narrowing of the large intestine). Patients will be followed at their regular clinical care visits over a 10-year period and approached if they develop symptoms of fibrosing colonopathy for collection and use of further detailed information.', 'detailedDescription': 'This is a prospective, observational, population-based cohort study in US cystic fibrosis patients participating in the Cystic Fibrosis Patient Registry in order to assess the incidence of and risk factors for fibrosing colonopathy. Cystic fibrosis (CF) patients participating in the registry from participating sites, as well as new CF patients enrolled in the registry at these sites over a 2-year period, will serve as the base study population (estimated to include 24,500-25,000 cystic fibrosis patients between the first patient encounter documented in the registry from any participating site and the 31st of July 2014). Cystic fibrosis patients in the base study population will be followed at their regular clinical care visits and, any patients presenting over a 10-year period with signs and symptoms of suspected fibrosing colonopathy, based on a prospective definition, will be approached to obtain a study-specific informed consent for collection of additional data outside the standard registry data collection form in order to augment surveillance. Data routinely collected via the standard CF registry will be used to determine exposure to any specific pancreatic enzyme replacement therapy and to assess potential risk factors for the outcome of confirmed fibrosing colonopathy. An independent adjudication panel will be utilized to validate the diagnosis of fibrosing colonopathy based on a prospective case definition as well as decision rules.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'maximumAge': '99 Years', 'minimumAge': '0 Months', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Cystic fibrosis patients who are active in the Cystic Fibrosis Patient Registry', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\nThe inclusion criteria for enrollment in the Base Study Population\n\n* Diagnosed with cystic fibrosis,\n* Enrolled in the Cystic Fibrosis Patient Registry\n* Receiving medical care at a Cystic Fibrosis Foundation-accredited care center providing data to the Cystic Fibrosis Patient Registry\n\nExclusion Criteria:\n\n* None'}, 'identificationModule': {'nctId': 'NCT01652157', 'briefTitle': 'Long-term Study in US Cystic Fibrosis Patients Receiving Digestive Enzyme Supplements to Assess Narrowing of the Large Intestine Causing Adverse Intestinal Symptoms (Fibrosing Colonopathy)', 'organization': {'class': 'INDUSTRY', 'fullName': 'AbbVie'}, 'officialTitle': 'A Long-Term Prospective Observational Safety Study of the Incidence of and Risk Factors for Fibrosing Colonopathy in US Patients With Cystic Fibrosis Treated With Pancreatic Enzyme Replacement Therapy: A Harmonized Protocol Across Sponsors(The CF-FC Study)', 'orgStudyIdInfo': {'id': 'CFFC-OB-11'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Cystic fibrosis (CF) patients in the CF Patient Registry', 'description': 'Patients diagnosed with cystic fibrosis at participating sites who are providing data to the Cystic Fibrosis Patient Registry', 'interventionNames': ['Biological: ULTRESA', 'Biological: PANCREAZE', 'Biological: CREON', 'Biological: ZENPEP', 'Biological: other non-sponsor pancreatic enzyme replacement therapy', 'Biological: PERTZYE', 'Other: No pancreatic enzyme replacement therapy']}], 'interventions': [{'name': 'ULTRESA', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'PANCREAZE', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'CREON', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'ZENPEP', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'other non-sponsor pancreatic enzyme replacement therapy', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'PERTZYE', 'type': 'BIOLOGICAL', 'otherNames': ['pancrelipase'], 'description': 'pancreatic enzyme replacement therapy', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}, {'name': 'No pancreatic enzyme replacement therapy', 'type': 'OTHER', 'description': 'Cystic fibrosis patients in the cystic fibrosis registry not receiving any pancreatic enzyme replacement therapy (approximately 10%)', 'armGroupLabels': ['Cystic fibrosis (CF) patients in the CF Patient Registry']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': "Children's Hospital of Alabama /ID# 78920", 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '99508', 'city': 'Anchorage', 'state': 'Alaska', 'country': 'United States', 'facility': 'Alaska Medical Center /ID# 79256', 'geoPoint': {'lat': 61.21806, 'lon': -149.90028}}, {'zip': '85016-7710', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': "Phoenix Children's Hospital /ID# 78906", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85719-1478', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'University of Arizona Cancer Center - North Campus /ID# 78939', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '72202', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': "Arkansas Children's Hospital /ID# 79265", 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'University of Arkansas for Medical Sciences /ID# 76785', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '92093', 'city': 'La Jolla', 'state': 'California', 'country': 'United States', 'facility': 'Ucsd /Id# 105039', 'geoPoint': {'lat': 32.84727, 'lon': -117.2742}}, {'zip': '92354', 'city': 'Loma Linda', 'state': 'California', 'country': 'United States', 'facility': 'Loma Linda University /ID# 79237', 'geoPoint': {'lat': 34.04835, 'lon': -117.26115}}, {'zip': '90806', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'facility': 'Miller Childrens Hospital /ID# 78896', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90027', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Kaiser Permanente Regional Met /ID# 79235', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Usc /Id# 76793', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94609', 'city': 'Oakland', 'state': 'California', 'country': 'United States', 'facility': "Children's Hosp and Res Ctr /ID# 79295", 'geoPoint': {'lat': 37.80437, 'lon': -122.2708}}, {'zip': '94611', 'city': 'Oakland', 'state': 'California', 'country': 'United States', 'facility': 'Kaiser Permanente /ID# 78899', 'geoPoint': {'lat': 37.80437, 'lon': -122.2708}}, {'zip': '95817', 'city': 'Sacramento', 'state': 'California', 'country': 'United States', 'facility': 'UC Davis Comprehensive Cancer Center - Main /ID# 118935', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '94115', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'California Pacific Medical Ctr /ID# 76775', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94143-2204', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'Univ California, San Francisco /ID# 78925', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '94305', 'city': 'Stanford', 'state': 'California', 'country': 'United States', 'facility': 'Stanford University /ID# 95156', 'geoPoint': {'lat': 37.42411, 'lon': -122.16608}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'country': 'United States', 'facility': 'Univ of Colorado Cancer Center /ID# 79277', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80206', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'National Jewish Health /ID# 76784', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '06106', 'city': 'Hartford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'CT Childrens Medical Ctr, US /ID# 78923', 'geoPoint': {'lat': 41.76371, 'lon': -72.68509}}, {'zip': '06510', 'city': 'New Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Yale University /ID# 78940', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '19803', 'city': 'Wilmington', 'state': 'Delaware', 'country': 'United States', 'facility': 'Nemours/Alfred duPont Hospital for Children /ID# 78945', 'geoPoint': {'lat': 39.74595, 'lon': -75.54659}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': "Children's National Medical Center /ID# 79373", 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '32701', 'city': 'Altamonte Springs', 'state': 'Florida', 'country': 'United States', 'facility': 'Central FL Pulmonary Altamonte /ID# 76776', 'geoPoint': {'lat': 28.66111, 'lon': -81.36562}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Florida - Archer /ID# 76790', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Florida - Archer /ID# 78928', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33021-5402', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': "Joe DiMaggio Children's Hospital at Memorial /ID# 79234", 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '32207', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Nemour Child Clin FL, US /ID# 78898', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33136', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Miami, Miller School of Medicine /ID# 78927', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32801', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': "Nemours Children's Clinic /ID# 78917", 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Arnold Palmer Hosp Children /ID# 96075', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33701', 'city': 'St. Petersburg', 'state': 'Florida', 'country': 'United States', 'facility': "All Children's Hospital /ID# 79264", 'geoPoint': {'lat': 27.77086, 'lon': -82.67927}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University Hospital /ID# 79394', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342-1605', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': "Children's Healthcare of Atlanta - Ferry Rd /ID# 116275", 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30912', 'city': 'Augusta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Georgia Regents University /ID# 79395', 'geoPoint': {'lat': 33.47097, 'lon': -81.97484}}, {'zip': '83702', 'city': 'Boise', 'state': 'Idaho', 'country': 'United States', 'facility': "St Luke's Cystic Fibrosis Center of Idaho /ID# 79259", 'geoPoint': {'lat': 43.6135, 'lon': -116.20345}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'Duplicate_Childrens Hospital of Chicago /ID# 79296', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60637-1443', 'city': 'Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'University of Chicago /ID# 78924', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60153', 'city': 'Maywood', 'state': 'Illinois', 'country': 'United States', 'facility': 'Loyola University Medical Ctr /ID# 76780', 'geoPoint': {'lat': 41.8792, 'lon': -87.84312}}, {'zip': '60068', 'city': 'Park Ridge', 'state': 'Illinois', 'country': 'United States', 'facility': 'Advocate Lutheran Gen Children /ID# 76781', 'geoPoint': {'lat': 42.01114, 'lon': -87.84062}}, {'zip': '61603', 'city': 'Peoria', 'state': 'Illinois', 'country': 'United States', 'facility': 'OSF Saint Francis Medical Ctr /ID# 78905', 'geoPoint': {'lat': 40.69365, 'lon': -89.58899}}, {'zip': '46804', 'city': 'Fort Wayne', 'state': 'Indiana', 'country': 'United States', 'facility': 'Lutheran Hospital of Indiana /ID# 79238', 'geoPoint': {'lat': 41.1306, 'lon': -85.12886}}, {'zip': '46202', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Indiana University /ID# 121395', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '46202', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Indiana University /ID# 78903', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'country': 'United States', 'facility': 'University of Iowa Hospitals and Clinics /ID# 78921', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '66160-8500', 'city': 'Kansas City', 'state': 'Kansas', 'country': 'United States', 'facility': 'University of Kansas Health Sy /ID# 78929', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '67214', 'city': 'Wichita', 'state': 'Kansas', 'country': 'United States', 'facility': 'Via Christi Specialty Clinics /ID# 78946', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '40506', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Kentucky Clinic /ID# 78922', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'University of Louisville /ID# 78926', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '70112', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Tulane Univ /ID# 78916', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '71130', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Louisiana State Univ HSC /ID# 78943', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '04102', 'city': 'Portland', 'state': 'Maine', 'country': 'United States', 'facility': "MMP Women's Health /ID# 78894", 'geoPoint': {'lat': 43.65737, 'lon': -70.2589}}, {'zip': '21287', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'Johns Hopkins University /ID# 78893', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02111', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Tufts-New England Medical Ctr /ID# 79254', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Massachusetts General Hospital /ID# 78895', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02115', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Boston Childrens Hospital /ID# 79276', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '01199', 'city': 'Springfield', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Baystate Medical Center /ID# 103437', 'geoPoint': {'lat': 42.10148, 'lon': -72.58981}}, {'zip': '01655', 'city': 'Worcester', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'UMass Memorial Medical Center /ID# 78954', 'geoPoint': {'lat': 42.26259, 'lon': -71.80229}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'University of Michigan Hospitals /ID# 99035', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '48201', 'city': 'Detroit', 'state': 'Michigan', 'country': 'United States', 'facility': "Children's Hospital of MI /ID# 79278", 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '48824', 'city': 'East Lansing', 'state': 'Michigan', 'country': 'United States', 'facility': 'Michigan State University /ID# 78950', 'geoPoint': {'lat': 42.73698, 'lon': -84.48387}}, {'zip': '49503', 'city': 'Grand Rapids', 'state': 'Michigan', 'country': 'United States', 'facility': 'Helen DeVos Childrens Hospital /ID# 79397', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '55455-0356', 'city': 'Minneapolis', 'state': 'Minnesota', 'country': 'United States', 'facility': 'University of Minnesota /ID# 76791', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '39216-4643', 'city': 'Jackson', 'state': 'Mississippi', 'country': 'United States', 'facility': 'Univ of Mississippi Med Ctr,US /ID# 78934', 'geoPoint': {'lat': 32.29876, 'lon': -90.18481}}, {'zip': '65212', 'city': 'Columbia', 'state': 'Missouri', 'country': 'United States', 'facility': 'University of Missouri /ID# 109755', 'geoPoint': {'lat': 38.95171, 'lon': -92.33407}}, {'zip': '64108', 'city': 'Kansas City', 'state': 'Missouri', 'country': 'United States', 'facility': "The Children's Mercy Hospital /ID# 78948", 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '63104', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': "Cardinal Glennon Children's Ho /ID# 79275", 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '63110', 'city': 'St Louis', 'state': 'Missouri', 'country': 'United States', 'facility': "Children's Hospital St Louis /ID# 78910", 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '68198', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Univ Nebraska Med Ctr /ID# 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