Ignite Creation Date:
2025-12-24 @ 6:46 PM
Ignite Modification Date:
2025-12-25 @ 4:18 PM
Study NCT ID:
NCT05353257
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-01-28
First Post:
2022-04-25
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D055752', 'term': 'Small Cell Lung Carcinoma'}], 'ancestors': [{'id': 'D002283', 'term': 'Carcinoma, Bronchogenic'}, {'id': 'D001984', 'term': 'Bronchial Neoplasms'}, {'id': 'D008175', 'term': 'Lung Neoplasms'}, {'id': 'D012142', 'term': 'Respiratory Tract Neoplasms'}, {'id': 'D013899', 'term': 'Thoracic Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D016190', 'term': 'Carboplatin'}, {'id': 'C075609', 'term': 'PE regimen'}], 'ancestors': [{'id': 'D056831', 'term': 'Coordination Complexes'}, {'id': 'D009930', 'term': 'Organic Chemicals'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 511}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2022-05-17', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-01', 'completionDateStruct': {'date': '2026-12-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-23', 'studyFirstSubmitDate': '2022-04-25', 'studyFirstSubmitQcDate': '2022-04-25', 'lastUpdatePostDateStruct': {'date': '2025-01-28', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-04-29', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-07-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall survival(OS', 'timeFrame': 'up to 36 months', 'description': 'the time from randomization to death due to any cause'}], 'secondaryOutcomes': [{'measure': 'Progression-free survival', 'timeFrame': 'up to approximately 24months', 'description': 'PFS, assessed by the investigator as per RECIST v1.1'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Limited-Stage Small Cell Lung Cancer', 'Serplulimab'], 'conditions': ['Limited-Stage Small Cell Lung Cancer']}, 'descriptionModule': {'briefSummary': 'This study is a randomized, double-blind, multicenter, phase III clinical study to compare the clinical efficacy and safety of Serplulimab + chemotherapy+ concurrent radiotherapy vs chemotherapy+ concurrent radiotherapy in subjects with Limited-Stage Small Cell Lung Cancer.', 'detailedDescription': 'Eligible subjects in this study will be randomized to Arm A or Arm B at 1:1 ratio.\n\nArm A (Serplulimab arm): Serplulimab + chemotherapy(Carboplatin/Cisplatin-Etoposide)+concurrent radiotherapy; Arm B (placebo arm): Placebo + chemotherapy(Carboplatin/Cisplatin-Etoposide)+concurrent radiotherapy; The 4 stratification factors for randomization include: ECOG PS (0 or 1), staging (I/II or III), radiation fraction (bid or qd), and region (Asia or non-Asia).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Male or female, aged ≥18 years when signing the ICF.\n2. Histologically diagnosed with SCLC.\n3. Diagnosed with LS-SCLC (stage Ⅰ-Ⅲ of the AJCC 8th edition of the cancer staging), which can be safely treated with curative radiation doses.\n4. Major organs are functioning well.\n\nExclusion Criteria:\n\n1. Histologically or cytologically confirmed mixed SCLC.\n2. Subjects suitable for surgery. Subjects who are suitable for surgery but refuse surgical treatment can be included.\n3. Patients who have previously received systematic anti-tumor treatments for small cell lung cancer, including but not limited to radiotherapy, chemotherapy, and immunotherapy.\n4. Patients with other active malignancies within 5 years or at the same time.\n5. Subjects with known history of severe allergy to any monoclonal antibody.\n6. Subjects with known anaphylaxis to carboplatin/cisplatin or etoposide.\n7. In the judgment of the investigator, subjects who have any other factors that may lead to a premature discontinuation.'}, 'identificationModule': {'nctId': 'NCT05353257', 'briefTitle': 'A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer', 'organization': {'class': 'INDUSTRY', 'fullName': 'Shanghai Henlius Biotech'}, 'officialTitle': 'A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of Serplulimab or Placebo in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer', 'orgStudyIdInfo': {'id': 'HLX10-020-SCLC302'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Serplulimab + carboplatin/cisplatin-etoposide + radiotherapy', 'description': 'Participants will receive 4 cycles of standard-of-care chemotherapy (carboplatin/cisplatin-etoposide) plus Serplulimab 300 mg every 3 weeks (Q3W) concurrently with standard thoracic radiotherapy, with maximum 1 year after completion of cCRT or until disease progression, intolerable toxicity or other reasons specified in the protocol, whichever occurs first.', 'interventionNames': ['Drug: HLX10', 'Drug: carboplatin/cisplatin-etoposide', 'Radiation: Thoracic radiotherapy', 'Radiation: Prophylactic Cranial Irradiation (PCI)']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'placebo + carboplatin/cisplatin-etoposide + radiotherapy', 'description': 'Participants will receive 4 cycles of standard-of-care chemotherapy (carboplatin/cisplatin-etoposide) plus placebo every 3 weeks (Q3W) concurrently with standard thoracic radiotherapy, with maximum 1 year after completion of cCRT or until disease progression, intolerable toxicity or other reasons specified in the protocol, whichever occurs first.', 'interventionNames': ['Drug: carboplatin/cisplatin-etoposide', 'Radiation: Thoracic radiotherapy', 'Drug: Placebo', 'Radiation: Prophylactic Cranial Irradiation (PCI)']}], 'interventions': [{'name': 'HLX10', 'type': 'DRUG', 'otherNames': ['Serplulimab'], 'description': 'Serplulimab is an innovative monoclonal antibody targeting PD-1，developed by Shanghai Henlius Biotech, Inc.\n\n300mg Q3W', 'armGroupLabels': ['Serplulimab + carboplatin/cisplatin-etoposide + radiotherapy']}, {'name': 'carboplatin/cisplatin-etoposide', 'type': 'DRUG', 'description': "Etoposide: 100 mg/m2, IV, on Days 1, 2, and 3 of each cycle. Carboplatin: AUC = 5, IV, on Day 1 of each cycle up to a dose of 750 mg. investigator's choice.\n\nCisplatin: 75mg/m2, IV, on Days 1 of each cycle. investigator's choice.", 'armGroupLabels': ['Serplulimab + carboplatin/cisplatin-etoposide + radiotherapy', 'placebo + carboplatin/cisplatin-etoposide + radiotherapy']}, {'name': 'Thoracic radiotherapy', 'type': 'RADIATION', 'description': 'Standard Thoracic Radiotherapy', 'armGroupLabels': ['Serplulimab + carboplatin/cisplatin-etoposide + radiotherapy', 'placebo + carboplatin/cisplatin-etoposide + radiotherapy']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo Q3W', 'armGroupLabels': ['placebo + carboplatin/cisplatin-etoposide + radiotherapy']}, {'name': 'Prophylactic Cranial Irradiation (PCI)', 'type': 'RADIATION', 'description': 'PCI will be strongly recommended for participants who achieve CR or PR after completion of chemoradiation treatment.', 'armGroupLabels': ['Serplulimab + carboplatin/cisplatin-etoposide + radiotherapy', 'placebo + carboplatin/cisplatin-etoposide + radiotherapy']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91007', 'city': 'Arcadia', 'state': 'California', 'country': 'United States', 'facility': 'OPN-Glendale', 'geoPoint': {'lat': 34.13973, 'lon': -118.03534}}, {'zip': '90720', 'city': 'Los Alamitos', 'state': 'California', 'country': 'United States', 'facility': 'OPN-Los Alamitos', 'geoPoint': {'lat': 33.80307, 'lon': -118.07256}}, {'zip': '90034', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Southern California Permanente Group', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92373', 'city': 'Redlands', 'state': 'California', 'country': 'United States', 'facility': 'Emad Ibrahim, MD, Inc', 'geoPoint': {'lat': 34.05557, 'lon': -117.18254}}, {'zip': '95403', 'city': 'Santa Rosa', 'state': 'California', 'country': 'United States', 'facility': 'Providence Medical Foundation', 'geoPoint': {'lat': 38.44047, 'lon': -122.71443}}, {'zip': '80401', 'city': 'Golden', 'state': 'Colorado', 'country': 'United States', 'facility': 'Lutheran Medical Center - Cancer Centers of Colorado', 'geoPoint': {'lat': 39.75554, 'lon': -105.2211}}, {'zip': '06360', 'city': 'Norwich', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Eastern Connecticut Hematology & Oncology Associates', 'geoPoint': {'lat': 41.52426, 'lon': -72.07591}}, {'zip': '32257', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Cancer Specialists of North Florida', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32763', 'city': 'Orange City', 'state': 'Florida', 'country': 'United States', 'facility': 'Mid Florida Hematology and Oncology Center', 'geoPoint': {'lat': 28.94888, 'lon': -81.29867}}, {'zip': '32804', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Advent Health Orlando', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '33064', 'city': 'Pompano Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Napa Research', 'geoPoint': {'lat': 26.23786, 'lon': -80.12477}}, {'zip': '66205', 'city': 'Fairway', 'state': 'Kansas', 'country': 'United States', 'facility': 'Kansas University Mediacal Center', 'geoPoint': {'lat': 39.02223, 'lon': -94.6319}}, {'zip': '70433', 'city': 'Covington', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Pontchartrain Cancer Center', 'geoPoint': {'lat': 30.47549, 'lon': -90.10042}}, {'zip': '70112', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Tulane University', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '55425', 'city': 'Bloomington', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Health Partners', 'geoPoint': {'lat': 44.8408, 'lon': -93.29828}}, {'zip': '89502', 'city': 'Reno', 'state': 'Nevada', 'country': 'United States', 'facility': 'Renown Health', 'geoPoint': {'lat': 39.52963, 'lon': -119.8138}}, {'zip': '03756', 'city': 'Lebanon', 'state': 'New Hampshire', 'country': 'United States', 'facility': 'Dartmouth Hitchcock Medical Center', 'geoPoint': {'lat': 43.64229, 'lon': -72.25176}}, {'zip': '11373', 'city': 'Elmhurst', 'state': 'New York', 'country': 'United States', 'facility': 'New York City Health+HospitalsCorporation Elmhurst Hospital Center', 'geoPoint': {'lat': 40.73649, 'lon': -73.87791}}, {'zip': '11040', 'city': 'Queens', 'state': 'New York', 'country': 'United States', 'facility': 'Northwell Health', 'geoPoint': {'lat': 40.68149, 'lon': -73.83652}}, {'zip': '10467', 'city': 'The Bronx', 'state': 'New York', 'country': 'United States', 'facility': 'Montefiore Medical Center', 'geoPoint': {'lat': 40.84985, 'lon': -73.86641}}, {'zip': '44708', 'city': 'Canton', 'state': 'Ohio', 'country': 'United States', 'facility': 'Cleveland Clinic Mercy Hospital', 'geoPoint': {'lat': 40.79895, 'lon': -81.37845}}, {'zip': '44718', 'city': 'Canton', 'state': 'Ohio', 'country': 'United States', 'facility': 'Gabrail Cancer Center', 'geoPoint': {'lat': 40.79895, 'lon': -81.37845}}, {'zip': '44646', 'city': 'Massillon', 'state': 'Ohio', 'country': 'United States', 'facility': 'Tricounty Hematology and Oncology Associates', 'geoPoint': {'lat': 40.79672, 'lon': -81.52151}}, {'zip': '97229', 'city': 'Portland', 'state': 'Oregon', 'country': 'United States', 'facility': 'Kaiser Permanente Northwest', 'geoPoint': {'lat': 45.52345, 'lon': -122.67621}}, {'zip': '76104', 'city': 'Fort Worth', 'state': 'Texas', 'country': 'United States', 'facility': 'The Center for Cancer and Blood Disorders', 'geoPoint': {'lat': 32.72541, 'lon': -97.32085}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'The University of Texas MD Anderson Cancer Center', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77090', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Millennium Research & Clinical Development', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77339', 'city': 'Kingwood', 'state': 'Texas', 'country': 'United States', 'facility': 'Pro Research Tools, INC DBA Lumi Research', 'geoPoint': {'lat': 30.05691, 'lon': -95.18349}}, {'zip': '75701', 'city': 'Tyler', 'state': 'Texas', 'country': 'United States', 'facility': 'The University of Texas - Hope Cancer Center', 'geoPoint': {'lat': 32.35126, 'lon': -95.30106}}, {'zip': '22031', 'city': 'Fairfax', 'state': 'Virginia', 'country': 'United States', 'facility': 'Innova Schar Cancer Insitute', 'geoPoint': {'lat': 38.84622, 'lon': -77.30637}}, {'zip': '98405', 'city': 'Tacoma', 'state': 'Washington', 'country': 'United States', 'facility': 'Northwest Medical Specialties', 'geoPoint': {'lat': 47.25288, 'lon': -122.44429}}, {'zip': '9020', 'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Klinikum Klagenfurt am Worthersee', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'zip': '9020', 'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'Klinikum Klagenfurt am Wörthersee', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'zip': '1210', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Karl Landsteiner Institut für Lungenforschung und pneumologische Onkologie, c/o Klinik Floridsdorf Abteilung für Innere Medizin und Pneumologie', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '1210', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Karl Landsteiner Institute for Lung Research and Pneumological Oncology, c/o Klinik Floridsdorf Department for Inner Medicine und Pneumology', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '233099', 'city': 'Bengbu', 'state': 'Anhui', 'country': 'China', 'facility': 'The First Affiliated Hospital of Bengbu Medical College', 'geoPoint': {'lat': 32.94083, 'lon': 117.36083}}, {'zip': '230031', 'city': 'Hefei', 'state': 'Anhui', 'country': 'China', 'facility': 'Anhui Chest Hospital', 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '100021', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Cancer Hospital Chinese Academy of Medical Sciences', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100142', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'Beijing Cancer Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '400016', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'The First Affiliated Hospital of Chongqing Medical', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '400030', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'country': 'China', 'facility': 'Chongqing University Cancer Hospital', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '350011', 'city': 'Fuzhou', 'state': 'Fujian', 'country': 'China', 'facility': 'Fujian Cancer Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '510000', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'The First Affiliated Hospital of Guangdong Pharmaceutical University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510030', 'city': 'Guangzhou', 'state': 'Guangdong', 'country': 'China', 'facility': 'Sun Yat-Sen University Cancer Center', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '518036', 'city': 'Shenzhen', 'state': 'Guangdong', 'country': 'China', 'facility': 'Peking University Shenzhen Hospital', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '541100', 'city': 'Guilin', 'state': 'Guangxi', 'country': 'China', 'facility': 'The Second Affiliated Hospital of Guilin Medical University', 'geoPoint': {'lat': 25.28022, 'lon': 110.29639}}, {'zip': '530021', 'city': 'Nanning', 'state': 'Guangxi', 'country': 'China', 'facility': 'Guangxi Medical University Cancer Hospital', 'geoPoint': {'lat': 22.81667, 'lon': 108.31667}}, {'zip': '510095', 'city': 'Guangzhou', 'state': 'Guangzhou', 'country': 'China', 'facility': 'Gungzhouyikedaxuefushuzhongliuyiyuan', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '071000', 'city': 'Baoding', 'state': 'Hebei', 'country': 'China', 'facility': 'Affiliated Hospital of Hebei University', 'geoPoint': {'lat': 38.87288, 'lon': 115.46246}}, {'zip': '061019', 'city': 'Cangzhou', 'state': 'Hebei', 'country': 'China', 'facility': "Cangzhou People's Hospital", 'geoPoint': {'lat': 38.31124, 'lon': 116.85334}}, {'zip': '063001', 'city': 'Tangshan', 'state': 'Hebei', 'country': 'China', 'facility': "Tangshan People's Hospital", 'geoPoint': {'lat': 39.64381, 'lon': 118.18319}}, {'zip': '150000', 'city': 'Harbin', 'state': 'Heilongjiang', 'country': 'China', 'facility': 'Harbin Medical University Cancer Hospital', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '154007', 'city': 'Jiamusi', 'state': 'Heilongjiang', 'country': 'China', 'facility': 'Jiamusi Cancer Hospital', 'geoPoint': {'lat': 46.79711, 'lon': 130.31118}}, {'zip': '471000', 'city': 'Luoyang', 'state': 'Henan', 'country': 'China', 'facility': 'The First Affiliated Hospital of Henan University of Science and Technology', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '453100', 'city': 'Xinxiang', 'state': 'Henan', 'country': 'China', 'facility': 'The First Affiliated Hospital of Xinxiang Medical University', 'geoPoint': {'lat': 35.19033, 'lon': 113.80151}}, {'zip': '450008', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'facility': 'Henan Cancer Hospital', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '450052', 'city': 'Zhengzhou', 'state': 'Henan', 'country': 'China', 'facility': 'The First Affiliated Hospital of Zhengzhou University', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '999077', 'city': 'Hong Kong', 'state': 'Hong Kong', 'country': 'China', 'facility': 'Hong Kong United Oncology Centre', 'geoPoint': {'lat': 22.27832, 'lon': 114.17469}}, {'zip': '999077', 'city': 'Hong Kong', 'state': 'Hong Kong', 'country': 'China', 'facility': 'Queen Elizabeth Hospital', 'geoPoint': {'lat': 22.27832, 'lon': 114.17469}}, {'zip': '999077', 'city': 'Hong Kong', 'state': 'Hong Kong', 'country': 'China', 'facility': 'Queen Mary Hospital', 'geoPoint': {'lat': 22.27832, 'lon': 114.17469}}, {'zip': '442000', 'city': 'Shiyan', 'state': 'Hubei', 'country': 'China', 'facility': 'TaiHe Hospital Affiliated Hospital of Hubei University of Medicine', 'geoPoint': {'lat': 32.6475, 'lon': 110.77806}}, {'zip': '430030', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'facility': 'Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430071', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'facility': 'Zhongnan hospital of wuhan university', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430079', 'city': 'Wuhan', 'state': 'Hubei', 'country': 'China', 'facility': 'Hubei Cancer Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '415000', 'city': 'Changde', 'state': 'Hunan', 'country': 'China', 'facility': "The First People's Hospital Of Changde City", 'geoPoint': {'lat': 29.03205, 'lon': 111.69844}}, {'zip': '410008', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'facility': 'The Second Xiangya Hospita', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410013', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'facility': 'Hunan Cancer Hospital', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410013', 'city': 'Changsha', 'state': 'Hunan', 'country': 'China', 'facility': 'Xiangya Hospital Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '221000', 'city': 'Xuzhou', 'state': 'Jiangsu', 'country': 'China', 'facility': 'Xuzhou Central Hospital', 'geoPoint': {'lat': 34.20442, 'lon': 117.28386}}, {'zip': '210008', 'city': 'Yangzhou', 'state': 'Jiangsu', 'country': 'China', 'facility': "Northern Jiangsu people's Hospital", 'geoPoint': {'lat': 32.39722, 'lon': 119.43583}}, {'zip': '341001', 'city': 'Ganzhou', 'state': 'Jiangxi', 'country': 'China', 'facility': 'First Affiliated Hospital of Gannan Medical University', 'geoPoint': {'lat': 25.84664, 'lon': 114.9326}}, {'zip': '341005', 'city': 'Ganzhou', 'state': 'Jiangxi', 'country': 'China', 'facility': 'Ganzhou Cancer Hospital', 'geoPoint': {'lat': 25.84664, 'lon': 114.9326}}, {'zip': '330006', 'city': 'Nanchang', 'state': 'Jiangxi', 'country': 'China', 'facility': 'The First Affiliated Hospital of Nanchang University', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '130000', 'city': 'Changchun', 'state': 'Jilin', 'country': 'China', 'facility': 'Jilin Cancer Hospital', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '110042', 'city': 'Shenyang', 'state': 'Liaoning', 'country': 'China', 'facility': 'Liaoning Cancer Hospital & Institute', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '110044', 'city': 'Shenyang', 'state': 'Liaoning', 'country': 'China', 'facility': "Shenyang The Tenth People's Hospital", 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '250012', 'city': 'Jinan', 'state': 'Shandong', 'country': 'China', 'facility': 'Qilu Hospital of Shandong University', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '250117', 'city': 'Jinan', 'state': 'Shandong', 'country': 'China', 'facility': 'Shandong Cancer Hospital', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '276002', 'city': 'Linyi', 'state': 'Shandong', 'country': 'China', 'facility': 'Linyi Tumor Hospital', 'geoPoint': {'lat': 35.06306, 'lon': 118.34278}}, {'zip': '266031', 'city': 'Qingdao', 'state': 'Shandong', 'country': 'China', 'facility': 'Affiliated Hospital of Qingdao University', 'geoPoint': {'lat': 36.06488, 'lon': 120.38042}}, {'zip': '200030', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'country': 'China', 'facility': 'Shanghai Chest Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200032', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'country': 'China', 'facility': 'Fudan University Shanghai Cancer Center', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200032', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'country': 'China', 'facility': 'Zhongshan Hospital of Fudan University', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200032', 'city': 'Wenzhou', 'state': 'Shanghai Municipality', 'country': 'China', 'facility': 'Wenzhou University Hospital'}, {'zip': '721008', 'city': 'Baoji', 'state': 'Shanxi', 'country': 'China', 'facility': 'Baoji Central Hospital', 'geoPoint': {'lat': 35.90348, 'lon': 111.38866}}, {'zip': '030013', 'city': 'Taiyuan', 'state': 'Shanxi', 'country': 'China', 'facility': 'Shanxi Provincial Cancer Hospital', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '710061', 'city': 'Xi’an', 'state': 'Shanxi', 'country': 'China', 'facility': "First Affiliated Hospital of Xi'an Jiaotong University", 'geoPoint': {'lat': 35.99785, 'lon': 113.52486}}, {'zip': '610041', 'city': 'Chengdu', 'state': 'Sichuan', 'country': 'China', 'facility': 'West China Hospital of Sichuan University', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '300052', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'country': 'China', 'facility': 'Tianjin Medical University Cancer Institute & Hospital', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '300052', 'city': 'Tianjin', 'state': 'Tianjin Municipality', 'country': 'China', 'facility': 'Tianjin Medical University General Hospital', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '644000', 'city': 'Sichuan', 'state': 'Yibin', 'country': 'China', 'facility': "The Second People's Hospital Of Yibin", 'geoPoint': {'lat': 35.1221, 'lon': 105.48032}}, {'zip': '650118', 'city': 'Kunming', 'state': 'Yunnan', 'country': 'China', 'facility': 'Yunnan Cancer Hospital', 'geoPoint': {'lat': 25.03889, 'lon': 102.71833}}, {'zip': '310000', 'city': 'Hangzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'Sir Run Run Shaw Hospital Zhejiang University School of Medicine', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '310003', 'city': 'Hangzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'Yuhang Branch of the First Affiliated Hospital of Zhejiang University', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '310005', 'city': 'Hangzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'Zhejiang Cancer Hospital', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '310009', 'city': 'Hangzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'The Second Affiliated Hospital Zhejiang University School of Medicine', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'zip': '317000', 'city': 'Taizhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'Taizhou Hospital of Zhejiang Province', 'geoPoint': {'lat': 28.66266, 'lon': 121.43312}}, {'zip': '325000', 'city': 'Wenzhou', 'state': 'Zhejiang', 'country': 'China', 'facility': 'The 1st Affiliated Hospital of WMU', 'geoPoint': {'lat': 27.99942, 'lon': 120.66682}}, {'zip': '625 00', 'city': 'Brno', 'country': 'Czechia', 'facility': 'University Hospital Brno (Clinic For Lung Diseases and Tuberculosis)', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'zip': '625 00', 'city': 'Brno', 'country': 'Czechia', 'facility': 'University Hospital Brno', 'geoPoint': {'lat': 49.19522, 'lon': 16.60796}}, {'zip': '775 20', 'city': 'Olomouc', 'country': 'Czechia', 'facility': 'University Hospital Olomouc (Oncology Clinic)', 'geoPoint': {'lat': 49.59552, 'lon': 17.25175}}, {'zip': '570852', 'city': 'Ostrava-Poruba', 'country': 'Czechia', 'facility': 'University Hospital Ostrava (oncology department)'}, {'city': 'Ostrava-Poruba', 'country': 'Czechia', 'facility': 'University Hospital Ostrava'}, {'zip': '703 00', 'city': 'Ostrava-Vitkovice', 'country': 'Czechia', 'facility': 'Nemocnice AGEL Ostrava-Vítkovice'}, {'zip': '703 00', 'city': 'Ostrava-Vítkovice', 'country': 'Czechia', 'facility': 'Nemocnice AGEL Ostrava-Vítkovice'}, {'zip': '128 08', 'city': 'Prague', 'country': 'Czechia', 'facility': 'General University hospital in Prague (Oncology department)', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '150 06', 'city': 'Prague', 'country': 'Czechia', 'facility': 'University Hospital Motol', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'city': 'Prague', 'country': 'Czechia', 'facility': 'University Hospital Motol (Pneumology Clinic 2.LF UK and FN Motol)', 'geoPoint': {'lat': 50.08804, 'lon': 14.42076}}, {'zip': '51109', 'city': 'Cologne', 'country': 'Germany', 'facility': 'Kliniken der Stadt Cologne GmbH', 'geoPoint': {'lat': 50.93333, 'lon': 6.95}}, {'zip': '23538', 'city': 'Travemünde', 'country': 'Germany', 'facility': 'University hospital Schleswig-Holstein', 'geoPoint': {'lat': 53.96304, 'lon': 10.8709}}, {'zip': '115 27', 'city': 'Athens', 'country': 'Greece', 'facility': '"Sotiria" Thoracic Diseases General Hospital of Athens', 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '11528', 'city': 'Athens', 'country': 'Greece', 'facility': 'General Hospital of Athens "Alexandra"', 'geoPoint': {'lat': 37.98376, 'lon': 23.72784}}, {'zip': '8000', 'city': 'Székesfehérvár', 'country': 'Hungary', 'facility': 'Fejer County Szent Gyorgy University Teaching Hospital', 'geoPoint': {'lat': 47.18995, 'lon': 18.41034}}, {'zip': '2045', 'city': 'Törökbálint', 'country': 'Hungary', 'facility': 'Pulmonary Institute of Torokbalint', 'geoPoint': {'lat': 47.42931, 'lon': 18.91356}}, {'zip': 'LV 1079', 'city': 'Riga', 'country': 'Latvia', 'facility': 'Riga East University Hospital, Latvian Oncology Center', 'geoPoint': {'lat': 56.946, 'lon': 24.10589}}, {'zip': 'LV-1002', 'city': 'Riga', 'country': 'Latvia', 'facility': 'Clinic of Oncology, Pauls Stradins Clinical university hospital', 'geoPoint': {'lat': 56.946, 'lon': 24.10589}}, {'zip': '3844', 'city': 'Harderwijk', 'country': 'Netherlands', 'facility': 'Hospital St. Jansdal', 'geoPoint': {'lat': 52.34167, 'lon': 5.62083}}, {'zip': '8025', 'city': 'Zwolle', 'country': 'Netherlands', 'facility': 'Isala Hospital', 'geoPoint': {'lat': 52.5125, 'lon': 6.09444}}, {'zip': '60-693', 'city': 'Poznan', 'country': 'Poland', 'facility': 'MedPoloniaSp. z o.o.', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'zip': '02-781', 'city': 'Warsaw', 'country': 'Poland', 'facility': 'Lung and Chest Cancer Clinic, National Institute of Oncology', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'zip': '6006', 'city': 'Badajoz', 'country': 'Spain', 'facility': 'Hospital Universitario de Badajoz', 'geoPoint': {'lat': 38.87789, 'lon': -6.97061}}, {'zip': '8916', 'city': 'Badalona', 'country': 'Spain', 'facility': 'Hospital German Trias i Pujol/ ICO Badalona', 'geoPoint': {'lat': 41.45004, 'lon': 2.24741}}, {'zip': '8025', 'city': 'Barcelona', 'country': 'Spain', 'facility': 'Hospital de la Santa Creu i Sant Pau', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '14004', 'city': 'Córdoba', 'country': 'Spain', 'facility': 'Hospital Universitario Reina Sofía', 'geoPoint': {'lat': 37.89155, 'lon': -4.77275}}, {'zip': '28007', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Gregorio Marañon', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '2822', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Universitario Puerta de Hierro', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '41013', 'city': 'Seville', 'country': 'Spain', 'facility': 'Hospital Quironsalud Sagrado Corazón', 'geoPoint': {'lat': 37.38283, 'lon': -5.97317}}, {'zip': '39008', 'city': 'Valdecilla', 'country': 'Spain', 'facility': 'Hospital Marques de Valdecilla', 'geoPoint': {'lat': 43.38347, 'lon': -3.73158}}, {'zip': '46026', 'city': 'Valencia', 'country': 'Spain', 'facility': 'University Hospital La Fe', 'geoPoint': {'lat': 39.47391, 'lon': -0.37966}}], 'overallOfficials': [{'name': 'Jinming Yu, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Shandong Cancer Hospital & Institute-department'}, {'name': 'Ying Cheng', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Jilin Provincial Tumor Hospital'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Shanghai Henlius Biotech', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}