Ignite Creation Date:
2025-12-24 @ 6:43 PM
Ignite Modification Date:
2026-02-27 @ 3:13 AM
Study NCT ID:
NCT01715857
Status:
COMPLETED
Last Update Posted:
2014-08-19
First Post:
2012-09-02
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Clinical Practice of Inhalation Anesthesia With Sevoflurane in China
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'phone': '800-633-9110', 'title': 'Global Medical Services', 'organization': 'AbbVie (prior sponsor, Abbott)'}, 'certainAgreement': {'otherDetails': 'AbbVie requests that any investigator or institution that plans on presenting/publishing results disclosure, provide written notification of their request 60 days prior to their presentation/publication. AbbVie requests that no presentation/publication will be instituted until 12 months after a study is completed, or after the first presentation/publication whichever occurs first. A delay may be proposed of a presentation/publication if AbbVie needs to secure patent or proprietary protection.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': "All serious adverse events (SAEs) were required to be collected in the registry from the time the physician obtained the participant's informed consent until 30 days following treatment (approximately 31 days).", 'description': "Spontaneous adverse events (AEs) were also to be collected from the time the physician obtained the participant's informed consent until 30 days following treatment (total of approximately 31 days); there were no spontaneously reported AEs from the registry.", 'eventGroups': [{'id': 'EG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China', 'otherNumAtRisk': 4004, 'otherNumAffected': 0, 'seriousNumAtRisk': 4004, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Anesthesiologist Satisfaction With the Anesthesia Using a Numeric Analog Scale (NAS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4004', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '9.14', 'spread': '0.85', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'End of surgery', 'description': 'Anesthesiologist satisfaction with the anesthesia was recorded by the anesthesiologist at the end of the operation using a NAS from 0 (not satisfied at all) to 10 (completely satisfied). The satisfaction of induction, maintenance, and emergence accounts for 20%, 50%, and 30% of the score, respectively.', 'unitOfMeasure': 'scores on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Participant Satisfaction With the Anesthesia Using a Numeric Analog Scale (NAS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '4004', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '9.21', 'spread': '0.91', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 hours after end of surgery', 'description': 'Participant satisfaction with the anesthesia recorded approximately 24 hours after the end of the operation using a NAS from 0 (not satisfied at all) to 10 (completely satisfied).', 'unitOfMeasure': 'scores on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All participants who received study drug and with available data.'}, {'type': 'SECONDARY', 'title': 'Time to Eye Opening', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3982', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '17.30', 'spread': '11.56', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'From cessation of sevoflurane administration until the participant opened their eyes, up to 80 minutes', 'description': "After cessation of anesthesia, the investigators lightly tapped on the participant's forehead or shoulder and asked the participant to open their eyes. This process was repeated approximately every minute until eye opening occurred.", 'unitOfMeasure': 'minutes', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All participants who received study drug and with available data.'}, {'type': 'SECONDARY', 'title': 'Time to Extubation', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3981', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '20.28', 'spread': '13.50', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'From cessation of sevoflurane administration until tracheal extubation occurred, up to 80 minutes', 'description': 'Time to extubation was measured from the time sevoflurane administration had stopped until tracheal extubation or laryngeal mask airway (LMA) removal occurred.', 'unitOfMeasure': 'minutes', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All participants who received study drug and with available data.'}, {'type': 'SECONDARY', 'title': 'Cost of Anesthetics Including Sevoflurane (Yuan Renminbi [RMB]/Hour)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3874', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '249.79', 'spread': '168.01', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Anesthetic duration between 1 to 5 hours', 'description': 'Cost of anesthetics is the sum of the cost of sevoflurane and other anesthetics including narcotics and muscle relaxants. Cost of sevoflurane = unit price of sevoflurane multiplied by the used volume of sevoflurane. Cost of other anesthetics = unit price of anesthetics multiplied by the total volume of anesthetics in the ampoule.', 'unitOfMeasure': 'Yuan renminbi [RMB]/hour', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'All participants who received study drug and with available data.'}, {'type': 'SECONDARY', 'title': 'Non-compliance of Sevoflurane End Tidal Concentration Following the Consensus', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3941', 'groupId': 'OG000'}]}, {'units': 'Timepoints for Maintenance Period', 'counts': [{'value': '44374', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '17.82', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'During maintenance (up to 5 hours)', 'description': 'Non-compliance of sevoflurane end tidal concentration was defined as the percentage of time points for the maintenance period (excluding washout phase) that were below the sevoflurane end tidal concentration boundary of 0.6 minimal alveolar concentration (MAC) based on the Consensus. A higher percentage indicates a higher degree of non-compliance.', 'unitOfMeasure': 'percentage of timepoints', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'Timepoints for Maintenance Period', 'denomUnitsSelected': 'Participants', 'populationDescription': 'All participants who received study drug and with available data.'}, {'type': 'SECONDARY', 'title': 'Non-compliance of Sevoflurane Vaporizer Setting Following the Consensus', 'denoms': [{'units': 'Participants', 'counts': [{'value': '3972', 'groupId': 'OG000'}]}, {'units': 'Timepoints During Maintenance', 'counts': [{'value': '54454', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'classes': [{'categories': [{'measurements': [{'value': '42.31', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'During maintenance (up to 5 hours)', 'description': 'Non-compliance of sevoflurane vaporizer setting was defined as the percentage of time points for the maintenance period outside the range of 1.0 - 1.5 minimal alveolar concentration (MAC) during the maintenance period (excluding washout phase) based on the Consensus. A higher percentage indicates a higher degree of non-compliance.', 'unitOfMeasure': 'percentage of timepoints', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'Timepoints During Maintenance', 'denomUnitsSelected': 'Participants', 'populationDescription': 'All participants who received study drug and with available data.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4100'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '4004'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '96'}]}], 'dropWithdraws': [{'type': 'Did Not Meet Eligibility Criteria', 'reasons': [{'groupId': 'FG000', 'numSubjects': '96'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '4004', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Chinese Patients Requiring Surgery With Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '45.54', 'spread': '12.57', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '2720', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '1284', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'American Society of Anesthesiologist (ASA) Physical Status', 'classes': [{'title': 'ASA Physical Status I', 'categories': [{'measurements': [{'value': '47.33', 'groupId': 'BG000'}]}]}, {'title': 'ASA Physical Status II', 'categories': [{'measurements': [{'value': '49.18', 'groupId': 'BG000'}]}]}, {'title': 'ASA Physical Status III', 'categories': [{'measurements': [{'value': '3.50', 'groupId': 'BG000'}]}]}, {'title': 'ASA Physical Status IV', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}]}]}, {'title': 'ASA Physical Status V', 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'description': 'ASA Physical Status Classification System: ASA Physical Status I = A normal healthy patient; ASA Physical Status II = A patient with mild systemic disease; ASA Physical Status III = A patient with severe systemic disease; ASA Physical Status IV = A patient with severe systemic disease that is a constant threat to life; ASA Physical Status V = A moribund patient who is not expected to survive without the operation; ASA Physical Status VI = A declared brain-dead patient whose organs are being removed for donor purposes', 'unitOfMeasure': 'percentage of participants'}, {'title': 'Type of Surgery', 'classes': [{'title': 'General Surgery', 'categories': [{'measurements': [{'value': '55.09', 'groupId': 'BG000'}]}]}, {'title': 'Gynecologic Surgery', 'categories': [{'measurements': [{'value': '28.17', 'groupId': 'BG000'}]}]}, {'title': 'Orthopedic Surgery', 'categories': [{'measurements': [{'value': '16.73', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'percentage of participants'}, {'title': 'Body Weight', 'classes': [{'categories': [{'measurements': [{'value': '62.19', 'spread': '10.96', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'kilograms', 'dispersionType': 'STANDARD_DEVIATION'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_ONLY'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 4100}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2012-07'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2014-08', 'completionDateStruct': {'date': '2013-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2014-08-15', 'studyFirstSubmitDate': '2012-09-02', 'resultsFirstSubmitDate': '2014-07-23', 'studyFirstSubmitQcDate': '2012-10-25', 'lastUpdatePostDateStruct': {'date': '2014-08-19', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2014-07-23', 'studyFirstPostDateStruct': {'date': '2012-10-29', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2014-08-13', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2013-07', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Anesthesiologist Satisfaction With the Anesthesia Using a Numeric Analog Scale (NAS)', 'timeFrame': 'End of surgery', 'description': 'Anesthesiologist satisfaction with the anesthesia was recorded by the anesthesiologist at the end of the operation using a NAS from 0 (not satisfied at all) to 10 (completely satisfied). The satisfaction of induction, maintenance, and emergence accounts for 20%, 50%, and 30% of the score, respectively.'}, {'measure': 'Participant Satisfaction With the Anesthesia Using a Numeric Analog Scale (NAS)', 'timeFrame': '24 hours after end of surgery', 'description': 'Participant satisfaction with the anesthesia recorded approximately 24 hours after the end of the operation using a NAS from 0 (not satisfied at all) to 10 (completely satisfied).'}], 'secondaryOutcomes': [{'measure': 'Time to Eye Opening', 'timeFrame': 'From cessation of sevoflurane administration until the participant opened their eyes, up to 80 minutes', 'description': "After cessation of anesthesia, the investigators lightly tapped on the participant's forehead or shoulder and asked the participant to open their eyes. This process was repeated approximately every minute until eye opening occurred."}, {'measure': 'Time to Extubation', 'timeFrame': 'From cessation of sevoflurane administration until tracheal extubation occurred, up to 80 minutes', 'description': 'Time to extubation was measured from the time sevoflurane administration had stopped until tracheal extubation or laryngeal mask airway (LMA) removal occurred.'}, {'measure': 'Cost of Anesthetics Including Sevoflurane (Yuan Renminbi [RMB]/Hour)', 'timeFrame': 'Anesthetic duration between 1 to 5 hours', 'description': 'Cost of anesthetics is the sum of the cost of sevoflurane and other anesthetics including narcotics and muscle relaxants. Cost of sevoflurane = unit price of sevoflurane multiplied by the used volume of sevoflurane. Cost of other anesthetics = unit price of anesthetics multiplied by the total volume of anesthetics in the ampoule.'}, {'measure': 'Non-compliance of Sevoflurane End Tidal Concentration Following the Consensus', 'timeFrame': 'During maintenance (up to 5 hours)', 'description': 'Non-compliance of sevoflurane end tidal concentration was defined as the percentage of time points for the maintenance period (excluding washout phase) that were below the sevoflurane end tidal concentration boundary of 0.6 minimal alveolar concentration (MAC) based on the Consensus. A higher percentage indicates a higher degree of non-compliance.'}, {'measure': 'Non-compliance of Sevoflurane Vaporizer Setting Following the Consensus', 'timeFrame': 'During maintenance (up to 5 hours)', 'description': 'Non-compliance of sevoflurane vaporizer setting was defined as the percentage of time points for the maintenance period outside the range of 1.0 - 1.5 minimal alveolar concentration (MAC) during the maintenance period (excluding washout phase) based on the Consensus. A higher percentage indicates a higher degree of non-compliance.'}]}, 'conditionsModule': {'keywords': ['Economics, Pharmaceutical', "Physician's Practice Patterns", 'Chinese', 'Sevoflurane'], 'conditions': ['Anesthesia, General']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://rxabbvie.com', 'label': 'Related Info'}]}, 'descriptionModule': {'briefSummary': 'Until recently, there was a lack of understanding and consensus among Chinese anesthesiologists how they should practice general anesthesia with volatile anesthetics, since there was no standard of inhalation practice. In August 2011, the Anesthesiology branch of the Chinese Medical Association launched the first version of Chinese Consensus of Standard Clinical Practice for Inhalation Anesthesia (Consensus) in order to standardize the practice in China.\n\nThe proposed registry is aimed to evaluate the current inhalation practice one year after the Consensus has been released, and related patient outcome. This registry evaluated sevoflurane anesthesia, including screening, induction, maintenance, emergence, and follow-up within 24 hours post-operation.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Chinese patients undergoing surgery require general anesthesia (sevoflurane) with endotracheal intubation or laryngeal mask.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Man or woman, aged from 18 to 70 years old.\n2. American Society of Anesthesiologists (ASA) physical status: I, II and III.\n3. Surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA).\n4. The type of surgery is either general surgery, or orthopedics, or gynecology.\n5. The duration of anesthesia ranges from 1 to 5 hours.\n\nExclusion Criteria:\n\n1. History of clinically significant cardiovascular, pulmonary, renal, hepatic or central nervous system or muscle disease.\n2. Known hypersensitivity or history of unusual response to any halogenated anesthetics.\n3. Personal or familial history of malignant hyperthermia.\n4. Female patients who are either pregnant or breast feeding.\n5. General anesthesia is administered with total intravenous anesthesia (TIVA) of propofol or sevoflurane maintenance combined with propofol continuous infusion during maintenance.'}, 'identificationModule': {'nctId': 'NCT01715857', 'briefTitle': 'Clinical Practice of Inhalation Anesthesia With Sevoflurane in China', 'organization': {'class': 'INDUSTRY', 'fullName': 'AbbVie'}, 'officialTitle': 'A Multicenter Registry on the Clinical Practice of Inhalation Anesthesia With Sevoflurane in China', 'orgStudyIdInfo': {'id': 'P13-934'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Chinese Patients Requiring Surgery with Sevoflurane Anesthesia', 'description': 'Participants who were scheduled for surgery requiring sevoflurane anesthesia with endotracheal intubation or laryngeal mask airway (LMA) per approved product information of sevoflurane in China'}]}, 'contactsLocationsModule': {'locations': [{'zip': '100000', 'city': 'Beijing', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84317', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100029', 'city': 'Beijing', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86755', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100191', 'city': 'Beijing', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 96155', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100730', 'city': 'Beijing', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84320', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100044', 'city': 'Beijing, Xicheng District', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84316', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '130031', 'city': 'Changchun, Jilin', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84321'}, {'zip': '130033', 'city': 'Changchun, Jilin', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86754'}, {'zip': '410008', 'city': 'Changsha, Hunan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86764'}, {'zip': '410013', 'city': 'Changsha, Hunan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86767'}, {'zip': '610041', 'city': 'Chengdu', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 100206', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'zip': '400042', 'city': 'Chongqing', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86762', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '510030', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84338', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510405', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 106416', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510515', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84337', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '511400', 'city': 'Guangzhou', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 102457', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510010', 'city': 'Guangzhou, Guangdong', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84333'}, {'zip': '510655', 'city': 'Guangzhou, Guangdong', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 100095'}, {'zip': '150081', 'city': 'Harbin, Heilongjiang', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84334'}, {'zip': '250014', 'city': 'Jinan, Shandong', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86759'}, {'zip': '650032', 'city': 'Kunming, Yunnan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84318'}, {'zip': '650101', 'city': 'Kunming, Yunnan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86757'}, {'zip': '730000', 'city': 'Lanzhou, Gansu', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84336'}, {'zip': '730030', 'city': 'Lanzhou, Gansu', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84322'}, {'zip': '330006', 'city': 'Nanchang, Jiangxi', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86761'}, {'zip': '266011', 'city': 'Qingdao', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 102455', 'geoPoint': {'lat': 36.06488, 'lon': 120.38042}}, {'zip': '200025', 'city': 'Shanghai', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 78434', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200127', 'city': 'Shanghai', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86073', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200438', 'city': 'Shanghai', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84342', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '110042', 'city': 'Shenyang, Liao Ning', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84314', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '500011', 'city': 'Shijiazhuang Hebei', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 84319'}, {'zip': '300052', 'city': 'Tianjin', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 100207', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '300162', 'city': 'Tianjin', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 95295', 'geoPoint': {'lat': 39.14222, 'lon': 117.17667}}, {'zip': '430022', 'city': 'Wuhan, Hubei', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86760'}, {'zip': '450000', 'city': 'Zhengzhou, Henan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86766'}, {'zip': '450008', 'city': 'Zhengzhou, Henan', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86763'}, {'zip': '563099', 'city': 'Zunyi, Guizhou', 'country': 'China', 'facility': 'Site Reference ID/Investigator# 86769'}], 'overallOfficials': [{'name': 'Yue Kang, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': 'AbbVie'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'AbbVie (prior sponsor, Abbott)', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}