Ignite Creation Date:
2025-12-24 @ 5:47 PM
Ignite Modification Date:
2025-12-28 @ 12:52 AM
Study NCT ID:
NCT06926868
Status:
RECRUITING
Last Update Posted:
2025-12-15
First Post:
2025-04-08
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'D064726', 'term': 'Triple Negative Breast Neoplasms'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C520255', 'term': '130-nm albumin-bound paclitaxel'}, {'id': 'D017239', 'term': 'Paclitaxel'}, {'id': 'D000069287', 'term': 'Capecitabine'}, {'id': 'D016190', 'term': 'Carboplatin'}, {'id': 'D000093542', 'term': 'Gemcitabine'}], 'ancestors': [{'id': 'D043823', 'term': 'Taxoids'}, {'id': 'D043822', 'term': 'Cyclodecanes'}, {'id': 'D003516', 'term': 'Cycloparaffins'}, {'id': 'D006840', 'term': 'Hydrocarbons, Alicyclic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D004224', 'term': 'Diterpenes'}, {'id': 'D013729', 'term': 'Terpenes'}, {'id': 'D003841', 'term': 'Deoxycytidine'}, {'id': 'D003562', 'term': 'Cytidine'}, {'id': 'D011741', 'term': 'Pyrimidine Nucleosides'}, {'id': 'D011743', 'term': 'Pyrimidines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D005472', 'term': 'Fluorouracil'}, {'id': 'D014498', 'term': 'Uracil'}, {'id': 'D011744', 'term': 'Pyrimidinones'}, {'id': 'D003853', 'term': 'Deoxyribonucleosides'}, {'id': 'D009705', 'term': 'Nucleosides'}, {'id': 'D009706', 'term': 'Nucleic Acids, Nucleotides, and Nucleosides'}, {'id': 'D056831', 'term': 'Coordination Complexes'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 500}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-09-11', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2030-05-15', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-09', 'studyFirstSubmitDate': '2025-04-08', 'studyFirstSubmitQcDate': '2025-04-08', 'lastUpdatePostDateStruct': {'date': '2025-12-15', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-04-15', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-03-13', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression-Free Survival (PFS)', 'timeFrame': 'Approximately 31 months from first participant randomization', 'description': 'Assessed using Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) by blinded independent central review (BICR)'}], 'secondaryOutcomes': [{'measure': 'Overall Survival (OS)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Recommended Phase 3 Dose (RP3D) of BMS-986507', 'timeFrame': 'Approximately 19 months from first participant randomization'}, {'measure': 'Number of participants with treatment-related Adverse Events (AEs)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Number of participants with laboratory abnormalities', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Number of participants with serious AEs (SAEs)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Number of participants with AEs leading to treatment discontinuation, interruption, dose reduction or dose delay', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Number of deaths', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Objective Response (OR)', 'timeFrame': 'Approximately 31 months from first participant randomization'}, {'measure': 'PFS rate', 'timeFrame': 'Approximately 31 months from first participant randomization', 'description': 'Assessed using RECIST v1.1 by BICR'}, {'measure': 'PFS', 'timeFrame': 'Approximately 31 months from first participant randomization', 'description': 'Assessed by Investigator'}, {'measure': 'Disease control rate (DCR)', 'timeFrame': 'Approximately 31 months from first participant randomization'}, {'measure': 'Duration of Response (DOR)', 'timeFrame': 'Approximately 31 months from first participant randomization'}, {'measure': 'Time to Response (TTR)', 'timeFrame': 'Approximately 31 months from first participant randomization'}, {'measure': 'Time to subsequent treatment (TTST)', 'timeFrame': 'Approximately up to 57 months from first participant randomization', 'description': 'Defined as time from randomization to the start of subsequent therapy or death'}, {'measure': 'Progression-free survival after next line of treatment (PFS2)', 'timeFrame': 'Approximately up to 57 months from first participant randomization', 'description': 'Defined as the time from randomization to the date of investigator-defined documented disease progression after next line of treatment or death due to any cause, whichever comes first'}, {'measure': 'Change from baseline in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Change from baseline in EORTC Breast Cancer-specific Quality of Life Questionnaire (QLQ-BR23)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Functional Assessment of Chronic Illness Therapy item GP5 (FACIT GP5) score', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}, {'measure': 'Change from baseline in European Quality of Life 5 Dimensions 5 Levels (EQ-5D-5L)', 'timeFrame': 'Approximately up to 57 months from first participant randomization'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['triple-negative breast cancer', 'antibody-drug conjugate'], 'conditions': ['Breast Neoplasms']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html', 'label': 'BMS Clinical Trial Information'}, {'url': 'https://www.bmsclinicaltrials.com/us/en/clinical-trials/NCT06926868.html', 'label': 'BMS Clinical Trial Patient Recruiting'}]}, 'descriptionModule': {'briefSummary': "The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physician's choice (TPC) (paclitaxel, nab-paclitaxel, carboplatin plus gemcitabine, and capecitabine) for the treatment of first-line metastatic triple-negative breast cancer (TNBC) or estrogen receptor (ER)-low, human epidermal growth factor receptor 2 (HER2)-negative BC patients who are not candidates for anti-PD(L)1 therapy and endocrine therapies."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria\n\n* Histologically or cytologically confirmed and documented locally-advanced, recurrent inoperable, or metastatic TNBC (ER \\< 1%, PgR \\< 1%, HER2 IHC 0, 1+, or 2+ with FISH negative for HER2 gene amplification) or ER-low, HER2-negative BC (ER and / or PgR 1% to 10%, HER2 IHC 0, 1+, or 2+ with FISH negative for HER2 gene amplification) per ASCO/CAP criteria, based on the most recently analyzed biopsy or other pathology specimen.\n* Patients with recurrent disease must have experienced disease relapse at least 6 months after finishing their last therapy with curative intent.\n* Patients with TNBC must be considered ineligible for 1L chemotherapy combination treatment with an anti-PD-1 or an anti-PD-L1 due to either one of the following criteria:.\n* Investigator-determined ineligibility based on PD-L1 negative disease determined and documented prior to trial screening as part of SoC.\n* Has experienced disease relapse between 6 to 12 months after the completion of (neo)adjuvant therapy with an anti-PD(L)1.\n* Has a severe auto-immune disease or other contraindication.\n* Patients with ER-low, HER2-negative BC must be ineligible, in the opinion of the Investigator, for endocrine therapy-based treatments.\n* No previous systemic therapy in the locally advanced, recurrent inoperable or metastatic setting (ie incurable setting).\n* Measurable disease by CT or MRI as per RECIST v1.1.\n* Other protocol-defined Inclusion/Exclusion criteria apply.'}, 'identificationModule': {'nctId': 'NCT06926868', 'briefTitle': 'A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bristol-Myers Squibb'}, 'officialTitle': "A Randomized, Open-label, Inferentially Seamless Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Treatment of Physician's Choice in Patients With Previously Untreated, Locally Advanced, Recurrent Inoperable,or Metastatic Triple-negative Breast Cancer (TNBC)or ER-low, HER2-negative BC Who Are Ineligible for Anti-PD1/PD-L1 Treatment", 'orgStudyIdInfo': {'id': 'CA244-0008'}, 'secondaryIdInfos': [{'id': '2024-519871-24', 'type': 'OTHER', 'domain': 'EU CTR'}, {'id': 'U1111-1316-1533', 'type': 'OTHER', 'domain': 'WHO'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm A1', 'interventionNames': ['Drug: Iza-bren']}, {'type': 'EXPERIMENTAL', 'label': 'Arm A2', 'interventionNames': ['Drug: Iza-bren']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm B', 'interventionNames': ['Drug: Nab-paclitaxel', 'Drug: Paclitaxel', 'Drug: Capecitabine', 'Drug: Carboplatin', 'Drug: Gemcitabine']}], 'interventions': [{'name': 'Iza-bren', 'type': 'DRUG', 'otherNames': ['BMS-986507', 'BL-B01D1', 'Izalontamab brengitecan'], 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm A1', 'Arm A2']}, {'name': 'Nab-paclitaxel', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm B']}, {'name': 'Paclitaxel', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm B']}, {'name': 'Capecitabine', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm B']}, {'name': 'Carboplatin', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm B']}, {'name': 'Gemcitabine', 'type': 'DRUG', 'description': 'Specified dose on specified days', 'armGroupLabels': ['Arm B']}]}, 'contactsLocationsModule': {'locations': [{'zip': '71913', 'city': 'Hot Springs', 'state': 'Arkansas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0303', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0303', 'geoPoint': {'lat': 34.5037, 'lon': -93.05518}}, {'zip': '90703', 'city': 'Cerritos', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Omkar Marathe, Site 0328', 'role': 'CONTACT', 'phone': '562-693-4477'}], 'facility': 'Helios Clinical Research', 'geoPoint': {'lat': 33.85835, 'lon': -118.06479}}, {'zip': '90703', 'city': 'Cerritos', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0307', 'geoPoint': {'lat': 33.85835, 'lon': -118.06479}}, {'zip': '90703', 'city': 'Cerritos', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0308', 'geoPoint': {'lat': 33.85835, 'lon': -118.06479}}, {'zip': '90703', 'city': 'Cerritos', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0309', 'geoPoint': {'lat': 33.85835, 'lon': -118.06479}}, {'zip': '90805', 'city': 'Long Beach', 'state': 'California', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0311', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daphne Stewart, Site 0290', 'role': 'CONTACT', 'phone': '323-865-3906'}], 'facility': 'USC/Norris Comprehensive Cancer Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90067', 'city': 'Los Angeles', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'David Berz, Site 0283', 'role': 'CONTACT', 'phone': '424-535-1874'}], 'facility': 'Valkyrie Clinical Trials', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92663', 'city': 'Newport Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daphne Stewart, Site 0353', 'role': 'CONTACT', 'phone': '323-397-5954'}], 'facility': 'USC Norris Oncology/Hematology-Newport Beach', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '94305', 'city': 'Stanford', 'state': 'California', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0358', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0358', 'geoPoint': {'lat': 37.42411, 'lon': -122.16608}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0289', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0289', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80220', 'city': 'Denver', 'state': 'Colorado', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0367', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0367', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jamal Misleh, Site 0304', 'role': 'CONTACT', 'phone': '302-366-1200'}], 'facility': 'Medical Oncology Hematology Consultants, PA', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '33136', 'city': 'Miami', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0282', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0282', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33028', 'city': 'Pembroke Pines', 'state': 'Florida', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0296', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0296', 'geoPoint': {'lat': 26.00315, 'lon': -80.22394}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0294', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0294', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0357', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0357', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60612', 'city': 'Chicago', 'state': 'Illinois', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0278', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '60637', 'city': 'Chicago', 'state': 'Illinois', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0280', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0280', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '62526', 'city': 'Decatur', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'James Wade, Site 0275', 'role': 'CONTACT', 'phone': '217-876-6611'}], 'facility': 'Decatur Memorial Hospital', 'geoPoint': {'lat': 39.84031, 'lon': -88.9548}}, {'zip': '62269', 'city': "O'Fallon", 'state': 'Illinois', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0324', 'geoPoint': {'lat': 38.59227, 'lon': -89.91121}}, {'zip': '70433', 'city': 'Covington', 'state': 'Louisiana', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0286', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0286', 'geoPoint': {'lat': 30.47549, 'lon': -90.10042}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0288', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0288', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0287', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0287', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48202', 'city': 'Detroit', 'state': 'Michigan', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0359', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0359', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '55369', 'city': 'Maple Grove', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Eric Lander, Site 0313', 'role': 'CONTACT'}], 'facility': 'Minnesota Oncology Hematology', 'geoPoint': {'lat': 45.07246, 'lon': -93.45579}}, {'zip': '55455', 'city': 'Minneapolis', 'state': 'Minnesota', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0372', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0372', 'geoPoint': {'lat': 44.97997, 'lon': -93.26384}}, {'zip': '64111', 'city': 'Kansas City', 'state': 'Missouri', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0284', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0284', 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Local Institution - 0312', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10021', 'city': 'New York', 'state': 'New York', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0279', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0279', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '11590', 'city': 'Westbury', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': "James D'Olimpio, Site 0295", 'role': 'CONTACT', 'phone': '646-872-8630'}], 'facility': 'Clinical Research Alliance', 'geoPoint': {'lat': 40.75566, 'lon': -73.58763}}, {'zip': '10601', 'city': 'White Plains', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Dan Costin, Site 0285', 'role': 'CONTACT', 'phone': '914-849-7630'}], 'facility': 'White Plains Hospital', 'geoPoint': {'lat': 41.03399, 'lon': -73.76291}}, {'zip': '27710', 'city': 'Durham', 'state': 'North Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0276', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0276', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '97401', 'city': 'Eugene', 'state': 'Oregon', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Miho Dougherty, Site 0316', 'role': 'CONTACT'}], 'facility': 'Willamette Valley Cancer Institute', 'geoPoint': {'lat': 44.05207, 'lon': -123.08675}}, {'zip': '18103', 'city': 'Allentown', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0356', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0356', 'geoPoint': {'lat': 40.60843, 'lon': -75.49018}}, {'zip': '19104-5127', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0310', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0310', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '15213-3403', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0360', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0360', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '29607', 'city': 'Greenville', 'state': 'South Carolina', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0281', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0281', 'geoPoint': {'lat': 34.85262, 'lon': -82.39401}}, {'zip': '79606', 'city': 'Abilene', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0368', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0368', 'geoPoint': {'lat': 32.44874, 'lon': -99.73314}}, {'zip': '78705', 'city': 'Austin', 'state': 'Texas', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0315', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0315', 'geoPoint': {'lat': 30.26715, 'lon': -97.74306}}, {'zip': '75028', 'city': 'Flower Mound', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Vibha Thomas, Site 0305', 'role': 'CONTACT', 'phone': '303-925-0700'}], 'facility': 'Texas Oncology - Northeast Texas', 'geoPoint': {'lat': 33.01457, 'lon': -97.09696}}, {'zip': '77024-2843', 'city': 'Houston', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Dhatri Kodali, Site 0314', 'role': 'CONTACT', 'phone': '555-555-5555'}], 'facility': '(USOR) Texas Oncology', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '23114', 'city': 'Midlothian', 'state': 'Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'William Irvin, Site 0277', 'role': 'CONTACT'}], 'facility': 'Bon Secours St. Francis Medical Center', 'geoPoint': {'lat': 37.50598, 'lon': -77.64916}}, {'zip': '24014', 'city': 'Roanoke', 'state': 'Virginia', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Site 0301', 'role': 'CONTACT'}], 'facility': 'Local Institution - 0301', 'geoPoint': {'lat': 37.27097, 'lon': -79.94143}}, {'zip': '22601', 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