Ignite Creation Date:
2025-12-24 @ 5:36 PM
Ignite Modification Date:
2025-12-28 @ 5:29 AM
Study NCT ID:
NCT01118468
Status:
UNKNOWN
Last Update Posted:
2017-02-08
First Post:
2010-05-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 40}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2010-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-02', 'completionDateStruct': {'date': '2019-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2017-02-06', 'studyFirstSubmitDate': '2010-05-05', 'studyFirstSubmitQcDate': '2010-05-05', 'lastUpdatePostDateStruct': {'date': '2017-02-08', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2010-05-06', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2019-12', 'type': 'ESTIMATED'}}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['Competitive Flow', 'Coronary artery bypass', 'Wave Intensity Analysis'], 'conditions': ['Coronary Artery Bypass']}, 'descriptionModule': {'briefSummary': 'Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Patients with previous bypass grafts undergoing angiography/ angioplasty who meet stduy criteria', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Patients with previous coronary artery bypass grafts undergoing coronary angiography and graft restudy\n\nExclusion Criteria:\n\n* Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure\n* Unable to consent\n* Contraindications to adenosine\n* Contraindications to cardiac MRI"}, 'identificationModule': {'nctId': 'NCT01118468', 'briefTitle': 'Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis', 'organization': {'class': 'OTHER', 'fullName': 'Imperial College London'}, 'officialTitle': 'Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis', 'orgStudyIdInfo': {'id': '1426'}}, 'contactsLocationsModule': {'locations': [{'city': 'London', 'status': 'RECRUITING', 'country': 'United Kingdom', 'contacts': [{'name': 'Justin E Davies, MRCP, PhD', 'role': 'CONTACT', 'email': 'justin.davies@imperial.ac.uk', 'phone': '020 7594 33 86'}, {'name': 'Sayan Sen', 'role': 'CONTACT', 'email': 'sayan.sen@imperial.ac.uk', 'phone': '020 7594 33 86'}], 'facility': 'Imperial College NHS Trust', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}], 'centralContacts': [{'name': 'Justin E Davies, MRCP, PhD', 'role': 'CONTACT', 'email': 'justin.davies@imperial.ac.uk', 'phone': '020 7594 33 86'}, {'name': 'Sayan Sen, MRCP', 'role': 'CONTACT', 'email': 'sayan.sen@imperial.ac.uk', 'phone': '020 7594 33 86'}], 'overallOfficials': [{'name': 'Justin E Davies, MRCP PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Imperial College London'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Imperial College London', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}