Ignite Creation Date:
2025-12-24 @ 5:34 PM
Ignite Modification Date:
2026-02-27 @ 4:09 PM
Study NCT ID:
NCT02878668
Status:
UNKNOWN
Last Update Posted:
2016-08-25
First Post:
2016-08-22
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Value of Infectious Biomarkers for Prediction of Complication After Hepatopancreatobiliary Surgery
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_ONLY'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 700}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2016-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2016-08', 'completionDateStruct': {'date': '2017-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2016-08-24', 'studyFirstSubmitDate': '2016-08-22', 'studyFirstSubmitQcDate': '2016-08-24', 'lastUpdatePostDateStruct': {'date': '2016-08-25', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2016-08-25', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2017-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'post operative complication', 'timeFrame': 'within the first 30 days after he operation'}], 'secondaryOutcomes': [{'measure': 'sepsis', 'timeFrame': 'within the first 30 days after he operation'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['procalcitonin', 'post-operative', 'complication', 'CRP'], 'conditions': ['Post-operative Complication']}, 'referencesModule': {'references': [{'pmid': '8094770', 'type': 'BACKGROUND', 'citation': 'Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993 Feb 27;341(8844):515-8. doi: 10.1016/0140-6736(93)90277-n.'}, {'pmid': '19541012', 'type': 'BACKGROUND', 'citation': 'Mofidi R, Suttie SA, Patil PV, Ogston S, Parks RW. The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review. Surgery. 2009 Jul;146(1):72-81. doi: 10.1016/j.surg.2009.02.013. Epub 2009 May 8.'}, {'pmid': '17309964', 'type': 'BACKGROUND', 'citation': 'Rau BM, Frigerio I, Buchler MW, Wegscheider K, Bassi C, Puolakkainen PA, Beger HG, Schilling MK. Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study. Arch Surg. 2007 Feb;142(2):134-42. doi: 10.1001/archsurg.142.2.134.'}, {'pmid': '19081471', 'type': 'BACKGROUND', 'citation': 'Novotny AR, Emmanuel K, Hueser N, Knebel C, Kriner M, Ulm K, Bartels H, Siewert JR, Holzmann B. Procalcitonin ratio indicates successful surgical treatment of abdominal sepsis. Surgery. 2009 Jan;145(1):20-6. doi: 10.1016/j.surg.2008.08.009. Epub 2008 Sep 26.'}, {'pmid': '20347867', 'type': 'BACKGROUND', 'citation': 'Limper M, de Kruif MD, Duits AJ, Brandjes DP, van Gorp EC. The diagnostic role of procalcitonin and other biomarkers in discriminating infectious from non-infectious fever. J Infect. 2010 Jun;60(6):409-16. doi: 10.1016/j.jinf.2010.03.016. Epub 2010 Mar 27.'}, {'pmid': '16148175', 'type': 'BACKGROUND', 'citation': 'Tavares E, Maldonado R, Ojeda ML, Minano FJ. Circulating inflammatory mediators during start of fever in differential diagnosis of gram-negative and gram-positive infections in leukopenic rats. Clin Diagn Lab Immunol. 2005 Sep;12(9):1085-93. doi: 10.1128/CDLI.12.9.1085-1093.2005.'}, {'pmid': '11138776', 'type': 'BACKGROUND', 'citation': 'Scapini P, Lapinet-Vera JA, Gasperini S, Calzetti F, Bazzoni F, Cassatella MA. The neutrophil as a cellular source of chemokines. Immunol Rev. 2000 Oct;177:195-203. doi: 10.1034/j.1600-065x.2000.17706.x.'}, {'pmid': '15273542', 'type': 'BACKGROUND', 'citation': 'Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004 Aug;240(2):205-13. doi: 10.1097/01.sla.0000133083.54934.ae.'}, {'pmid': '17122618', 'type': 'BACKGROUND', 'citation': 'DeOliveira ML, Winter JM, Schafer M, Cunningham SC, Cameron JL, Yeo CJ, Clavien PA. Assessment of complications after pancreatic surgery: A novel grading system applied to 633 patients undergoing pancreaticoduodenectomy. Ann Surg. 2006 Dec;244(6):931-7; discussion 937-9. doi: 10.1097/01.sla.0000246856.03918.9a.'}, {'pmid': '16003309', 'type': 'BACKGROUND', 'citation': 'Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M; International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005 Jul;138(1):8-13. doi: 10.1016/j.surg.2005.05.001.'}]}, 'descriptionModule': {'briefSummary': 'Post operative complication after hepatopancreatobiliary surgery is high as 30-50%，which is the main reason for patient admitted to ICU. Several biomarkers have been shown to be useful in the early diagnosis of sepsis and systemic bacterial infection. The purpose of this study is to assess the predictive value of biomarkers for early complication after hepatopancreatobiliary surgery and assess the effectiveness of anti-infectious therapy.', 'detailedDescription': "Postoperative complication after major abdominal surgery, such as pancreatic surgery and hilar cholangiocarcinoma surgery, is higher, up to 30 to 50%.It is the mainly reason for the patient to admit to ICU. Among this, the most common and difficult to handle complication is mainly anastomotic fistula, abdominal effusion and subsequent secondary infection. Delayed diagnosis can cause systemic inflammatory response syndrome (SIRS), multiple organ failure ( MODS), and even death. From a surgical point of view, it leads to surgical failure and often need the second surgery. However, the diagnosis and treatment of postoperative infection is also facing two problems: it is difficult to confirm the diagnosis and make treatment decision. Hence, there is a strong need of an additional tool to early diagnose post operative complication.\n\nSerum procalcitonin (PCT), is a 116 amino-acids protein produced by C-cells of the thyroid gland. PCT baseline levels are low (\\<0.05 ng/ml), but increase significantly in patients with severe bacterial infections. Therefore, PCT levels are used to monitor the course and prognosis of systemic bacterial infections and to tailor the therapeutic interventions more efficiently. Furthermore, PCT could serve as an early predictive marker for the clinical course of septic complications after abdominal surgery. The aim of this study is to demonstrate if PCT is a more sensible, specific and reliable biomarker of post operative complication than other biomarkers\n\nThe investigators conducted a observational, prospective study. All patients undergoing electively hepatopancreatobiliary surgery in seven centres are recruited. In all cases white blood count (WBC), C-reactive protein (CRP) and PCT levels are measured in 1st, 3rd and 5th postoperative day (POD). Informed consent was obtained in all patients.The study is approved by the hospital's Ethical Committee."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': '1000 elective hepatopancreatobiliary sugery hospitalized patients will be included', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* age \\> = 18 years\n* Hospitalized patients with elective hepatopancreatobiliary surgery\n\nExclusion Criteria:\n\n* age \\<18 years\n* emergency operative patients\n* Preoperative fever, white blood cell elevation and preoperative infection\n* Systemic inflammatory disease\n* renal failure\n* hematology disease\n* preoperative abnormal PCT, IL-6, IL-8, CRP\n* Laparoscopic cholecystectomy\n* Bile duct infection'}, 'identificationModule': {'nctId': 'NCT02878668', 'briefTitle': 'The Value of Infectious Biomarkers for Prediction of Complication After Hepatopancreatobiliary Surgery', 'organization': {'class': 'OTHER', 'fullName': 'Shanghai Zhongshan Hospital'}, 'officialTitle': 'The Predictor of Infectious Complication After Hepatopancreatobiliary Surgery and Monitoring Indicator of Anti-infectious Therapy', 'orgStudyIdInfo': {'id': 'ZS-LWH-2016'}}, 'armsInterventionsModule': {'interventions': [{'name': 'hepatopancreatobiliary surgery', 'type': 'PROCEDURE', 'description': 'hepatopancreatobiliary surgery'}]}, 'contactsLocationsModule': {'locations': [{'zip': '100050', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhongtao Zhang, MD', 'role': 'CONTACT'}, {'name': 'Zhongtao Zhang, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Wei Guo, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jiegao Zhu, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Beijing Friendship hospital, Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '510120', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yajin Chen, MD', 'role': 'CONTACT'}, {'name': 'Yajin Chen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jun Cao, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Sun Yat-Sen Memorial Hospital，Sun Yat-Sen University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '150001', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Bei Sun, MD', 'role': 'CONTACT'}, {'name': 'Bei Sun, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Xuewei Bai, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'The first affiliated hospital of Harbin Medical University', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '210029', 'city': 'Nanjing', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Kuirong Jiang, MD', 'role': 'CONTACT'}, {'name': 'Kuirong Jiang, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jishu Wei, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Jiangsu Province Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '200032', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenhui Lou, MD', 'role': 'CONTACT', 'email': 'wenhuilou@aliyun.com', 'phone': '021-64041990', 'phoneExt': '3450'}, {'name': 'Wenchuan Wu, MD', 'role': 'CONTACT', 'email': 'wu.wenchuan@zs-hospital.sh.cn', 'phone': '021-64041990', 'phoneExt': '2909'}, {'name': 'Wenhui Lou, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Wenchuan Wu, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Yuan Fang, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Zhongshan Hospital, Fudan University', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200433', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Gang Jin, MD', 'role': 'CONTACT'}, {'name': 'Gang Jin, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Kailian Zheng, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Changhai Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '610041', 'city': 'Chengdu', 'state': 'Sichuan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xubao Liu, MD', 'role': 'CONTACT'}, {'name': 'Xubao Liu, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Hao Zhang, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'West China Hospital, Sichuan University', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}], 'centralContacts': [{'name': 'Wenhui Lou, MD', 'role': 'CONTACT', 'email': 'wenhuilou@aliyun.com', 'phone': '021-64041990', 'phoneExt': '3450'}, {'name': 'Wenchuan Wu, MD', 'role': 'CONTACT', 'email': 'wu.wenchuan@zs-hospital.sh.cn', 'phone': '021-64041990', 'phoneExt': '2909'}], 'overallOfficials': [{'name': 'Wenhui Lou, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Shanghai Zhongshan Hospital'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Shanghai Zhongshan Hospital', 'class': 'OTHER'}, 'collaborators': [{'name': 'Changhai Hospital', 'class': 'OTHER'}, {'name': 'The First Affiliated Hospital with Nanjing Medical University', 'class': 'OTHER'}, {'name': 'West China Hospital', 'class': 'OTHER'}, {'name': 'Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University', 'class': 'OTHER'}, {'name': 'First Affiliated Hospital of Harbin Medical University', 'class': 'OTHER'}, {'name': 'Beijing Friendship Hospital', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'professor', 'investigatorFullName': 'Wenhui Lou', 'investigatorAffiliation': 'Shanghai Zhongshan Hospital'}}}}