Ignite Creation Date:
2025-12-24 @ 5:31 PM
Ignite Modification Date:
2025-12-28 @ 7:23 AM
Study NCT ID:
NCT04985968
Status:
TERMINATED
Last Update Posted:
2023-12-27
First Post:
2021-07-22
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Efficacy and Safety of Cobitolimod in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'submissionTracking': {'submissionInfos': [{'resetDate': '2024-06-18', 'mcpReleaseN': 7, 'releaseDate': '2024-05-23'}], 'estimatedResultsFirstSubmitDate': '2024-05-23'}}, 'conditionBrowseModule': {'meshes': [{'id': 'D003093', 'term': 'Colitis, Ulcerative'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D015212', 'term': 'Inflammatory Bowel Diseases'}], 'ancestors': [{'id': 'D003092', 'term': 'Colitis'}, {'id': 'D005759', 'term': 'Gastroenteritis'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000711771', 'term': 'cobitolimod'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 171}}, 'statusModule': {'whyStopped': 'Due to futility', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2021-11-24', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2023-12', 'completionDateStruct': {'date': '2023-12-20', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2023-12-21', 'studyFirstSubmitDate': '2021-07-22', 'studyFirstSubmitQcDate': '2021-07-30', 'lastUpdatePostDateStruct': {'date': '2023-12-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2021-08-02', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-12-20', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Induction - Proportion of participants with clinical remission.', 'timeFrame': 'Week 6', 'description': 'Clinical remission defined by the 3-component Mayo score.'}, {'measure': 'Maintenance - Proportion of participants with clinical remission.', 'timeFrame': 'Week 52', 'description': 'Clinical remission defined by the 3-component Mayo score.'}], 'secondaryOutcomes': [{'measure': 'Induction - Proportion of participants with endoscopic improvement.', 'timeFrame': 'Week 6', 'description': 'Endoscopic improvement defined by the Mayo Endoscopic score.'}, {'measure': 'Induction - Proportion of participants with symptomatic remission.', 'timeFrame': 'Week 6', 'description': 'Symptomatic remission defined by the 2-component Mayo score.'}, {'measure': 'Induction - Proportion of participants with clinical response.', 'timeFrame': 'Week 6', 'description': 'Clinical remission defined by the 3-component Mayo score.'}, {'measure': 'Induction - Proportion of participants with normalisation of stool frequency.', 'timeFrame': 'Week 6', 'description': 'Stool frequency defined by the Mayo score for Stool Frequency.'}, {'measure': 'Induction - Proportion of participants with absence of rectal bleeding.', 'timeFrame': 'Week 6', 'description': 'Rectal bleeding defined by the Mayo score for Rectal Bleeding.'}, {'measure': 'Induction - Mean stool frequency.', 'timeFrame': 'Week 6', 'description': 'Mean stool frequency defined by the Mayo score for Stool Frequency.'}, {'measure': 'Induction - Proportion of participants with histologic improvement.', 'timeFrame': 'Week 6', 'description': 'Defined by the Robarts Histologic Index.'}, {'measure': 'Induction - Proportion of participants with histologic remission.', 'timeFrame': 'Week 6', 'description': 'Histologic remission defined by the Robarts Histologic Index.'}, {'measure': 'Induction - Proportion of participants with mucosal healing.', 'timeFrame': 'Week 6', 'description': 'Mucosal healing defined by the Mayo Endoscopic score and Robarts Histologic Index.'}, {'measure': 'Induction - Mean ln-transformed faecal calprotectin.', 'timeFrame': 'Week 6', 'description': 'Mean ln-transformed faecal calprotectin defined by faecal calprotectin values.'}, {'measure': 'Induction - Mean 3-component and 4-component Mayo scores.', 'timeFrame': 'Week 6', 'description': 'Defined by 3-component and 4-component Mayo scores.'}, {'measure': 'Induction - Mean IBDQ total score.', 'timeFrame': 'Week 6', 'description': 'Defined by the Inflammatory Bowel Disease Questionnaire (IBDQ).'}, {'measure': 'Induction - Proportion of participants with an improvement in IBDQ total score.', 'timeFrame': 'Week 6', 'description': 'Defined by the IBDQ.'}, {'measure': 'Maintenance - Proportion of participants with endoscopic improvement.', 'timeFrame': 'Week 52', 'description': 'Endoscopic improvement defined by the Mayo Endoscopic score.'}, {'measure': 'Maintenance - Proportion of participants with clinical remission and steroid-free.', 'timeFrame': 'Week 52', 'description': 'Defined by the 3-component Mayo score and use of glucocorticosteroids.'}, {'measure': 'Maintenance - Proportion of participants with clinical remission among those who achieved clinical remission', 'timeFrame': 'Week 52', 'description': 'Defined by the 3-component Mayo score.'}, {'measure': 'Maintenance - Proportion of participants with symptomatic remission.', 'timeFrame': 'Week 52', 'description': 'Symptomatic remission defined by the 2-component Mayo score.'}, {'measure': 'Maintenance - Proportion of participants with histologic improvement.', 'timeFrame': 'Week 52', 'description': 'Histologic improvement defined by the Robarts Histologic Index.'}, {'measure': 'Maintenance - Proportion of participants with histologic remission.', 'timeFrame': 'Week 52', 'description': 'Histologic remission defined by the Robarts Histologic Index.'}, {'measure': 'Maintenance - Proportion of participants with mucosal healing.', 'timeFrame': 'Week 52', 'description': 'Mucosal healing defined by the Mayo Endoscopic score and Robarts Histologic Index.'}, {'measure': 'Maintenance - Proportion of participants with clinical response.', 'timeFrame': 'Week 52', 'description': 'Clinical response defined by the 3-component Mayo score.'}, {'measure': 'Maintenance - Proportion of participants with absence of rectal bleeding.', 'timeFrame': 'Week 52', 'description': 'Rectal bleeding defined by the Mayo score for Rectal Bleeding.'}, {'measure': 'Maintenance - Proportion of participants with normalisation of stool frequency.', 'timeFrame': 'Week 52', 'description': 'Stool frequency defined by the Mayo score for Stool Frequency.'}, {'measure': 'Maintenance - Mean stool frequency.', 'timeFrame': 'Week 52', 'description': 'Mean stool frequency defined by the Mayo score for Stool Frequency.'}, {'measure': 'Maintenance - Mean ln-transformed faecal calprotectin.', 'timeFrame': 'Week 52', 'description': 'Mean ln-transformed faecal calprotectin.'}, {'measure': 'Maintenance - Mean 3-component and 4-component Mayo scores.', 'timeFrame': 'Week 52', 'description': 'Defined by 3-component and 4-component Mayo scores.'}, {'measure': 'Maintenance - Mean IBDQ total score.', 'timeFrame': 'Week 52', 'description': 'Defined by the use of the Inflammatory Bowel Disease Questionnaire (IBDQ).'}, {'measure': 'Maintenance - Proportion of participants with an improvement in IBDQ total score.', 'timeFrame': 'Week 52', 'description': 'Defined by the IBDQ.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Colitis, Ulcerative', 'Gastrointestinal Disease', 'Inflammatory Bowel Diseases', 'Glucocorticosteroids', 'Anti-Inflammatory Agents', 'Therapeutic uses', 'Cobitolimod', 'Toll like receptor 9 agonist', 'TLR9 agonist', 'Kappaproct', 'IDX0150', 'DIMS0150'], 'conditions': ['Ulcerative Colitis']}, 'descriptionModule': {'briefSummary': 'The purpose of the study is to evaluate the efficacy of cobitolimod treatment compared to placebo in inducing clinical remission, in participants with moderate to severe active left-sided UC and to evaluate the efficacy of cobitolimod maintenance treatment compared to placebo in inducing or maintaining clinical remission at week 52, in participants with clinical response at week 6 after induction treatment with cobitolimod.', 'detailedDescription': 'This phase III study protocol includes an induction study for 6 weeks and a maintenance study for an additional 45 weeks.\n\nIn the induction study there will be an initial phase to explore the best dose, between cobitolimod 250 mg and cobitolimod 500 mg using adaptive design.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria Induction:\n\n* Male or female ≥ 18 years of age.\n* Established diagnosis of UC.\n* Moderate to severe active left-sided UC assessed by central reading.\n* Have inadequate response, loss of response or be intolerant of at least one of the following treatments: Oral GCS, AZA/6-MP, Biologics, JAK-inhibitors, or other approved advanced therapies for UC.\n* Allowed to receive a therapeutic dose of the following UC drugs during the study: Oral GCS therapy (≤20 mg prednisone or equivalent/day) , Oral 5-ASA/SP compounds, AZA/6-MP.\n* Ability to understand the treatment, willingness to comply with all study requirements, and ability to provide informed consent.\n\nExclusion Criteria Induction:\n\n* Suspicion of differential diagnosis.\n* Acute fulminant UC and/or signs of systemic toxicity.\n* UC limited to the rectum or extending beyond the splenic flexure.\n* Have failed treatment with more than three advanced therapies of two different therapeutic classes.\n* Have had surgery for treatment of UC.\n* History of malignancy, unless treated with no relapse of the disease and ≥ 5 years since last treatment (cured).\n* History or presence of any clinically significant disorder.\n* Concomitant treatment with cyclosporine, methotrexate, tacrolimus, or advanced therapies or similar immunosuppressants and immunomodulators.\n* Treatment with rectal GCS, 5-ASA/SP or tacrolimus.\n* Long-term treatment (\\>14 days) with antibiotics or NSAIDs .\n* Serious known active infection including history of latent or active tuberculosis.\n* Gastrointestinal infections including positive Clostridium difficile stool assay.\n* Females who are lactating or have a positive serum pregnancy test.\n* Women of childbearing potential not using highly effective contraceptive methods.\n* Concurrent participation in another clinical study.\n* Previous exposure to cobitolimod.\n\nInclusion Criteria Maintenance:\n\n* Participants are eligible to be included in the maintenance study if they have achieved clinical response at week 6 and have adhered to the protocol procedures of the induction study.\n\nExclusion Criteria Maintenance:\n\n* Participants will not be eligible for the maintenance study if they are not willing to comply with all further study requirements.'}, 'identificationModule': {'nctId': 'NCT04985968', 'acronym': 'CONCLUDE', 'briefTitle': 'The Efficacy and Safety of Cobitolimod in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis', 'organization': {'class': 'INDUSTRY', 'fullName': 'InDex Pharmaceuticals'}, 'officialTitle': 'A Randomised Double-Blind Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of Cobitolimod as an Induction and Maintenance Therapy in Participants With Moderate to Severe Active Left-Sided Ulcerative Colitis', 'orgStudyIdInfo': {'id': 'CSUC-01/21'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Cobitolimod 250 mg', 'description': 'Dose of 250 mg cobitolimod\n\n2 treatments during induction study and subsequently every third week', 'interventionNames': ['Drug: Cobitolimod 250 mg']}, {'type': 'EXPERIMENTAL', 'label': 'Cobitolimod 500 mg', 'description': 'Dose of 500 mg cobitolimod\n\n2 treatments during induction study and subsequently every third week', 'interventionNames': ['Drug: Cobitolimod 500 mg']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Dose of Placebo\n\n2 treatments during induction study and subsequently every third week', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Cobitolimod 250 mg', 'type': 'DRUG', 'otherNames': ['Kappaproct'], 'description': 'Rectal administration', 'armGroupLabels': ['Cobitolimod 250 mg']}, {'name': 'Cobitolimod 500 mg', 'type': 'DRUG', 'otherNames': ['Kappaproct'], 'description': 'Rectal administration', 'armGroupLabels': ['Cobitolimod 500 mg']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Rectal administration', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91344', 'city': 'Granada Hills', 'state': 'California', 'country': 'United States', 'facility': 'Amicis Research Center', 'geoPoint': {'lat': 34.26472, 'lon': -118.52314}}, {'zip': '92691', 'city': 'Mission Viejo', 'state': 'California', 'country': 'United States', 'facility': 'Allameh Medical Corporation', 'geoPoint': {'lat': 33.60002, 'lon': -117.672}}, {'zip': '91730', 'city': 'Rancho Cucamonga', 'state': 'California', 'country': 'United States', 'facility': 'Prospective Research Innovations Inc.', 'geoPoint': {'lat': 34.1064, 'lon': -117.59311}}, {'zip': '91356', 'city': 'Tarzana', 'state': 'California', 'country': 'United States', 'facility': 'Valiance Clinical Research', 'geoPoint': {'lat': 34.17334, 'lon': -118.55397}}, {'zip': '33472', 'city': 'Boynton Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'RecioMed Clinical Research Network, Inc.', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '33172', 'city': 'Doral', 'state': 'Florida', 'country': 'United States', 'facility': 'MB & V Medical Research', 'geoPoint': {'lat': 25.81954, 'lon': -80.35533}}, {'zip': '33012', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'A+ Research, Inc.', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33136', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'SouthCoast Research Center, Inc', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33144', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'I.V.A.M. Clinical & Investigational Center LLC', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33155', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'D&H National Research Centers, Inc.', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '33165', 'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Medical Professionals Clinical Research Center', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '34102', 'city': 'Naples', 'state': 'Florida', 'country': 'United States', 'facility': 'Gastroenterology Group Of Naples', 'geoPoint': {'lat': 26.14234, 'lon': -81.79596}}, {'zip': '33615', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'Alliance Clinical Research - Gastroenterology', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '66606', 'city': 'Topeka', 'state': 'Kansas', 'country': 'United States', 'facility': "Cotton O'Neil Clinical Research Center", 'geoPoint': {'lat': 39.04833, 'lon': -95.67804}}, {'zip': '48098', 'city': 'Troy', 'state': 'Michigan', 'country': 'United States', 'facility': 'Clinical Research Institute of Michigan', 'geoPoint': {'lat': 42.60559, 'lon': -83.14993}}, {'zip': '10075', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Lenox Hill Hospital', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '28209', 'city': 'Charlotte', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Carolina Digestive Health Associates, PA', 'geoPoint': {'lat': 35.22709, 'lon': -80.84313}}, {'zip': '27834', 'city': 'Greenville', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Carolina Research', 'geoPoint': {'lat': 35.61266, 'lon': -77.36635}}, {'zip': '27262', 'city': 'High Point', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Peters Medical Research', 'geoPoint': {'lat': 35.95569, 'lon': -80.00532}}, {'zip': '45440', 'city': 'Beavercreek', 'state': 'Ohio', 'country': 'United States', 'facility': 'Dayton Gastroenterology', 'geoPoint': {'lat': 39.70923, 'lon': -84.06327}}, {'zip': '75019', 'city': 'Carrollton', 'state': 'Texas', 'country': 'United States', 'facility': 'Digestive Health Associates of Texas, PA', 'geoPoint': {'lat': 32.95373, 'lon': -96.89028}}, {'zip': '77024', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Clinical Research Solution: Digestive Health Associates', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'Baylor College of Medicine - Gastroeneterology', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '22031', 'city': 'Fairfax', 'state': 'Virginia', 'country': 'United States', 'facility': 'Gastroenterology Associates of Northern Virginia', 'geoPoint': {'lat': 38.84622, 'lon': -77.30637}}, {'zip': '53215', 'city': 'Milwaukee', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Wisconsin Center For Advanced Research', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'city': 'Clayton', 'country': 'Australia', 'facility': 'Monash Health', 'geoPoint': {'lat': -37.91667, 'lon': 145.11667}}, {'city': 'Fitzroy', 'country': 'Australia', 'facility': "St Vincent's Hospital Melbourne", 'geoPoint': {'lat': -37.79839, 'lon': 144.97833}}, {'city': 'Melbourne', 'country': 'Australia', 'facility': 'The Alfred Hospital', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'city': 'Parkville', 'country': 'Australia', 'facility': 'Royal Melbourne Hospital', 'geoPoint': {'lat': -37.78333, 'lon': 144.95}}, {'city': 'South Brisbane', 'country': 'Australia', 'facility': 'Mater Health Services', 'geoPoint': {'lat': -27.48034, 'lon': 153.02049}}, {'city': 'Woolloongabba', 'country': 'Australia', 'facility': 'Princess Alexandra Hospital', 'geoPoint': {'lat': -27.48855, 'lon': 153.03655}}, {'city': 'Innsbruck', 'country': 'Austria', 'facility': 'MedUn Innsbruck', 'geoPoint': {'lat': 47.26266, 'lon': 11.39454}}, {'city': 'Klagenfurt', 'country': 'Austria', 'facility': 'LKH Klagenfurt', 'geoPoint': {'lat': 46.62472, 'lon': 14.30528}}, {'city': 'Salzburg', 'country': 'Austria', 'facility': 'Universitätsklinikum Salzburg', 'geoPoint': {'lat': 47.79941, 'lon': 13.04399}}, {'city': 'Vienna', 'country': 'Austria', 'facility': 'Akh Wien', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'city': 'Antwerp', 'country': 'Belgium', 'facility': 'UZ Antwerpen', 'geoPoint': {'lat': 51.22047, 'lon': 4.40026}}, {'city': 'Bonheiden', 'country': 'Belgium', 'facility': 'Imelda Ziekenhuis', 'geoPoint': {'lat': 51.02261, 'lon': 4.54714}}, {'city': 'Brussels', 'country': 'Belgium', 'facility': 'Erasme University Hospital', 'geoPoint': {'lat': 50.85045, 'lon': 4.34878}}, {'city': 'Ghent', 'country': 'Belgium', 'facility': 'Universitair Ziekenhuis Gent', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'city': 'Kortrijk', 'country': 'Belgium', 'facility': 'AZ Groeninge - Campus Kennedylaan', 'geoPoint': {'lat': 50.82803, 'lon': 3.26487}}, {'city': 'Roeselare', 'country': 'Belgium', 'facility': 'AZ Delta', 'geoPoint': {'lat': 50.94653, 'lon': 3.12269}}, {'city': 'Banja Luka', 'country': 'Bosnia and Herzegovina', 'facility': 'University Clinical Centre of the Republic of Srpska - Gastroenterology', 'geoPoint': {'lat': 44.77879, 'lon': 17.20629}}, {'city': 'Foča', 'country': 'Bosnia and Herzegovina', 'facility': 'The University Hospital Foca', 'geoPoint': {'lat': 43.50646, 'lon': 18.77854}}, {'city': 'Sarajevo', 'country': 'Bosnia and Herzegovina', 'facility': 'Clinical Center University of Sarajevo - Gastroenterology', 'geoPoint': {'lat': 43.84864, 'lon': 18.35644}}, {'city': 'Sarajevo', 'country': 'Bosnia and Herzegovina', 'facility': 'General Hospital "Prim.dr.Abdulah Nakas"', 'geoPoint': {'lat': 43.84864, 'lon': 18.35644}}, {'city': 'Sarajevo', 'country': 'Bosnia and Herzegovina', 'facility': 'Polyclinic Dr. Al-Tawil', 'geoPoint': {'lat': 43.84864, 'lon': 18.35644}}, {'city': 'Tešanj', 'country': 'Bosnia and Herzegovina', 'facility': 'Opca Bolnica Tesanj', 'geoPoint': {'lat': 44.61191, 'lon': 17.98552}}, {'city': 'Tuzla', 'country': 'Bosnia and Herzegovina', 'facility': 'Plava Medical Group', 'geoPoint': {'lat': 44.53842, 'lon': 18.66709}}, {'city': 'Zenica', 'country': 'Bosnia and Herzegovina', 'facility': 'Cantonal Hospital Zenica', 'geoPoint': {'lat': 44.20169, 'lon': 17.90397}}, {'city': 'Goiânia', 'country': 'Brazil', 'facility': 'Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'city': 'Porto Alegre', 'country': 'Brazil', 'facility': 'Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'city': 'Rio de Janeiro', 'country': 'Brazil', 'facility': 'Ufrj - Hospital Universitario Clementino Fraga Filho', 'geoPoint': {'lat': -22.90642, 'lon': -43.18223}}, {'city': 'Santo André', 'country': 'Brazil', 'facility': 'Praxis Pesquisa Medica', 'geoPoint': {'lat': -23.66389, 'lon': -46.53833}}, {'city': 'São Bernardo do Campo', 'country': 'Brazil', 'facility': 'CEMEC - Centro Multidisciplinar de Estudos Clinicos', 'geoPoint': {'lat': -23.69389, 'lon': -46.565}}, {'city': 'São José do Rio Preto', 'country': 'Brazil', 'facility': 'Kaiser Clinica', 'geoPoint': {'lat': -20.81972, 'lon': -49.37944}}, {'city': 'Hamilton', 'country': 'Canada', 'facility': 'MUMC - Hamilton Health Sciences', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'city': 'Montreal', 'country': 'Canada', 'facility': 'Installation Hospital Maisonneuve-Rosemont', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'city': 'Saskatoon', 'country': 'Canada', 'facility': 'Royal University Hospital', 'geoPoint': {'lat': 52.13238, 'lon': -106.66892}}, {'city': 'Bjelovar', 'country': 'Croatia', 'facility': 'Opca bolnica Bjelovar', 'geoPoint': {'lat': 45.89789, 'lon': 16.85071}}, {'city': 'Osijek', 'country': 'Croatia', 'facility': 'Clinical Hospital Osijek', 'geoPoint': {'lat': 45.55066, 'lon': 18.6942}}, {'city': 'Pula', 'country': 'Croatia', 'facility': 'Opca bolnica Pula', 'geoPoint': {'lat': 44.86833, 'lon': 13.84806}}, {'city': 'Zadar', 'country': 'Croatia', 'facility': 'Zadar General Hospital', 'geoPoint': {'lat': 44.11578, 'lon': 15.22514}}, {'city': 'Zagreb', 'country': 'Croatia', 'facility': 'Poliklinika Solmed', 'geoPoint': {'lat': 45.81444, 'lon': 15.97798}}, {'city': 'Zagreb', 'country': 'Croatia', 'facility': 'University Hospital Centre Zagreb', 'geoPoint': {'lat': 45.81444, 'lon': 15.97798}}, {'city': 'Aalborg', 'country': 'Denmark', 'facility': 'Aalborg University Hospital', 'geoPoint': {'lat': 57.048, 'lon': 9.9187}}, {'city': 'Aarhus', 'country': 'Denmark', 'facility': 'Aarhus University Hospital', 'geoPoint': {'lat': 56.15674, 'lon': 10.21076}}, {'city': 'Herlev', 'country': 'Denmark', 'facility': 'Herlev Hospital', 'geoPoint': {'lat': 55.72366, 'lon': 12.43998}}, {'city': 'Hillerød', 'country': 'Denmark', 'facility': 'Hillerod Hospital', 'geoPoint': {'lat': 55.92791, 'lon': 12.30081}}, {'city': 'Vejle', 'country': 'Denmark', 'facility': 'Lillebælt Hospital Vejle', 'geoPoint': {'lat': 55.70927, 'lon': 9.5357}}, {'city': 'Lille', 'country': 'France', 'facility': 'CHRU de Lille - Hôpital Claude Huriez', 'geoPoint': {'lat': 50.63391, 'lon': 3.05512}}, {'city': 'Montpellier', 'country': 'France', 'facility': 'CHRU Montpellier-Hopital Saint Eloi - Hepato-gastro-enterologie', 'geoPoint': {'lat': 43.61093, 'lon': 3.87635}}, {'city': 'Nancy', 'country': 'France', 'facility': 'CHU de Nancy Brabois', 'geoPoint': {'lat': 48.68439, 'lon': 6.18496}}, {'city': 'Nice', 'country': 'France', 'facility': "CHU de Nice - Hôpital de l'Archet II - Gastro-Entérologie, Hépatologie", 'geoPoint': {'lat': 43.70313, 'lon': 7.26608}}, {'city': 'Paris', 'country': 'France', 'facility': 'Hopital Bichat - Gastroenterology', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'city': 'Paris', 'country': 'France', 'facility': 'Hopital Saint Antoine', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'city': 'Pierre-Bénite', 'country': 'France', 'facility': 'Centre Hospitalier Lyon Sud', 'geoPoint': {'lat': 45.70359, 'lon': 4.82424}}, {'city': 'Poitiers', 'country': 'France', 'facility': 'Centre Hospitalier Universitaire de Poitiers', 'geoPoint': {'lat': 46.58261, 'lon': 0.34348}}, {'city': 'Saint-Etienne', 'country': 'France', 'facility': 'CHU de Saint Etienne, Hôpital Nord - Service de Gastroentérologie', 'geoPoint': {'lat': 45.43389, 'lon': 4.39}}, {'city': 'Salouël', 'country': 'France', 'facility': 'CHU Amiens - Hopital Sud - Service Hepato-Gastroenterolog', 'geoPoint': {'lat': 49.86988, 'lon': 2.2434}}, {'city': 'Toulouse', 'country': 'France', 'facility': 'Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil', 'geoPoint': {'lat': 43.60426, 'lon': 1.44367}}, {'city': 'Batumi', 'country': 'Georgia', 'facility': 'JSC " Evex Hospitals"', 'geoPoint': {'lat': 41.64077, 'lon': 41.6306}}, {'city': 'Tbilisi', 'country': 'Georgia', 'facility': 'LTD Israel-Georgian Medical Research Clinic Helsicore', 'geoPoint': {'lat': 41.69143, 'lon': 44.83412}}, {'city': 'Augsburg', 'country': 'Germany', 'facility': 'Universitätsklinikum Augsburg', 'geoPoint': {'lat': 48.37154, 'lon': 10.89851}}, {'city': 'Berlin', 'country': 'Germany', 'facility': 'Charité - Universitätsmedizin Berlin KöR', 'geoPoint': {'lat': 52.52437, 'lon': 13.41053}}, {'city': 'Cologne', 'country': 'Germany', 'facility': 'University Hospital Cologne AöR', 'geoPoint': {'lat': 50.93333, 'lon': 6.95}}, {'city': 'Duisburg', 'country': 'Germany', 'facility': 'MVZ Sanaklinikum Duisburg', 'geoPoint': {'lat': 51.43247, 'lon': 6.76516}}, {'city': 'Erlangen', 'country': 'Germany', 'facility': 'Universitätsklinikum Erlangen', 'geoPoint': {'lat': 49.59099, 'lon': 11.00783}}, {'city': 'Frankfurt am Main', 'country': 'Germany', 'facility': 'Agaplesion Markus Krankenhaus', 'geoPoint': {'lat': 50.11552, 'lon': 8.68417}}, {'city': 'Frankfurt am Main', 'country': 'Germany', 'facility': 'Klinikum der Johann Wolfgang Goethe-Universität - Medizinische Klinik I', 'geoPoint': {'lat': 50.11552, 'lon': 8.68417}}, {'city': 'Freiburg im Breisgau', 'country': 'Germany', 'facility': 'Universitätsklinikum Freiburg', 'geoPoint': {'lat': 47.9959, 'lon': 7.85222}}, {'city': 'Halle', 'country': 'Germany', 'facility': 'Uniklinik Halle (Saale)', 'geoPoint': {'lat': 51.48158, 'lon': 11.97947}}, {'city': 'Heidelberg', 'country': 'Germany', 'facility': 'Gastroenterology Outpatient Clinic Prof. Dr. med. Ehehalt', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'city': 'Kiel', 'country': 'Germany', 'facility': 'University Hospital Schleswig-Holstein', 'geoPoint': {'lat': 54.32133, 'lon': 10.13489}}, {'city': 'Mannheim', 'country': 'Germany', 'facility': 'Universitätsmedizin Mannheim', 'geoPoint': {'lat': 49.4891, 'lon': 8.46694}}, {'city': 'Nürtingen', 'country': 'Germany', 'facility': 'Medius Klinik Nürtingen', 'geoPoint': {'lat': 48.62565, 'lon': 9.34203}}, {'city': 'Rostock', 'country': 'Germany', 'facility': 'Universitätsklinikum Rostock', 'geoPoint': {'lat': 54.0887, 'lon': 12.14049}}, {'city': 'Ulm', 'country': 'Germany', 'facility': 'Universitätsklinikum Ulm', 'geoPoint': {'lat': 48.39841, 'lon': 9.99155}}, {'city': 'Weyhe', 'country': 'Germany', 'facility': 'Internistische Praxis Weyhe', 'geoPoint': {'lat': 52.96667, 'lon': 8.66667}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Clinexpert Egészségügyi Szolgáltató És Kereskedelmi Kft.', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Pannónia Magánorvosi Centrum Kft', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Semmelweis Egyetem Altalanos Orvostudomanyi Kar Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Budapest', 'country': 'Hungary', 'facility': 'Semmelweis Egyetem Altalanos Orvostudomanyi Kar', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'city': 'Szeged', 'country': 'Hungary', 'facility': 'SzTE Szt-Gy A Orvostud Kar Bel Klin', 'geoPoint': {'lat': 46.253, 'lon': 20.14824}}, {'city': 'Ashkelon', 'country': 'Israel', 'facility': 'The Barzilai Medical Center', 'geoPoint': {'lat': 31.66926, 'lon': 34.57149}}, {'city': 'Holon', 'country': 'Israel', 'facility': 'The Edith Wolfson Medical Center', 'geoPoint': {'lat': 32.01034, 'lon': 34.77918}}, {'city': 'Jerusalem', 'country': 'Israel', 'facility': 'Hadassah Medical Organization, Hadassah Medical Center, Ein-', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'city': 'Jerusalem', 'country': 'Israel', 'facility': 'Shaare Zedek Medical Center', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}, {'city': 'Nahariya', 'country': 'Israel', 'facility': 'Galilee Medical Center (Western Galilee Hospital)', 'geoPoint': {'lat': 33.00892, 'lon': 35.09814}}, {'city': 'Rehovot', 'country': 'Israel', 'facility': 'Kaplan Medical Center', 'geoPoint': {'lat': 31.89421, 'lon': 34.81199}}, {'city': 'Bergamo', 'country': 'Italy', 'facility': 'ASST Papa Giovanni XXIII - Cardiologia - Bergamo', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'city': 'Cagliari', 'country': 'Italy', 'facility': 'AO Brotzu', 'geoPoint': {'lat': 39.23054, 'lon': 9.11917}}, {'city': 'Florence', 'country': 'Italy', 'facility': 'Universita degli Studi di Firenze - Azienda Ospedaliero - Un', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'city': 'Milan', 'country': 'Italy', 'facility': 'IRCCS Ospedale San Raffaele', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'city': 'Monza', 'country': 'Italy', 'facility': 'Azienda Ospedaliera San Gerardo', 'geoPoint': {'lat': 45.58005, 'lon': 9.27246}}, {'city': 'Padua', 'country': 'Italy', 'facility': 'AOU di Padova', 'geoPoint': {'lat': 45.40797, 'lon': 11.88586}}, {'city': 'Roma', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Policlinico Tor Vergata (P', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'country': 'Italy', 'facility': 'Policlinico Universitario Agostino Gemelli', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Rome', 'country': 'Italy', 'facility': 'Policlinico Universitario Campus Biomedico', 'geoPoint': {'lat': 41.89193, 'lon': 12.51133}}, {'city': 'Torino', 'country': 'Italy', 'facility': 'A.O. Ordine Mauriziano Di Torino', 'geoPoint': {'lat': 44.88856, 'lon': 11.99138}}, {'city': 'Udine', 'country': 'Italy', 'facility': 'AOU S. Maria della Misericordia', 'geoPoint': {'lat': 46.0693, 'lon': 13.23715}}, {'city': 'Varese', 'country': 'Italy', 'facility': "Universita degli Studi dell'Insubria - Ospedale di Circolo e", 'geoPoint': {'lat': 45.82058, 'lon': 8.82511}}, {'city': 'Kaunas', 'country': 'Lithuania', 'facility': 'Hospital of Lithuanian University of Health Sciences Kauno Klinikos', 'geoPoint': {'lat': 54.90156, 'lon': 23.90909}}, {'city': 'Klaipėda', 'country': 'Lithuania', 'facility': "Klaipeda Seamen's Hospital", 'geoPoint': {'lat': 55.7068, 'lon': 21.13912}}, {'city': 'Klaipėda', 'country': 'Lithuania', 'facility': 'Republic Klaipeda Hospital', 'geoPoint': {'lat': 55.7068, 'lon': 21.13912}}, {'city': 'Panevezys', 'country': 'Lithuania', 'facility': 'Panevezio ligonine', 'geoPoint': {'lat': 55.73186, 'lon': 24.35983}}, {'city': 'Vilnius', 'country': 'Lithuania', 'facility': 'Vilniaus Universiteto ligonines Santariskiu Klinikos', 'geoPoint': {'lat': 54.68916, 'lon': 25.2798}}, {'city': 'Durango', 'country': 'Mexico', 'facility': 'Instituto de Investigaciones Aplicadas a la Neurociencia A.C.', 'geoPoint': {'lat': 24.02032, 'lon': -104.65756}}, {'city': 'Mexico City', 'country': 'Mexico', 'facility': 'Clinicos Asociados Bocm, S.C.', 'geoPoint': {'lat': 19.42847, 'lon': -99.12766}}, {'city': 'Mérida', 'country': 'Mexico', 'facility': 'Medical Care and Research S. A. de C. V', 'geoPoint': {'lat': 20.967, 'lon': -89.62318}}, {'city': 'Monterrey', 'country': 'Mexico', 'facility': 'Centro Regiomontano de Estudios Clinicos Roma SC', 'geoPoint': {'lat': 25.68435, 'lon': -100.31721}}, {'city': 'Tlalnepantla', 'country': 'Mexico', 'facility': 'Clinical Research Institute S.C.', 'geoPoint': {'lat': 19.54005, 'lon': -99.19538}}, {'city': 'Nijmegen', 'country': 'Netherlands', 'facility': 'Radboud University Medical Center', 'geoPoint': {'lat': 51.8425, 'lon': 5.85278}}, {'city': 'Ålesund', 'country': 'Norway', 'facility': 'Ålesund Hospital, Møre & Romsdal Hospital trust, Dept. of Medicine, div of Gastroenterology and the Clinical research unit HMR', 'geoPoint': {'lat': 62.47225, 'lon': 6.15492}}, {'city': 'Lørenskog', 'country': 'Norway', 'facility': 'Akershus Universitetssykehus'}, {'city': 'Tromsø', 'country': 'Norway', 'facility': 'Universitetssykehuset Nord-Norge Tromsø, Gastrolab, Medisinsk poliklinikk, B8', 'geoPoint': {'lat': 69.6489, 'lon': 18.95508}}, {'city': 'Tønsberg', 'country': 'Norway', 'facility': 'Vestfold Hjertesenter As', 'geoPoint': {'lat': 59.26754, 'lon': 10.40762}}, {'city': 'Grudziądz', 'country': 'Poland', 'facility': 'MPS - MED sp. z o.o.', 'geoPoint': {'lat': 53.48411, 'lon': 18.75366}}, {'city': 'Knurów', 'country': 'Poland', 'facility': 'MZ Badania Slowik Zymla Spolka jawna', 'geoPoint': {'lat': 50.21971, 'lon': 18.65067}}, {'city': 'Krakow', 'country': 'Poland', 'facility': 'Centrum Medyczne Plejady', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'city': 'Krakow', 'country': 'Poland', 'facility': 'Centrum Medyczne PROMED', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'city': 'Krakow', 'country': 'Poland', 'facility': 'Krakowskie Centrum Medyczne Sp. z o.o.', 'geoPoint': {'lat': 50.06143, 'lon': 19.93658}}, {'city': 'Lodz', 'country': 'Poland', 'facility': 'Szpital Zakonu Bonifratrow Sw. Jana Bozego w Lodzi', 'geoPoint': {'lat': 51.77058, 'lon': 19.47395}}, {'city': 'Malbork', 'country': 'Poland', 'facility': 'Klinika Badawcza Centrum Badawcze Panaceum Agnieszka Brzezicka, Magdalena Lenkiewicz Sp. z o.o.', 'geoPoint': {'lat': 54.03591, 'lon': 19.0266}}, {'city': 'Opole', 'country': 'Poland', 'facility': 'Twoja Przychodnia - Opolskie Centrum Medyczne', 'geoPoint': {'lat': 50.67119, 'lon': 17.92604}}, {'city': 'Oświęcim', 'country': 'Poland', 'facility': 'Medicome Sp. z o.o.', 'geoPoint': {'lat': 50.03437, 'lon': 19.21037}}, {'city': 'Poznan', 'country': 'Poland', 'facility': 'Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu', 'geoPoint': {'lat': 52.40692, 'lon': 16.92993}}, {'city': 'Skierniewice', 'country': 'Poland', 'facility': 'ETG Skierniewice', 'geoPoint': {'lat': 51.95485, 'lon': 20.15837}}, {'city': 'Staszów', 'country': 'Poland', 'facility': 'KO-MED Centra Kliniczne Staszow', 'geoPoint': {'lat': 50.56307, 'lon': 21.16593}}, {'city': 'Szczecin', 'country': 'Poland', 'facility': 'Twoja Przychodnia - SCM', 'geoPoint': {'lat': 53.42894, 'lon': 14.55302}}, {'city': 'Torun', 'country': 'Poland', 'facility': 'GASTROMED Kopoń, Zmudziński i Wspólnicy spółka jawna, Specjalistyczne Centrum Gastrologii i Endoskopii, Specjalistyczne Gabinety Lekarskie', 'geoPoint': {'lat': 53.01375, 'lon': 18.59814}}, {'city': 'Warsaw', 'country': 'Poland', 'facility': 'Bodyclinic sp. z o.o. sp.k.', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'city': 'Warsaw', 'country': 'Poland', 'facility': 'Centralny Szpital Kliniczny MSWiA w Warszawie', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'city': 'Warsaw', 'country': 'Poland', 'facility': 'Centrum Zdrowia Matki, Dziecka i Mlodziezy', 'geoPoint': {'lat': 52.22977, 'lon': 21.01178}}, {'city': 'Wroclaw', 'country': 'Poland', 'facility': 'PlanetMed', 'geoPoint': {'lat': 51.10286, 'lon': 17.03006}}, {'city': 'Zamość', 'country': 'Poland', 'facility': 'ETG Zamosc', 'geoPoint': {'lat': 50.72314, 'lon': 23.25196}}, {'city': 'Amadora', 'country': 'Portugal', 'facility': 'Hospital Prof. Doutor Fernando Fonseca (HFF) (Hospital Amadora Sintra)', 'geoPoint': {'lat': 38.75382, 'lon': -9.23083}}, {'city': 'Braga', 'country': 'Portugal', 'facility': 'Hospital de Braga', 'geoPoint': {'lat': 41.5514, 'lon': -8.42311}}, {'city': 'Loures', 'country': 'Portugal', 'facility': 'Hospital Beatriz Angelo (HBA)', 'geoPoint': {'lat': 38.83091, 'lon': -9.16845}}, {'city': 'Santa Maria da Feira', 'country': 'Portugal', 'facility': 'Centro Hospitalar de Entre o Douro e Vouga (CHEDV)- Hospital São Sebastião', 'geoPoint': {'lat': 40.92726, 'lon': -8.54839}}, {'city': 'Bucharest', 'country': 'Romania', 'facility': 'Sana Monitoring', 'geoPoint': {'lat': 44.43225, 'lon': 26.10626}}, {'city': 'Bucharest', 'country': 'Romania', 'facility': 'Spitalul Clinic Colentina', 'geoPoint': {'lat': 44.43225, 'lon': 26.10626}}, {'city': 'Cluj-Napoca', 'country': 'Romania', 'facility': 'Spitalul Clinic Judetean de Urgenta Cluj-Napoca', 'geoPoint': {'lat': 46.76667, 'lon': 23.6}}, {'city': 'Iași', 'country': 'Romania', 'facility': 'Spitalul Clinic Judetean de Urgenta "Sf. Spiridon" Iasi', 'geoPoint': {'lat': 47.16667, 'lon': 27.6}}, {'city': 'Târgu Mureş', 'country': 'Romania', 'facility': 'Spitalul Clinic Judetean Mures', 'geoPoint': {'lat': 46.54245, 'lon': 24.55747}}, {'city': 'Timișoara', 'country': 'Romania', 'facility': 'Cabinet Particular Policlinic Algomed', 'geoPoint': {'lat': 45.75372, 'lon': 21.22571}}, {'city': 'Belgrade', 'country': 'Serbia', 'facility': 'Clinic Center of Serbia', 'geoPoint': {'lat': 44.80401, 'lon': 20.46513}}, {'city': 'Belgrade', 'country': 'Serbia', 'facility': 'Clinical Hospital Center "Dr. Dragisa Misovic"', 'geoPoint': {'lat': 44.80401, 'lon': 20.46513}}, {'city': 'Belgrade', 'country': 'Serbia', 'facility': 'Euromedik Hospital', 'geoPoint': {'lat': 44.80401, 'lon': 20.46513}}, {'city': 'Belgrade', 'country': 'Serbia', 'facility': 'Zvezdara University Medical Center', 'geoPoint': {'lat': 44.80401, 'lon': 20.46513}}, {'city': 'Kragujevac', 'country': 'Serbia', 'facility': 'Clinical Center Kragujevac - Center for Gastroenterohepatology', 'geoPoint': {'lat': 44.01667, 'lon': 20.91667}}, {'city': 'Zrenjanin', 'country': 'Serbia', 'facility': 'General Hospital Dr Djordje Joanovic', 'geoPoint': {'lat': 45.38361, 'lon': 20.38194}}, {'city': 'Zrenjanin', 'country': 'Serbia', 'facility': 'General hospital Zrenjanin', 'geoPoint': {'lat': 45.38361, 'lon': 20.38194}}, {'city': 'Banská Bystrica', 'country': 'Slovakia', 'facility': 'FNsP F.D.R. Banska Bystrica', 'geoPoint': {'lat': 48.73947, 'lon': 19.14932}}, {'city': 'Bratislava', 'country': 'Slovakia', 'facility': 'CLINIQ s.r.o.', 'geoPoint': {'lat': 48.14816, 'lon': 17.10674}}, {'city': 'Košice', 'country': 'Slovakia', 'facility': 'ENDOMED s.r.o.', 'geoPoint': {'lat': 48.71441, 'lon': 21.25802}}, {'city': 'Nové Zámky', 'country': 'Slovakia', 'facility': 'GASTROMEDIC, s.r.o.', 'geoPoint': {'lat': 47.98544, 'lon': 18.16195}}, {'city': 'Šahy', 'country': 'Slovakia', 'facility': 'Accout Center s.r.o.', 'geoPoint': {'lat': 48.07408, 'lon': 18.94946}}, {'city': 'Busan', 'country': 'South Korea', 'facility': 'Inje University Haeundae Paik Hospital', 'geoPoint': {'lat': 35.10168, 'lon': 129.03004}}, {'city': 'Daegu', 'country': 'South Korea', 'facility': 'Kyungpook National University Hospital', 'geoPoint': {'lat': 35.87028, 'lon': 128.59111}}, {'city': 'Guri-si', 'country': 'South Korea', 'facility': 'Hanyang University Guri Hospital', 'geoPoint': {'lat': 37.5986, 'lon': 127.1394}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Kyung Hee University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Seoul National University Bundang Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Seoul National University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Soeul', 'country': 'South Korea', 'facility': 'Kyung Hee University Hospital - Internal Medicine', 'geoPoint': {'lat': 36.9168, 'lon': 126.7319}}, {'city': 'Soeul', 'country': 'South Korea', 'facility': 'Kyung Hee University Hospital', 'geoPoint': {'lat': 36.9168, 'lon': 126.7319}}, {'city': 'Suwon', 'country': 'South Korea', 'facility': "The Catholic University of Korea, St. Vincent's Hospital", 'geoPoint': {'lat': 37.29111, 'lon': 127.00889}}, {'city': 'Wŏnju', 'country': 'South Korea', 'facility': 'Yonsei University, Wonju Severance Christian Hospital', 'geoPoint': {'lat': 37.35139, 'lon': 127.94528}}, {'city': 'Örebro', 'country': 'Sweden', 'facility': 'Örebro Univ. Hospital', 'geoPoint': {'lat': 59.27412, 'lon': 15.2066}}, {'city': 'Stockholm', 'country': 'Sweden', 'facility': 'Karolinska Universitetssjukhuset - Gastroenterology', 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'city': 'Uppsala', 'country': 'Sweden', 'facility': 'Uppsala University Hospital, Akademiska', 'geoPoint': {'lat': 59.85882, 'lon': 17.63889}}, {'city': 'Ankara', 'country': 'Turkey (Türkiye)', 'facility': 'Hacettepe University Medical Faculty - Hematology', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'city': 'Istanbul', 'country': 'Turkey (Türkiye)', 'facility': 'Istanbul University Medical Faculty', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'city': 'Mersin', 'country': 'Turkey (Türkiye)', 'facility': 'Mersin Universtiy Medical Faculty', 'geoPoint': {'lat': 36.81196, 'lon': 34.63886}}, {'city': 'Bury', 'country': 'United Kingdom', 'facility': 'Northern Care Alliance NHS Foundation Trust-Fairfield General Hospital - Gastroenterology', 'geoPoint': {'lat': 53.6, 'lon': -2.3}}, {'city': 'Coventry', 'country': 'United Kingdom', 'facility': 'Accellacare Warwickshire Quality Research Site', 'geoPoint': {'lat': 52.40656, 'lon': -1.51217}}, {'city': 'Darlington', 'country': 'United Kingdom', 'facility': 'County Durham and Darlington NHS Foundation Trust (CDDFT) - Darlington Memorial Hospital', 'geoPoint': {'lat': 54.52429, 'lon': -1.55039}}, {'city': 'Glasgow', 'country': 'United Kingdom', 'facility': 'Glasgow Royal Infirmary', 'geoPoint': {'lat': 55.86515, 'lon': -4.25763}}, {'city': 'Harrow', 'country': 'United Kingdom', 'facility': 'North West London Hospitals NHS Trust', 'geoPoint': {'lat': 51.57835, 'lon': -0.33208}}, {'city': 'London', 'country': 'United Kingdom', 'facility': 'Central Middlesex Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'city': 'London', 'country': 'United Kingdom', 'facility': 'Kings College Hospital', 'geoPoint': {'lat': 51.50853, 'lon': -0.12574}}, {'city': 'Northwood', 'country': 'United Kingdom', 'facility': 'Accellacare North London', 'geoPoint': {'lat': 51.61162, 'lon': -0.42454}}, {'city': 'Orpington', 'country': 'United Kingdom', 'facility': 'Accellacare Limited/Accellacare of South London', 'geoPoint': {'lat': 51.37457, 'lon': 0.09785}}, {'city': 'Reading', 'country': 'United Kingdom', 'facility': 'Royal Berkshire Hospital', 'geoPoint': {'lat': 51.45625, 'lon': -0.97113}}], 'overallOfficials': [{'name': 'Raja Atreya, Professor', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Friedrich-Alexander University Erlangen-Nuremberg'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'InDex Pharmaceuticals', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}