Ignite Creation Date:
2025-12-24 @ 5:30 PM
Ignite Modification Date:
2025-12-28 @ 4:05 AM
Study NCT ID:
NCT05270668
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-10-17
First Post:
2022-02-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D045743', 'term': 'Scleroderma, Diffuse'}, {'id': 'D017563', 'term': 'Lung Diseases, Interstitial'}], 'ancestors': [{'id': 'D012595', 'term': 'Scleroderma, Systemic'}, {'id': 'D003240', 'term': 'Connective Tissue Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 154}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2022-03-29', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-07', 'completionDateStruct': {'date': '2029-07-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-10-15', 'studyFirstSubmitDate': '2022-02-27', 'studyFirstSubmitQcDate': '2022-03-07', 'lastUpdatePostDateStruct': {'date': '2025-10-17', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2022-03-08', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-04-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Participants who Experience an Adverse Event (AE)', 'timeFrame': 'Up to Week 50', 'description': 'An AE is any untoward medical occurrence associated with the use of a drug in humans, whether or not considered drug related. The number of participants who experience an AE will be reported.'}, {'measure': 'Number of Participants who Experience a Serious Adverse Event (SAE)', 'timeFrame': 'Up to Week 50', 'description': 'An AE is any untoward medical occurrence associated with the use of a drug in humans, whether or not considered drug related. The number of participants who experience an SAE will be reported.'}, {'measure': 'Number of Participants who Discontinue due to an AE', 'timeFrame': 'Up to Week 50', 'description': 'An AE is any untoward medical occurrence associated with the use of a drug in humans, whether or not considered drug related. The number of participants who discontinue due to an AE will be reported.'}, {'measure': 'Change from Baseline in the Annual Rate of Change in Forced Vital Capacity (FVC) at Week 50', 'timeFrame': 'Baseline and up to Week 50', 'description': 'FVC, as measured in milliliters by spirometry, is the amount of air forcibly exhaled from the lungs after taking the deepest breath possible.'}], 'secondaryOutcomes': [{'measure': 'Change from Baseline in FVC at Week 50', 'timeFrame': 'Baseline and Week 50', 'description': 'FVC, as measured in milliliters by spirometry, is the amount of air forcibly exhaled from the lungs after taking the deepest breath possible.'}, {'measure': 'Change from Baseline in High-Resolution Computer Tomography (HRCT) Quantitative Interstitial Lung Disease - Whole Lung (QILD-WL) at Week 50', 'timeFrame': 'Baseline and Week 50', 'description': 'QILD-WL will be measured as percent lung involvement using HRCT.'}, {'measure': 'Percentage of Participants with an Improvement in the Revised Composite Response Index in Systemic Sclerosis (CRISS) Score at Week 50', 'timeFrame': 'Baseline and Week 50', 'description': 'The Revised CRISS is a two-step process designed to evaluate the likelihood of improvement in early SSc. The first step assesses worsening or incident cases of internal organ involvement (scleroderma renal crisis, pulmonary arterial hypertension, congestive heart failure, ILD, severe gastrointestinal dysmotility requiring parenteral or enteral nutrition, and digital ischemia requiring hospitalization, gangrene, or amputation). The second step assesses changes from baseline in five core set measures: modified Rodnan skin score (mRSS), percent predicted forced vital capacity (FVC%), health assessment questionnaire-disability index (HAQ-DI), patient (PGA), and physician (PhGA) global assessments.'}, {'measure': 'Change from Baseline in Health Assessment Questionnaire Disability Index (HAQ-DI) at Week 50', 'timeFrame': 'Baseline and Week 50', 'description': 'HAQ is an instrument to assess physical function. It consists of 20 questions, covering eight types of activities. For each question, scores range from 0 to 3 (0 = without any difficulty; 1 = with some difficulty; 2 = with much difficulty or with assistance; 3 = unable to do). HAQ Disability Index (HAQ-DI) score is the average of the highest score in each of the eight categories.'}, {'measure': 'Change from Baseline in Living with Pulmonary Fibrosis (L-PF) Quality of Life (QoL) Outcome at Week 50', 'timeFrame': 'Baseline and Week 50', 'description': 'The L-PF is a questionnaire designed to assess the quality of life of patients with pulmonary fibrosis. It contains 44 questions (items) split into two modules, 23 which assess symptoms (including shortness of breath, cough, and fatigue) and 21 which assess impacts to quality of life. Individual items are scored on a 5-point scale (0 = Not at All to 4 = Extremely). Overall scores range from 0 to 100 with higher scores indicating a greater impairment.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isUnapprovedDevice': True, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'keywords': ['ATHENA SSc-ILD', 'ATHENA', 'Diffuse Cutaneous Scleroderma', 'Interstitial Lung Disease'], 'conditions': ['Diffuse Cutaneous Systemic Sclerosis', 'Interstitial Lung Disease']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://www.merckclinicaltrials.com', 'label': 'Merck Clinical Trials Information'}, {'url': 'https://msd.trialsummaries.com/Study/StudyDetails?id=26198&tenant=MT_MSD_9011', 'label': 'Plain Language Summary'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to assess the safety and efficacy of tulisokibart in participants with SSc-ILD.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Has confirmed diagnosis of systemic sclerosis with onset of disease ≤ 5 years ago.\n* Has diffuse cutaneous scleroderma\n* Has systemic sclerosis related interstitial lung disease confirmed by HRCT\n* FVC ≥ 45% of predicted normal\n* Diffusing capacity of lung for carbon monoxide (DLCO)≥ 45% of predicted normal\n* If on background therapy, meets stable dosing requirements for nintedanib, mycophenolate mofetil (MMF), methotrexate (MTX) OR azathioprine, and corticosteroids\n* Women of childbearing potential are eligible to participate if not pregnant or breastfeeding and either willing to use an acceptable contraceptive method or sexually abstinent\n* Able to provide written informed consent and understand and comply with the requirements of the study\n\nExclusion Criteria:\n\n* Has an airway obstruction per pulmonary function test (PFT) or clinically significant pulmonary arterial hypertension\n* Has current clinical diagnosis of another inflammatory connective tissue disease\n* Has any active infections, a serious infection within the past 3 months, or chronic bacterial infection\n* Is a current smoker or smoking within 6 months of screening\n* Has any concomitant medical conditions that, in the opinion of the investigator, might place them in unacceptable risk for participation in the study\n* Meets the protocol criteria for important laboratory exclusion criteria'}, 'identificationModule': {'nctId': 'NCT05270668', 'acronym': 'ATHENA-SSc-ILD', 'briefTitle': 'Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)', 'organization': {'class': 'INDUSTRY', 'fullName': 'Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)'}, 'officialTitle': 'A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-7240/PRA023 in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD)', 'orgStudyIdInfo': {'id': '7240-007'}, 'secondaryIdInfos': [{'id': 'PR200-104', 'type': 'OTHER', 'domain': 'PrometheusBio'}, {'id': 'MK-7240-007', 'type': 'OTHER', 'domain': 'MSD'}, {'id': '2023-509743-27-00', 'type': 'REGISTRY', 'domain': 'EU CT'}, {'id': 'U1111-1309-6150', 'type': 'REGISTRY', 'domain': 'UTN'}, {'id': '2021-005206-10', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Tulisokibart', 'description': 'Tulisokibart IV administered by IV infusion', 'interventionNames': ['Drug: Tulisokibart', 'Diagnostic Test: Companion diagnostic ( CDx)']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'Placebo administered by IV infusion', 'interventionNames': ['Diagnostic Test: Companion diagnostic ( CDx)', 'Drug: Placebo']}], 'interventions': [{'name': 'Tulisokibart', 'type': 'DRUG', 'otherNames': ['PRA023', 'MK-7240'], 'description': 'Tulisokibart administered at timepoints as directed by the protocol', 'armGroupLabels': ['Tulisokibart']}, {'name': 'Companion diagnostic ( CDx)', 'type': 'DIAGNOSTIC_TEST', 'description': 'CDx+ or CDx-', 'armGroupLabels': ['Placebo', 'Tulisokibart']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '85054', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Mayo Clinic - Scottsdale ( Site 4014)', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90045', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Pacific Arthritis Care Center ( Site 4008)', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Cedars Sinai Medical Center ( Site 4010)', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90095-1670', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'UCLA School of Medicine ( Site 4006)', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94304', 'city': 'Palo Alto', 'state': 'California', 'country': 'United States', 'facility': 'Stanford Health Care ( Site 4009)', 'geoPoint': {'lat': 37.44188, 'lon': -122.14302}}, {'zip': '80206', 'city': 'Denver', 'state': 'Colorado', 'country': 'United States', 'facility': 'National Jewish Health Medical Center ( Site 4015)', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '06519', 'city': 'New Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Yale University ( Site 4017)', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '20007', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'MedStar Georgetown University Hospital ( Site 4005)', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '21224', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'facility': 'Johns Hopkins Asthma and Allergy Center [Baltimore, MD] ( Site 4018)', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Massachusetts General Hospital ( Site 4003)', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02118', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Boston University School of Medicine ( Site 4021)', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'University of Michigan Hospital ( Site 4001)', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '08901', 'city': 'New Brunswick', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Rutgers Robert Wood Johnson Medical School ( Site 4013)', 'geoPoint': {'lat': 40.48622, 'lon': -74.45182}}, {'zip': '10021', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Hospital For Special Surgery ( Site 4020)', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '44195', 'city': 'Cleveland', 'state': 'Ohio', 'country': 'United States', 'facility': 'Cleveland Clinic Foundation ( Site 4019)', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '43614', 'city': 'Toledo', 'state': 'Ohio', 'country': 'United States', 'facility': 'University of Toledo Medical Center ( Site 4002)', 'geoPoint': {'lat': 41.66394, 'lon': -83.55521}}, {'zip': '15213', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pittsburgh Medical Center ( Site 4016)', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '29425', 'city': 'Charleston', 'state': 'South Carolina', 'country': 'United States', 'facility': 'Medical University of South Carolina - PPDS ( Site 4004)', 'geoPoint': {'lat': 32.77632, 'lon': -79.93275}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'UT Physicians Rheumatology ( Site 4007)', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '53226', 'city': 'Milwaukee', 'state': 'Wisconsin', 'country': 'United States', 'facility': 'Froedtert and Medical College of Wisconsin ( Site 4012)', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': 'C1426ABP', 'city': 'CABA', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Consultorios Médicos Dr. Doreski ( Site 4800)'}, {'zip': '1605', 'city': 'Munro', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Clínica Privada Independencia ( Site 4802)', 'geoPoint': {'lat': -34.53021, 'lon': -58.52421}}, {'zip': '5800', 'city': 'Río Cuarto', 'state': 'Córdoba Province', 'country': 'Argentina', 'facility': 'Centro de Investigación Instituto Médico Río Cuarto ( Site 4801)', 'geoPoint': {'lat': -33.13044, 'lon': -64.35272}}, {'zip': 'S2000CEJ', 'city': 'Rosario', 'state': 'Santa Fe Province', 'country': 'Argentina', 'facility': 'Instituto Medico de la Fundacion Estudios Clinicos ( Site 4803)', 'geoPoint': {'lat': -32.94682, 'lon': -60.63932}}, {'zip': '5000', 'city': 'Adelaide', 'state': 'South Australia', 'country': 'Australia', 'facility': 'Royal Adelaide Hospital ( Site 4050)', 'geoPoint': {'lat': -34.92866, 'lon': 138.59863}}, {'zip': '3065', 'city': 'Melbourne', 'state': 'Victoria', 'country': 'Australia', 'facility': 'St Vincents Hospital Melbourne ( Site 4051)', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': '9000', 'city': 'Ghent', 'state': 'Oost-Vlaanderen', 'country': 'Belgium', 'facility': 'UZ Gent ( Site 4401)', 'geoPoint': {'lat': 51.05, 'lon': 3.71667}}, {'zip': '3000', 'city': 'Leuven', 'state': 'Vlaams-Brabant', 'country': 'Belgium', 'facility': 'UZ Leuven ( Site 4402)', 'geoPoint': {'lat': 50.87959, 'lon': 4.70093}}, {'zip': '4000', 'city': 'Liège', 'state': 'Wallonne, Region', 'country': 'Belgium', 'facility': 'CHU de Liege ( Site 4400)', 'geoPoint': {'lat': 50.63373, 'lon': 5.56749}}, {'zip': 'T6G 1W9', 'city': 'Edmonton', 'state': 'Alberta', 'country': 'Canada', 'facility': 'University Of Alberta Hospital ( Site 4702)', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'zip': 'N6A 4V2', 'city': 'London', 'state': 'Ontario', 'country': 'Canada', 'facility': "St. Joseph's Health Care London ( Site 4701)", 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'M5T 3L9', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Mount Sinai Hospital [Toronto, Canada] ( Site 4700)', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': '8320000', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'country': 'Chile', 'facility': 'BIOCINETIC Ltda ( Site 4854)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '8330034', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'country': 'Chile', 'facility': 'Centro de Investigacion Clinica UC CICUC ( Site 4855)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '8420383', 'city': 'Santiago', 'state': 'Region M. de Santiago', 'country': 'Chile', 'facility': 'Centro Internacional de Estudios Clinicos CIEC ( Site 4851)', 'geoPoint': {'lat': -33.45694, 'lon': -70.64827}}, {'zip': '7640881', 'city': 'Vitacura', 'state': 'Region M. de Santiago', 'country': 'Chile', 'facility': 'Clinica Dermacross ( Site 4853)', 'geoPoint': {'lat': -33.39227, 'lon': -70.58275}}, {'zip': '4780000', 'city': 'Temuco', 'state': 'Región de la Araucanía', 'country': 'Chile', 'facility': 'Centro de especialidades médicas Vanguardia ( Site 4850)', 'geoPoint': {'lat': -38.73628, 'lon': -72.59738}}, {'zip': '2520598', 'city': 'Viña del Mar', 'state': 'Región de Valparaíso', 'country': 'Chile', 'facility': 'ONCOCENTRO APYS ( Site 4852)', 'geoPoint': {'lat': -33.02457, 'lon': -71.55183}}, {'zip': '33076', 'city': 'Bordeaux', 'state': 'Nord', 'country': 'France', 'facility': 'CHU de Bordeaux. Hopital Pellegrin ( Site 4202)', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}, {'zip': '59000', 'city': 'Lille', 'state': 'Nord', 'country': 'France', 'facility': 'Hôpital Claude Huriez ( Site 4200)', 'geoPoint': {'lat': 50.63391, 'lon': 3.05512}}, {'zip': '75679', 'city': 'Paris', 'country': 'France', 'facility': 'Hopital Cochin ( Site 4203)', 'geoPoint': {'lat': 48.85341, 'lon': 2.3488}}, {'zip': '79106', 'city': 'Freiburg im Breisgau', 'state': 'Baden-Wurttemberg', 'country': 'Germany', 'facility': 'Universitaetsklinikum Freiburg ( Site 4152)', 'geoPoint': {'lat': 47.9959, 'lon': 7.85222}}, {'zip': '61231', 'city': 'Bad Nauheim', 'state': 'Hesse', 'country': 'Germany', 'facility': 'Kerckhoff-Klinik-Forschungs-GmbH ( Site 4153)', 'geoPoint': {'lat': 50.36463, 'lon': 8.73859}}, {'zip': '18209', 'city': 'Hohenfelde B Bad Doberan', 'state': 'Mecklenburg-Vorpommern', 'country': 'Germany', 'facility': 'Rheumazentrum am Krankenhaus Bad Doberan ( Site 4150)'}, {'zip': '50937', 'city': 'Cologne', 'state': 'North Rhine-Westphalia', 'country': 'Germany', 'facility': 'Universitaetsklinikum Koeln ( Site 4151)', 'geoPoint': {'lat': 50.93333, 'lon': 6.95}}, {'zip': '7632', 'city': 'Pécs', 'state': 'Baranya', 'country': 'Hungary', 'facility': 'Pecsi Tudomanyegyetem AOK ( Site 4250)', 'geoPoint': {'lat': 46.07617, 'lon': 18.22814}}, {'zip': '1023', 'city': 'Budapest', 'country': 'Hungary', 'facility': 'Budai Irgalmasrendi Korhaz ( Site 4252)', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '1097', 'city': 'Budapest', 'country': 'Hungary', 'facility': 'Del-pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet ( Site 4253)', 'geoPoint': {'lat': 47.49835, 'lon': 19.04045}}, {'zip': '4032', 'city': 'Debrecen', 'country': 'Hungary', 'facility': 'Debreceni Egyetem Klinikai Kozpont ( Site 4251)', 'geoPoint': {'lat': 47.53167, 'lon': 21.62444}}, {'zip': '3109601', 'city': 'Haifa', 'country': 'Israel', 'facility': 'Rambam Medical Center ( Site 4601)', 'geoPoint': {'lat': 32.81303, 'lon': 34.99928}}, {'zip': '4428164', 'city': 'Kfar Saba', 'country': 'Israel', 'facility': 'Meir Medical Center. ( Site 4604)', 'geoPoint': {'lat': 32.175, 'lon': 34.90694}}, {'zip': '2210001', 'city': 'Nahariya', 'country': 'Israel', 'facility': 'Galilee Medical Center ( Site 4602)', 'geoPoint': {'lat': 33.00892, 'lon': 35.09814}}, {'zip': '49100', 'city': 'Petach Tikvah', 'country': 'Israel', 'facility': 'Rabin Medical Center ( Site 4603)'}, {'zip': '5265601', 'city': 'Ramat Gan', 'country': 'Israel', 'facility': 'Sheba Medical Center ( Site 4605)', 'geoPoint': {'lat': 32.08227, 'lon': 34.81065}}, {'zip': '6423906', 'city': 'Tel Aviv', 'country': 'Israel', 'facility': 'Tel Aviv Sourasky Medical Center ( Site 4606)', 'geoPoint': {'lat': 32.08088, 'lon': 34.78057}}, {'zip': '10126', 'city': 'Turin', 'state': 'Piedmont', 'country': 'Italy', 'facility': 'A.O.U. Citta della Salute e della Scienza di Torino ( Site 4304)', 'geoPoint': {'lat': 45.07049, 'lon': 7.68682}}, {'zip': '50141', 'city': 'Florence', 'country': 'Italy', 'facility': 'Azienda Ospedaliera Universitaria Careggi ( Site 4301)', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'zip': '16132', 'city': 'Genova', 'country': 'Italy', 'facility': 'Ospedale Policlinico San Martino ( Site 4305)', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'zip': '20122', 'city': 'Milan', 'country': 'Italy', 'facility': 'IRCCS Osp. 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