Ignite Creation Date:
2025-12-24 @ 5:12 PM
Ignite Modification Date:
2025-12-26 @ 3:15 PM
Study NCT ID:
NCT06208150
Status:
RECRUITING
Last Update Posted:
2025-12-19
First Post:
2024-01-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D009101', 'term': 'Multiple Myeloma'}], 'ancestors': [{'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000730985', 'term': 'talquetamab'}, {'id': 'C467566', 'term': 'pomalidomide'}, {'id': 'C546027', 'term': 'elotuzumab'}, {'id': 'D003907', 'term': 'Dexamethasone'}, {'id': 'D000069286', 'term': 'Bortezomib'}], 'ancestors': [{'id': 'D011246', 'term': 'Pregnadienetriols'}, {'id': 'D011245', 'term': 'Pregnadienes'}, {'id': 'D011278', 'term': 'Pregnanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D013259', 'term': 'Steroids, Fluorinated'}, {'id': 'D001897', 'term': 'Boronic Acids'}, {'id': 'D000148', 'term': 'Acids, Noncarboxylic'}, {'id': 'D000143', 'term': 'Acids'}, {'id': 'D007287', 'term': 'Inorganic Chemicals'}, {'id': 'D001896', 'term': 'Boron Compounds'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D011719', 'term': 'Pyrazines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 795}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-01-22', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-03-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-18', 'studyFirstSubmitDate': '2024-01-05', 'studyFirstSubmitQcDate': '2024-01-05', 'lastUpdatePostDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-01-17', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-04-23', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression Free Survival (PFS)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'PFS is defined as the duration from the date of randomization to either progressive disease or death, whichever comes first.'}], 'secondaryOutcomes': [{'measure': 'Overall Response Rate (ORR)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'ORR is defined as the percentage of participants with best overall response of partial response (PR) or better according to international myeloma working group (IMWG) response criteria.'}, {'measure': 'Complete Response (CR) or Better Rate', 'timeFrame': 'Up to 3 years 5 months', 'description': 'CR or better is defined as the percentage of participants with best overall response of CR or better according to IMWG response criteria.'}, {'measure': 'Very Good Partial Response (VGPR) or Better Rate', 'timeFrame': 'Up to 3 years 5 months', 'description': 'VGPR or better is defined as the percentage of participants with best overall response of VGPR or better rate according to IMWG response criteria.'}, {'measure': 'Minimal Residual Disease (MRD)-negative CR Rate', 'timeFrame': 'Up to 3 years 5 months', 'description': 'MRD-negative CR is defined as the percentage of participants who achieve both CR or better and MRD negativity at a threshold of 10\\^-5 at any timepoint after the date of randomization and before disease progression or start of subsequent antimyeloma therapy (SST).'}, {'measure': 'Overall Survival (OS)', 'timeFrame': 'Up to 3 years 5 months', 'description': "OS is defined as the time from randomization to the date of participant's death."}, {'measure': 'Progression Free Survival on Next-line Therapy (PFS2)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'PFS2 is defined as time from randomization to progression on the next line of therapy or death, whichever comes first.'}, {'measure': 'Time to Next Treatment (TTNT)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'TTNT is defined as the time from randomization to the start of SST.'}, {'measure': 'Serum Concentration of Talquetamab and Teclistamab', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Serum concentration of talquetamab and teclistamab will be reported.'}, {'measure': 'Number of Participants with Anti-drug Antibodies (ADAs) to Talquetamab and Teclistamab', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Number of participants with ADAs to talquetamab and teclistamab will be reported.'}, {'measure': 'Time to Sustained Worsening in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by Multiple Myeloma Symptom and Impact Questionnaire (MySIm-Q)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Time to sustained worsening in symptoms, functioning and HRQoL is defined as the interval from the date of randomization to the start date of meaningful change. The MySIm-Q is a disease-specific patient-reported outcome (PRO) assessment complementary to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC-QLQ-C30). It includes 17 items resulting in a symptom subscale and an impact subscale.'}, {'measure': 'Time to Sustained Worsening in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by EORTC-QLQ-C30', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Time to sustained worsening in symptoms, functioning and HRQoL is defined as the interval from the date of randomization to the start date of meaningful change. EORTC-QLQ-C30 Version 3 includes 30 items that make up 5 functional scales (physical role, emotional, cognitive, and social), 1 global health status scale, 3 symptom scales (pain, fatigue, and nausea or vomiting), and 5 single symptom items (dyspnea, insomnia, appetite loss, constipation, and diarrhea) and a single impact item (financial difficulties). The recall period is 7 days ("past week"), and responses are reported using a verbal and numeric rating scales. The item and scale scores are transformed to a 0 to 100 scale. A high scale score represents a higher response level.'}, {'measure': 'Time to Sustained Worsening in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by EuroQol Five Dimension Questionnaire 5-Level (EQ-5D-5L)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Time to sustained worsening in symptoms, functioning and HRQoL is defined as the interval from the date of randomization to the start date of meaningful change. The EQ-5D-5L is a 5-item questionnaire that assesses 5 domains including mobility, self-care, usual activities, pain or discomfort, and anxiety or depression plus a visual analog scale rating "health today" with anchors ranging from 0 (worst imaginable health state) to 100 (best imaginable health state).'}, {'measure': 'Time to Sustained Worsening in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by Patient Global Impression -Severity (PGI-S)', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Time to sustained worsening in symptoms, functioning and HRQoL is defined as the interval from the date of randomization to the start date of meaningful change. The PGI-S will be used as an anchor, external criterion, to determine meaningful change in scores for the MySIm-Q and EORTC-QLQ-C30 in this population. The response options are presented as a 5-point verbal rating scale from "none" to "very severe."'}, {'measure': 'Time to Sustained Worsening in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by Epstein Taste Survey', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Time to sustained worsening in symptoms, functioning and HRQoL is defined as the interval from the date of randomization to the start date of meaningful change. The epstein taste survey consists of 17 items from the full 71 item PRO instrument, specific to taste changes developed for use in patients with head and neck cancer as a composite of the Vanderbilt Head and Neck Symptom Survey.'}, {'measure': 'Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by MySIm-Q', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Change from baseline in symptoms, functioning, and HRQoL as assessed by MySIm-Q will be reported. The MySIm-Q is a disease-specific patient-reported outcome (PRO) assessment complementary to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC-QLQ-C30). It includes 17 items resulting in a symptom subscale and an impact subscale.'}, {'measure': 'Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by EORTC-QLQ-C30', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Change from baseline in symptoms, functioning, and HRQoL as assessed by EORTC-QLQ-C30 will be reported. The EORTC-QLQ-C30 Version 3 includes 30 items that make up 5 functional scales (physical, role, emotional, cognitive, and social), 1 global health status scale, 3 symptom scales (pain, fatigue, and nausea or vomiting), and 5 single symptom items (dyspnea, insomnia, appetite loss, constipation, and diarrhea) and a single impact item (financial difficulties). The recall period is 7 days ("past week"), and responses are reported using a verbal and numeric rating scales. The item and scale scores are transformed to a 0 to 100 scale. A high scale score represents a higher response level. Thus, a high score for a functional scale represents a high or healthy level of functioning and a high score for the global health status represents high HRQoL, but a high score for a symptom scale or item represents a high level of symptomatology or problems.'}, {'measure': 'Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by EQ-5D-5L', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Change from baseline in symptoms, functioning, and HRQoL as assessed by EQ-5D-5L will be reported. The EQ-5D-5L is a 5-item questionnaire that assesses 5 domains including mobility, self-care, usual activities, pain or discomfort, and anxiety or depression plus a visual analog scale rating "health today" with anchors ranging from 0 (worst imaginable health state) to 100 (best imaginable health state).'}, {'measure': 'Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by PGI-S', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Change from baseline in symptoms, functioning, and HRQoL as assessed by PGI-S will be reported. The PGI-S will be used as an anchor, external criterion, to determine meaningful change in scores for the MySIm-Q and EORTC-QLQ-C30 in this population. The response options are presented as a 5-point verbal rating scale from "none" to "very severe."'}, {'measure': 'Change from Baseline in Symptoms, Functioning, and Health-related Quality of Life (HRQoL) as Assessed by Epstein Taste Survey', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Change from baseline in symptoms, functioning, and HRQoL as assessed by epstein taste survey will be reported. The epstein taste survey consists of 17 items from the full 71 item PRO instrument, specific to taste changes. developed for use in patients with head and neck cancer as a composite of the Vanderbilt Head and Neck Symptom Survey.'}, {'measure': 'Percentage of Participants With Meaningful Improvement in HRQoL as Assessed by EORTC-QLQ-C30', 'timeFrame': 'Up to 3 years 5 months', 'description': 'Percentage of participants with meaningful improvement in HRQol as assessed by EORTC-QLQ-C30 will be reported. The EORTC-QLQ-C30 Version 3 includes 30 items that make up 5 functional scales (physical, role, emotional, cognitive, and social), 1 global health status scale, 3 symptom scales (pain, fatigue, and nausea or vomiting), and 5 single symptom items (dyspnea, insomnia, appetite loss, constipation, and diarrhea) and a single impact item (financial difficulties). The recall period is 7 days ("past week"), and responses are reported using a verbal and numeric rating scales. The item and scale scores are transformed to a 0 to 100 scale. A high scale score represents a higher response level. Thus, a high score for a functional scale represents a high or healthy level of functioning and a high score for the global health status represents high HRQoL, but a high score for a symptom scale or item represents a high level of symptomatology or problems.'}, {'measure': 'Number of Participants with Adverse Events (AEs) by Severity', 'timeFrame': 'Up to 3 years 5 months', 'description': 'An AE is any untoward medical occurrence in a clinical study participant administered a pharmaceutical (investigational or non investigational) product. An AE does not necessarily have a causal relationship with the treatment. Severity of AEs will be graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) v5.0. by using standard grades as follows: Grade 1: Mild; asymptomatic or mild symptoms; Grade 2: Moderate; minimal, local or noninvasive intervention indicated; Grade 3: Severe but not immediately life threatening; hospitalization or prolongation of hospitalization indicated; Grade 4: Life-threatening consequences; and Grade 5: Death related to AE.'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Multiple Myeloma']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Documented multiple myeloma as defined by the criteria below: (a) multiple myeloma diagnosis according to the international myeloma working group (IMWG) diagnostic criteria (b) measurable disease at screening as assessed by central laboratory, defined by any of the following: (i) serum M-protein level greater than or equal to (\\>=) 0.5 gram per deciliter (g/dL); or (ii) urine M-protein level \\>= 200 milligram (mg) per 24 hours; or (iii) light chain multiple myeloma without measurable M-protein in the serum or the urine: serum immunoglobulin (Ig) free light chain (FLC) \\>= 10 milligrams per deciliter (mg/dL) and abnormal serum Ig kappa lambda FLC ratio\n* Relapsed or refractory disease as defined below: a) Relapsed disease is defined as an initial response to prior treatment, followed by confirmed progressive disease (PD) by IMWG criteria greater than (\\>) 60 days after cessation of treatment. b) Refractory disease is defined as less than (\\<) 25 percent (%) reduction in M-protein or confirmed PD by IMWG criteria during previous treatment or less than or equal to (\\<=) 60 days after cessation of treatment\n* Documented evidence of PD or failure to achieve a minimal response to the last line of therapy based on investigator's determination of response by IMWG criteria on or after their last regimen\n* Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 at screening and immediately prior to the start of administration of study treatment\n* A participant must agree not to be pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 6 months after the last dose of study treatment\n\nExclusion Criteria:\n\n* Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any study drug or its excipients\n* Stroke, transient ischemic attack, or seizure within 6 months prior to signing informed consent form (ICF)\n* Major surgery or had significant traumatic injury within 2 weeks prior to the start of administration of study treatment, or will not have fully recovered from surgery, or has major surgery planned during the time the participant is expected to be treated in the study or within 2 weeks after administration of the last dose of study treatment\n* A maximum cumulative dose of corticosteroids of \\>=140 mg of prednisone or equivalent within 14-day period before the first dose of study drug\n* Known active central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of multiple myeloma. If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required"}, 'identificationModule': {'nctId': 'NCT06208150', 'acronym': 'MonumenTAL-6', 'briefTitle': 'A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide', 'organization': {'class': 'INDUSTRY', 'fullName': 'Janssen Research & Development, LLC'}, 'officialTitle': "A Phase 3 Randomized Study Comparing Talquetamab in Combination With Pomalidomide (Tal-P), Talquetamab in Combination With Teclistamab (Tal-Tec), and Investigator's Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants With Relapsed or Refractory Myeloma Who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide", 'orgStudyIdInfo': {'id': '64407564MMY3009'}, 'secondaryIdInfos': [{'id': '64407564MMY3009', 'type': 'OTHER', 'domain': 'Janssen Research & Development, LLC'}, {'id': '2022-502446-27-00', 'type': 'REGISTRY', 'domain': 'EUCT number'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm A: Talquetamab + Pomalidomide (Tal-P)', 'description': 'Participants will receive talquetamab as subcutaneous (SC) injections; pomalidomide will be self-administered as a single dose orally; dexamethasone may be given orally or intravenously as a pretreatment medication and study drug.', 'interventionNames': ['Drug: Talquetamab', 'Drug: Pomalidomide', 'Drug: Dexamethasone']}, {'type': 'EXPERIMENTAL', 'label': 'Arm B: Talquetamab + Teclistamab (Tal-Tec)', 'description': 'Participants will receive teclistamab in combination with talquetamab both as SC injection; dexamethasone may be given orally or intravenously as a pretreatment medication and study drug.', 'interventionNames': ['Drug: Talquetamab', 'Drug: Teclistamab', 'Drug: Dexamethasone']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)', 'description': 'Participants will either receive elotuzumab intravenous (IV) injection in combination with pomalidomide and dexamethasone orally; or pomalidamide orally in combination with bortezomib SC injection and dexamethasone orally as per investigator choice. Dexamethasone will be administered as a pretreatment medication.', 'interventionNames': ['Drug: Pomalidomide', 'Drug: Elotuzumab', 'Drug: Dexamethasone', 'Drug: Bortezomib']}], 'interventions': [{'name': 'Talquetamab', 'type': 'DRUG', 'otherNames': ['JNJ-64407564', 'Talvey'], 'description': 'Talquetamab will be administered as a SC injection.', 'armGroupLabels': ['Arm A: Talquetamab + Pomalidomide (Tal-P)', 'Arm B: Talquetamab + Teclistamab (Tal-Tec)']}, {'name': 'Pomalidomide', 'type': 'DRUG', 'otherNames': ['Pomalyst', 'Imnovid'], 'description': 'Pomalidomide will be administered orally.', 'armGroupLabels': ['Arm A: Talquetamab + Pomalidomide (Tal-P)', 'Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)']}, {'name': 'Teclistamab', 'type': 'DRUG', 'otherNames': ['JNJ-64007957', 'Tecvayli'], 'description': 'Teclistamab will be administered as a SC injection.', 'armGroupLabels': ['Arm B: Talquetamab + Teclistamab (Tal-Tec)']}, {'name': 'Elotuzumab', 'type': 'DRUG', 'otherNames': ['Empliciti'], 'description': 'Elotuzumab will be administered intravenously.', 'armGroupLabels': ['Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)']}, {'name': 'Dexamethasone', 'type': 'DRUG', 'description': 'Dexamethasone will be administered either orally or intravenously.', 'armGroupLabels': ['Arm A: Talquetamab + Pomalidomide (Tal-P)', 'Arm B: Talquetamab + Teclistamab (Tal-Tec)', 'Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)']}, {'name': 'Bortezomib', 'type': 'DRUG', 'otherNames': ['Velcade'], 'description': 'Bortezomib will be administered as a SC injection.', 'armGroupLabels': ['Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '93611', 'city': 'Clovis', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCSF Fresno', 'geoPoint': {'lat': 36.82523, 'lon': -119.70292}}, {'zip': '90404', 'city': 'Santa Monica', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'UCLA', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '06519', 'city': 'New Haven', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Yale University School Of Medicine', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '19713', 'city': 'Newark', 'state': 'Delaware', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Medical Oncology Hematology Consultants, PA', 'geoPoint': {'lat': 39.68372, 'lon': -75.74966}}, {'zip': '33021', 'city': 'Hollywood', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Memorial Healthcare System', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '33612', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Moffitt Cancer Center', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Winship Cancer Institute Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30265', 'city': 'Newnan', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'City of Hope Cancer Center', 'geoPoint': {'lat': 33.38067, 'lon': -84.79966}}, {'zip': '83814', 'city': "Coeur d'Alene", 'state': 'Idaho', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Kootenai Health', 'geoPoint': {'lat': 47.67768, 'lon': -116.78047}}, {'zip': '50263', 'city': 'Waukee', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Iowa Health Care', 'geoPoint': {'lat': 41.61166, 'lon': -93.88523}}, {'zip': '40207', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Norton Cancer Institute', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '70808', 'city': 'Baton Rouge', 'state': 'Louisiana', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Our Lady of the Lake Hospital', 'geoPoint': {'lat': 30.44332, 'lon': -91.18747}}, {'zip': '21401', 'city': 'Annapolis', 'state': 'Maryland', 'status': 'COMPLETED', 'country': 'United States', 'facility': 'Luminis Health Center for Cancer and Blood Disorders', 'geoPoint': {'lat': 38.97859, 'lon': -76.49184}}, {'zip': '21201', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Maryland School of Medicine', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '21287', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'The Sidney Kimmel Comprehensive Cancer Center at John Hopkins', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, 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