Ignite Creation Date:
2025-12-24 @ 5:12 PM
Ignite Modification Date:
2026-02-20 @ 6:39 PM
Study NCT ID:
NCT02414750
Status:
TERMINATED
Last Update Posted:
2022-11-30
First Post:
2015-02-11
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Vemurafenib Plus Cobimetinib in Metastatic Melanoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D008545', 'term': 'Melanoma'}], 'ancestors': [{'id': 'D018358', 'term': 'Neuroendocrine Tumors'}, {'id': 'D017599', 'term': 'Neuroectodermal Tumors'}, {'id': 'D009373', 'term': 'Neoplasms, Germ Cell and Embryonal'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009380', 'term': 'Neoplasms, Nerve Tissue'}, {'id': 'D018326', 'term': 'Nevi and Melanomas'}, {'id': 'D012878', 'term': 'Skin Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077484', 'term': 'Vemurafenib'}, {'id': 'C574276', 'term': 'cobimetinib'}, {'id': 'D049268', 'term': 'Positron-Emission Tomography'}, {'id': 'D001706', 'term': 'Biopsy'}, {'id': 'D001800', 'term': 'Blood Specimen Collection'}], 'ancestors': [{'id': 'D013449', 'term': 'Sulfonamides'}, {'id': 'D000577', 'term': 'Amides'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D013450', 'term': 'Sulfones'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D007211', 'term': 'Indoles'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D014055', 'term': 'Tomography, Emission-Computed'}, {'id': 'D007090', 'term': 'Image Interpretation, Computer-Assisted'}, {'id': 'D003952', 'term': 'Diagnostic Imaging'}, {'id': 'D019937', 'term': 'Diagnostic Techniques and Procedures'}, {'id': 'D003933', 'term': 'Diagnosis'}, {'id': 'D007089', 'term': 'Image Enhancement'}, {'id': 'D010781', 'term': 'Photography'}, {'id': 'D011877', 'term': 'Radionuclide Imaging'}, {'id': 'D014054', 'term': 'Tomography'}, {'id': 'D003947', 'term': 'Diagnostic Techniques, Radioisotope'}, {'id': 'D003581', 'term': 'Cytodiagnosis'}, {'id': 'D003584', 'term': 'Cytological Techniques'}, {'id': 'D019411', 'term': 'Clinical Laboratory Techniques'}, {'id': 'D013048', 'term': 'Specimen Handling'}, {'id': 'D003949', 'term': 'Diagnostic Techniques, Surgical'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D011677', 'term': 'Punctures'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'OTHER', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 78}}, 'statusModule': {'whyStopped': 'Slow accrual and changing treatment landscape', 'overallStatus': 'TERMINATED', 'startDateStruct': {'date': '2014-12'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-11', 'completionDateStruct': {'date': '2020-11', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2022-11-24', 'studyFirstSubmitDate': '2015-02-11', 'studyFirstSubmitQcDate': '2015-04-07', 'lastUpdatePostDateStruct': {'date': '2022-11-30', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2015-04-13', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2020-11', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Progression Free survival (PFS)', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'Standardized Uptake Value (SUV) of 18F-FDG and 18F-FLT as measured by PET.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'RECIST 1.1 tumor size measurement on diagnostic CT.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'Cut-off values of metabolic tracer uptake of 18F-FDG/FLT on PET as a measure of response.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}], 'secondaryOutcomes': [{'measure': 'Diagnostic accuracy of metabolic tracer uptake on PET in responders and non-responders.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'Glycolytic Index, Metabolic Tumor Volume and % Injected Dose of 18F-FDG/FLT on PET.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'Immunohistochemical analysis of tumor tissue in responders and non-responders.', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}, {'measure': 'Changes of DNA in tumor tissue as measured by DNA deep sequencing analysis.', 'timeFrame': 'Changes from Baseline to progression, an expected median of 10 months'}, {'measure': 'Changes of RNA in tumor tissue as measured by RNA expression analysis.', 'timeFrame': 'Changes from Baseline to progression, an expected median of 10 months'}, {'measure': 'Changes of phosphoproteomic profiles in tumor tissue measured by nano-liquid chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS).', 'timeFrame': 'Changes from Baseline to progression, an expected median of 10 months'}, {'measure': 'Changes in vemurafenib and cobimetinib drug concentrations in plasma as measured by a validated Liquid Chromotography tandem Mass Spectrometry assay', 'timeFrame': 'Changes from Baseline to progression, an expected median of 10 months'}, {'measure': 'Overall Survival (OS)', 'timeFrame': '3 years'}, {'measure': 'ECOG Performance status', 'timeFrame': 'Participants will be followed until they have progressive disease based on RECIST1.1, an expected median of 10 months.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Vemurafenib/cobimetinib (GDC-0973)', 'Melanoma', 'Positron Emission Tomography', 'Tumor Characteristics', 'Response monitoring', 'Resistance prediction', 'molecular targeted therapy'], 'conditions': ['Metastatic Melanoma']}, 'referencesModule': {'references': [{'pmid': '40434500', 'type': 'DERIVED', 'citation': 'van der Hiel B, de Wit-van der Veen BJ, van den Eertwegh AJM, Vogel WV, Stokkel MPM, Lopez-Yurda M, Boellaard R, Kapiteijn EW, Hospers GAP, Aarts MJB, de Vos FYFL, Boers-Sonderen MJ, van der Veldt AAM, de Groot JWB, Haanen JBAG. Metabolic parameters on baseline and early [18F]FDG PET/CT as a predictive biomarker for resistance to BRAF/MEK inhibition in advanced cutaneous BRAFV600-mutated melanoma. EJNMMI Res. 2025 May 28;15(1):60. doi: 10.1186/s13550-025-01259-x.'}, {'pmid': '28915798', 'type': 'DERIVED', 'citation': 'van der Hiel B, Haanen JBAG, Stokkel MPM, Peeper DS, Jimenez CR, Beijnen JH, van de Wiel BA, Boellaard R, van den Eertwegh AJM; REPOSIT study group. Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter study. BMC Cancer. 2017 Sep 15;17(1):649. doi: 10.1186/s12885-017-3626-5.'}], 'seeAlsoLinks': [{'url': 'http://www.win-o.nl/', 'label': 'Site of the Netherlands Working Group on Immunotherapy of Oncology (Wino)'}]}, 'descriptionModule': {'briefSummary': 'This is a single arm explorative phase II clinical trial in 90 subjects with advanced stage melanoma harbouring a BRAFV600 mutation. PET imaging and molecular diagnostics are combined in order to monitor response to treatment with vemurafenib plus cobimetinib, examine development of resistance and correlate changes in metabolic/proliferative activity with extend of target inhibition.', 'detailedDescription': "Molecular targeted therapy with BRAF inhibitor vemurafenib is now currently used as first line treatment for patients with unresectable stage IIIc or metastatic melanoma harboring the BRAFV600 mutation, which is present in about 50% of melanoma patients. Despite the improvement in Progression Free Survival (PFS) en Overall Survival (OS) compared to dacabarzine, acquired resistance that develops in virtually all patients treated with vemurafenib is a great concern.\n\nCombining a BRAF inhibitor with a MEK inhibitor that targets the MAPK pathway further downstream, however, may overcome acquired resistance to BRAF inhibition and recent studies in which both MEK inhibitors and BRAF inhibitors are combined as monotherapy seem promising.\n\nIn a phase IB trial preliminary efficacy of vemurafenib with cobimetinib (GDC-0973), a highly selective inhibitor of MEK1 seems encouraging with an initial response rate of 85% and currently a phase III study of vemurafenib versus vemurafenib plus cobimetinib in BRAFV600 mutation positive patients with advanced stage melanoma is underway. It is expected that in the near future combined BRAF and MEK inhibition will be standard of care for patients with BRAFV600 mutated metastatic melanoma.\n\nDiagnostic CT cannot assess reduction in tumor size within days after the initiation of therapy and anatomic size does not provide information about the development of therapy response or resistance at a molecular level. It has been clearly demonstrated that alterations in metabolism occur earlier than anatomical size reduction after the initiation of therapy. Molecular imaging with PET visualizes metabolic activity in tumors and is a sensitive method to detect alterations in cell metabolism, even shortly after the start of therapy. 18F-Fluorodeoxyglucose (18F-FDG) is used to visualize glucose metabolism, whereas 18F-Fluoro-3'-deoxy-3'L-fluorothymidine (18F-FLT) is used to visualize proliferation. In preclinical mouse models 18F-FLT appears to predict response or resistance to therapy better than 18F-FDG. However, so far only 18F-FDG PET has been used to monitor response to vemurafenib in some BRAFV600 mutated metastatic melanoma patients, showing a rapid decline of 18F-FDG within 2 weeks following treatment. Preclinical studies and the observation that melanoma is a highly proliferative malignancy in most patients suggest that 18F-FLT might be the radiopharmaceutical of first choice in this setting.\n\nBy detecting these metabolic alterations, responders might be distinguished from non-responders at an earlier phase compared with anatomical imaging with CT. This way, unnecessary expensive treatment of combined BRAF/MEK-inhibitor therapy and its side effects can be prevented in patients who will not benefit from this therapy. Furthermore, the level of decline in metabolic activity in the first two weeks after the initiation of therapy might predict progression free survival (PFS) as preliminary results in literature suggest.\n\nThis is a single arm explorative phase II clinical trial in 90 subjects with advanced stage melanoma harbouring a BRAFV600 mutation. PET imaging and molecular diagnostics are combined in order to monitor response to treatment with vemurafenib plus cobimetinib, examine development of resistance and correlate changes in metabolic/proliferative activity with extend of target inhibition."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Patients with histologically confirmed melanoma, either unresectable stage IIIc or stage IV metastatic melanoma, as defined by AJCC 7th edition.\n* Patients must be naïve to treatment for locally advanced unresectable or metastatic disease. Prior immunotherapy (including ipilimumab) is allowed.\n* Documentation of BRAFV600E or BRAFV600K mutation-positive status in melanoma tumor tissue (archival or newly obtained tumor samples).\n* Measurable disease per RECIST v1.1, which are accessible to biopsies.\n* Biopsy lesion is within scan reach of diagnostic CT and PET-CT (thorax- abdomen-pelvis)\n* ECOG performance status of 0 or 1.\n* Male or female patient aged ≥ 18 years.\n* Life expectancy ≥ 12 weeks.\n* Adequate hematologic and end organ function within 14 days prior to first dose of study drug treatment.\n\nExclusion Criteria:\n\n* History of prior RAF or MEK pathway inhibitor treatment.\n* Palliative radiotherapy, major surgery or traumatic injury within 14 days prior to the first dose of study treatment.\n* Active malignancy within the past 3 years other than melanoma that could potentially interfere with the interpretation of efficacy measures, except for patients with resected BCC or SCC of the skin, melanoma in-situ, carcinoma in-situ of the cervix, and carcinoma in-situ of the breast.\n* History of or evidence of retinal pathology, clinically significant cardiac dysfunction, patients with active CNS lesions, renal or liver dysfunction as described in main protocol (REPOSIT NL48639.031.14).\n* Pregnant, lactating, or breast-feeding.\n* Unwillingness or inability to comply with study and follow-up procedures (i.e. severe anxiety disorder preventing PET/CT imaging.'}, 'identificationModule': {'nctId': 'NCT02414750', 'acronym': 'REPOSIT', 'briefTitle': 'Vemurafenib Plus Cobimetinib in Metastatic Melanoma', 'organization': {'class': 'OTHER', 'fullName': 'Netherlands Working Group on Immunotherapy of Oncology'}, 'officialTitle': 'A Phase II, Open-Label, Multicenter Study of Vemurafenib Plus Cobimetinib (GDC-0973) in Unresectable Stage IIIc or Stage IV Melanoma; Response Monitoring and Resistance Prediction With Positron Emission Tomography and Tumor Characteristics', 'orgStudyIdInfo': {'id': 'M14REP'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Treatment with BRAF/MEK inhibitor', 'description': 'Treatment with vemurafenib 2dd 960 mg 28/28 plus cobimetinib 1dd 60 mg 21/28. During treatment patient will undergo PET scanning with FLT and FDG, to compare both types of PET scanning.\n\nDuring the study biopsies and blood will be taken from the patients.', 'interventionNames': ['Drug: Vemurafenib plus cobimetinib', 'Device: Positron Emission Tomography', 'Procedure: Tissue sampling', 'Procedure: Blood sampling']}], 'interventions': [{'name': 'Vemurafenib plus cobimetinib', 'type': 'DRUG', 'otherNames': ['Zelboraf plus GDC-0973'], 'description': 'Molecular targeted therapy for BRAF mutated advanced melanoma patients', 'armGroupLabels': ['Treatment with BRAF/MEK inhibitor']}, {'name': 'Positron Emission Tomography', 'type': 'DEVICE', 'description': 'Patient will need to undergo FDG and FLT PET scanning before and during treatment, and at time of progression', 'armGroupLabels': ['Treatment with BRAF/MEK inhibitor']}, {'name': 'Tissue sampling', 'type': 'PROCEDURE', 'otherNames': ['Biopsy'], 'description': 'Before and during treatment and at time of progression patients will undergo tissue sampling of a melanoma lesion', 'armGroupLabels': ['Treatment with BRAF/MEK inhibitor']}, {'name': 'Blood sampling', 'type': 'PROCEDURE', 'description': 'Before and during treatment and at time of progression patients will undergo blood sampling', 'armGroupLabels': ['Treatment with BRAF/MEK inhibitor']}]}, 'contactsLocationsModule': {'locations': [{'zip': '1066CX', 'city': 'Amsterdam', 'country': 'Netherlands', 'facility': 'The Netherlands Cancer Institute', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'city': 'Amsterdam', 'country': 'Netherlands', 'facility': 'VU medical center', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'city': 'Enschede', 'country': 'Netherlands', 'facility': 'Medisch Spectrum Twente', 'geoPoint': {'lat': 52.21833, 'lon': 6.89583}}, {'city': 'Groningen', 'country': 'Netherlands', 'facility': 'University Medical Center Groningen', 'geoPoint': {'lat': 53.21917, 'lon': 6.56667}}, {'city': 'Leiden', 'country': 'Netherlands', 'facility': 'Leiden University Medical Center', 'geoPoint': {'lat': 52.15833, 'lon': 4.49306}}, {'city': 'Maastricht', 'country': 'Netherlands', 'facility': 'Maastricht University Medical Center', 'geoPoint': {'lat': 50.84833, 'lon': 5.68889}}, {'city': 'Nijmegen', 'country': 'Netherlands', 'facility': 'University Medical Center St Radboud', 'geoPoint': {'lat': 51.8425, 'lon': 5.85278}}, {'city': 'Rotterdam', 'country': 'Netherlands', 'facility': 'Erasmus Medical Center', 'geoPoint': {'lat': 51.9225, 'lon': 4.47917}}, {'city': 'Utrecht', 'country': 'Netherlands', 'facility': 'University Medical Center Utrecht', 'geoPoint': {'lat': 52.09083, 'lon': 5.12222}}, {'city': 'Zwolle', 'country': 'Netherlands', 'facility': 'Isala Klinieken', 'geoPoint': {'lat': 52.5125, 'lon': 6.09444}}], 'overallOfficials': [{'name': 'Fons JM Van den Eertwegh, MD PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Amsterdam UMC, location VUmc'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Netherlands Working Group on Immunotherapy of Oncology', 'class': 'OTHER'}, 'collaborators': [{'name': 'Hoffmann-La Roche', 'class': 'INDUSTRY'}, {'name': 'Amsterdam UMC, location VUmc', 'class': 'OTHER'}, {'name': 'The Netherlands Cancer Institute', 'class': 'OTHER'}], 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Medical Oncologist', 'investigatorFullName': 'A.J.M. van den Eertwegh', 'investigatorAffiliation': 'Netherlands Working Group on Immunotherapy of Oncology'}}}}